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1. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Published
2024
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4. (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study

Author

Mokhtar, Sara B. A., van der Heide, Frank C. T., Oyaert, Karel A. M., van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Scarpa, Fabio, Colonna, Alessia, de Galan, Bastiaan E., van Greevenbroek, Marleen M. J., Dagnelie, Pieter C., Schalkwijk, Casper G., Nuijts, Rudy M. M. A., Schaper, Nicolaas C., Kroon, Abraham A., Schram, Miranda T., Webers, Carroll A. B., and Stehouwer, Coen D. A.

Published
2023
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5. Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Author

van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., and Stehouwer, Coen D. A.

Published
2023
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7. Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van Greevenbroek, Marleen M. J., Kusters, Yvo H. A. M., Vos, Rimke C., Bots, Michiel L., Kooi, M. Eline, Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Brouwers, Martijn C. G., van der Sangen, Niels M. R., Peters, Sanne A. E., van der Kallen, Carla J. H., and Stehouwer, Coen D. A.

Published
2023
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8. Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Author

Tore, Elena C., Elshorbagy, Amany K., Bakers, Frans C. H., Brouwers, Martijn C. G. J., Dagnelie, Pieter C., Eussen, Simone J. P. M., Jansen, Jacobus F. A., Kooi, M. Eline, Kusters, Yvo H. A. M., Meex, Steven J. R., Olsen, Thomas, Refsum, Helga, Retterstøl, Kjetil, Schalkwijk, Casper G., Stehouwer, Coen D. A., Vinknes, Kathrine J., and van Greevenbroek, Marleen M. J.

Published
2023
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10. Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study

Author

Vandercappellen, Evelien J., Koster, Annemarie, Savelberg, Hans H. C. M., Eussen, Simone J. P. M., Dagnelie, Pieter C., Schaper, Nicolaas C., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Kroon, Abraham A., Henry, Ronald M. A., and Stehouwer, Coen D. A.

Published
2022
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11. (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study

Author

van der Heide, Frank C. T., Foreman, Yuri D., Franken, Iris W. M., Henry, Ronald M. A., Kroon, Abraham A., Dagnelie, Pieter C., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Schaper, Nicolaas C., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2022
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14. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Subjects
AIR pollutants, TYPE 2 diabetes, PARTICULATE matter, FRACTAL dimensions, AIR pollution
Abstract

Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy. Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM2.5, PM10, NO2, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension). Results: After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM2.5 and PM10 were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM2.5 -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM10 -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO2 and EC and corneal nerve measures. Conclusions: Our population-based study demonstrated that exposure to higher levels of PM2.5 and PM10 are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data.

Author

van Hilten, Arno, van Rooij, Jeroen, Heijmans, Bastiaan T., 't Hoen, Peter A. C., Meurs, Joyce van, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, and Beekman, Marian

Subjects
GENE expression, MULTIOMICS, PREDICTION models, NETWORK performance, INDIVIDUALIZED medicine
Abstract

Integrating multi-omics data into predictive models has the potential to enhance accuracy, which is essential for precision medicine. In this study, we developed interpretable predictive models for multi-omics data by employing neural networks informed by prior biological knowledge, referred to as visible networks. These neural networks offer insights into the decision-making process and can unveil novel perspectives on the underlying biological mechanisms associated with traits and complex diseases. We tested the performance, interpretability and generalizability for inferring smoking status, subject age and LDL levels using genome-wide RNA expression and CpG methylation data from the blood of the BIOS consortium (four population cohorts, Ntotal = 2940). In a cohort-wise cross-validation setting, the consistency of the diagnostic performance and interpretation was assessed. Performance was consistently high for predicting smoking status with an overall mean AUC of 0.95 (95% CI: 0.90–1.00) and interpretation revealed the involvement of well-replicated genes such as AHRR, GPR15 and LRRN3. LDL-level predictions were only generalized in a single cohort with an R2 of 0.07 (95% CI: 0.05–0.08). Age was inferred with a mean error of 5.16 (95% CI: 3.97–6.35) years with the genes COL11A2, AFAP1, OTUD7A, PTPRN2, ADARB2 and CD34 consistently predictive. For both regression tasks, we found that using multi-omics networks improved performance, stability and generalizability compared to interpretable single omic networks. We believe that visible neural networks have great potential for multi-omics analysis; they combine multi-omic data elegantly, are interpretable, and generalize well to data from different cohorts. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study

