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1. Re-attendance in supplemental breast MRI screening rounds of the DENSE trial for women with extremely dense breasts

Author

Veenhuizen, Stefanie G. A., van Grinsven, Sophie E. L., Laseur, Isabelle L., Bakker, Marije F., Monninkhof, Evelyn M., de Lange, Stéphanie V., Pijnappel, Ruud M., Mann, Ritse M., Lobbes, Marc B. I., Duvivier, Katya M., de Jong, Mathijn D. F., Loo, Claudette E., Karssemeijer, Nico, van Diest, Paul J., Veldhuis, Wouter B., and van Gils, Carla H.

Published
2024
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2. Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study

Author

O’Driscoll, Jessica, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Eliassen, A. Heather, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M., Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A., Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo-Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham, Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H., Wanders, Johanna O. P., Sirous, Reza, Sirous, Mehri, Hipwell, John, Kim, Jisun, Lee, Jong Won, Hartman, Mikael, Li, Jingmei, Scott, Christopher, Chiarelli, Anna M., Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman, dos-Santos-Silva, Isabel, McCormack, Valerie, and Mullooly, Maeve

Published
2024
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9. The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density

Author

Ward, Sarah V., Burton, Anya, Tamimi, Rulla M., Pereira, Ana, Garmendia, Maria Luisa, Pollan, Marina, Boyd, Norman, dos-Santos-Silva, Isabel, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo-Hwang, Mariapun, Shivaani, Peplonska, Beata, Bukowska-Damska, Agnieszka, Nagata, Chisato, Hopper, John, Giles, Graham, Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H., Wanders, Johanna O. P., Sirous, Reza, Sirous, Mehri, Hipwell, John, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee-Seng, Scott, Christopher, Chiarelli, Anna M., Linton, Linda, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, McCormack, Valerie, and Stone, Jennifer

Published
2022
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15. Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Andersen, Zorana Jovanovic, Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Concin, Hans, Fecht, Daniela, Forastiere, Francesco, van Gils, Carla H., Gulliver, John, Hertel, Ole, Hoek, Gerard, Hoffmann, Barbara, de Hoogh, Kees, Janssen, Nicole, Jørgensen, Jeanette Therming, Katsouyanni, Klea, Jöckel, Karl-Heinz, Ketzel, Matthias, Klompmaker, Jochem O., Lang, Alois, Leander, Karin, Liu, Shuo, Ljungman, Petter L.S., Magnusson, Patrik K.E., Mehta, Amar Jayant, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peter, Raphael Simon, Peters, Annette, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, Schwarze, Per Everhard, Severi, Gianluca, Sigsgaard, Torben, Stafoggia, Massimo, Strak, Maciej, Vienneau, Danielle, Weinmayr, Gudrun, Wolf, Kathrin, and Raaschou-Nielsen, Ole

Published
2021
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16. Long-term low-level ambient air pollution exposure and risk of lung cancer – A pooled analysis of 7 European cohorts

Author

Hvidtfeldt, Ulla Arthur, Severi, Gianluca, Andersen, Zorana Jovanovic, Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Boutron-Ruault, Marie-Christine, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, Concin, Hans, Forastiere, Francesco, van Gils, Carla H., Gulliver, John, Hertel, Ole, Hoek, Gerard, Hoffmann, Barbara, de Hoogh, Kees, Janssen, Nicole, Jöckel, Karl-Heinz, Jørgensen, Jeanette Therming, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O., Krog, Norun Hjertager, Lang, Alois, Leander, Karin, Liu, Shuo, Ljungman, Petter L.S., Magnusson, Patrik K.E., Mehta, Amar Jayant, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peter, Raphael Simon, Peters, Annette, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, Schwarze, Per Everhard, Sigsgaard, Torben, Simonsen, Mette Kildevæld, Stafoggia, Massimo, Strak, Maciek, Vienneau, Danielle, Weinmayr, Gudrun, Wolf, Kathrin, Raaschou-Nielsen, Ole, and Fecht, Daniela

Published
2021
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17. Healthy lifestyle and the risk of pancreatic cancer in the EPIC study

