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3. ASL to PET Translation by a Semi-supervised Residual-based Attention-guided Convolutional Neural Network

Author

Yousefi, Sahar, Sokooti, Hessam, Teeuwisse, Wouter M., Heijtel, Dennis F. R., Nederveen, Aart J., Staring, Marius, and van Osch, Matthias J. P.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Positron Emission Tomography (PET) is an imaging method that can assess physiological function rather than structural disturbances by measuring cerebral perfusion or glucose consumption. However, this imaging technique relies on injection of radioactive tracers and is expensive. On the contrary, Arterial Spin Labeling (ASL) MRI is a non-invasive, non-radioactive, and relatively cheap imaging technique for brain hemodynamic measurements, which allows quantification to some extent. In this paper we propose a convolutional neural network (CNN) based model for translating ASL to PET images, which could benefit patients as well as the healthcare system in terms of expenses and adverse side effects. However, acquiring a sufficient number of paired ASL-PET scans for training a CNN is prohibitive for many reasons. To tackle this problem, we present a new semi-supervised multitask CNN which is trained on both paired data, i.e. ASL and PET scans, and unpaired data, i.e. only ASL scans, which alleviates the problem of training a network on limited paired data. Moreover, we present a new residual-based-attention guided mechanism to improve the contextual features during the training process. Also, we show that incorporating T1-weighted scans as an input, due to its high resolution and availability of anatomical information, improves the results. We performed a two-stage evaluation based on quantitative image metrics by conducting a 7-fold cross validation followed by a double-blind observer study. The proposed network achieved structural similarity index measure (SSIM), mean squared error (MSE) and peak signal-to-noise ratio (PSNR) values of $0.85\pm0.08$, $0.01\pm0.01$, and $21.8\pm4.5$ respectively, for translating from 2D ASL and T1-weighted images to PET data. The proposed model is publicly available via https://github.com/yousefis/ASL2PET., Comment: 11 pages, 4 tables, 4 figures

Published
2021

4. An Adaptive Intelligence Algorithm for Undersampled Knee MRI Reconstruction

Author

Pezzotti, Nicola, Yousefi, Sahar, Elmahdy, Mohamed S., van Gemert, Jeroen, Schülke, Christophe, Doneva, Mariya, Nielsen, Tim, Kastryulin, Sergey, Lelieveldt, Boudewijn P. F., van Osch, Matthias J. P., de Weerdt, Elwin, and Staring, Marius

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Adaptive intelligence aims at empowering machine learning techniques with the additional use of domain knowledge. In this work, we present the application of adaptive intelligence to accelerate MR acquisition. Starting from undersampled k-space data, an iterative learning-based reconstruction scheme inspired by compressed sensing theory is used to reconstruct the images. We adopt deep neural networks to refine and correct prior reconstruction assumptions given the training data. The network was trained and tested on a knee MRI dataset from the 2019 fastMRI challenge organized by Facebook AI Research and NYU Langone Health. All submissions to the challenge were initially ranked based on similarity with a known groundtruth, after which the top 4 submissions were evaluated radiologically. Our method was evaluated by the fastMRI organizers on an independent challenge dataset. It ranked #1, shared #1, and #3 on respectively the 8x accelerated multi-coil, the 4x multi-coil, and the 4x single-coil track. This demonstrates the superior performance and wide applicability of the method.

Published
2020

5. Adaptive-CS-Net: FastMRI with Adaptive Intelligence

Author

Pezzotti, Nicola, de Weerdt, Elwin, Yousefi, Sahar, Elmahdy, Mohamed S., van Gemert, Jeroen, Schülke, Christophe, Doneva, Mariya, Nielsen, Tim, Kastryulin, Sergey, Lelieveldt, Boudewijn P. F., van Osch, Matthias J. P., and Staring, Marius

Subjects
Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Adaptive intelligence aims at empowering machine learning techniques with the extensive use of domain knowledge. In this work, we present the application of adaptive intelligence to accelerate MR acquisition. Starting from undersampled k-space data, an iterative learning-based reconstruction scheme inspired by compressed sensing theory is used to reconstruct the images. We adopt deep neural networks to refine and correct prior reconstruction assumptions given the training data. Our results show that an adaptive intelligence approach performs better than traditional methods as well as deep learning methods that do not take prior knowledge into account.