Author

Bakker, Lieke, Ramakers, Inez H. G. B., van Boxtel, Martin P. J., Schram, Miranda T., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Greevenbroek, Marleen M. J., Wesselius, Anke, Midttun, Øivind, Ueland, Per M., Verhey, Frans R. J., Eussen, Simone J. P. M., and Köhler, Sebastian

Published
2021
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17. Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study

Author

van Gennip, April C. E., primary, Gupta, Monideepa D., additional, Houben, Alfons J. H. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J. H., additional, Koster, Annemarie, additional, Wesselius, Anke, additional, Eussen, Simone J. P. M., additional, Schalkwijk, Casper G., additional, de Galan, Bastiaan E., additional, Köhler, Sebastian, additional, Schram, Miranda T., additional, Stehouwer, Coen D. A., additional, and van Sloten, Thomas T., additional

Published
2024
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18. A Federated Database for Obesity Research: An IMI-SOPHIA Study

Author

Delfin, Carl, primary, Dragan, Iulian, additional, Kuznetsov, Dmitry, additional, Tajes, Juan Fernandez, additional, Smit, Femke, additional, Coral, Daniel E., additional, Farzaneh, Ali, additional, Haugg, André, additional, Hungele, Andreas, additional, Niknejad, Anne, additional, Hall, Christopher, additional, Jacobs, Daan, additional, Marek, Diana, additional, Fraser, Diane P., additional, Thuillier, Dorothee, additional, Ahmadizar, Fariba, additional, Mehl, Florence, additional, Pattou, Francois, additional, Burdet, Frederic, additional, Hawkes, Gareth, additional, Arts, Ilja C. W., additional, Blanch, Jordi, additional, Van Soest, Johan, additional, Fernández-Real, José-Manuel, additional, Boehl, Juergen, additional, Fink, Katharina, additional, van Greevenbroek, Marleen M. J., additional, Kavousi, Maryam, additional, Minten, Michiel, additional, Prinz, Nicole, additional, Ipsen, Niels, additional, Franks, Paul W., additional, Ramos, Rafael, additional, Holl, Reinhard W., additional, Horban, Scott, additional, Duarte-Salles, Talita, additional, Tran, Van Du T., additional, Raverdy, Violeta, additional, Leal, Yenny, additional, Lenart, Adam, additional, Pearson, Ewan, additional, Sparsø, Thomas, additional, Giordano, Giuseppe N., additional, Ioannidis, Vassilios, additional, Soh, Keng, additional, Frayling, Timothy M., additional, Le Roux, Carel W., additional, and Ibberson, Mark, additional

Published
2024
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19. Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study

Author

Foreman, Yuri D., van Doorn, William P. T. M., Schaper, Nicolaas C., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Henry, Ronald M. A., Koster, Annemarie, Eussen, Simone J. P. M., Wesselius, Anke, Reesink, Koen D., Schram, Miranda T., Dagnelie, Pieter C., Kroon, Abraham A., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2021
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20. A Federated Database for Obesity Research: An IMI-SOPHIA Study

Author

RWE/Causal inference, Child Health, Delfin, Carl, Dragan, Iulian, Kuznetsov, Dmitry, Tajes, Juan Fernandez, Smit, Femke, Coral, Daniel E, Farzaneh, Ali, Haugg, André, Hungele, Andreas, Niknejad, Anne, Hall, Christopher, Jacobs, Daan, Marek, Diana, Fraser, Diane P, Thuillier, Dorothee, Ahmadizar, Fariba, Mehl, Florence, Pattou, Francois, Burdet, Frederic, Hawkes, Gareth, Arts, Ilja C W, Blanch, Jordi, Van Soest, Johan, Fernández-Real, José-Manuel, Boehl, Juergen, Fink, Katharina, van Greevenbroek, Marleen M J, Kavousi, Maryam, Minten, Michiel, Prinz, Nicole, Ipsen, Niels, Franks, Paul W, Ramos, Rafael, Holl, Reinhard W, Horban, Scott, Duarte-Salles, Talita, Tran, Van Du T, Raverdy, Violeta, Leal, Yenny, Lenart, Adam, Pearson, Ewan, Sparsø, Thomas, Giordano, Giuseppe N, Ioannidis, Vassilios, Soh, Keng, Frayling, Timothy M, Le Roux, Carel W, Ibberson, Mark, RWE/Causal inference, Child Health, Delfin, Carl, Dragan, Iulian, Kuznetsov, Dmitry, Tajes, Juan Fernandez, Smit, Femke, Coral, Daniel E, Farzaneh, Ali, Haugg, André, Hungele, Andreas, Niknejad, Anne, Hall, Christopher, Jacobs, Daan, Marek, Diana, Fraser, Diane P, Thuillier, Dorothee, Ahmadizar, Fariba, Mehl, Florence, Pattou, Francois, Burdet, Frederic, Hawkes, Gareth, Arts, Ilja C W, Blanch, Jordi, Van Soest, Johan, Fernández-Real, José-Manuel, Boehl, Juergen, Fink, Katharina, van Greevenbroek, Marleen M J, Kavousi, Maryam, Minten, Michiel, Prinz, Nicole, Ipsen, Niels, Franks, Paul W, Ramos, Rafael, Holl, Reinhard W, Horban, Scott, Duarte-Salles, Talita, Tran, Van Du T, Raverdy, Violeta, Leal, Yenny, Lenart, Adam, Pearson, Ewan, Sparsø, Thomas, Giordano, Giuseppe N, Ioannidis, Vassilios, Soh, Keng, Frayling, Timothy M, Le Roux, Carel W, and Ibberson, Mark