Author

Naudin, Sabine, Viallon, Vivian, Hashim, Dana, Freisling, Heinz, Jenab, Mazda, Weiderpass, Elisabete, Perrier, Flavie, McKenzie, Fiona, Bueno-de-Mesquita, H Bas, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Mancini, Francesca R., Rebours, Vinciane, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Peppa, Eleni, Karakatsani, Anna, Trichopoulou, Antonia, Pala, Valeria, Masala, Giovana, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., van Gils, Carla H., Rylander, Charlotta, Borch, Kristin Benjaminsen, López, María Dolores Chirlaque, Sánchez, Maria-Jose, Ardanaz, Eva, Quirós, José Ramón, Exezarreta, Pilar Amiano, Sund, Malin, Drake, Isabel, Regnér, Sara, Travis, Ruth C., Wareham, Nick, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., Duell, Eric J., Brennan, Paul, and Ferrari, Pietro

Published
2020

19. Validation of the BOADICEA model in a prospective cohort of BRCA1/2 pathogenic variant carriers.

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Genetica Klinische Genetica, Yang, Xin, Mooij, Thea M, Leslie, Goska, Ficorella, Lorenzo, Andrieu, Nadine, Kast, Karin, Singer, Christian F, Jakubowska, Anna, van Gils, Carla H, Tan, Yen Y, Engel, Christoph, Adank, Muriel A, van Asperen, Christi J, Ausems, Margreet G E M, Berthet, Pascaline, Collee, Margriet J, Cook, Jackie A, Eason, Jacqueline, Spaendonck-Zwarts, Karin Y van, Evans, D Gareth, Gómez García, Encarna B, Hanson, Helen, Izatt, Louise, Kemp, Zoe, Lalloo, Fiona, Lasset, Christine, Lesueur, Fabienne, Musgrave, Hannah, Nambot, Sophie, Noguès, Catherine, Oosterwijk, Jan C, Stoppa-Lyonnet, Dominique, Tischkowitz, Marc, Tripathi, Vishakha, Wevers, Marijke R, Zhao, Emily, van Leeuwen, Flora E, Schmidt, Marjanka K, Easton, Douglas F, Rookus, Matti A, Antoniou, Antonis C, EMBRACE Collaborators, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Genetica Klinische Genetica, Yang, Xin, Mooij, Thea M, Leslie, Goska, Ficorella, Lorenzo, Andrieu, Nadine, Kast, Karin, Singer, Christian F, Jakubowska, Anna, van Gils, Carla H, Tan, Yen Y, Engel, Christoph, Adank, Muriel A, van Asperen, Christi J, Ausems, Margreet G E M, Berthet, Pascaline, Collee, Margriet J, Cook, Jackie A, Eason, Jacqueline, Spaendonck-Zwarts, Karin Y van, Evans, D Gareth, Gómez García, Encarna B, Hanson, Helen, Izatt, Louise, Kemp, Zoe, Lalloo, Fiona, Lasset, Christine, Lesueur, Fabienne, Musgrave, Hannah, Nambot, Sophie, Noguès, Catherine, Oosterwijk, Jan C, Stoppa-Lyonnet, Dominique, Tischkowitz, Marc, Tripathi, Vishakha, Wevers, Marijke R, Zhao, Emily, van Leeuwen, Flora E, Schmidt, Marjanka K, Easton, Douglas F, Rookus, Matti A, Antoniou, Antonis C, and EMBRACE Collaborators

Published
2024

20. Re-attendance in supplemental breast MRI screening rounds of the DENSE trial for women with extremely dense breasts

Author

Epi Kanker Team B, Epi Kanker Team A, Cancer, Arts-Assistenten Onderwijs Radiologie, Arts-assistenten Radiologie, MS Radiologie, Pathologie, Circulatory Health, JC onderzoeksprogramma Cancer, Veenhuizen, Stefanie G A, van Grinsven, Sophie E L, Laseur, Isabelle L, Bakker, Marije F, Monninkhof, Evelyn M, de Lange, Stéphanie V, Pijnappel, Ruud M, Mann, Ritse M, Lobbes, Marc B I, Duvivier, Katya M, de Jong, Mathijn D F, Loo, Claudette E, Karssemeijer, Nico, van Diest, Paul J, Veldhuis, Wouter B, van Gils, Carla H, DENSE Trial Study Group, Epi Kanker Team B, Epi Kanker Team A, Cancer, Arts-Assistenten Onderwijs Radiologie, Arts-assistenten Radiologie, MS Radiologie, Pathologie, Circulatory Health, JC onderzoeksprogramma Cancer, Veenhuizen, Stefanie G A, van Grinsven, Sophie E L, Laseur, Isabelle L, Bakker, Marije F, Monninkhof, Evelyn M, de Lange, Stéphanie V, Pijnappel, Ruud M, Mann, Ritse M, Lobbes, Marc B I, Duvivier, Katya M, de Jong, Mathijn D F, Loo, Claudette E, Karssemeijer, Nico, van Diest, Paul J, Veldhuis, Wouter B, van Gils, Carla H, and DENSE Trial Study Group