Published
2019

6. Perfusion and apparent oxygenation in the human placenta (PERFOX)

Author

Hutter, Jana, Harteveld, Anita A., Jackson, Laurence H., Franklin, Suzanne, Bos, Clemens, van Osch, Matthias J. P., OMuircheartaigh, Jonathan, Ho, Alison, Chappell, Lucy, Hajnal, Joseph V, Rutherford, Mary, and De Vita, Enrico

Subjects
Physics - Medical Physics
Abstract

Purpose: To study placental function - both perfusion and an oxygenation surrogate (T2*)-simultaneously and quantitatively in-vivo. Methods: 15 pregnant women were scanned on a 3T MR scanner. For perfusion measurements, a velocity selective arterial spin labelling preparation module was placed before a multi-echo gradient echo EPI readout to integrate T2* and perfusion measurements in one joint perfusion-oxygenation (PERFOX) acquisition. Joint motion correction and quantification were performed to evaluate changes in T2* and perfusion over GA. Results: The optimised integrated PERFOX protocol and post-processing allowed successful visualization and quantification of perfusion and T2* in all subjects. Areas of high T2* and high perfusion appear to correspond to placental sub-units and show a systematic offset in location along the maternal-fetal axis. The areas of highest perfusion are consistently closer to the maternal basal plate and the areas of highest T2* closer to the fetal chorionic plate. Quantitative results show a strong negative correlation of gestational age with T2* and weak negative correlation with perfusion. Conclusion: A strength of the joint sequence is that it provides truly simultaneous and co-registered estimates of local T2* and perfusion, however, to achieve this, the time per slice is prolonged compared to a perfusion only scan which can potentially limit coverage. The achieved interlocking can be particularly useful when quantifying transient physiological effects such as uterine contractions. PERFOX opens a new avenue to elucidate the relationship between maternal supply and oxygen uptake, both of which are central to placental function and dysfunction.

Published
2019

8. Cognition in (pre)symptomatic Dutch‐type hereditary and sporadic cerebral amyloid angiopathy.

Author

van Dort, Rosemarie, Kaushik, Kanishk, Rasing, Ingeborg, van der Zwet, Reinier G. J., Schipper, Manon R., van der Grond, Jeroen, van Rooden, Sanneke, van Zwet, Erik W., Terwindt, Gisela M., Middelkoop, Huub A. M., Hart, Ellen P., van Osch, Matthias J. P., van Walderveen, Marianne A. A., and Wermer, Marieke J. H.

Abstract

INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited. METHODS: We included Dutch‐type hereditary CAA (D‐CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age‐matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI‐cSVD burden and cognition. RESULTS: D‐CAA ICH− mutation carriers exhibited poorer global cognition and executive function compared to age‐matched controls. Patients with sCAA performed worse across all cognitive domains compared to D‐CAA ICH+ mutation carriers and age‐matched controls. MRI‐cSVD burden is associated with decreased processing speed. DISCUSSION: CAA is associated with dysfunction in multiple cognitive domains, even before ICH, with increased MRI‐cSVD burden being associated with slower processing speed. Highlights: Cognitive dysfunction is present in early disease stages of cerebral amyloid angiopathy (CAA) before the occurrence of symptomatic intracerebral hemorrhage (sICH).Presymptomatic Dutch‐type CAA (D‐CAA) mutation carriers show worse cognition than age‐matched controls.More early awareness of cognitive dysfunction in CAA before first sICH is needed.Increased cerebral small vessel disease CAA‐burden on magnetic resonance imaging is linked to a decrease in processing speed. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Evaluation of the Robustness of Learned MR Image Reconstruction to Systematic Deviations Between Training and Test Data for the Models from the fastMRI Challenge

Author

Johnson, Patricia M., Jeong, Geunu, Hammernik, Kerstin, Schlemper, Jo, Qin, Chen, Duan, Jinming, Rueckert, Daniel, Lee, Jingu, Pezzotti, Nicola, De Weerdt, Elwin, Yousefi, Sahar, Elmahdy, Mohamed S., Van Gemert, Jeroen Hendrikus Franciscus, Schülke, Christophe, Doneva, Mariya, Nielsen, Tim, Kastryulin, Sergey, Lelieveldt, Boudewijn P. F., Van Osch, Matthias J. P., Staring, Marius, Chen, Eric Z., Wang, Puyang, Chen, Xiao, Chen, Terrence, Patel, Vishal M., Sun, Shanhui, Shin, Hyungseob, Jun, Yohan, Eo, Taejoon, Kim, Sewon, Kim, Taeseong, Hwang, Dosik, Putzky, Patrick, Karkalousos, Dimitrios, Teuwen, Jonas, Miriakov, Nikita, Bakker, Bart, Caan, Matthan, Welling, Max, Muckley, Matthew J., Knoll, Florian, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Haq, Nandinee, editor, Johnson, Patricia, editor, Maier, Andreas, editor, Würfl, Tobias, editor, and Yoo, Jaejun, editor

Published
2021
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10. ASL-BIDS, the brain imaging data structure extension for arterial spin labeling

Author

Clement, Patricia, Castellaro, Marco, Okell, Thomas W., Thomas, David L., Vandemaele, Pieter, Elgayar, Sara, Oliver-Taylor, Aaron, Kirk, Thomas, Woods, Joseph G., Vos, Sjoerd B., Kuijer, Joost P. A., Achten, Eric, van Osch, Matthias J. P., Detre, John A., Lu, Hanzhang, Alsop, David C., Chappell, Michael A., Hernandez-Garcia, Luis, Petr, Jan, and Mutsaerts, Henk J. M. M.

