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1. Development and validation of a machine learning–based, point-of-care risk calculator for post-ERCP pancreatitis and prophylaxis selection

Author

Brenner, Todd, Kuo, Albert, Sperna Weiland, Christina J., Kamal, Ayesha, Elmunzer, B. Joseph, Luo, Hui, Buxbaum, James, Gardner, Timothy B., Mok, Shaffer S., Fogel, Evan S., Phillip, Veit, Choi, Jun-Ho, Lua, Guan W., Lin, Ching-Chung, Reddy, D. Nageshwar, Lakhtakia, Sundeep, Goenka, Mahesh K., Kochhar, Rakesh, Khashab, Mouen A., van Geenen, Erwin J.M., Singh, Vikesh K., Tomasetti, Cristian, and Akshintala, Venkata S.

Published
2025
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2. Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial

Author

Goltstein, Lia C.M.J., Grooteman, Karina V., Bernts, Lucas H.P., Scheffer, Robert C.H., Laheij, Robert J.F., Gilissen, Lennard P.L., Schrauwen, Ruud W.M., Talstra, Nynke C., Zuur, Abraham T., Braat, Henri, Hadithi, Muhammed, Brouwer, Johannes T., Nagengast, Wouter B., Oort, Frank A., Tenthof van Noorden, Jacco, Kievit, Wietske, van Geenen, Erwin J.M., and Drenth, Joost P.H.

Published
2024
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3. Rectal INdomethacin, oral TacROlimus, or their combination for the prevention of post-ERCP pancreatitis (INTRO Trial): Protocol for a randomized, controlled, double-blinded trial

Author

Akshintala, Venkata S., Husain, Sohail Z., Brenner, Todd A., Singh, Anmol, Singh, Vikesh K., Khashab, Mouen A., Sperna Weiland, Christina J., van Geenen, Erwin J.M., Bush, Nikhil, Barakat, Monique, Srivastava, Ananta, Kochhar, Rakesh, Talukdar, Rupjyoti, Rodge, Gajanan, Wu, Clement C.H., Lakhtakia, Sundeep, Sinha, Saroj K., Goenka, Mahesh K., and Reddy, D. Nageshwar

Published
2022
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4. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Published
2022
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5. The Role of Clips in Preventing Delayed Bleeding After Colorectal Polyp Resection: An Individual Patient Data Meta-Analysis

Author

Rex, Douglas K., Lim, Brian S., Kwok, Karl K., Togashi, Kazutomo, Coriat, Romain, Umar, Sarah B., Chen, Chun-Wei, Terhaar sive Droste, Jochim, Schrauwen, Ruud, Kemper, Gijs, Turan, Ayla S., Pohl, Heiko, Matsumoto, Mio, Lee, Brian S., Aizawa, Masato, Desideri, Federico, Albéniz, Eduardo, Raju, Gottumukkala S., Luba, Daniel, Barret, Maximilien, Gurudu, Suryakanth R., Ramirez, Francisco C., Lin, Wey-Ran, Atsma, Femke, Siersema, Peter D., and van Geenen, Erwin J.M.

Published
2022
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6. Recurrences of advanced sessile and lateral spreading colorectal adenoma after endoscopic mucosal resection (EMR) thermal ablation versus no adjuvant therapy (RESPECT):a protocol of an international randomized controlled trial

Author

Kemper, Gijs, Gerges, Christian, Schoon, Erik J., Schreuder, Ramon Michel, Schrauwen, Ruud R.W., Epping, Ludger S.M., Beyna, Torsten, Drenth, Joost P.H., Gündug, Ufuk, Siersema, Peter D., van Geenen, Erwin J.M., Kemper, Gijs, Gerges, Christian, Schoon, Erik J., Schreuder, Ramon Michel, Schrauwen, Ruud R.W., Epping, Ludger S.M., Beyna, Torsten, Drenth, Joost P.H., Gündug, Ufuk, Siersema, Peter D., and van Geenen, Erwin J.M.