Published
2024

21. Automated rating of background parenchymal enhancement in MRI of extremely dense breasts without compromising the association with breast cancer in the DENSE trial

Author

Beeldverwerking ISI, Cancer, Strategische Impuls RvB ISI, Epi Kanker Team A, MS Radiologie, Circulatory Health, JC onderzoeksprogramma Kanker, Wang, Hui, H.M.van der Velden, Bas, Verburg, Erik, Bakker, Marije F., Pijnappel, Ruud M., Veldhuis, Wouter B., van Gils, Carla H., Gilhuijs, Kenneth G.A., Beeldverwerking ISI, Cancer, Strategische Impuls RvB ISI, Epi Kanker Team A, MS Radiologie, Circulatory Health, JC onderzoeksprogramma Kanker, Wang, Hui, H.M.van der Velden, Bas, Verburg, Erik, Bakker, Marije F., Pijnappel, Ruud M., Veldhuis, Wouter B., van Gils, Carla H., and Gilhuijs, Kenneth G.A.

Published
2024

22. Diagnostic accuracy of supplemental three-dimensional breast ultrasound in the work-up of BI-RADS 0 screening recalls

Author

Cancer, Onderzoek Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, den Dekker, Bianca M, Broeders, Mireille J M, Meeuwis, Carla, Setz-Pels, Wikke, Venmans, Alexander, van Gils, Carla H, Pijnappel, Ruud M, Cancer, Onderzoek Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, den Dekker, Bianca M, Broeders, Mireille J M, Meeuwis, Carla, Setz-Pels, Wikke, Venmans, Alexander, van Gils, Carla H, and Pijnappel, Ruud M

Published
2024

23. Prophylactic pectoralis major flap to compensate for increased risk of pharyngocutaneous fistula in laryngectomy patients with low skeletal muscle mass (PECTORALIS): study protocol for a randomized controlled trial

Author

MS Hoofd-Hals Chirurgische Oncologie, MS KNO, MKA/BT Onderzoek, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, HEE, Child Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Brain, Circulatory Health, van Beers, Maartje A, Speksnijder, Caroline M, van Gils, Carla H, Frederix, Geert W J, Dankbaar, Jan Willem, de Bree, Remco, MS Hoofd-Hals Chirurgische Oncologie, MS KNO, MKA/BT Onderzoek, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, HEE, Child Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Brain, Circulatory Health, van Beers, Maartje A, Speksnijder, Caroline M, van Gils, Carla H, Frederix, Geert W J, Dankbaar, Jan Willem, and de Bree, Remco

Published
2024

25. Validation of the BOADICEA model in a prospective cohort of BRCA1/2 pathogenic variant carriers.

Author

Xin Yang, Mooij, Thea M., Leslie, Goska, Ficorella, Lorenzo, Andrieu, Nadine, Kast, Karin, Singer, Christian F., Jakubowska, Anna, van Gils, Carla H., Yen Y. Tan, Engel, Christoph, Adank, Muriel A., van Asperen, Christi J., Ausems, Margreet G. E. M., Berthet, Pascaline, Collee, Margriet J., Cook, Jackie A., Eason, Jacqueline, van Spaendonck-Zwarts, Karin Y., and Evans, D. Gareth

