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2. Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts

Author

Asllani, Julijana, Douagui, Habib, Asayag, Estrella, Elizabeth, Castro Maria, Crisci, Carlos D., Gomez, René Maximiliano, Ivancevich, Juan Carlos, Jares, Edgardo, Máspero, Jorge Fernando, Moreno, Pablo, Neffen, Hugo Eduardo, Zernotti, Mario Emilio, Bosnic-Anticevich, Sinthia, Chahhoud Carson, Kristin, Cvetkovski, Biljana, Davies, Janet M., Kritikos, Vicky, O'Hehir, Robyn, Oliver, Brian, Tan, House Rachel, Tattersall, Jessica, Zubrinich, Celia, Aberer, Werner, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Doyen, Virginie, Ebo, Didier, Louis, Renaud, Rombaux, Philippe, Scheire, Sophie, Bennoor, Kazi, Barreto, Bruno A., Camargos, Paulo, Chong-Neto, Herberto Jose, Cruz, Alvaro A., da Silva, Jane, Marta, Guidacci, Rizzo, José Angelo, Rosario Filho, Nelson, Faradiba, Sarquis Serpa, Solé, Dirceu, Urrutia-Pereira, Marilyn, Christoff, George, Mariana, Mandazhieva-Pepelanova, Cvetanka, Odjakova, Popov, Todor A., Vicheva, Dilyana, Teixeira Maria, do Ceu, Bouchard, Jacques, Brozek, Jan, Chu, Derek K., Denburg, Judah, Eiwegger, Thomas, Keith, Paul K., To, Teresa, Waserman, Susan, Abusada, Nancy, Alvarez Cuesta, Emilio, Calvo-Gil, Mario A., Guzmán, Maria Antonieta, Pérez Gomez, Tamara, Wong Gary, Wing Kin, Zhang, Luo, Caraballo, Luis, Cepeda Sarabia, Alfonso, Nyembue, Dieudonné, Soto-Martinez, Manuel, Miculinic, Neven, Plavec, Davor, Pitsios, Constantinos, Yiallouros, Panayiotis, Panzner, Petr, Sova, Milan, Vachova, Martina, Bindslev-Jensen, Carsten, Dahl, Ronald, Malling, Hans-Jorgen, Münter, Lars, Poulsen, Lars K., Charlotte, Suppli Ulrik, Tannert, Line Kring, Mahboub, Bassam, Salameh, Laila, Cherrez-Ojeda, Ivan, Robles, de Guevara Karla, El-Owaidy, Rasha Hassan, El-Sayed, Zeinab A., El-Sayed, Shereen Saad, Hossny, Elham, Mostafa, Badr Eldin, Julge, Kaja, Billo, Nils Eric, Eklund, Patrik, Erhola, Marina, Haahtela, Tari, Karjalainen, Jussi, Makela, Mika, Toppila-Salmi, Sanna, Valovirta, Erkka, Vasankari, Tuula, Annesi-Maesano, Isabella, Bossé, Isabelle, Bourgoin-Heck, Melisande, Charpin, Denis, Coste, André, de Blay, Frédéric, Devillier, Philippe, Didier, Alain, Dinh-Xuan, Anh Tuan, Fontaine, Jean-François, Just, Jocelyne, Nadif, Rachel, Pham-Thi, Nhân, Pigearias, Bernard, Roche, Nicolas, Ganse Eric, Van, Chkhartishvili, Ekaterine, Gamkrelidze, Amiran, Gotua, Maia, Becker, Sven, Bergmann, Karl-Christian, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Chaker, Adam M., Darsow, Ulf, Hamelmann, Eckard, Heinrich, Joachim, Keil, Thomas, Klimek, Ludger, Kolkhir, Pavel, Lau, Susanne, Maurer, Marcus, Mösges, Ralph, Neou, Angelos, Pfaar, Oliver, Ring, Johannes, Wagenmann, Martin, Zuberbier, Torsten, Ramanauskaite, Aiste, Lingnau, Anja, Christou, Demetrios, Neisinger, Sophia, Aggelidis, Xenophon, Constantinidis, Jannis, Dimou, Maria, Grigoreas, Christos, Kapsali, Trisevgeni, Katotomichelakis, Michael, Loukides, Stelios, Makris, Michael, Manousakis, Emmanouil, Mikos, Nikolaos, Pagkalos, Aris, Papadopoulos, Nikolaos G., Papanikolaou, Vasileios, Paraskevopoulos, Giannis, Piskou, Konstantina, Prokopakis, Emmanuel, Psarros, Fotios, Samitas, Konstantinos, Stamataki, Sofia, Stefanaki Lina, Evangelia, Syrigou, Ekaterini, Tsiligianni, Ioanna, Vallianatou, Mina, Vourdas, Dimitrios, Xepapadaki, Paraskevi, Karavelia, Aspasia, Wai San Ko, Fanny, Wong, Gary, Hirschberg, Andor, Kraxner, Helga, Nekam, Kristof, Lane, Stephen, Rottem, Menachem, Artesani Maria, Cristina, Barbaglia, Simona, Beghé, Bianca, Bilo Maria, Beatrice, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Braido, Fulvio, Brussino, Luisa, Canonica, G Walter, Cecchi, Lorenzo, Ciprandi, Giorgio, Compalati, Enrico, D'Amato, Gennaro, De Feo, Giulia, Del Giacco, Stefano, Fiocchi, Alessandro, Heffler, Enrico, Lombardi, Carlo, Monti, Riccardo, Muraro, Antonella, Nettis, Eustachio, Nicola, Stefania, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Rolla, Giovanni, Romano, Antonino, Scichilone, Nicola, Triggiani, Massimo, Ventura