Abstract

Background: Nowadays, large benign lateral spreading lesions (LSLs) and sessile polyps in the colorectum are mostly resected by endoscopic mucosal resection (EMR). A major drawback of EMR is the polyp recurrence rate of up to 20%. Snare tip soft coagulation (STSC) is considered an effective technique to reduce recurrence rates. However, clinical trials on STSC have mainly been conducted in expert referral centers. In these studies, polyp recurrence was assessed optically, and additional adjunctive techniques were excluded. In the current trial, we will evaluate the efficacy and safety of STSC in daily practice, by allowing adjunctive techniques during EMR and the use of both optical and histological polyp recurrence to assess recurrences during follow-up. Methods: The RESPECT study is a multicenter, parallel-group, international single blinded randomized controlled superiority trial performed in the Netherlands and Germany. A total of 306 patients undergoing piecemeal EMR for LSLs or sessile colorectal polyps sized 20–60 mm will be randomized during the procedure after endoscopic complete polyp resection to the intervention or control group. Post-EMR defects allocated to the intervention group will be treated with thermal ablation with STSC of the entire resection margin. Primary outcome will be polyp recurrence by optical and histological confirmation at the first surveillance colonoscopy after 6 months. Secondary outcomes include technical success and complication rates. Discussion: The RESPECT study will evaluate if STSC is effective in reducing recurrence rates after piecemeal EMR of large colorectal lesions in daily clinical practice performed by expert and non-expert endoscopists. Moreover, endoscopists will be allowed to use adjunctive techniques to remove remaining adenomatous tissue during the procedure. Finally, adenomatous polyp recurrence during follow-up will be defined by histologic identificat

Published
2024

8. Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial

Author

Goltstein, Lia C.M.J., primary, Grooteman, Karina V., additional, Bernts, Lucas H.P., additional, Scheffer, Robert C.H., additional, Laheij, Robert J.F., additional, Gilissen, Lennard P.L., additional, Schrauwen, Ruud W.M., additional, Talstra, Nynke C., additional, Zuur, Abraham T., additional, Braat, Henri, additional, Hadithi, Muhammed, additional, Brouwer, Johannes T., additional, Nagengast, Wouter B., additional, Oort, Frank A., additional, Tenthof van Noorden, Jacco, additional, Kievit, Wietske, additional, van Geenen, Erwin J.M., additional, and Drenth, Joost P.H., additional

Published
2023
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9. Impact of nationwide implementation of best practices in pancreatic cancer care (PACAP-1): a stepped-wedge cluster randomised controlled trial

Author

Augustinus, Simone, primary, Mackay, Tara M., additional, Latenstein, Anouk E.J., additional, van der Geest, Lydia G., additional, Bogte, Auke, additional, Bonsing, Bert A., additional, Bos, Hendrik, additional, Bosscha, Koop, additional, Borsens, Lodewijk A.A., additional, Cirkel, Geert A., additional, Hol, Lieke, additional, Busch, Olivier R.C., additional, Creemers, Geert-Jan, additional, Curvers, Wouter L., additional, Derks, Sarah, additional, Dulk, Marcel den, additional, van Dieren, Susan, additional, van Driel, Lydi M.J.W., additional, Festen, Sebastiaan, additional, van Geenen, Erwin J.M., additional, de Groot, Derk-Jan A., additional, de Groot, Jan-Willem B., additional, Koerkamp, Bas Groot, additional, Mohammad, Nadia Haj, additional, Haberkorn, Brigitte C.M., additional, Haver, Joyce T., additional, van der Harst, Erwin, additional, Hemmink, G.J. Maarten, additional, de Hingh, Ignace H., additional, Hoge, Chantal, additional, Homs, Marjolein Y.V., additional, Inderson, Akin, additional, Jacobs, Maarten A.J.M., additional, Kerver, Emile D., additional, Liem, Mike S.L., additional, Los, Maartje, additional, Lubbinge, Hans, additional, Luelmo, Saskia A.C., additional, de Meijer, Vincent E., additional, Mekenkamp, Leonie, additional, Molenaar, I. Quintus, additional, Patijn, Gijs A., additional, Quispel, Rutger, additional, Römkens, Tessa E.H., additional, van Santvoort, Hjalmar C., additional, Schreinemakers, Jennifer M.J., additional, Schut, Heidi, additional, Seerden, Tom, additional, Stommel, Martijn W.J., additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Verheij, Joanne, additional, van Vilsteren, Frederike G.I., additional, de Vos-Geelen, Judith, additional, Vulink, Annelie, additional, Wientjes, Caroline A., additional, Wit, Fennie, additional, Wessels, Frank J., additional, Zonderhuis, Babs, additional, Henri van Werkhoven, C., additional, van Hooft, Jeanin E., additional, van Eijck, Casper H.J., additional, Wilmink, Johanna W., additional, van Laarhoven, Hanneke W.M., additional, and Besselink, Marc G., additional