Published
2022
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11. Erratum to: Velocity‐selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528–1547)

Author

Qin, Qin, primary, Alsop, David C., additional, Bolar, Divya S., additional, Hernandez‐Garcia, Luis, additional, Meakin, James, additional, Liu, Dapeng, additional, Nayak, Krishna S., additional, Schmid, Sophie, additional, van Osch, Matthias J. P., additional, Wong, Eric C., additional, Woods, Joseph G., additional, Zaharchuk, Greg, additional, Zhao, Moss Y., additional, Zun, Zungho, additional, and Guo, Jia, additional

Published
2024
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12. On the influence of the vascular architecture on Gradient Echo and Spin Echo BOLD fMRI signals across cortical depth: a simulation approach based on realistic 3D vascular networks

Author

Neurovascular Imaging Group, Precision Imaging Group, Cancer, Brain, Báez-Yáñez, Mario Gilberto, Siero, Jeroen C W, Curcic, Vanja, van Osch, Matthias J P, Petridou, Natalia, Neurovascular Imaging Group, Precision Imaging Group, Cancer, Brain, Báez-Yáñez, Mario Gilberto, Siero, Jeroen C W, Curcic, Vanja, van Osch, Matthias J P, and Petridou, Natalia

Published
2024

13. A fully synthetic three-dimensional human cerebrovascular model based on histological characteristics to investigate the hemodynamic fingerprint of the layer BOLD fMRI signal formation

Author

Neurovascular Imaging Group, Highfield Research Group, Brain, Cancer, Circulatory Health, Precision Imaging Group, Báez-Yáñez, Mario Gilberto, Schellekens, Wouter, Bhogal, Alex A, Roefs, Emiel C A, van Osch, Matthias J P, Siero, Jeroen CW, Petridou, Natalia, Neurovascular Imaging Group, Highfield Research Group, Brain, Cancer, Circulatory Health, Precision Imaging Group, Báez-Yáñez, Mario Gilberto, Schellekens, Wouter, Bhogal, Alex A, Roefs, Emiel C A, van Osch, Matthias J P, Siero, Jeroen CW, and Petridou, Natalia

Published
2024

14. Human brain clearance imaging : pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood

Author

van Osch, Matthias J. P., Wåhlin, Anders, Scheyhing, Paul, Mossige, Ingrid, Hirschler, Lydiane, Eklund, Anders, Mogensen, Klara, Gomolka, Ryszard, Radbruch, Alexander, Qvarlander, Sara, Decker, Andreas, Nedergaard, Maiken, Mori, Yuki, Eide, Per Kristian, Deike, Katerina, Ringstad, Geir, van Osch, Matthias J. P., Wåhlin, Anders, Scheyhing, Paul, Mossige, Ingrid, Hirschler, Lydiane, Eklund, Anders, Mogensen, Klara, Gomolka, Ryszard, Radbruch, Alexander, Qvarlander, Sara, Decker, Andreas, Nedergaard, Maiken, Mori, Yuki, Eide, Per Kristian, Deike, Katerina, and Ringstad, Geir

Abstract

Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal role in brain solute clearance through perivascular pathways and interactions between the brain and meningeal lymphatic vessels. Whereas most of this fundamental knowledge was gained from rodent models, human brain clearance imaging has provided important insights into the human system and highlighted the existence of important interspecies differences. Current gold standard techniques for human brain clearance imaging involve the injection of gadolinium-based contrast agents and monitoring their distribution and clearance over a period from a few hours up to 2 days. With both intrathecal and intravenous injections being used, which each have their own specific routes of distribution and thus clearance of contrast agent, a clear understanding of the kinetics associated with both approaches, and especially the differences between them, is needed to properly interpret the results. Because it is known that intrathecally injected contrast agent reaches the blood, albeit in small concentrations, and that similarly some of the intravenously injected agent can be detected in CSF, both pathways are connected and will, in theory, reach the same compartments. However, because of clear differences in relative enhancement patterns, both injection approaches will result in varying sensitivities for assessment of different subparts of the brain clearance system. In this opinion review article, the "EU Joint Programme – Neurodegenerative Disease Research (JPND)" consortium on human brain clearance imaging provides an overview of contrast agent pharmacokinetics in vivo following intrathecal and intravenous injections and what typical concentrations and concentration–time curves should be expected. This can be the basis for optimizing and interpreting contrast-enhanced MRI for brain clearance imaging. Furthermore, this can shed light on how molecules may exchange between blood, brain, and CSF.