Maria, Teresa, Viegi, Giovanni, Boccabella, Cristina, Giovannini, Mattia, Mahesh Padukudru, Anand, Iinuma, Tomohisa, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Pawankar, Ruby, Sakurai, Daiju, Suzukawa, Maho, Yamaguchi, Masao, Ispayeva, Zhanat, Chang, Yoon-Seok, Park, Hae-Sim, Al-Ahmad, Mona, Cirule, Ieva, Grisle, Ineta, Irani, Carla, Rouadi, Philip, Zaitoun, Fares, Dubakiene, Ruta, Emuzyte, Regina, Kvedariene, Violeta, Gradauskiene, Brigita, Valiulis, Arunas, Ollert, Markus, Hannachi, Farah, Dokic, Dejan, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Palaniappan, S.P., Woo, Kent, Montefort, Stephen, Bedolla Barajas, Martín, Costa Domínguez, María del Carmen, Espinoza Contreras, Jesús Guillermo, Fuentes Pèrez, Jose Miguel, Gálvez Romero, José Luis, García Cruz, María de la Luz Hortensia, González Diaz, Sandra, Huerta Villalobos, Yunuen Rocío, Larenas-Linnemann, Désiree E., Luna-Pech, Jorge Agustin, Matta Campos, Juan José, Rivero Yeverino, Daniela, Rodríguez González, Mónica, Rodríguez Zagal, Eréndira, Lkhagvaa, Battur, Mavale-Manuel, Sandra, Nunes Elizabete, Abrantes, Chavannes, Niels, Fokkens, Wytske J., Koppelman, Gerard, Maitland-van der Zee, Anke-Hilse, Reitsma, Sietze, Chandrasekharan, Ramanathan, Yusuf, Osman, Repka-Ramirez, Maria Susana, Sisul, Juan Carlos, Gereda, José E., Recto, Marysia T., Bialek, Slawomir, Bialoszewski, Artur, Chelminska, Marta, Gawlik, Radoslaw, Jassem, Ewa, Jutel, Marek, Kuna, Piotr, Kupczyk, Maciej, Moniuszko, Marcin, Niedoszytko, Marek, Raciborski, Filip, Romantowski, Jan, Samolinski, Boleslaw, Specjalski, Krzysztof, Carreiro Martins, Pedro, Correia de Sousa, Jaime, Costa, Elisio, Fonseca, Joao A., Lourenço, Olga, Morais-Almeida, Mario, Pereira Ana, Margarida, Regateiro, Frederico, Robalo Cordeiro, Carlos, Rosado Pinto, Jose, Sousa-Pinto, Bernardo, Taborda Barata, Luis, Todo-Bom, Ana Maria, Vieira Rafael, José, Carvalho, Daniela, Al-Nesf, Maryam Ali, Agache, Ioana, Berghea Elena, Camelia, Bumbacea, Roxana, Deleanu, Diana, Mihaltan, Florin, Panaitescu Bunu, Carmen, Khaitov, Musa, Namazova-Baranova, Leyla, Vishneva, Elena, Alshaikh Nada, Ali, Dimic-Janjic, Sanja, Milenkovic, Branislava, Wang, De Yun, Hrubiško, Martin, Edelbaher, Natalija, Jošt, Maja, Kopac, Peter, Košnik, Mitja, Lalek, Nika, Poplas Susic, Antonija, Rozman Sinur, Irma, Soklic Košak, Tanja, Triller, Nadja, Triller, Katja, Urbancic, Jure, Zidarn, Mihaela, Levin, Michael, Potter, Paul, Zar, Heather, Alobid, Isam, Anto, Aram, Bartra, Joan, Bobolea, Irina, Campo, Paloma, Cardona, Vicky, Carriazo Ana, Maria, Castillo Vizuete, José Antonio, Chivato, Tomas, Davila Gonzalez, Ignacio Jesus, Mullol, Joaquim, Nieto Garcia, Antonio, Picado, César, Quirce, Santiago, Sastre, Joaquin, de las Vecillas, Leticia, Benson, Mikael, Kull, Inger, van Hage, Marianne, Wickman, Magnus, Khaltaev, Nikolai, Mohammad, Yousser, Tantilipikorn, Pongsakorn, Vichyanond, Pakit, Cingi, Cemal, Gemicioglu, Bilun, Goksel, Ozlem, Kalayci, Omer, Kalyoncu, Ali Fuat, Meço, Cem, Vardaloglu, Koyuncu Ilgim, Yorgancioglu, Arzu, Karabacak, Deniz Eyice, Kirenga, Bruce, Adcock, Ian Michael, Arshad, Hasan S., Bewick, Mike, Bond, Christine, Brightling, Christopher, Bush, Andrew, Calderon, Moïses, Chung, Kian Fan, Custovic, Adnan, Djukanovic, Ratko, Durham, Stephen, Farrell, John, Halpin, David, Hyland, Michael, Johnston, Sebastian, Lipworth, Brian, Nakonechna, Alla, Price, David, Roberts, Graham, Ryan, Dermot, Schwarze, Jürgen, Sheikh, Aziz, Shields, Mike, Walker, Samantha, Williams, Sian, Kaidashev, Igor, Kurchenko, Andrii Igorevich, Tsaryk, Vladyslav, Bernstein, David, Bernstein, Jonathan A., Casale, Thomas B., Chinthrajah, Sharon, Dykewicz, Mark, Marshall, Gailen D., Meltzer, Eli O., Naclerio, Robert M., Togias, Alkis, Toskala, Elina, Wallace, Dana, Williams, Dennis M., Yawn, Barbara, Caballero-Fonseca, Fernan, Le Thi Tuyet, Lan, Vu, Tran Thien Quan, Gil-Mata, Sara, Teixeira, Tatiana, Bedbrook, Anna, Bousquet, Jean, and Vieira, Rafael José