Published
2023
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10. Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial):study protocol for a stepped-wedge cluster-randomized controlled trial

Author

de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., van Werkhoven, Cornelis H., de Jonge, Pieter Jan F., Bruno, Marco J., Verdonk, Robert C., de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., van Werkhoven, Cornelis H., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Abstract

Background: Chronic pancreatitis (CP) is an inflammatory disease that may be complicated by abdominal pain, pancreatic dysfunction, nutritional deficiencies, and diminished bone density. Importantly, it is also associated with a substantially impaired quality of life and reduced life expectancy. This may partly be explained by suboptimal treatment, in particular the long-term management of this chronic condition, despite several national and international guidelines. Standardization of care through a structured implementation of guideline recommendations may improve the level of care and lower the complication rate of these patients. Therefore, the aim of the present study is to evaluate to what extent patient education and standardization of care, through the implementation of an evidence-based integrated management algorithm, improve quality of life and reduce pain severity in patients with CP. Methods: The COMBO trial is a nationwide stepped-wedge cluster-randomized controlled trial. In a stepwise manner, 26 centers, clustered in 6 health regions, cross-over from current practice to care according to an evidence-based integrated management algorithm. During the current practice phase, study participants are recruited and followed longitudinally through questionnaires. Individual patients contribute data to both study periods. Co-primary study endpoints consist of quality of life (assessed by the PANQOLI score) and level of pain (assessed by the Izbicki questionnaire). Secondary outcomes include process measure outcomes, clinical outcomes (e.g., pancreatic function, nutritional status, bone health, interventions, medication use), utilization of healthcare resources, (in) direct costs, and the level of social participation. Standard follow-up is 35 months from the start of the trial. Discussion: This is the first stepped-wedge cluster-randomized controlled trial to investigate whether an evidence-based integrated therapeutic approach improves quality of life and

Published
2023

11. Computed Tomography-Based Radiomics Using Tumor and Vessel Features to Assess Resectability in Cancer of the Pancreatic Head

Author

Beeldverwerking ISI, Cancer, Litjens, Geke, Broekmans, Joris P.E.A., Boers, Tim, Caballo, Marco, van den Hurk, Maud H.F., Ozdemir, Dilek, van Schaik, Caroline J., Janse, Markus H.A., van Geenen, Erwin J.M., van Laarhoven, Cees J.H.M., Prokop, Mathias, de With, Peter H.N., van der Sommen, Fons, Hermans, John J., Beeldverwerking ISI, Cancer, Litjens, Geke, Broekmans, Joris P.E.A., Boers, Tim, Caballo, Marco, van den Hurk, Maud H.F., Ozdemir, Dilek, van Schaik, Caroline J., Janse, Markus H.A., van Geenen, Erwin J.M., van Laarhoven, Cees J.H.M., Prokop, Mathias, de With, Peter H.N., van der Sommen, Fons, and Hermans, John J.

Published
2023

16. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis:An international expert survey and case vignette study

Author

de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J. Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., Verdonk, Robert C., de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J. Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Abstract

Introduction: Despite evidence-based guidelines, exocrine pancreatic insufficiency is frequently underdiagnosed and undertreated in patients with chronic pancreatitis. Therefore, the aim of this study is to provide insight into the current opinion and clinical decision-making of international pancreatologists regarding the management of exocrine pancreatic insufficiency. Methods: An online survey and case vignette study was sent to experts in chronic pancreatitis and members of various pancreatic associations: EPC, E-AHPBA and DPSG. Experts were selected based on publication record from the past 5 years. Results: Overall, 252 pancreatologists participated of whom 44% had ≥ 15 years of experience and 35% treated ≥ 50 patients with chronic pancreatitis per year. Screening for exocrine pancreatic insufficiency as part of the diagnostic work-up for chronic pancreatitis is performed by 69% and repeated annually by 21%. About 74% considers nutritional assessment to be part of the standard work-up. Patients are most frequently screened for deficiencies of calcium (47%), iron (42%), vitamin D (61%) and albumin (59%). In case of clinically steatorrhea, 71% prescribes enzyme supplementation. Of all pancreatologists, 40% refers more than half of their patients to a dietician. Despite existing guidelines, 97% supports the need for more specific and tailored instructions regarding the management of exocrine pancreatic insufficiency. Conclusion: This survey identified a lack of consensus and substantial practice variation among international pancreatologists regarding guidelines pertaining the management of exocrine pancreatic insufficiency. These results highlight the need for further adaptation of these guidelines according to current expert opinion and the level of available scientific evidence.