Published
2024
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15. Advancing 7T perfusion imaging by pulsed arterial spin labeling: Using a parallel transmit coil for enhanced labeling robustness and temporal SNR

Author

Oliveira, Ícaro Agenor Ferreira, Schnabel, Robin, van Osch, Matthias J P, Zwaag, Wietske van der, Hirschler, Lydiane, Oliveira, Ícaro Agenor Ferreira, Schnabel, Robin, van Osch, Matthias J P, Zwaag, Wietske van der, and Hirschler, Lydiane

Abstract

Non-invasive perfusion imaging by Arterial spin labeling (ASL) can be advantageous at Ultra-high field (UHF) MRI, since the image SNR and the T1 relaxation time both increase with the static field. However, ASL implementation, especially at 7T, is not trivial. Especially for ASL, UHF MRI comes with many challenges, mainly due to B1+ inhomogeneities. This study aimed to investigate the effects of different transmit coil configurations on perfusion-weighted imaging at 7T using a flow-sensitive alternating inversion recovery (FAIR) technique with time-resolved frequency offset corrected inversion (TR-FOCI) pulses for labeling and background suppression. We conducted a performance comparison between a parallel transmit (pTx) system equipped with 32 receive (Rx) and 8 transmit (Tx) channels and a standard setup with 32Rx and 2Tx channels. Our findings demonstrate that the pTx system, characterized by a more homogeneous B1 transmit field, resulted in a significantly higher contrast-to-noise ratio, temporal signal-to-noise ratio, and lower coefficient of variance (CoV) than the standard 2Tx setup. Additionally, both setups demonstrated comparable capabilities for functional mapping of the hand region in the motor cortex, achieving reliable results within a short acquisition time of approximately 5 minutes.

Published
2024

16. Arterial input function estimation compensating for inflow and partial voluming in dynamic contrast-enhanced MRI

Author

Tseng, Chih-Hsien, Nagtegaal, Martijn A., van Osch, Matthias J. P., Jaspers, Jaap, Romero, Alejandra Mendez, Wielopolski, Piotr, Smits, Marion, Vos, Frans M., Tseng, Chih-Hsien, Nagtegaal, Martijn A., van Osch, Matthias J. P., Jaspers, Jaap, Romero, Alejandra Mendez, Wielopolski, Piotr, Smits, Marion, and Vos, Frans M.

Abstract

Both inflow and the partial volume effect (PVE) are sources of error when measuring the arterial input function (AIF) in dynamic contrast-enhanced (DCE) MRI. This is relevant, as errors in the AIF can propagate into pharmacokinetic parameter estimations from the DCE data. A method was introduced for flow correction by estimating and compensating the number of the perceived pulse of spins during inflow. We hypothesized that the PVE has an impact on concentration–time curves similar to inflow. Therefore, we aimed to study the efficiency of this method to compensate for both effects simultaneously. We first simulated an AIF with different levels of inflow and PVE contamination. The peak, full width at half-maximum (FWHM), and area under curve (AUC) of the reconstructed AIFs were compared with the true (simulated) AIF. In clinical data, the PVE was included in AIFs artificially by averaging the signal in voxels surrounding a manually selected point in an artery. Subsequently, the artificial partial volume AIFs were corrected and compared with the AIF from the selected point. Additionally, corrected AIFs from the internal carotid artery (ICA), the middle cerebral artery (MCA), and the venous output function (VOF) estimated from the superior sagittal sinus (SSS) were compared. As such, we aimed to investigate the effectiveness of the correction method with different levels of inflow and PVE in clinical data. The simulation data demonstrated that the corrected AIFs had only marginal bias in peak value, FWHM, and AUC. Also, the algorithm yielded highly correlated reconstructed curves over increasingly larger neighbourhoods surrounding selected arterial points in clinical data. Furthermore, AIFs measured from the ICA and MCA produced similar peak height and FWHM, whereas a significantly larger peak and lower FWHM was found compared with the VOF. Our findings indicate that the proposed method has high potential to compensate for PVE and inflow simultaneously. The corrected

Published
2024

17. Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “<scp>ISMRM</scp> Imaging Neurofluids Study group” Workshop in Rome