Published
2024
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5. Shared DNA methylation signatures in childhood allergy: The MeDALL study

Author

Xu, Cheng-Jian, Gruzieva, Olena, Qi, Cancan, Esplugues, Ana, Gehring, Ulrike, Bergström, Anna, Mason, Dan, Chatzi, Leda, Porta, Daniela, Lodrup Carlsen, Karin C., Baïz, Nour, Madore, Anne-Marie, Alenius, Harri, van Rijkom, Bianca, Jankipersadsing, Soesma A., van der Vlies, Pieter, Kull, Inger, van Hage, Marianne, Bustamante, Mariona, Lertxundi, Aitana, Torrent, Matias, Santorelli, Gillian, Fantini, Maria Pia, Hovland, Vegard, Pesce, Giancarlo, Fyhrquist, Nanna, Laatikainen, Tiina, Nawijn, Martijn C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Bousquet, Jean, Anto, Josep M., Laprise, Catherine, Haahtela, Tari, Annesi-Maesano, Isabella, Carlsen, Kai-Håkon, Gori, Davide, Kogevinas, Manolis, Wright, John, Söderhäll, Cilla, Vonk, Judith M., Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H.

Published
2021
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7. Air pollution and IgE sensitization in 4 European birth cohorts—the MeDALL project

Author

Melén, Erik, Standl, Marie, Gehring, Ulrike, Altug, Hicran, Antó, Josep Maria, Berdel, Dietrich, Bergström, Anna, Bousquet, Jean, Heinrich, Joachim, Koppelman, Gerard H., Kull, Inger, Lupinek, Christian, Markevych, Iana, Schikowski, Tamara, Thiering, Elisabeth, Valenta, Rudolf, van Hage, Marianne, von Berg, Andrea, Vonk, Judith M., Wickman, Magnus, Wijga, Alet, and Gruzieva, Olena

Published
2021
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8. Childhood PUFA levels in relation to allergic sensitization and rhinitis up to young adulthood.

Author

Ekström, Sandra, Sdona, Emmanouela, Klevebro, Susanna, Westman, Marit, van Hage, Marianne, Georgelis, Antonios, Kull, Inger, Melén, Erik, Risérus, Ulf, and Bergström, Anna

Subjects
YOUNG adults, UNSATURATED fatty acids, GENERALIZED estimating equations, ALLERGIC rhinitis, ALLERGIES
Abstract

Background: Very long‐chain (VLC) polyunsaturated fatty acids (PUFA) have been hypothesized to influence the risk of allergic disease. The aim of the study was to investigate the role of plasma levels of omega‐3 (n‐3) and omega‐6 (n‐6) PUFA in childhood and adolescence, for the development of rhinitis and allergic sensitization up to young adulthood. Methods: The study included n = 933 participants from the BAMSE cohort. Proportions of n‐3 and n‐6 PUFA in plasma phospholipids were analyzed at 8 and 16 years using gas chromatography. Associations between PUFA and rhinitis as well as allergic sensitization, analyzed by IgE reactivity against airborne allergens, up to age 24 years were analyzed by generalized estimating equations and logistic regression models. Results: High plasma levels of VLC n‐3 PUFA as well as the n‐6 PUFA arachidonic acid (AA) at 8 years were inversely associated with rhinitis (overall OR up to 24 years: 0.72, 95% CI 0.55, 0.0.93 and 0.69 [0.53, 0.89], respectively) and aeroallergen sensitization (0.64 [0.49, 0.83] and 0.71 [0.54, 0.92], respectively). However, excluding prevalent cases at 8 years attenuated the associations. Conclusion: Plasma levels of n‐3 and certain n‐6 PUFA in childhood were inversely associated with allergic sensitization and allergic rhinitis up to young adulthood. The association may to some extent be explained by persistent childhood disease, rather than new incident cases in adolescence and young adulthood. To what extent these associations are driven by dietary PUFA intake versus metabolism remains to be clarified for the prevention of rhinitis and allergic sensitization. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Toward personalization of asthma treatment according to trigger factors

Author

Niespodziana, Katarzyna, Borochova, Kristina, Pazderova, Petra, Schlederer, Thomas, Astafyeva, Natalia, Baranovskaya, Tatiana, Barbouche, Mohamed-Ridha, Beltyukov, Evgeny, Berger, Angelika, Borzova, Elena, Bousquet, Jean, Bumbacea, Roxana S., Bychkovskaya, Snezhana, Caraballo, Luis, Chung, Kian Fan, Custovic, Adnan, Docena, Guillermo, Eiwegger, Thomas, Evsegneeva, Irina, Emelyanov, Alexander, Errhalt, Peter, Fassakhov, Rustem, Fayzullina, Rezeda, Fedenko, Elena, Fomina, Daria, Gao, Zhongshan, Giavina-Bianchi, Pedro, Gotua, Maia, Greber-Platzer, Susanne, Hedlin, Gunilla, Ilina, Natalia, Ispayeva, Zhanat, Idzko, Marco, Johnston, Sebastian L., Kalayci, Ömer, Karaulov, Alexander, Karsonova, Antonina, Khaitov, Musa, Kovzel, Elena, Kowalski, Marek L., Kudlay, Dmitry, Levin, Michael, Makarova, Svetlana, Matricardi, Paolo Maria, Nadeau, Kari C., Namazova-Baranova, Leyla, Naumova, Olga, Nazarenko, Oleksandr, O’Byrne, Paul M., Osier, Faith, Pampura, Alexander N., Panaitescu, Carmen, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pohl, Wolfgang, Renz, Harald, Riabova, Ksenja, Sampath, Vanitha, Sekerel, Bülent E., Sibanda, Elopy, Siroux, Valérie, Sizyakina, Ludmila P., Sun, Jin-Lyu, Szepfalusi, Zsolt, Umanets, Tetiana, Van Bever, Hugo P.S., van Hage, Marianne, Vasileva, Margarita, von Mutius, Erika, Wang, Jiu-Yao, Wong, Gary W.K., Zaikov, Sergii, Zidarn, Mihaela, and Valenta, Rudolf

Published
2020
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11. The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