Abstract

Background No validation has been conducted for the BOADICEA multifactorial breast cancer risk prediction model specifically in BRCA1/2 pathogenic variant (PV) carriers to date. Here, we evaluated the performance of BOADICEA in predicting 5-year breast cancer risks in a prospective cohort of BRCA1/2 PV carriers ascertained through clinical genetic centres. Methods We evaluated the model calibration and discriminatory ability in the prospective TRANsIBCCS cohort study comprising 1614 BRCA1 and 1365 BRCA2 PV carriers (209 incident cases). Study participants had lifestyle, reproductive, hormonal, anthropometric risk factor information, a polygenic risk score based on 313 SNPs and family history information. Results The full multifactorial model considering family history together with all other risk factors was well calibrated overall (E/O=1.07, 95% CI: 0.92 to 1.24) and in quintiles of predicted risk. Discrimination was maximised when all risk factors were considered (Harrell's C-index=0.70, 95% CI: 0.67 to 0.74; area under the curve=0.79, 95% CI: 0.76 to 0.82). The model performance was similar when evaluated separately in BRCA1 or BRCA2 PV carriers. The full model identified 5.8%, 12.9% and 24.0% of BRCA1/2 PV carriers with 5-year breast cancer risks of <1.65%, <3% and <5%, respectively, risk thresholds commonly used for different management and risk-reduction options. Conclusion BOADICEA may be used to aid personalised cancer risk management and decision-making for BRCA1 and BRCA2 PV carriers. It is implemented in the free-access CanRisk tool (https:// www.canrisk.org/). [ABSTRACT FROM AUTHOR]

Published
2024
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26. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

Author

Siddiq, Afshan, Couch, Fergus J, Chen, Gary K, Lindström, Sara, Eccles, Diana, Millikan, Robert C, Michailidou, Kyriaki, Stram, Daniel O, Beckmann, Lars, Rhie, Suhn Kyong, Ambrosone, Christine B, Aittomäki, Kristiina, Amiano, Pilar, Apicella, Carmel, Investigators, Australian Breast Cancer Tissue Bank, Baglietto, Laura, Bandera, Elisa V, Beckmann, Matthias W, Berg, Christine D, Bernstein, Leslie, Blomqvist, Carl, Brauch, Hiltrud, Brinton, Louise, Bui, Quang M, Buring, Julie E, Buys, Saundra S, Campa, Daniele, Carpenter, Jane E, Chasman, Daniel I, Chang-Claude, Jenny, Chen, Constance, Clavel-Chapelon, Françoise, Cox, Angela, Cross, Simon S, Czene, Kamila, Deming, Sandra L, Diasio, Robert B, Diver, W Ryan, Dunning, Alison M, Durcan, Lorraine, Ekici, Arif B, Fasching, Peter A, Study, Familial Breast Cancer, Feigelson, Heather Spencer, Fejerman, Laura, Figueroa, Jonine D, Fletcher, Olivia, Flesch-Janys, Dieter, Gaudet, Mia M, Consortium, The GENICA, Gerty, Susan M, Rodriguez-Gil, Jorge L, Giles, Graham G, van Gils, Carla H, Godwin, Andrew K, Graham, Nikki, Greco, Dario, Hall, Per, Hankinson, Susan E, Hartmann, Arndt, Hein, Rebecca, Heinz, Judith, Hoover, Robert N, Hopper, John L, Hu, Jennifer J, Huntsman, Scott, Ingles, Sue A, Irwanto, Astrid, Isaacs, Claudine, Jacobs, Kevin B, John, Esther M, Justenhoven, Christina, Kaaks, Rudolf, Kolonel, Laurence N, Coetzee, Gerhard A, Lathrop, Mark, Le Marchand, Loic, Lee, Adam M, Lee, I-Min, Lesnick, Timothy, Lichtner, Peter, Liu, Jianjun, Lund, Eiliv, Makalic, Enes, Martin, Nicholas G, McLean, Catriona A, Meijers-Heijboer, Hanne, Meindl, Alfons, Miron, Penelope, Monroe, Kristine R, Montgomery, Grant W, Müller-Myhsok, Bertram, Nickels, Stefan, Nyante, Sarah J, Olswold, Curtis, Overvad, Kim, Palli, Domenico, Park, Daniel J, Palmer, Julie R, and Pathak, Harsh

Subjects
Biological Sciences, Genetics, Human Genome, Cancer Genomics, Cancer, Aging, Prevention, Women's Health, Breast Cancer, 2.1 Biological and endogenous factors, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Receptors, Estrogen, Australian Breast Cancer Tissue Bank Investigators, Familial Breast Cancer Study, GENICA Consortium, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; P = 1.1 × 10(-8)) but showed a weaker association with overall breast cancer (OR = 1.08, P = 1.3 × 10(-6)) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, P = 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; P = 1.1 × 10(-9)), and with both ER-positive (OR = 1.09; P = 1.5 × 10(-5)) and ER-negative (OR = 1.16, P = 2.5 × 10(-7)) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci.