Published
2024

21. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study

Author

Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, van Sloten, Thomas T, Cardiovasculaire Epi Team 7a, Circulatory Health, Cardiovasculaire Epi Team 5, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Beran, Magdalena, van Gennip, April C E, Stehouwer, Coen D A, Jansen, Jacobus F A, Gupta, Monideepa D, Houben, Alfons J H M, Berendschot, Tos T J M, Webers, Carroll A B, Wesselius, Anke, Schalkwijk, Casper G, Backes, Walter H, de Jong, Joost J A, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Köhler, Sebastian, Vonk, Jet M J, Geerlings, Mirjam I, Schram, Miranda T, and van Sloten, Thomas T

Published
2024

22. A Federated Database for Obesity Research:An IMI-SOPHIA Study

Author

Delfin, Carl, Dragan, Iulian, Kuznetsov, Dmitry, Tajes, Juan Fernandez, Smit, Femke, Coral, Daniel E., Farzaneh, Ali, Haugg, Andre, Hungele, Andreas, Niknejad, Anne, Hall, Christopher, Jacobs, Daan, Marek, Diana, Fraser, Diane P., Thuillier, Dorothee, Ahmadizar, Fariba, Mehl, Florence, Pattou, Francois, Burdet, Frederic, Hawkes, Gareth, Arts, Ilja C. W., Blanch, Jordi, Van Soest, Johan, Fernandez-Real, Jose-Manuel, Boehl, Juergen, Fink, Katharina, van Greevenbroek, Marleen M. J., Kavousi, Maryam, Minten, Michiel, Prinz, Nicole, Ipsen, Niels, Franks, Paul W., Ramos, Rafael, Holl, Reinhard W., Horban, Scott, Duarte-Salles, Talita, Tran, Van Du T., Raverdy, Violeta, Leal, Yenny, Lenart, Adam, Pearson, Ewan, Sparso, Thomas, Giordano, Giuseppe N., Ioannidis, Vassilios, Soh, Keng, Frayling, Timothy M., Le Roux, Carel W., Ibberson, Mark, Delfin, Carl, Dragan, Iulian, Kuznetsov, Dmitry, Tajes, Juan Fernandez, Smit, Femke, Coral, Daniel E., Farzaneh, Ali, Haugg, Andre, Hungele, Andreas, Niknejad, Anne, Hall, Christopher, Jacobs, Daan, Marek, Diana, Fraser, Diane P., Thuillier, Dorothee, Ahmadizar, Fariba, Mehl, Florence, Pattou, Francois, Burdet, Frederic, Hawkes, Gareth, Arts, Ilja C. W., Blanch, Jordi, Van Soest, Johan, Fernandez-Real, Jose-Manuel, Boehl, Juergen, Fink, Katharina, van Greevenbroek, Marleen M. J., Kavousi, Maryam, Minten, Michiel, Prinz, Nicole, Ipsen, Niels, Franks, Paul W., Ramos, Rafael, Holl, Reinhard W., Horban, Scott, Duarte-Salles, Talita, Tran, Van Du T., Raverdy, Violeta, Leal, Yenny, Lenart, Adam, Pearson, Ewan, Sparso, Thomas, Giordano, Giuseppe N., Ioannidis, Vassilios, Soh, Keng, Frayling, Timothy M., Le Roux, Carel W., and Ibberson, Mark

Abstract

Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.