Published
2022

17. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction

Author

Sperna Weiland, Christina J., Busch, Celine B.E., Bhalla, Abha, Bruno, Marco J., Fockens, Paul, van Hooft, Jeanin E., Poen, Alexander C., Timmerhuis, Hester C., Umans, Devica S., Venneman, Niels G., Verdonk, Robert C., Drenth, Joost P.H., de Wijkerslooth, Thomas R., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Busch, Celine B.E., Bhalla, Abha, Bruno, Marco J., Fockens, Paul, van Hooft, Jeanin E., Poen, Alexander C., Timmerhuis, Hester C., Umans, Devica S., Venneman, Niels G., Verdonk, Robert C., Drenth, Joost P.H., de Wijkerslooth, Thomas R., and van Geenen, Erwin J.M.

Abstract

Background: Acute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been studied and might therefore impose unnecessary ERCPs, we aimed to evaluate this. Methods: We established a nationwide prospective cohort of patients with suspected biliary obstruction who underwent an ERCP. We assessed the diagnostic performance of Tokyo Guidelines (TG18), Dutch Pancreatitis Study Group (DPSG) criteria, and Charcot triad relative to real-world cholangitis as the reference standard. Results: 127 (16%) of 794 patients were diagnosed with real-world cholangitis. Using the TG18, DPSG, and Charcot triad, 345 (44%), 55 (7%), and 66 (8%) patients were defined as having cholangitis, respectively. Sensitivity for TG18 was 82% (95% CI 74-88) and specificity 60% (95% CI 56-63). The sensitivity for DPSG and Charcot was 42% (95% CI 33-51) and 46% (95% CI 38-56), specificity was 99.7% (95% CI 99-100) and 99% (95% CI 98-100), respectively. Conclusions: TG18 criteria incorrectly diagnoses four out of ten patients with real-world cholangitis, while DPSG and Charcot criteria failed to diagnose more than half of patients. As the cholangitis diagnosis has many consequences for treatment, there is a need for more accurate diagnostic tools or work-up towards ERCP.