Published
2012

27. A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Author

Coviello, Andrea D, Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimäki, Terho, Keildson, Sarah, Lunetta, Kathryn L, He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Liu, Yong Mei, Koster, Annemarie, Lohman, Kurt, Lyytikäinen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R, Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G, Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J, Hankinson, Susan E, Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D, Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P, Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello RP, Mellström, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Papunen, Laure Morin, Peeters, Petra HM, Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P, Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M, Siscovick, David, Soranzo, Nicole, Stöckl, Doris, Tworoger, Shelley, Uitterlinden, André G, van Gils, Carla H, Vasan, Ramachandran S, Wichmann, H-Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J, De Vivo, Immaculata, Harris, Tamara B, Hunter, David J, Kähönen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D, van der Schouw, Yvonne T, Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I, Frayling, Timothy M, Murray, Anna, Franks, Steve, Järvelin, Marjo-Riitta, de Jong, Frank H, Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M, and Perry, John RB

Subjects
Biological Sciences, Genetics, Cancer, Estrogen, Women's Health, Aging, Prostate Cancer, Urologic Diseases, Human Genome, Cancer Genomics, Breast Cancer, 2.1 Biological and endogenous factors, Metabolic and endocrine, Alleles, Female, Genetic Heterogeneity, Genome-Wide Association Study, Gonadal Steroid Hormones, Humans, Male, Metabolic Networks and Pathways, Polymorphism, Single Nucleotide, Sex Characteristics, Sex Hormone-Binding Globulin, Developmental Biology
Abstract

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8 × 10(-106)), PRMT6 (rs17496332, 1p13.3, p = 1.4 × 10(-11)), GCKR (rs780093, 2p23.3, p = 2.2 × 10(-16)), ZBTB10 (rs440837, 8q21.13, p = 3.4 × 10(-09)), JMJD1C (rs7910927, 10q21.3, p = 6.1 × 10(-35)), SLCO1B1 (rs4149056, 12p12.1, p = 1.9 × 10(-08)), NR2F2 (rs8023580, 15q26.2, p = 8.3 × 10(-12)), ZNF652 (rs2411984, 17q21.32, p = 3.5 × 10(-14)), TDGF3 (rs1573036, Xq22.3, p = 4.1 × 10(-14)), LHCGR (rs10454142, 2p16.3, p = 1.3 × 10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7 × 10(-08)), and UGT2B15 (rs293428, 4q13.2, p = 5.5 × 10(-06)). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p = 2.5 × 10(-08), women p = 0.66, heterogeneity p = 0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ~15.6% and ~8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.

Published
2012

29. Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiotherapy in head and neck cancer patients with low skeletal muscle mass: The CISLOW-study protocol

Author

Schaeffers, Anouk W. M. A., primary, Devriese, Lot A., additional, van Gils, Carla H., additional, Dankbaar, Jan Willem, additional, Voortman, Jens, additional, de Boer, Jan Paul, additional, Slingerland, Marije, additional, Hendriks, Mathijs P., additional, Smid, Ernst J., additional, Frederix, Geert W. J., additional, and de Bree, Remco, additional

Published
2023
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31. Cancer detection during the COVID-19 pandemic-Experiences in primary care and recommendations for the future

Author

Siepman Van den Berg, Marinde F.R., Grant, Matthew, van Erp, Nicole, van Gils, Carla H., Muris, Jean, Brandenbarg, Daan, van Asselt, Kristel M., de Wit, Niek J., Helsper, Charles W., General practice, APH - Personalized Medicine, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, CCA - Imaging and biomarkers, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CAPHRI - R5 - Optimising Patient Care, and Family Medicine

Subjects
family medicine, primary care, cancer diagnosis, Internal Medicine, cancer, Geriatrics and Gerontology, Family Practice, COVID
Abstract

Background: To describe general practitioners (GPs) experiences with the impact COVID-19 on the duration of cancer detection. Methods: Cross-sectional survey study among Dutch GPs. Results: Fifty-eight GPs participated. During the first wave, COVID-19-related delays were experienced by 88%, 52%, and 67% of GPs in the contact-seeking, primary care, and referral phases, respectively. GPs reported delays due to telehealth consultations, longer waiting times and patient's concerns of COVID infections and overburdening GPs. Conclusions: The majority of GPs experienced delays in cancer diagnostic processes during the beginning of the COVID pandemic, which was most prominent in the timeliness in which patients sought GP care.