Published
2024

23. The effect of bolus advisors on glycaemic parameters in adults with diabetes on intensive insulin therapy: A systematic review with meta‐analysis.

Author

den Brok, Elisabeth J., Svensson, Cecilie H., Panagiotou, Maria, van Greevenbroek, Marleen M. J., Mertens, Peter R., Vazeou, Andriani, Mitrakou, Asimina, Makrilakis, Konstantinos, Franssen, Gregor H. L. M., van Kuijk, Sander, Proennecke, Stephan, Mougiakakou, Stavroula, Pedersen‐Bjergaard, Ulrik, and de Galan, Bastiaan E.

Subjects
INSULIN therapy, INSULIN, INSULIN aspart, RANDOM effects model, TYPE 1 diabetes, ADULTS, PATIENT satisfaction, PEOPLE with diabetes
Abstract

Aim: To conduct a systematic review with meta‐analysis to provide a comprehensive synthesis of randomized controlled trials (RCTs) and prospective cohort studies investigating the effects of currently available bolus advisors on glycaemic parameters in adults with diabetes. Materials and Methods: An electronic search of PubMed, Embase, CINAHL, Cochrane Library and ClinicalTrials.gov was conducted in December 2022. The risk of bias was assessed using the revised Cochrane Risk of Bias tool. (Standardized) mean difference (MD) was selected to determine the difference in continuous outcomes between the groups. A random‐effects model meta‐analysis and meta‐regression were performed. This systematic review was registered on PROSPERO (CRD42022374588). Results: A total of 18 RCTs involving 1645 adults (50% females) with a median glycated haemoglobin (HbA1c) concentration of 8.45% (7.95%–9.30%) were included. The majority of participants had type 1 diabetes (N = 1510, 92%) and were on multiple daily injections (N = 1173, 71%). Twelve of the 18 trials had low risk of bias. The meta‐analysis of 10 studies with available data on HbA1c showed that the use of a bolus advisor modestly reduced HbA1c compared to standard treatment (MD −011%, 95% confidence interval −0.22 to −0.01; I2 = 0%). This effect was accompanied by small improvements in low blood glucose index and treatment satisfaction, but not with reductions in hypoglycaemic events or changes in other secondary outcomes. Conclusion: Use of a bolus advisor is associated with slightly better glucose control and treatment satisfaction in people with diabetes on intensive insulin treatment. Future studies should investigate whether personalizing bolus advisors using artificial intelligence technology can enhance these effects. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., de Jong, Marit, Vos, Rimke C., Bots, Michiel L., Reulen, Jos P. H., Houben, Alfons J. H. M., Webers, Carroll A. B., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Peters, Sanne A. E., and Stehouwer, Coen D. A.

Published
2021
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27. Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Author

Liu, Jun, Lahousse, Lies, Nivard, Michel G., Bot, Mariska, Chen, Lianmin, van Klinken, Jan Bert, Thesing, Carisha S., Beekman, Marian, van den Akker, Erik Ben, Slieker, Roderick C., Waterham, Eveline, van der Kallen, Carla J. H., de Boer, Irene, Li-Gao, Ruifang, Vojinovic, Dina, Amin, Najaf, Radjabzadeh, Djawad, Kraaij, Robert, Alferink, Louise J. M., Murad, Sarwa Darwish, Uitterlinden, André G., Willemsen, Gonneke, Pool, Rene, Milaneschi, Yuri, van Heemst, Diana, Suchiman, H. Eka D., Rutters, Femke, Elders, Petra J. M., Beulens, Joline W. J., van der Heijden, Amber A. W. A., van Greevenbroek, Marleen M. J., Arts, Ilja C. W., Onderwater, Gerrit L. J., van den Maagdenberg, Arn M. J. M., Mook-Kanamori, Dennis O., Hankemeier, Thomas, Terwindt, Gisela M., Stehouwer, Coen D. A., Geleijnse, Johanna M., ‘t Hart, Leen M., Slagboom, P. Eline, van Dijk, Ko Willems, Zhernakova, Alexandra, Fu, Jingyuan, Penninx, Brenda W. J. H., Boomsma, Dorret I., Demirkan, Ayşe, Stricker, Bruno H. C., and van Duijn, Cornelia M.