Published
2022

18. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

de Rijk, Florence E.M., primary, van Veldhuisen, Charlotte L., additional, Besselink, Marc G., additional, van Hooft, Jeanin E., additional, van Santvoort, Hjalmar C., additional, van Geenen, Erwin J.M., additional, Hegyi, Peter, additional, Löhr, J-Matthias, additional, Dominguez-Munoz, Juan E., additional, de Jonge, Pieter Jan F., additional, Bruno, Marco J., additional, Verdonk, Robert C., additional, Falconi, Massimo, additional, Zou, Wen-Bin, additional, Engjom, Trond, additional, Ooi, Chee Y., additional, Sutton, Robert, additional, Frulloni, Luca, additional, Neoptolemos, John, additional, Wilcox, Charles, additional, Miroslav, Vujasinovic, additional, Trikudanathan, Guru, additional, Liao, Zhuan, additional, Hauge, Truls, additional, Mössner, Joachim, additional, Hoge, Chantal, additional, Fockens, Paul, additional, Mieog, Sven, additional, Capurso, Gabriele, additional, Cui, Yunfeng, additional, de Madaria, Enrique, additional, Distler, Marius, additional, Aghdassi, Ali, additional, Whitcomb, David C., additional, Russell, Kylie, additional, Beyer, Georg, additional, Kunovsky, Lumír, additional, Kwanten, Wilhelmus, additional, Nava, Andrea Kazemi, additional, Conlon, Kevin, additional, Siriwardena, A.K., additional, Paiella, Salvatore, additional, Alconchel, Felipe, additional, Marino, Marco Vito, additional, de Meijer, Vincent E., additional, Domingo, Carlos, additional, Kleeff, Jorg, additional, Lakshmanan, Aarti, additional, Lie Chu, Michael Jen, additional, Bouwense, Stefan, additional, Nashidengo, Pueya Rashid, additional, Konstantinos, Perivoliotis, additional, Muttillo, Edoardo Maria, additional, Umar, Garzali Ibrahim, additional, Castro Santiago, Maria Jesus, additional, Lopez-Lopez, Victor, additional, Torri, Francesco, additional, Schmelzle, Moritz, additional, Ignatavicius, Povilas, additional, Wicherts, Dennis, additional, Gomes, Antonio, additional, Machairas, Nikolaos A., additional, Dorovinis, Panagiotis I., additional, Serrablo, Alejandro, additional, Soreide, Kjetil, additional, Rahbari, Mohammad, additional, Jie Chu, Michael Jen, additional, Ptasnuka, Margarita, additional, Petrulionis, Marius, additional, Noel, Colin Byron, additional, Castro, Ernest, additional, Di Martino, Marcello, additional, Recordare, Alfonso, additional, Stättner, Stefan, additional, Ausania, Fabio, additional, Hartman, Vera, additional, Roeyen, Geert, additional, Egorov, Viacheslav, additional, Vanagas, Tomas, additional, Ebrahim, Mohamed, additional, Arabadzhieva, Elena, additional, Malleo, Giuseppe, additional, Li, Liang, additional, Adams, David, additional, Oracz, Grzegorz, additional, Nageshwar, Reddy D., additional, Waldthaler, Alexander, additional, Masamune, Atsushi, additional, Drewes, Asbjorn Mohr, additional, Amodio, Antonio, additional, Tirkes, Temel, additional, Srivastava, Anshu, additional, Beilman, Gregory J., additional, Berger, Zoltan, additional, Lindkvist, Bjorn, additional, Cavestro, Giulia Martina, additional, Gariepy, Cheryl, additional, Czakó, Laszlo, additional, Di Leo, Milena, additional, Sharma, Vishal, additional, Lakhtakia, Sundeep, additional, Rana, Surinder Singh, additional, Duggan, Sinaed N., additional, Kwon, Chang-Il, additional, Phillips, Anna Evans, additional, Forsmark, Christopher E., additional, Gleeson, Ferga C., additional, Lehman, Glen A., additional, Greenhalf, William, additional, Costamagna, Guido, additional, Halloran, Christopher M., additional, Friess, Helmut, additional, Rasmussen, Henrik Hojgaard, additional, Ikeura, Tsukasa, additional, Haldorsen, Ingfrid S., additional, Itoi, Takao, additional, Izbicki, Jacob R., additional, Windsor, John, additional, Poulsen, Jakob Lykke, additional, Frokjaer, Jens Brondum, additional, Larino-Noia, Jose, additional, Wang, Dan, additional, Garcia, Julio Iglesias, additional, Kalaitzakis, Evangelos, additional, Wertheim-Tysarowska, Kararzyna, additional, Kubota, Kensuke, additional, Larusch, Jessica, additional, Lerch, Markus M., additional, Hu, Liang-Hao, additional, Erkan, Mert, additional, Machicado, Jorg D., additional, Arvanitakis, Marianna, additional, Buchler, Markus W., additional, Levy, Marlon F., additional, Heyman, Melvin B., additional, Nojgaard, Camilla, additional, Khashab, Mouen A., additional, Delhaye, Myriam, additional, Ogura, Takeshi, additional, Okazaki, Kazuichi, additional, Ghaneh, Paula, additional, Banks, Peter A., additional, Gupta, Pankaj, additional, Papachristou, Georgios I., additional, Michl, Patrick, additional, Levy, Philippe, additional, Pukitis, Aldis, additional, Pezzilli, Raffaele, additional, Baron, Ryan D., additional, Amann, Stephen T., additional, Schwarzenberg, Sarah Jane, additional, Isaji, Shuiji, additional, Olesen, Soren Schou, additional, Novovic, Srdan, additional, Hughes, Steven J., additional, Werlin, Steven L., additional, Gonska, Tanja, additional, Gardner, Timothy B., additional, Topazian, Mark D., additional, Weiss, Frank Ulrich, additional, Akshintala, Venakata S., additional, Morinville, Veronique D., additional, Rebours, Vinciane, additional, Vincze, Aron, additional, Singh, Vikesh K., additional, Cui, Naiqiang, additional, Zhang, Hong, additional, and Li, Zhao-shen, additional