Author

Caraballo, Luis, Valenta, Rudolf, Puerta, Leonardo, Pomés, Anna, Zakzuk, Josefina, Fernandez-Caldas, Enrique, Acevedo, Nathalie, Sanchez-Borges, Mario, Ansotegui, Ignacio, Zhang, Luo, van Hage, Marianne, Abel-Fernández, Eva, Karla Arruda, L., Vrtala, Susanne, Curin, Mirela, Gronlund, Hans, Karsonova, Antonina, Kilimajer, Jonathan, Riabova, Ksenja, Trifonova, Daria, and Karaulov, Alexander

Published
2020
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14. Th2-skewed T cells correlate with B cell response to [alpha]-Gal and tick antigens in [alpha]-Gal syndrome

Author

Apostolovic, Danijela, Grundstrom, Jeanette, Kiewiet, Mensiena B. Gea, Perusko, Marija, Hamsten, Carl, Starkhammar, Maria, Paulie, Staffan, and van Hage, Marianne

Subjects
Physiological aspects, Development and progression, Health aspects, Causes of, Food hypersensitivity -- Causes of -- Development and progression -- Physiological aspects, Hard ticks -- Health aspects, Immune response -- Health aspects, CD4 lymphocytes -- Physiological aspects -- Health aspects, Food allergy -- Causes of -- Development and progression -- Physiological aspects
Abstract

Introduction Vector-borne zoonotic diseases are emerging at an increasing rate worldwide and are of major concern, largely due to changing global ecology (1). Among the most common pathogens transferred by [...], Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-[alpha]-1,3-galactose ([alpha]-Gal) syndrome (AGS). Cellular responses to [alpha]-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and [alpha]-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing [alpha]-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the [alpha]-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to [alpha]-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.

Published
2023
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15. A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Gómez, R. Maximiliano, Jensen-Jarolim, Erika, Ebisawa, Motohiro, Luengo, Olga, Caraballo, Luis, Passalacqua, Giovanni, Poulsen, Lars K., Savi, Eleonora, Zuberbier, Torsten, Villa, Elisa, Oppenheimer, John, Asero, Riccardo, Bernstein, Jonathan, Bousquet, Jean, Cardona, Victoria, Cox, Lindo, Demoly, Pascal, Ferreira, Fatima, Giavina Bianchi, Pedro, Gonzalez Diaz, Sandra, Jakob, Thilo, Kase Tanno, Luciana, Kleine-Tebbe, Jorg, Levin, Michael, Martin, Bryan, Matricardi, Paolo Maria, Monge Ortega, Olga Patricia, Morais Almeida, Mario, Nunes, Carlos, Ortega Martell, José Antonio, Pawankar, Ruby, Renz, Harald, Rosário Filho, Nelson, Rouadi, Philip, Ruiba, Alessia, Sampson, Hugh, Sánchez Borges, Mario, Scala, Enrico, Schmid-Grendelmeier, Peter, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Valenta, Rudolf, van Hage, Marianne, Wong, Gary W.K., and Yáñez, Anahí

Published
2020
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16. Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans

Author

Lin, Ang, Apostolovic, Danijela, Jahnmatz, Maja, Liang, Frank, Ols, Sebastian, Tecleab, Teghesti, Wu, Chenyan, van Hage, Marianne, Solovay, Ken, Rubin, Keith, Thorstensson, Camille LochRigmor, Thalen, Marcel, and Lore, Karin

Subjects
Analysis, Antigens -- Analysis, Vaccines -- Analysis, B cells -- Analysis, Vaccination -- Analysis, Immune response -- Analysis, Immunoglobulin G -- Analysis, T cells -- Analysis, Immunoglobulin A, Prejudice, Criminal investigation, Youth
Abstract

Introduction Despite high vaccination coverage worldwide, pertussis remains a major infectious disease globally in infants and young children (1, 2). Importantly, it has reemerged over the past decades, even in [...], BACKGROUND. The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1. METHODS. We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified. RESULTS. All BPZE1 vaccinees showed robust B. pertussis-specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1-specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1. CONCLUSION. The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission. TRIAL REGISTRATION. ClinicalTrials.gov NCT02453048, NCT00870350. FUNDING. ILiAD Biotechnologies, Swedish Research Council (Vetenskapsradet), Swedish Heart-Lung Foundation.

Published
2020
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Author

Leth-Møller, Katja Biering, van Hage, Marianne, Linneberg, Allan, Kårhus, Line Lund, Leth-Møller, Katja Biering, van Hage, Marianne, Linneberg, Allan, and Kårhus, Line Lund

Abstract

Alpha-gal IgE level can change rapidly. Reassessment of a patient's alpha-gal IgE level may be helpful in the patient's clinical follow-up. Pruritus related to the site of a previous tick bite strengthens the diagnosis of alpha-gal syndrome.

Published
2024

18. Navigating the evolving landscape of atopic dermatitis:Challenges and future opportunities: The 4th Davos declaration