Author

Agarwal, Nivedita; https://orcid.org/0000-0002-1387-9566, Lewis, Laura D, Hirschler, Lydiane; https://orcid.org/0000-0003-2379-0861, Rivera, Leonardo Rivera; https://orcid.org/0000-0001-5629-8721, Naganawa, Shinji; https://orcid.org/0000-0002-0214-613X, Levendovszky, Swati Rane; https://orcid.org/0000-0001-8863-3168, Ringstad, Geir; https://orcid.org/0000-0003-0919-4510, Klarica, Marijan, Wardlaw, Joanna; https://orcid.org/0000-0002-9812-6642, Iadecola, Costantino; https://orcid.org/0000-0001-9797-073X, Hawkes, Cheryl; https://orcid.org/0000-0001-9007-0130, Carare, Roxana Octavia, Wells, Jack; https://orcid.org/0000-0002-4171-3539, Bakker, Erik N T P; https://orcid.org/0000-0003-2819-5818, Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995, Bilston, Lynne; https://orcid.org/0000-0001-8250-9019, Nedergaard, Maiken, Mori, Yuki; https://orcid.org/0000-0003-4208-0005, Stoodley, Marcus; https://orcid.org/0000-0002-4207-8493, Alperin, Noam; https://orcid.org/0000-0002-3828-2950, de Leon, Mony, van Osch, Matthias J P; https://orcid.org/0000-0001-7034-8959, Agarwal, Nivedita; https://orcid.org/0000-0002-1387-9566, Lewis, Laura D, Hirschler, Lydiane; https://orcid.org/0000-0003-2379-0861, Rivera, Leonardo Rivera; https://orcid.org/0000-0001-5629-8721, Naganawa, Shinji; https://orcid.org/0000-0002-0214-613X, Levendovszky, Swati Rane; https://orcid.org/0000-0001-8863-3168, Ringstad, Geir; https://orcid.org/0000-0003-0919-4510, Klarica, Marijan, Wardlaw, Joanna; https://orcid.org/0000-0002-9812-6642, Iadecola, Costantino; https://orcid.org/0000-0001-9797-073X, Hawkes, Cheryl; https://orcid.org/0000-0001-9007-0130, Carare, Roxana Octavia, Wells, Jack; https://orcid.org/0000-0002-4171-3539, Bakker, Erik N T P; https://orcid.org/0000-0003-2819-5818, Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995, Bilston, Lynne; https://orcid.org/0000-0001-8250-9019, Nedergaard, Maiken, Mori, Yuki; https://orcid.org/0000-0003-4208-0005, Stoodley, Marcus; https://orcid.org/0000-0002-4207-8493, Alperin, Noam; https://orcid.org/0000-0002-3828-2950, de Leon, Mony, and van Osch, Matthias J P; https://orcid.org/0000-0001-7034-8959

Abstract

Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the brain and spine that interact in a synchronized harmonious manner to assure a healthy microenvironment required for optimal neuroglial function. Neuroanatomists and biochemists have provided an incredible wealth of evidence revealing the anatomy of perivascular spaces, meninges and glia and their role in drainage of neuronal waste products. Human studies have been limited due to the restricted availability of noninvasive imaging modalities that can provide a high spatiotemporal depiction of the brain neurofluids. Therefore, animal studies have been key in advancing our knowledge of the temporal and spatial dynamics of fluids, for example, by injecting tracers with different molecular weights. Such studies have sparked interest to identify possible disruptions to neurofluids dynamics in human diseases such as small vessel disease, cerebral amyloid angiopathy, and dementia. However, key differences between rodent and human physiology should be considered when extrapolating these findings to understand the human brain. An increasing armamentarium of noninvasive MRI techniques is being built to identify markers of altered drainage pathways. During the three‐day workshop organized by the International Society of Magnetic Resonance in Medicine that was held in Rome in September 2022, several of these concepts were discussed by a distinguished international faculty to lay the basis of what is known and where we still lack evidence. We envision that in the next decade, MRI will allow imaging of the physiology of neurofluid dynamics and drainage pathways in the human brain to identify true pathological processes underlying disease and to discover new avenues for early diagnoses and treatments including drug delivery.Evidence level

Published
2024

18. Influence of arterial transit time delays on the differentiation between tumor progression and pseudoprogression in glioblastoma by arterial spin labeling magnetic resonance imaging.

Author

van Dorth, Daniëlle, Jiang, Feng Yan, Schmitz‐Abecassis, Bárbara, Croese, Robert J. I., Taphoorn, Martin J. B., Smits, Marion, Koekkoek, Johan A. F., Dirven, Linda, de Bresser, Jeroen, and van Osch, Matthias J. P.

Subjects
MAGNETIC resonance imaging, SPIN labels, CANCER invasiveness, GLIOBLASTOMA multiforme, PERFUSION
Abstract

Arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) have shown potential for differentiating tumor progression from pseudoprogression. For pseudocontinuous ASL with a single postlabeling delay, the presence of delayed arterial transit times (ATTs) could affect the evaluation of ASL‐MRI perfusion data. In this study, the influence of ATT artifacts on the perfusion assessment and differentiation between tumor progression and pseudoprogression were studied. This study comprised 66 adult patients (mean age 60 ± 13 years; 40 males) with a histologically confirmed glioblastoma who received postoperative radio (chemo)therapy. ASL‐MRI and DSC‐MRI scans were acquired at 3 months postradiotherapy as part of the standard clinical routine. These scans were visually scored regarding (i) the severity of ATT artifacts (%) on the ASL‐MRI scans only, scored by two neuroradiologists; (ii) perfusion of the enhancing tumor lesion; and (iii) radiological evaluation of tumor progression versus pseudoprogression by one neuroradiologist. The final outcome was based on combined clinical and radiological follow‐up until 9 months postradiotherapy. ATT artifacts were identified in all patients based on the mean scores of two raters. A significant difference between the radiological evaluation of ASL‐MRI and DSC‐MRI was observed only for ASL images with moderate ATT severity (30%–65%). The perfusion assessment showed ASL‐MRI tending more towards hyperperfusion than DSC‐MRI in the case of moderate ATT artifacts. In addition, there was a significant difference between the prediction of tumor progression with ASL‐MRI and the final outcome in the case of severe ATT artifacts (McNemar test, p = 0.041). Despite using ASL imaging parameters close to the recommended settings, ATT artifacts frequently occur in patients with treated brain tumors. Those artifacts could hinder the radiological evaluation of ASL‐MRI data and the detection of true disease progression, potentially affecting treatment decisions for patients with glioblastoma. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Time‐encoded ASL reveals lower cerebral blood flow in the early AD continuum.