Published
2020
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28. Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Author

van der Heide, Frank C T, Mokhtar, Sara, Khanna, Anjani, Said, Mozhda, Henry, Ronald M A, Kroon, Abraham A, Dagnelie, Pieter C, Eussen, Simone J P M, Berendschot, Tos T J M, Schouten, Jan S A G, Schram, Miranda T, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Wesselius, Anke, Savelberg, Hans H C M, Schaper, Nicolaas C, Webers, Carroll A B, Stehouwer, Coen D A, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, RS: MHeNs - R3 - Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: HVC Pieken Maastricht Studie (8), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, MUMC+: MA Endocrinologie (9), MUMC+: University Eye Center Maastricht (3), MUMC+: *MA Oogheelkunde (3), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), and MUMC+: MA Maag Darm Lever (9)

Subjects
Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology
Abstract

BACKGROUND: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.OBJECTIVE: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.METHODS: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).RESULTS: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.CONCLUSION: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.

Published
2023

29. Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study.

Author

Beran, Magdalena, van Gennip, April C. E., Stehouwer, Coen D. A., Jansen, Jacobus F. A., Gupta, Monideepa D., Houben, Alfons J. H. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., Wesselius, Anke, Schalkwijk, Casper G., Backes, Walter H., de Jong, Joost J. A., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Köhler, Sebastian, Vonk, Jet M. J., Geerlings, Mirjam I., Schram, Miranda T., and van Sloten, Thomas T.

Published
2024
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30. FRI615 The 1-Hour OGTT Plasma Glucose As A Biomarker Of β-cell Function

Author

Thomas Legvold, Brian, primary, Zhang, Amanda, additional, Marie Utzschneider, Kristina, additional, Kyung Rhee, Mary, additional, Staimez, Lisa R, additional, Easley, Kirk A, additional, Van Greevenbroek, Marleen M J, additional, Van Der Kallen, Carla J H, additional, Schalkwijk, Casper G, additional, Stehouwer, Coen D A, additional, and Phillips, Lawrence S, additional

Published
2023
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31. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study

Author

van der Heide, Frank C. T., primary, Steens, Indra L. M., additional, Limmen, Betsie, additional, Mokhtar, Sara, additional, van Boxtel, Martin P. J., additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Kroon, Abraham A., additional, van der Kallen, Carla J. H., additional, Dagnelie, Pieter C., additional, van Dongen, Martien C. J. M., additional, Eussen, Simone J. P. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, van Sloten, Thomas T., additional, Jansen, Jacobus F. A., additional, Backes, Walter H., additional, and Stehouwer, Coen D. A., additional

Published
2023
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35. Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study

Author

Erdős, Balázs, primary, van Sloun, Bart, additional, Goossens, Gijs H., additional, O’Donovan, Shauna D., additional, de Galan, Bastiaan E., additional, van Greevenbroek, Marleen M. J., additional, Stehouwer, Coen D. A., additional, Schram, Miranda T., additional, Blaak, Ellen E., additional, Adriaens, Michiel E., additional, van Riel, Natal A. W., additional, and Arts, Ilja C. W., additional

Published
2023
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36. The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study

Author

Foreman, Yuri D., Brouwers, Martijn C. G. J., Berendschot, Tos T. J. M., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., van Greevenbroek, Marleen M. J., Henry, Ronald M. A., Houben, Alfons J. H. M., van der Kallen, Carla J. H., Kroon, Abraham A., Reesink, Koen D., Schram, Miranda T., Schaper, Nicolaas C., and Stehouwer, Coen D. A.

Published
2019
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37. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study.

Author

van der Heide, Frank C. T., Steens, Indra L. M., Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P. J., Schram, Miranda T., Köhler, Sebastian, Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Koster, Annemarie, van Sloten, Thomas T., Jansen, Jacobus F. A., Backes, Walter H., and Stehouwer, Coen D. A.

Abstract

INTRODUCTION: The retina may provide non‐invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross‐sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank.