Author

Traidl-Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi, Akdis, Mübecel, Aydin, Handan, Bärenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi-Qi, Mei, Bonefeld, Charlotte Menné, Bösch, Stefanie, Brüggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans Werner, Fähndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, Garvey, Lena H., Gharbo, Raschid, Gökkaya, Mehmet, Grando, Karin, Guillet, Carole, Guler, Erman, Gutermuth, Jan, Herrmann, Nadine, Hijnen, Dirk Jan, Hülpüsch, Claudia, Irvine, Alan D., Jensen-Jarolim, Erika, Kong, Heidi H., Koren, Hillel, Lang, Claudia C.V., Lauener, Roger, Maintz, Laura, Mantel, Pierre Yves, Maverakis, Emanuel, Möhrenschlager, Matthias, Müller, Svenja, Nadeau, Kari, Neumann, Avidan U., O'Mahony, Liam, Rabenja, Fahafahantsoa Rapelanoro, Renz, Harald, Rhyner, Claudio, Rietschel, Ernst, Ring, Johannes, Roduit, Caroline, Sasaki, Mari, Schenk, Mirjam, Schröder, Jens, Simon, Dagmar, Simon, Hans Uwe, Sokolowska, Milena, Ständer, Sonja, Steinhoff, Martin, Piccirillo, Doris Straub, Taïeb, Alain, Takaoka, Roberto, Tapparo, Martin, Teixeira, Henrique, Thyssen, Jacob Pontoppidan, Traidl, Stephan, Uhlmann, Miriam, van de Veen, Willem, van Hage, Marianne, Virchow, Christian, Wollenberg, Andreas, Yasutaka, Mitamura, Zink, Alexander, Schmid-Grendelmeier, Peter, Traidl-Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi, Akdis, Mübecel, Aydin, Handan, Bärenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi-Qi, Mei, Bonefeld, Charlotte Menné, Bösch, Stefanie, Brüggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans Werner, Fähndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, Garvey, Lena H., Gharbo, Raschid, Gökkaya, Mehmet, Grando, Karin, Guillet, Carole, Guler, Erman, Gutermuth, Jan, Herrmann, Nadine, Hijnen, Dirk Jan, Hülpüsch, Claudia, Irvine, Alan D., Jensen-Jarolim, Erika, Kong, Heidi H., Koren, Hillel, Lang, Claudia C.V., Lauener, Roger, Maintz, Laura, Mantel, Pierre Yves, Maverakis, Emanuel, Möhrenschlager, Matthias, Müller, Svenja, Nadeau, Kari, Neumann, Avidan U., O'Mahony, Liam, Rabenja, Fahafahantsoa Rapelanoro, Renz, Harald, Rhyner, Claudio, Rietschel, Ernst, Ring, Johannes, Roduit, Caroline, Sasaki, Mari, Schenk, Mirjam, Schröder, Jens, Simon, Dagmar, Simon, Hans Uwe, Sokolowska, Milena, Ständer, Sonja, Steinhoff, Martin, Piccirillo, Doris Straub, Taïeb, Alain, Takaoka, Roberto, Tapparo, Martin, Teixeira, Henrique, Thyssen, Jacob Pontoppidan, Traidl, Stephan, Uhlmann, Miriam, van de Veen, Willem, van Hage, Marianne, Virchow, Christian, Wollenberg, Andreas, Yasutaka, Mitamura, Zink, Alexander, and Schmid-Grendelmeier, Peter

Abstract

The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient-centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world.

Published
2024

19. Rhinovirus-induced wheeze was associated with asthma development in predisposed children

Author

Holmdahl, Idun, Lüning, Sofia, Wärnberg Gerdin, Sabina, Asarnoj, Anna, Hoyer, Angela, Filiou, Anastasia, Sjölander, Anders, James, Anna, Borres, Magnus P., Hedlin, Gunilla, van Hage, Marianne, Söderhäll, Cilla, Konradsen, Jon R., Holmdahl, Idun, Lüning, Sofia, Wärnberg Gerdin, Sabina, Asarnoj, Anna, Hoyer, Angela, Filiou, Anastasia, Sjölander, Anders, James, Anna, Borres, Magnus P., Hedlin, Gunilla, van Hage, Marianne, Söderhäll, Cilla, and Konradsen, Jon R.

Abstract

Aim This study explored whether early-life factors, such as rhinovirus-induced wheeze and allergic sensitisation, were related to asthma at 11 years of age. Methods We focused on 107 children aged 6–48 months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008–2012. They also attended follow-up visits at 11 years of age and were compared with 46 age-matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression. Results We found that 62.6% of the acute wheeze cases had asthma at 11 years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02–5.6). Other increased risks were parental heredity for asthma and/or allergies (adjusted OR 3.4, 95% CI 1.1–9.9) and allergic sensitisation at 2 years of age (adjusted OR 3.0, 95% CI 1.02–8.7). The highest prevalence of asthma was when children had both rhinovirus-induced wheeze at inclusion and allergic sensitisation at 7 years of age. Conclusion Our findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children.

Published
2024
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20. This title is unavailable for guests, please login to see more information.

Author

Peruško, Marija, Grundström, Jeanette, Eldh, Maria, Reinhardt, Annika, Fuhrmann, Verena, Düzakin, Meltem, Hamsten, Carl, Starkhammar, Maria, Apostolović, Danijela, van Hage, Marianne, Peruško, Marija, Grundström, Jeanette, Eldh, Maria, Reinhardt, Annika, Fuhrmann, Verena, Düzakin, Meltem, Hamsten, Carl, Starkhammar, Maria, Apostolović, Danijela, and van Hage, Marianne

Published
2024

22. Recombinant PreS-fusion protein vaccine for birch pollen and apple allergy

Author

Khaitov, Musa, Shilovskiy, Igor, Valenta, Rudolf, Weber, Milena, Korneev, Artem, Tulaeva, Inna, Gattinger, Pia, van Hage, Marianne, Hofer, Gerhard, Konradsen, Jon R., Keller, Walter, Akinfenwa, Oluwatoyin, Poroshina, Alina, Ilina, Nataliya, Fedenko, Elena, Elisyutina, Olga, Litovkina, Alla, Smolnikov, Evgenii, Nikonova, Aleksandra, Rybalkin, Sergei, Aldobaev, Vladimir, Smirnov, Valeriy, Shershakova, Nadezhda, Petukhova, Olga, Kudlay, Dmitriy, Shatilov, Artem, Timofeeva, Anastasiya, Campana, Raffaela, Udin, Sergei, Skvortsova, Veronica, Khaitov, Musa, Shilovskiy, Igor, Valenta, Rudolf, Weber, Milena, Korneev, Artem, Tulaeva, Inna, Gattinger, Pia, van Hage, Marianne, Hofer, Gerhard, Konradsen, Jon R., Keller, Walter, Akinfenwa, Oluwatoyin, Poroshina, Alina, Ilina, Nataliya, Fedenko, Elena, Elisyutina, Olga, Litovkina, Alla, Smolnikov, Evgenii, Nikonova, Aleksandra, Rybalkin, Sergei, Aldobaev, Vladimir, Smirnov, Valeriy, Shershakova, Nadezhda, Petukhova, Olga, Kudlay, Dmitriy, Shatilov, Artem, Timofeeva, Anastasiya, Campana, Raffaela, Udin, Sergei, and Skvortsova, Veronica