Published
2023

38. International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries

Author

McCormack, Valerie A., Burton, Anya, dos-Santos-Silva, Isabel, Hipwell, John H., Dickens, Caroline, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Lee, Charmaine Pei Ling, Chia, Kee-Seng, Ozmen, Vahit, Aribal, Mustafa Erkin, Flugelman, Anath Arzee, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, van Gils, Carla H., Wanders, Johanna O.P., Vinayak, Sudhir, Ndumia, Rose, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Won Lee, Jong, Kim, Jisun, Pereira, Ana, Garmendia, Maria Luisa, Sirous, Reza, Sirous, Mehri, Peplonska, Beata, Bukowska, Agnieszka, Tamimi, Rulla M., Bertrand, Kimberly, Nagata, Chisato, Kwong, Ava, Vachon, Celine, Scott, Christopher, Perez-Gomez, Beatriz, Pollan, Marina, Maskarinec, Gertraud, Giles, Graham, Hopper, John, Stone, Jennifer, Rajaram, Nadia, Teo, Soo-Hwang, Mariapun, Shivaani, Yaffe, Martin J., Schüz, Joachim, Chiarelli, Anna M., Linton, Linda, and Boyd, Norman F.

Published
2016
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39. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Bakker, Marije F, Peeters, Petra HM, Klaasen, Veronique M, Bueno-de-Mesquita, H Bas, Jansen, Eugene HJM, Ros, Martine M, Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, and van Gils, Carla H

Published
2016
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40. Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort

Author

Emaus, Marleen J, Peeters, Petra HM, Bakker, Marije F, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Romieu, Isabelle, Ferrari, Pietro, Dossus, Laure, Boutron-Ruault, Marie Christine, Baglietto, Laura, Fortner, Renée T, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Skeie, Guri, Lund, Eiliv, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Winkvist, Anna, Wennberg, Maria, Bueno-de-Mesquita, H Bas, Khaw, Kay-Tee, Travis, Ruth C, Key, Timothy J, Aune, Dagfinn, Gunter, Marc, Riboli, Elio, and van Gils, Carla H

Published
2016
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41. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Author

Heath, Alicia K., Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna

Published
2020
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42. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, van Gils, Carla H., Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C., Vistisen, Helene Tilma, Bakker, Marije F., Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K., Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman

Published
2019
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43. Prospective analysis of circulating metabolites and breast cancer in EPIC

Author

His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina

Published
2019
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44. Impact of the COVID-19 pandemic on breast cancer incidence and tumor stage in the Netherlands and Norway: A population-based study

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Cancer, HAG Onderzoek, MS Radiologie, Eijkelboom, Anouk H., de Munck, Linda, Larsen, Marthe, Bijlsma, Maarten J., Tjan-Heijnen, Vivianne C.G., van Gils, Carla H., Broeders, Mireille J.M., Nygård, Jan F., Lobbes, Marc B.I., Helsper, Charles W., Pijnappel, Ruud M., Strobbe, Luc J.A., Wesseling, Jelle, Hofvind, Solveig, Siesling, Sabine, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Cancer, HAG Onderzoek, MS Radiologie, Eijkelboom, Anouk H., de Munck, Linda, Larsen, Marthe, Bijlsma, Maarten J., Tjan-Heijnen, Vivianne C.G., van Gils, Carla H., Broeders, Mireille J.M., Nygård, Jan F., Lobbes, Marc B.I., Helsper, Charles W., Pijnappel, Ruud M., Strobbe, Luc J.A., Wesseling, Jelle, Hofvind, Solveig, and Siesling, Sabine

Published
2023

45. Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiotherapy in head and neck cancer patients with low skeletal muscle mass: The CISLOW-study protocol