Author

Li Feng, Zhenyao Ye, Chen Mo, Jingtao Wang, Song Liu, Si Gao, Hongjie Ke, Canida, Travis A., Yezhi Pan, van Greevenbroek, Marleen M. J., Houben, Alfons J. H. M., Kai Wang, Hatch, Kathryn S., Yizhou Ma, Lei, David K. Y., Chixiang Chen, Mitchell, Braxton D., Hong, L. Elliot, Kochunov, Peter, and Shuo Chen

Published
2023
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40. Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression and quality of life: The Maastricht Study

Author

de Ritter, Rianneke, primary, Sep, Simone J. S., additional, van der Kallen, Carla J. H., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, Eussen, Simone J. P. M., additional, Dagnelie, Pieter C., additional, van Boxtel, Martin, additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Martens, Jordi A. J., additional, Snobl, Lucia, additional, Vos, Rimke C., additional, Stehouwer, Coen D. A., additional, and Peters, Sanne A. E., additional

Published
2023
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41. Circulating and adipose tissue immune cells in tissue‐specific insulin resistance in humans with overweight and obesity

Author

Trouwborst, Inez, primary, Wouters, Kristiaan, additional, Jocken, Johan W., additional, Jardon, Kelly M., additional, Gijbels, Anouk, additional, Dagnelie, Pieter C., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J., additional, Stehouwer, Coen D. A., additional, Schalkwijk, Casper G., additional, Richard, Nathalie, additional, Bendik, Igor, additional, Afman, Lydia A., additional, Blaak, Ellen E., additional, and Goossens, Gijs H., additional

Published
2023
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42. Association of physical activity with endothelial dysfunction among adults with and without chronic kidney disease: The Maastricht Study

Author

Bellos, Ioannis, Marinaki, Smaragdi, Lagiou, Pagona, Boletis, Ioannis N, Stehouwer, Coen D A, van Greevenbroek, Marleen M J, Eussen, Simone J P M, de Galan, Bastiaan E, Savelberg, Hans H C M, Koster, Annemarie, Wesselius, Anke, Benetou, Vassiliki, Bellos, Ioannis, Marinaki, Smaragdi, Lagiou, Pagona, Boletis, Ioannis N, Stehouwer, Coen D A, van Greevenbroek, Marleen M J, Eussen, Simone J P M, de Galan, Bastiaan E, Savelberg, Hans H C M, Koster, Annemarie, Wesselius, Anke, and Benetou, Vassiliki

Abstract

BACKGROUND AND AIMS: Physical activity (PA) constitutes an established protective factor while sedentary behavior (SB) an emerging independent risk factor for cardiovascular diseases. This study evaluated the association of PA and SB with endothelial dysfunction (ED) depending on kidney function status. METHODS: Cross-sectional data from the prospective, population-based Maastricht Study were used. PA and SB were measured using the ActivPAL3 accelerometer 24h/day for eight consecutive days. ED was evaluated by plasma levels of soluble vascular cell adhesion protein-1, intercellular adhesion molecule-1, E-selectin and von Willebrand factor, which were combined into an ED score with higher values depicting higher ED. RESULTS: Overall, 2,668 participants, 323 with chronic kidney disease, were included. In normal kidney function individuals, the ED score presented a significant negative association with total, lower-intensity and moderate-to-vigorous PA duration and a positive association with total sedentary time, sedentary breaks and sedentary bout duration. In participants with chronic kidney disease, a significant negative association of ED score with total [ß: -4.42, 95% confidence intervals (95% CI): -7.98; -0.87] and lower-intensity (ß: -7.08, 95% CI: -13.41; -0.74) PA duration, as well as a positive association of ED score with sedentary bout duration (ß: 43.72, 95% CI: 9.85; 77.59) were noted. The strength of associations did not significantly differ across kidney function subgroups (p > 0.05). CONCLUSIONS: This analysis showed that PA duration is inversely associated with ED both among patients with normal kidney function and chronic kidney disease. In chronic kidney disease, longer sedentary bouts were associated with greater endothelial dysfunction.