Abstract

Background: IgE cross-sensitization to major birch pollen allergen Bet v 1 and pathogenesis-related (PR10) plant food allergens is responsible for the pollen-food allergy syndrome. Methods: We designed a recombinant protein, AB-PreS, consisting of non-allergenic peptides derived from the IgE-binding sites of Bet v 1 and the cross-reactive apple allergen, Mal d 1, fused to the PreS domain of HBV surface protein as immunological carrier. AB-PreS was expressed in E. coli and purified by chromatography. The allergenic and inflammatory activity of AB-PreS was tested using basophils and PBMCs from birch pollen allergic patients. The ability of antibodies induced by immunization of rabbits with AB-PreS and birch pollen extract-based vaccines to inhibit allergic patients IgE binding to Bet v 1 and Mal d 1 was assessed by ELISA. Results: IgE-binding experiments and basophil activation test revealed the hypoallergenic nature of AB-PreS. AB-PreS induced lower T-cell activation and inflammatory cytokine production in cultured PBMCs from allergic patients. IgG antibodies induced by five injections with AB-PreS inhibited allergic patients' IgE binding to Bet v 1 and Mal d 1 better than did IgG induced by up to 30 injections of six licensed birch pollen allergen extract-based vaccines. Additionally, immunization with AB-PreS induced HBV-specific antibodies potentially protecting from infection with HBV. Conclusion: The recombinant AB-PreS-based vaccine is hypoallergenic and superior over currently registered allergen extract-based vaccines regarding the induction of blocking antibodies to Bet v 1 and Mal d 1 in animals.

Published
2024
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23. Natural course of pollen-induced allergic rhinitis from childhood to adulthood : A 20-year follow up

Author

Lindqvist, Magnus, Leth-Moller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergstrom, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melen, Erik, Westman, Marit, Lindqvist, Magnus, Leth-Moller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergstrom, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melen, Erik, and Westman, Marit

Abstract

Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide. There are limited prospective long-term data regarding persistency and remission of AR. The objective of this study was to investigate the natural course of pollen-induced AR (pollen-AR) over 20 years, from childhood into early adulthood. Methods: Data from 1137 subjects in the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic birth cohort (BAMSE) with a completed questionnaire regarding symptoms, asthma, treatment with allergen immunotherapy (AIT) and results of allergen-specific IgE for inhalant allergens at 4, 8, 16 and 24 years were analyzed. Pollen-AR was defined as sneezing, runny, itchy or blocked nose; and itchy or watery eyes when exposed to birch and/or grass pollen in combination with allergen-specific IgE >= 0.35kUA/L to birch and/or grass. Results: Approximately 75% of children with pollen-AR at 4 or 8 years had persistent disease up to 24 years, and 30% developed asthma. The probability of persistency was high already at low levels of pollen-specific IgE. The highest rate of remission from pollen-AR was seen between 16 and 24 years (21.5%); however, the majority remained sensitized. This period was also when pollen-specific IgE-levels stopped increasing and the average estimated annual incidence of pollen-AR decreased from 1.5% to 0.8% per year. Conclusion: Children with pollen-AR are at high risk of persistent disease for at least 20 years. Childhood up to adolescence seems to be the most dynamic period of AR progression. Our findings underline the close cross-sectional and longitudinal relationship between sensitization, AR and asthma.

Published
2024
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24. Natural course of pollen-induced allergic rhinitis from childhood to adulthood:A 20-year follow up

Author

Lindqvist, Magnus, Leth-Møller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergström, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melén, Erik, Westman, Marit, Lindqvist, Magnus, Leth-Møller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergström, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melén, Erik, and Westman, Marit

Abstract

Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide. There are limited prospective long-term data regarding persistency and remission of AR. The objective of this study was to investigate the natural course of pollen-induced AR (pollen-AR) over 20 years, from childhood into early adulthood. Methods: Data from 1137 subjects in the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic birth cohort (BAMSE) with a completed questionnaire regarding symptoms, asthma, treatment with allergen immunotherapy (AIT) and results of allergen-specific IgE for inhalant allergens at 4, 8, 16 and 24 years were analyzed. Pollen-AR was defined as sneezing, runny, itchy or blocked nose; and itchy or watery eyes when exposed to birch and/or grass pollen in combination with allergen-specific IgE ≥0.35kUA/L to birch and/or grass. Results: Approximately 75% of children with pollen-AR at 4 or 8 years had persistent disease up to 24 years, and 30% developed asthma. The probability of persistency was high already at low levels of pollen-specific IgE. The highest rate of remission from pollen-AR was seen between 16 and 24 years (21.5%); however, the majority remained sensitized. This period was also when pollen-specific IgE-levels stopped increasing and the average estimated annual incidence of pollen-AR decreased from 1.5% to 0.8% per year. Conclusion: Children with pollen-AR are at high risk of persistent disease for at least 20 years. Childhood up to adolescence seems to be the most dynamic period of AR progression. Our findings underline the close cross-sectional and longitudinal relationship between sensitization, AR and asthma.

Published
2024

29. WHO/IUIS Allergen Nomenclature: Providing a common language

Author

Pomés, Anna, Davies, Janet M., Gadermaier, Gabriele, Hilger, Christiane, Holzhauser, Thomas, Lidholm, Jonas, Lopata, Andreas L., Mueller, Geoffrey A., Nandy, Andreas, Radauer, Christian, Chan, Sanny K., Jappe, Uta, Kleine-Tebbe, Jörg, Thomas, Wayne R., Chapman, Martin D., van Hage, Marianne, van Ree, Ronald, Vieths, Stefan, Raulf, Monika, and Goodman, Richard E.