Author

Falcon, Carles, Montesinos, Paula, Václavů, Lena, Kassinopoulos, Michalis, Minguillon, Carolina, Fauria, Karine, Cascales‐Lahoz, Diego, Contador, José, Fernández‐Lebrero, Aida, Navalpotro, Irene, Puig‐Pijoan, Albert, Grau‐Rivera, Oriol, Kollmorgen, Gwendlyn, Quijano‐Rubio, Clara, Molinuevo, José Luis, Zetterberg, Henrik, Blennow, Kaj, Suárez‐Calvet, Marc, Van Osch, Matthias J. P., and Sanchez‐Gonzalez, Javier

Abstract

INTRODUCTION: Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer's disease (AD) patients. We checked the sensitivity of time‐encoded arterial spin labeling (te‐ASL) in measuring CBF alterations in individuals with positive AD biomarkers and associations with relevant biomarkers in cognitively unimpaired (CU) individuals. METHODS: We compared te‐ASL with single‐postlabel delay (PLD) ASL in measuring CBF in 59 adults across the AD continuum, classified as CU amyloid beta (Aβ) negative (−), CU Aβ positive (+), and CI Aβ+. We sought associations of CBF with biomarkers of AD, cerebrovascular disease, synaptic dysfunction, neurodegeneration, and cognition in CU participants. RESULTS: te‐ASL was more sensitive at detecting CBF reduction in the CU Aβ+ and CI Aβ+ groups. In CU participants, lower CBF was associated with altered biomarkers of Aβ, tau, synaptic dysfunction, and neurodegeneration. DISCUSSION: CBF reduction occurs early in the AD continuum. te‐ASL is more sensitive than single‐PLD ASL at detecting CBF changes in AD. Highlights: Lower CBF can be detected in CU subjects in the early AD continuum.te‐ASL is more sensitive than single‐PLD ASL at detecting CBF alterations in AD.CBF is linked to biomarkers of AD, synaptic dysfunction, and neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Water exchange across the blood–brain barrier and epilepsy: Review on pathophysiology and neuroimaging.

Author

Abdennadher, Myriam, Jacobellis, Sara, Václavů, Lena, Juttukonda, Meher, Inati, Sara, Goldstein, Lee, van Osch, Matthias J. P., Rosen, Bruce, Hua, Ning, and Theodore, William

Subjects
EPILEPSY in animals, SPIN labels, EPILEPSY, SEIZURES (Medicine), MAGNETIC resonance imaging, HOMEOSTASIS
Abstract

The blood–brain barrier (BBB) is a barrier protecting the brain and a milieu of continuous exchanges between blood and brain. There is emerging evidence that the BBB plays a major role in epileptogenesis and drug‐resistant epilepsy, through several mechanisms, such as water homeostasis dysregulation, overexpression of drug transporters, and inflammation. Studies have shown abnormal water homeostasis in epileptic tissue and altered aquaporin‐4 water channel expression in animal epilepsy models. This review focuses on abnormal water exchange in epilepsy and describes recent non‐invasive MRI methods of quantifying water exchange. Plain Language Summary: Abnormal exchange between blood and brain contribute to seizures and epilepsy. The authors describe why correct water balance is necessary for healthy brain functioning and how it is impacted in epilepsy. This review also presents recent MRI methods to measure water exchange in human brain. These measures would improve our understanding of factors leading to seizures. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Fluid biomarkers in cerebral amyloid angiopathy

Author

Savar, Seyed Mehrdad, primary, Ma, Bin, additional, Hone, Eugene, additional, Jahan, Farzana, additional, Markovic, Shaun, additional, Pedrini, Steve, additional, Shemehsavar, Soudabeh, additional, Easwaran, Vandhana, additional, Taddei, Kevin, additional, Gardener, Samantha, additional, Chhatwal, Jasmeer P., additional, van Etten, Ellis S., additional, van Osch, Matthias J. P., additional, Clarke, Daniel, additional, Gnjec, Anastazija, additional, van Buchem, Mark A., additional, Wermer, Marieke J. H., additional, Hankey, Graeme J., additional, Greenberg, Steven M., additional, Martins, Ralph N., additional, and Sohrabi, Hamid R., additional

Published
2024
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25. Evaluation of the Robustness of Learned MR Image Reconstruction to Systematic Deviations Between Training and Test Data for the Models from the fastMRI Challenge