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Medische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, Brain, Circulatory Health, MS Radiotherapie, HEE, Child Health, JC onderzoeksprogramma Methodologie, Schaeffers, Anouk W M A, Devriese, Lot A, van Gils, Carla H, Dankbaar, Jan Willem, Voortman, Jens, de Boer, Jan Paul, Slingerland, Marije, Hendriks, Mathijs P, Smid, Ernst J, Frederix, Geert W J, de Bree, Remco, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Medische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, Brain, Circulatory Health, MS Radiotherapie, HEE, Child Health, JC onderzoeksprogramma Methodologie, Schaeffers, Anouk W M A, Devriese, Lot A, van Gils, Carla H, Dankbaar, Jan Willem, Voortman, Jens, de Boer, Jan Paul, Slingerland, Marije, Hendriks, Mathijs P, Smid, Ernst J, Frederix, Geert W J, and de Bree, Remco

Published
2023

46. Assessing Quantitative Parenchymal Features at Baseline Dynamic Contrast-enhanced MRI and Cancer Occurrence in Women with Extremely Dense Breasts

Author

Beeldverwerking ISI, Cancer, Epi Kanker Team A, MS Radiologie, Circulatory Health, JC onderzoeksprogramma Kanker, Wang, Hui, van der Velden, Bas H.M., Verburg, Erik, Bakker, Marije F., Pijnappel, Ruud M., Veldhuis, Wouter B., van Gils, Carla H., Gilhuijs, Kenneth G.A., Beeldverwerking ISI, Cancer, Epi Kanker Team A, MS Radiologie, Circulatory Health, JC onderzoeksprogramma Kanker, Wang, Hui, van der Velden, Bas H.M., Verburg, Erik, Bakker, Marije F., Pijnappel, Ruud M., Veldhuis, Wouter B., van Gils, Carla H., and Gilhuijs, Kenneth G.A.

Published
2023

47. Development and validation of risk calculators for people with 'thin' melanomas on their skin to predict the likelihood that their cancer will return: a plain language summary of publication

Author

Pathologie Groep Van Diest, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, MS CGO, MS Dermatologie/Allergologie, Other research (not in main researchprogram), MS Medische Oncologie, Infection & Immunity, Pathologie, Epi Kanker Team A, Pathologie Pathologen staf, Sharouni, Mary-Ann El, Lo, Serigne N, Varey, Alexander Hr, Elias, Sjoerd G, Witkamp, Arjen J, Sigurdsson, Vigfús, Suijkerbuijk, Karijn Pm, van Diest, Paul J, van Gils, Carla H, Blokx, Willeke Am, Scolyer, Richard A, Thompson, John F, Pathologie Groep Van Diest, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, MS CGO, MS Dermatologie/Allergologie, Other research (not in main researchprogram), MS Medische Oncologie, Infection & Immunity, Pathologie, Epi Kanker Team A, Pathologie Pathologen staf, Sharouni, Mary-Ann El, Lo, Serigne N, Varey, Alexander Hr, Elias, Sjoerd G, Witkamp, Arjen J, Sigurdsson, Vigfús, Suijkerbuijk, Karijn Pm, van Diest, Paul J, van Gils, Carla H, Blokx, Willeke Am, Scolyer, Richard A, and Thompson, John F

Published
2023

48. Validation of Combined Deep Learning Triaging and Computer-Aided Diagnosis in 2901 Breast MRI Examinations From the Second Screening Round of the Dense Tissue and Early Breast Neoplasm Screening Trial

Author

Beeldverwerking ISI, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, Circulatory Health, Verburg, Erik, van Gils, Carla H, van der Velden, Bas H M, Bakker, Marije F, Pijnappel, Ruud M, Veldhuis, Wouter B, Gilhuijs, Kenneth G A, Beeldverwerking ISI, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS Radiologie, Circulatory Health, Verburg, Erik, van Gils, Carla H, van der Velden, Bas H M, Bakker, Marije F, Pijnappel, Ruud M, Veldhuis, Wouter B, and Gilhuijs, Kenneth G A

Published
2023

49. Challenges and Changes of the Breast Cancer Screening Paradigm

Author

Epidemiology & Health Economics, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, MS Radiologie, Circulatory Health, Cömert, Didem, van Gils, Carla H., Veldhuis, Wouter B., Mann, Ritse M., Epidemiology & Health Economics, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, MS Radiologie, Circulatory Health, Cömert, Didem, van Gils, Carla H., Veldhuis, Wouter B., and Mann, Ritse M.

Published
2023

50. Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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