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Background: Little is known about train suicide and factors influencing its prevalence. This study tests the hypotheses that railway density, railway transportation volume, familiarity with railway transportation and population density contribute to train suicide. It also tests the relationship between train suicide and general population suicide and examines the prevalence and the characteristics of high-risk locations and their contribution to the grand total of train suicides., Methods: Trends in train suicides were compared with trends in railway track length, train kilometres, passenger kilometres and national suicide figures over the period 1950-2007. The geographical distribution over the national network over the period 1980-2007 was studied. Data were obtained from The Netherlands Railways, Prorail and Statistics Netherlands., Results: 1. The incidence of train suicides is unrelated to railway parameters. 2. Being familiar with railway transportation as a passenger is not a contributory factor. 3. Train suicide rates are unrelated to regional population density. 4. The incidence of train suicides parallels that of general population suicides. 5. Half of the train suicides took place at a limited number of locations, the most important of which were situated within a village or town and were close to a psychiatric hospital., Limitations: Most conclusions are based on correlational relationships between variables., Conclusions: 1. Train suicide trends reflect trends in general population suicides. 2. Increased train transportation does not lead to more train suicides. 3. The prevention of train suicide at high-risk locations (HRLs) in built-up areas and near psychiatric hospitals deserves first priority., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Background: Not all suicide methods are evenly distributed among different psychiatric disorders., Methods: In a nationwide sample of 505 suicides by persons in mental health care, the relationship between psychiatric diagnosis and suicide method was examined with chi(2) tests, logistic regression analyses and multinomial logistic regression analysis, including interactions with age, gender and treatment status., Results: Psychotic disorders were associated with jumping from heights, and substance-related disorders were associated with self-poisoning. Depressive disorders were not associated with any particular suicide method. Male patients preferred hanging, female patients self-poisoning. Inpatients preferred jumping before a train, outpatients self-poisoning. Bipolar patients preferred jumping before a train over hanging., Limitations: Psychological mechanisms for selection of suicide methods are still unknown., Conclusions: Possible means of suicide prevention suggested by this study include limiting access to tall buildings or structures to patients with psychotic disorders; careful prescription of medication to female patients and particularly to patients with substance-related disorders; and limiting easy access to railways near clinical settings to patients with bipolar and psychotic disorders. Limiting access to means of suicide may be less effective for suicidal patients with depressive disorders who may switch to other available methods., (2009 Elsevier B.V. All rights reserved.)

Background: The objective of this study is to investigate mental healthcare status and psychiatric disorders in train suicides., Methods: Data of 4 published train suicide studies were combined with a study of 57 train suicides in The Netherlands., Results: 53% of all train suicides received psychiatric care at the time of suicide, with 49% of them being inpatients. These values are higher than those found in general suicides. When compared to general suicides, functional non-affective psychoses are overrepresented by 25% vs 14%. The percentage of affective disorders approximates that of general suicides namely: 39% vs 42%. "Other diagnoses" are underrepresented by 23% vs 40%., Limitations: All psychiatric diagnoses were based on clinical data, which may not accurately reflect the patient's psychiatric condition at the time of suicide., Conclusions: Train suicides receive mental healthcare more often than general suicides and are more often characterized by severe psychopathology. The study indicates that patients with affective and psychotic disorders in particular should be targeted in order to prevent train suicide.

Background: Annual patterns in suicide rates, peaking near the summer solstice, are well documented. It has been suggested that day length or total hours of sunshine has an impact on suicide rates. If these environmental factors are involved, we would expect changes in the daily pattern of suicide rates to occur over the year. To test this hypothesis, the 24-h patterns of suicide rate were investigated as a function of time of year., Method: Detailed information about the exact time of suicides in The Netherlands is only available for train suicides. Therefore, information concerning age, sex, time and place of occurrence of all verified train suicides over 15 years in The Netherlands (n=2830) was obtained from The Netherlands Railways archives., Results: Daily patterns in train suicides show systematic variations of two kinds. First, independently of time of year, suicide rates at night drop to about 10% of their daytime values. Second, there are two daily peaks in the patterns which shift their timing over the year, with one peak occurring shortly after sunset, and the other one consistently occurring 9-10 h earlier. Both peaks shift with the 5.5-h shift in sunset time., Limitations: Train suicidal behaviour may not represent fatal suicidal behaviour in general., Conclusions: There are pronounced and systematic daily variations in train suicide rates in The Netherlands. One of these is related to clock time, the others are related to the light-dark cycle. The consistency of the patterns suggests a strong environmental influence on train suicidal behaviour. Research on 24-h patterns of suicide rates should control for time of year.

Liver from normal Wistar rats was grafted into the liver of homozygous Gunn rats which are deficient in UDP glucuronyl transferase (UDPGT) (bilirubin) activity. After 3 months, UDPGT activity (bilirubin) remained absent in microsomal suspensions of liver from recipient rats and no bilirubin glucuronide was detected in their bile.