Published
2022
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19. The Role of Clips in Preventing Delayed Bleeding After Colorectal Polyp Resection: An Individual Patient Data Meta-Analysis

Author

Turan, Ayla S., primary, Pohl, Heiko, additional, Matsumoto, Mio, additional, Lee, Brian S., additional, Aizawa, Masato, additional, Desideri, Federico, additional, Albéniz, Eduardo, additional, Raju, Gottumukkala S., additional, Luba, Daniel, additional, Barret, Maximilien, additional, Gurudu, Suryakanth R., additional, Ramirez, Francisco C., additional, Lin, Wey-Ran, additional, Atsma, Femke, additional, Siersema, Peter D., additional, van Geenen, Erwin J.M., additional, Rex, Douglas K., additional, Lim, Brian S., additional, Kwok, Karl K., additional, Togashi, Kazutomo, additional, Coriat, Romain, additional, Umar, Sarah B., additional, Chen, Chun-Wei, additional, Terhaar sive Droste, Jochim, additional, Schrauwen, Ruud, additional, and Kemper, Gijs, additional

Published
2022
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20. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT):a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., and van Geenen, Erwin J.M.

Abstract

Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Prophylactic rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) is considered as standard of care to reduce the risk of post-ERCP pancreatitis. It has been suggested that aggressive hydration might further reduce this risk. Guidelines already recommend aggressive hydration in patients who are unable to receive rectal NSAIDs, although it is laborious and time consuming. We aimed to evaluate the added value of aggressive hydration in patients receiving prophylactic rectal NSAIDs. Methods: FLUYT, a multicentre, open-label, randomised, controlled trial done across 22 Dutch hospitals, included patients aged between 18 and 85 years with moderate to high risk of post-ERCP pancreatitis. Patients were randomly assigned (1:1) by a web-based module with varying block sizes to a combination of aggressive hydration and rectal NSAIDs (100 mg diclofenac or indomethacin; aggressive hydration group) or rectal NSAIDs (100 mg diclofenac or indomethacin) alone (control group). Randomisation was stratified according to treatment centre. Aggressive hydration comprised 20 mL/kg intravenous Ringer's lactate solution within 60 min from the start of ERCP, followed by 3 mL/kg per h for 8 h. The control group received normal intravenous saline with a maximum of 1·5 mL/kg per h and 3 L per 24 h. The primary endpoint was post-ERCP pancreatitis and was analysed on a modified intention-to-treat basis (including all patients who underwent randomisation and an ERCP and for whom data regarding the primary outcome were available). The trial is registered with the ISRCTN registry, ISRCTN13659155. Findings: Between June 5, 2015, and June 6, 2019, 826 patients were randomly assigned, of whom 388 in the aggressive hydration group and 425 in the control group were included in the modified intention-to-treat analysis. Post-ERCP pancreatitis occurred in 30 (8%) patients i

Published
2021

21. Factors involved in endoscopists’ choice for prophylactic clipping after colorectal endoscopic mucosal resection: a discrete choice experiment

Author

MS MDL 1, Cancer, Turan, Ayla S., Didden, Paul, Peters, Yonne, Moons, Leon M.G., Schreuder, Ramon Michel, Siersema, Peter D., van Geenen, Erwin J.M., on behalf of the Dutch EMR Study Group, MS MDL 1, Cancer, Turan, Ayla S., Didden, Paul, Peters, Yonne, Moons, Leon M.G., Schreuder, Ramon Michel, Siersema, Peter D., van Geenen, Erwin J.M., and on behalf of the Dutch EMR Study Group

Published
2020

25. The association between obesity and outcomes in acute pancreatitis: an individual patient data meta-analysis

Author

Smeets, Xavier J.N.M., primary, Knoester, Iris, additional, Grooteman, Karina V., additional, Singh, Vikesh K., additional, Banks, Peter A., additional, Papachristou, Georgios I., additional, Duarte-Rojo, Andres, additional, Robles-Diaz, Guillermo, additional, Kievit, Wietske, additional, Besselink, Marc G.H., additional, Verdonk, Robert C., additional, Van Santvoort, Hjalmar C., additional, Drenth, Joost P.H., additional, Belias, Michael, additional, and Van Geenen, Erwin J.M., additional

Published
2019
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