Author

Johnson, Patricia M., primary, Jeong, Geunu, additional, Hammernik, Kerstin, additional, Schlemper, Jo, additional, Qin, Chen, additional, Duan, Jinming, additional, Rueckert, Daniel, additional, Lee, Jingu, additional, Pezzotti, Nicola, additional, De Weerdt, Elwin, additional, Yousefi, Sahar, additional, Elmahdy, Mohamed S., additional, Van Gemert, Jeroen Hendrikus Franciscus, additional, Schülke, Christophe, additional, Doneva, Mariya, additional, Nielsen, Tim, additional, Kastryulin, Sergey, additional, Lelieveldt, Boudewijn P. F., additional, Van Osch, Matthias J. P., additional, Staring, Marius, additional, Chen, Eric Z., additional, Wang, Puyang, additional, Chen, Xiao, additional, Chen, Terrence, additional, Patel, Vishal M., additional, Sun, Shanhui, additional, Shin, Hyungseob, additional, Jun, Yohan, additional, Eo, Taejoon, additional, Kim, Sewon, additional, Kim, Taeseong, additional, Hwang, Dosik, additional, Putzky, Patrick, additional, Karkalousos, Dimitrios, additional, Teuwen, Jonas, additional, Miriakov, Nikita, additional, Bakker, Bart, additional, Caan, Matthan, additional, Welling, Max, additional, Muckley, Matthew J., additional, and Knoll, Florian, additional

Published
2021
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28. MRI phenotypes of glioblastomas early after treatment are suggestive of overall patient survival

Author

Abecassis, Bárbara Schmitz-, primary, Dirven, Linda, additional, Jiang, Janey, additional, Keller, Jasmin A, additional, Croese, Robert J I, additional, van Dorth, Daniëlle, additional, Ghaznawi, Rashid, additional, Kant, Ilse M J, additional, Taphoorn, Martin J B, additional, van Osch, Matthias J P, additional, Koekkoek, Johan A F, additional, and de Bresser, Jeroen, additional

Published
2023
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30. Structured low‐rank reconstruction for navigator‐free water/fat separated multi‐shot diffusion‐weighted EPI.

Author

Dong, Yiming, Koolstra, Kirsten, Li, Ziyu, Riedel, Malte, van Osch, Matthias J. P., and Börnert, Peter

Subjects
FAT
Abstract

Purpose: Multi‐shot diffusion‐weighted EPI allows an increase in image resolution and reduced geometric distortions and can be combined with chemical‐shift encoding (Dixon) to separate water/fat signals. However, such approaches suffer from physiological motion‐induced shot‐to‐shot phase variations. In this work, a structured low‐rank‐based navigator‐free algorithm is proposed to address the challenge of simultaneously separating water/fat signals and correcting for physiological motion‐induced shot‐to‐shot phase variations in multi‐shot EPI‐based diffusion‐weighted MRI. Theory and Methods: We propose an iterative, model‐based reconstruction pipeline that applies structured low‐rank regularization to estimate and eliminate the shot‐to‐shot phase variations in a data‐driven way, while separating water/fat images. The algorithm is tested in different anatomies, including head–neck, knee, brain, and prostate. The performance is validated in simulations and in‐vivo experiments in comparison to existing approaches. Results: In‐vivo experiments and simulations demonstrated the effectiveness of the proposed algorithm compared to extra‐navigated and an alternative self‐navigation approach. The proposed algorithm demonstrates the capability to reconstruct in the multi‐shot/Dixon hybrid space domain under‐sampled datasets, using the same number of acquired EPI shots compared to conventional fat‐suppression techniques but eliminating fat signals through chemical‐shift encoding. In addition, partial Fourier reconstruction can also be achieved by using the concept of virtual conjugate coils in conjunction with the proposed algorithm. Conclusion: The proposed algorithm effectively eliminates the shot‐to‐shot phase variations and separates water/fat images, making it a promising solution for future DWI on different anatomies. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Plasma amyloid beta 42 is a biomarker for patients with hereditary, but not sporadic, cerebral amyloid angiopathy

Author

de Kort, Anna M., primary, Kuiperij, H. Bea, additional, Jäkel, Lieke, additional, Kersten, Iris, additional, Rasing, Ingeborg, additional, van Etten, Ellis S., additional, van Rooden, Sanneke, additional, van Osch, Matthias J. P., additional, Wermer, Marieke J. H., additional, Terwindt, Gisela M., additional, Schreuder, Floris H. B. M., additional, Klijn, Catharina J. M., additional, and Verbeek, Marcel M., additional

Published
2023
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34. MR Vascular Fingerprinting with Hybrid Gradient-Spin Echo Dynamic Susceptibility Contrast MRI for Characterization of Microvasculature in Gliomas

Author

Venugopal, Krishnapriya, Arzanforoosh, Fatemeh, van Dorth, Danielle, Smits, Marion, van Osch, Matthias J. P., Hernandez-Tamames, Juan A. A., Warnert, Esther A. H., Poot, Dirk H. J., Venugopal, Krishnapriya, Arzanforoosh, Fatemeh, van Dorth, Danielle, Smits, Marion, van Osch, Matthias J. P., Hernandez-Tamames, Juan A. A., Warnert, Esther A. H., and Poot, Dirk H. J.