Published
2018
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30. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Author

Alfvén, Tobias, Alm, Johan, Bergström, Anna, Engstrand, Lars, Rosenlund, Helen, Hakansson, Niclas, Lilja, Gunnar, Nyberg, Frederik, Swartz, Jackie, Wickman, Magnus, Wildhaber, Johannes, Möller, Alex, Brunekreef, Bert, Boeve, Mirian, Douwes, Jeroen, Huber, Machteld, Gertraud Weiss, Mirjam Matze, Schreue, Mynda, Michles, Karin B., Sennhauser, Felix, Scheynius, Annika, Hirvonen, Maija-Riitta, Remes, Sami, Roponen, Marjut, Tiittanen, Pekka, Dalphin, Marie-Laure, Gisela Buchele, Vincent Kaulek, Ege, Markus, Kabesch, Michael, Pfefferle, Petra, Loss, Georg, Hyvärinen, Anne, Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F., Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M., Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A., von Mutius, Erika, O’Mahony, Liam, and Lauener, Roger P.

Published
2018
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31. Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes

Author

Djapovic, Milica, primary, Apostolovic, Danijela, additional, Postic, Vojislava, additional, Lujic, Tamara, additional, Jovanovic, Vesna, additional, Stanic-Vucinic, Dragana, additional, van Hage, Marianne, additional, Maslak, Veselin, additional, and Cirkovic Velickovic, Tanja, additional

Published
2023
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33. Allergenic Activity of Individual Cat Allergen Molecules

Author

Trifonova, Daria, primary, Curin, Mirela, additional, Riabova, Ksenja, additional, Karsonova, Antonina, additional, Keller, Walter, additional, Grönlund, Hans, additional, Käck, Ulrika, additional, Konradsen, Jon, additional, van Hage, Marianne, additional, Karaulov, Alexander, additional, and Valenta, Rudolf, additional

Published
2023
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34. Inflammatory related plasma proteins involved in acute preschool wheeze

Author

Holmdahl, Idun, primary, Chakraborty, Sandip, additional, Hoyer, Angela, additional, Filiou, Anastasia, additional, Asarnoj, Anna, additional, Sjölander, Anders, additional, Borres, Magnus P., additional, van Hage, Marianne, additional, Hedlin, Gunilla, additional, Konradsen, Jon R., additional, and Söderhäll, Cilla, additional

Published
2023
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39. Rhinovirus-induced preschool wheeze in combination with allergic sensitization increases the risk of asthma in early adolescence

Author

Holmdahl, Idun, primary, Lüning, Sofia, additional, Wärnberg Gerdin, Sabina, additional, Asarnoj, Anna, additional, Hoyer, Angela, additional, Filiou, Anastasia, additional, Sjölander, Anders, additional, James, Anna, additional, Borres, Magnus, additional, Hedlin, Gunilla, additional, Van Hage, Marianne, additional, Söderhäll, Cilla, additional, and Konradsen, Jon R, additional

Published
2023
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40. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author

Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten

Published
2016
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42. Inflammatory related plasma proteins involved in acute preschool wheeze

Author

Holmdahl, Idun, Chakraborty, Sandip, Hoyer, Angela, Filiou, Anastasia, Asarnoj, Anna, Sjölander, Anders, Borres, Magnus P., van Hage, Marianne, Hedlin, Gunilla, Konradsen, Jon R., Söderhäll, Cilla, Holmdahl, Idun, Chakraborty, Sandip, Hoyer, Angela, Filiou, Anastasia, Asarnoj, Anna, Sjölander, Anders, Borres, Magnus P., van Hage, Marianne, Hedlin, Gunilla, Konradsen, Jon R., and Söderhäll, Cilla

Published
2023
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43. Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes

Author

Djapovic, Milica, Apostolović, Danijela, Postic, Vojislava, Lujić, Tamara, Jovanović, Vesna B., Stanić-Vučinić, Dragana, van Hage, Marianne, Maslak, Veselin, Ćirković Veličković, Tanja, Djapovic, Milica, Apostolović, Danijela, Postic, Vojislava, Lujić, Tamara, Jovanović, Vesna B., Stanić-Vučinić, Dragana, van Hage, Marianne, Maslak, Veselin, and Ćirković Veličković, Tanja

Published
2023

44. Exploring proteomic plasma biomarkers in eosinophilic and neutrophilic asthma

Author

Kere, Maura, Klevebro, Susanna, Hernandez-Pacheco, Natalia, Ödling, Maria, Ekström, Sandra, Mogensen, Ida, Janson, Christer, Palmberg, Lena, van Hage, Marianne, Georgelis, Antonios, Bergström, Anna, Kull, Inger, Melén, Erik, Björkander, Sophia, Kere, Maura, Klevebro, Susanna, Hernandez-Pacheco, Natalia, Ödling, Maria, Ekström, Sandra, Mogensen, Ida, Janson, Christer, Palmberg, Lena, van Hage, Marianne, Georgelis, Antonios, Bergström, Anna, Kull, Inger, Melén, Erik, and Björkander, Sophia

Abstract

BACKGROUND: Few biomarkers identify eosinophilic and neutrophilic asthma beyond cell concentrations in blood or sputum. Finding novel biomarkers for asthma endotypes could give insight about disease mechanisms and guide tailored treatment. Our aim was to investigate clinical characteristics and inflammation-related plasma proteins in relation to blood eosinophil and neutrophil concentrations in subjects with and without asthma. METHODS: We included 24-26-year-old subjects (n = 2063) from the Swedish population-based cohort BAMSE. Subjects with asthma (n = 239) and without asthma (n = 1824) were subdivided based on blood eosinophil and neutrophil concentrations (cut-offs 0.3 × 109 /L and 5.0 × 109 /L, respectively). We measured the levels of 92 plasma proteins using Olink Proseek Multiplex Inflammation Panel Assay. Group statistics tests were used to analyse the data, as well as adjusted multiple logistic regression models. RESULTS: Among subjects with asthma, 21.8% had eosinophilic asthma and 20.5% neutrophilic asthma. Eosinophilic asthma, but not neutrophilic asthma, was associated with a distinct clinical phenotype with, for example, higher proportions of eczema and sensitization. Most plasma proteins that associated with high eosinophil and/or neutrophil blood concentrations in subjects with asthma showed similar associations in subjects without asthma. However, out of these proteins, MMP10 levels were associated with eosinophilic asthma and were significantly higher as compared to controls with high eosinophilic concentration, while CCL4 levels associated with high neutrophil concentration only in subjects with asthma. CONCLUSIONS: Eosinophilic asthma was associated with a clear clinical phenotype. With our definitions, we identified MMP10 as a possible plasma biomarker for eosinophilic asthma and CCL4 was linked to neutrophilic asthma. These proteins should be evaluated further in clinical settings and using sputum granulocytes to define the asthma endotypes.