Published
2023

43. The association between the food environment and adherence to healthy diet quality: the Maastricht Study.

Author

Chan, Jeffrey Alexander, Koster, Annemarie, Eussen, Simone J. P. M., Pinho, Maria Gabriela M., Lakerveld, Jeroen, Stehouwer, Coen D. A., Dagnelie, Pieter C., van der Kallen, Carla J., van Greevenbroek, Marleen M. J., Wesselius, Anke, and Bosma, Hans

Abstract

Objective: The purpose of this study is to determine if healthier neighbourhood food environments are associated with healthier diet quality. Design: This was a cross-sectional study using linear regression models to analyse data from the Maastricht Study. Diet quality was assessed using data collected with a FFQ to calculate the Dutch Healthy Diet (DHD). A buffer zone encompassing a 1000 m radius was created around each participant home address. The Food Environment Healthiness Index (FEHI) was calculated using a Kernel density analysis within the buffers of available food outlets. The association between the FEHI and the DHD score was analysed and adjusted for socio-economic variables. Setting: The region of Maastricht including the surrounding food retailers in the Netherlands. Participants: 7367 subjects aged 40–75 years in the south of the Netherlands. Results: No relationship was identified between either the FEHI (B = 0·62; 95 % CI = –2·54, 3·78) or individual food outlets, such as fast food (B = –0·07; 95 % CI = – 0·20, 0·07) and diet quality. Similar null findings using the FEHI were identified at the 500 m (B = 0·95; 95 % CI = –0·85, 2·75) and 1500 m (B = 1·57; 95 % CI = –3·30, 6·44) buffer. There was also no association between the food environment and individual items of the DHD including fruits, vegetables and sugar-sweetened beverages. Conclusion: The food environment in the Maastricht area appeared marginally unhealthy, but the differences in the food environment were not related to the quality of food that participants reported as intake. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Author

Tore, Elena C., primary, Elshorbagy, Amany K., additional, Bakers, Frans C. H., additional, Brouwers, Martijn C. G. J., additional, Dagnelie, Pieter C., additional, Eussen, Simone J. P. M., additional, Jansen, Jacobus F. A., additional, Kooi, M. Eline, additional, Kusters, Yvo H. A. M., additional, Meex, Steven J. R., additional, Olsen, Thomas, additional, Refsum, Helga, additional, Retterstøl, Kjetil, additional, Schalkwijk, Casper G., additional, Stehouwer, Coen D. A., additional, Vinknes, Kathrine J., additional, and van Greevenbroek, Marleen M. J., additional

Published
2022
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47. Daily patterns of physical activity, sedentary behavior, and prevalent and incident depression—The Maastricht Study

Author

Gianfredi, Vincenza, primary, Schaper, Nicolaas C., additional, Odone, Anna, additional, Signorelli, Carlo, additional, Amerio, Andrea, additional, Eussen, Simone J. P. M., additional, Köhler, Sebastian, additional, Savelberg, Hans H. C. M., additional, Stehouwer, Coen D. A., additional, Dagnelie, Pieter C., additional, Henry, Ronald M. A., additional, van der Kallen, Carla J. H., additional, van Greevenbroek, Marleen M. J., additional, Schram, Miranda T., additional, and Koster, Annemarie, additional

Published
2022
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48. Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

Author

Simons, Pomme I. H. G., primary, Valkenburg, Olivier, additional, van de Waarenburg, Marjo P. H., additional, van Greevenbroek, Marleen M. J., additional, Kooi, M. Eline, additional, Jansen, Jacobus F. A., additional, Schalkwijk, Casper G., additional, Stehouwer, Coen D. A., additional, and Brouwers, Martijn C. G. J., additional

Published
2022
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49. Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study

Author

Maasen, Kim, primary, Eussen, Simone J P M, additional, Dagnelie, Pieter C, additional, Houben, Alfons J H M, additional, Webers, Carroll A B, additional, Schram, Miranda T, additional, Berendschot, Tos T J M, additional, Stehouwer, Coen D A, additional, Opperhuizen, Antoon, additional, van Greevenbroek, Marleen M J, additional, and Schalkwijk, Casper G, additional

Published
2022
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50. Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Author

Luijk, René, Wu, Haoyu, Ward-Caviness, Cavin K, Hannon, Eilis, Carnero-Montoro, Elena, Min, Josine L., Mandaviya, Pooja, Müller-Nurasyid, Martina, Mei, Hailiang, van der Maarel, Silvere M., BIOS Consortium, Relton, Caroline, Mill, Jonathan, Waldenberger, Melanie, Bell, Jordana T., Jansen, Rick, Zhernakova, Alexandra, Franke, Lude, ‘t Hoen, Peter A. C., Boomsma, Dorret I., van Duijn, Cornelia M., van Greevenbroek, Marleen M. J., Veldink, Jan H., Wijmenga, Cisca, van Meurs, Joyce, Daxinger, Lucia, Slagboom, P. Eline, van Zwet, Erik W., and Heijmans, Bastiaan T.

Published
2018
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