Abstract

Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our understanding of tumor physiology.

Published
2023

35. Arterial spin labeling using spatio-temporal encoding readout for robust perfusion imaging in inhomogenous magnetic fields

Author

Researchgr. Beeldg. Moleculaire Interv., Klinische Fysica RT, Cancer, Franklin, Suzanne L, Schuurmans, Megan, Otikovs, Martins, Borman, Pim T S, van Osch, Matthias J P, Bos, Clemens, Researchgr. Beeldg. Moleculaire Interv., Klinische Fysica RT, Cancer, Franklin, Suzanne L, Schuurmans, Megan, Otikovs, Martins, Borman, Pim T S, van Osch, Matthias J P, and Bos, Clemens

Published
2023

37. White matter hyperintensity shape is associated with long‐term dementia risk.

Author

Keller, Jasmin Annica, Sigurdsson, Sigurdur, Klaassen, Kelly, Hirschler, Lydiane, van Buchem, Mark A., Launer, Lenore J., van Osch, Matthias J. P., Gudnason, Vilmundur, and de Bresser, Jeroen

Abstract

INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long‐term dementia risk in community‐dwelling older adults. METHODS: Three thousand seventy‐seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)‐Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow‐up: 9.9 ± 2.6 years). RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p <.001) and convexity 1.38 (1.28 to 1.49), p <.001); higher concavity index 1.43 (1.32 to 1.54), p <.001) and fractal dimension 1.45 (1.32 to 1.58), p <.001)), higher total WMH volume (1.68 (1.54 to 1.87), p <.001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p <.001), and higher deep WMH volume (1.17 (1.08 to 1.27), p <.001) were associated with an increased long‐term dementia risk. DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community‐dwelling older adults. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Impact of region of interest definition on visual stimulation‐based cerebral vascular reactivity functional MRI with a special focus on applications in cerebral amyloid angiopathy

Author

van Harten, Thijs W., primary, van Rooden, Sanneke, additional, Koemans, Emma A., additional, van Opstal, Anna M., additional, Greenberg, Steven M., additional, van der Grond, Jeroen, additional, Wermer, Marieke J. H., additional, and van Osch, Matthias J. P., additional

Published
2023
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42. Erratum to: Velocity‐selective arterial spin labeling perfusion MRI : A review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528–1547)

Author

Qin, Qin, primary, Alsop, David C., additional, Bolar, Divya S., additional, Hernandez‐Garcia, Luis, additional, Meakin, James, additional, Liu, Dapeng, additional, Nayak, Krishna S., additional, Schmid, Sophie, additional, van Osch, Matthias J. P., additional, Wong, Eric C., additional, Woods, Joseph G., additional, Zaharchuk, Greg, additional, Zhao, Moss Y., additional, Zun, Zungho, additional, and Guo, Jia, additional

Published
2022
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47. Recent Technical Developments in ASL: A Review of the State of the Art

Author

Hernandez‐Garcia, Luis, primary, Aramendía‐Vidaurreta, Verónica, additional, Bolar, Divya S., additional, Dai, Weiying, additional, Fernández‐Seara, Maria A., additional, Guo, Jia, additional, Madhuranthakam, Ananth J., additional, Mutsaerts, Henk, additional, Petr, Jan, additional, Qin, Qin, additional, Schollenberger, Jonas, additional, Suzuki, Yuriko, additional, Taso, Manuel, additional, Thomas, David L., additional, van Osch, Matthias J. P., additional, Woods, Joseph, additional, Zhao, Moss Y., additional, Yan, Lirong, additional, Wang, Ze, additional, Zhao, Li, additional, and Okell, Thomas W., additional

Published
2022
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50. The photobiology of the human circadian clock

Author

Schoonderwoerd, Robin A, de Rover, Mischa, Janse, Jan A M, Hirschler, Lydiane, Willemse, Channa R, Scholten, Leonie, Klop, Ilse, van Berloo, Sander, van Osch, Matthias J P, Swaab, Dick F, Meijer, Johanna H, Schoonderwoerd, Robin A, de Rover, Mischa, Janse, Jan A M, Hirschler, Lydiane, Willemse, Channa R, Scholten, Leonie, Klop, Ilse, van Berloo, Sander, van Osch, Matthias J P, Swaab, Dick F, and Meijer, Johanna H

Abstract

SignificanceThe function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color sensitivity of our clock. Here, we show that narrowband blue, green, and orange light were all effective in changing neuronal activity of the clock. While the clock of nocturnal rodents is excited by light, the human clock responds with a decrease in neuronal activity as indicated by a negative BOLD response. The sensitivity of the clock to multiple colors should be integrated in light therapy aimed to strengthen our 24-h rhythms.

Published
2022

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