Published
2023
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45. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles

Author

Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, Valenta, Rudolf, Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, and Valenta, Rudolf

Abstract

BACKGROUND: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy.METHODS: Immunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population-based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL-allergen chip.RESULTS: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5-sensitization dominated in North and West/Central Europe.CONCLUSION: We show regional, exposome- and climate-dependent differences in molecular IgE-reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine-based approaches for treatment and prevention of allergy.

Published
2023

46. Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation : A 24-year follow-up

Author

Tedner, Sandra G., Klevebro, Susanna, Bergström, Anna, Kull, Inger, Andersson, Niklas, Borres, Magnus P., Ballardini, Natalia, Westman, Marit, Konradsen, Jon R., van Hage, Marianne, Nilsson, Caroline, Melén, Erik, Asarnoj, Anna, Tedner, Sandra G., Klevebro, Susanna, Bergström, Anna, Kull, Inger, Andersson, Niklas, Borres, Magnus P., Ballardini, Natalia, Westman, Marit, Konradsen, Jon R., van Hage, Marianne, Nilsson, Caroline, Melén, Erik, and Asarnoj, Anna

Abstract

Background Long-time data of peanut allergy over time is sparse. We aimed to study the longitudinal development of sensitization to peanut extract and storage protein allergen molecules and associations with asthma status, airway and systemic inflammation markers. Methods The Swedish birth cohort BAMSE followed 4089 participants with questionnaires, clinical investigations and blood sampling between 0 and 24 years. Information on (i) background factors at 2 months, (ii) peanut allergy symptoms and IgE data (ImmunoCAP) at 4, 8, 16, and 24 years, and (iii) IgE to storage proteins, lung function data including exhaled nitric oxide (FENO) as well as systemic inflammatory markers at 24 years of age were collected. Results The prevalence of peanut extract sensitization, defined as IgE ≥ 0.35 kUA/L, was 5.4%, 8.0%, 7.5%, and 6.2% at 4, 8, 16, and 24 years of age, respectively. Between 8 and 24 years of age, (33/1565) participants developed IgE-ab to peanut extract (median 1,4, range 0.7–2.6 kUA/L), and among those 85% were also sensitized to birch. Only six individuals developed sensitization to Ara h 2 (≥0.1 kUA/L) between 8 and 24 years of age, of whom three had an IgE-ab level between 0.1–0.12 kUA/L. Storage protein sensitization was associated with elevated FENO, blood eosinophils and type 2 inflammation-related systemic proteins. Conclusion Sensitization to peanut extract after 4 years of age is mainly induced by birch cross-sensitization and IgE to Ara h 2 rarely emerges after eight years of age. Storage protein sensitization is associated with respiratory and systemic inflammation.

Published
2023
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47. House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Author

Ramos-Ramirez, Patricia, Liu, Jielu, Mogren, Sofia, Gregory, Joshua, Noreby, Malin, Petren, Anne, Lei, Ying, Olsson, Henric, van Hage, Marianne, Kervinen, Jukka, Hellman, Lars, Andersson, Cecilia, Nilsson, Gunnar, Adner, Mikael, Ramos-Ramirez, Patricia, Liu, Jielu, Mogren, Sofia, Gregory, Joshua, Noreby, Malin, Petren, Anne, Lei, Ying, Olsson, Henric, van Hage, Marianne, Kervinen, Jukka, Hellman, Lars, Andersson, Cecilia, Nilsson, Gunnar, and Adner, Mikael

Abstract

Background. Asthma is a chronic inflammatory disease with structural changes in the lungs defined as airway remodelling. Mast cell responses are important in asthma as they, upon activation, release mediators inducing bronchoconstriction, inflammatory cell recruitment, and often remodelling of the airways. As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs. Methods. Guinea pigs were exposed intranasally to HDM or CDE for 4, 8, and 12 weeks, and airway histology was examined at each time point. Hematoxylin and eosin, Picro-Sirius Red, and Periodic Acid-Schiff staining were performed to evaluate airway inflammation, collagen deposition, and mucus-producing cells. In addition, Astra blue and immunostaining against tryptase and chymase were used to visualize mast cells. Results. Repetitive administration of HDM or CDE led to the accumulation of inflammatory cells into the proximal and distal airways as well as increased airway smooth muscle mass. HDM exposure caused subepithelial collagen deposition and mucus cell hyperplasia at all three time points, whereas CDE exposure only caused these effects at 8 and 12 weeks. Both HDM and CDE induced a substantial increase in mast cells after 8 and 12 weeks of challenges. This increase was primarily due to mast cells expressing tryptase, but not chymase, thus indicating mucosal mast cells. Conclusions. We here show that exposure to HDM and CDE elicits asthma-like histopathology in guinea pigs with infiltration of inflammatory cells, airway remodelling, and accumulation of primarily mucosal mast cells. The results together encourage the use of HDM and CDE allergens for the stimulation of a clinically re

Published
2023
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48. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, Valenta, Rudolf, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, and Valenta, Rudolf

Published
2023

49. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Abstract

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

Published
2023

50. EAACI Molecular Allergology User's Guide 2.0

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Published
2023

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