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869 results on '"van Pelt J"'

2. Characterizing neuromorphologic alterations with additive shape functionals

Author

Barbosa, M. S., Costa, L. da F., Bernardes, E. S., Ramakers, G., and van Pelt, J.

Subjects
Quantitative Biology - Quantitative Methods, Condensed Matter - Statistical Mechanics
Abstract

The complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation. In this paper we develop a procedure to address the characterization of morphological changes induced in cultured neurons by over-expressing a gene involved in mental retardation. Measures associated with the multiscale connectivity, an additive image functional, are found to give a reasonable separation criterion between two categories of cells. One category consists of a control group and two transfected groups of neurons, and the other, a class of cat ganglionary cells. The reported framework also identified a trend towards lower complexity in one of the transfected groups. Such results establish the suggested measures as an effective descriptors of cell shape.

Published
2004
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5. Judges: A 12-Week Study

Author

Miles V. Van Pelt, J. I. Packer, Dane Ortlund, Lane T. Dennis, Dane C. Ortlund

Published
2018

6. Fail Again. Fail Better

Author

Gerbrandy, P., De Temmerman, K., Van Pelt, J., Staat, K., and ASH (FGw)

Abstract

In the 880s, Notker Balbulus (c. 840–912), a monk in the monastery of Sankt Gallen on the southern shore of the Bodensee, was challenged by his friend Tuotilo to write a new Life of the cloister’s eponymous saint.1 Although several Lives were already available, Notker decided to take up the gauntlet. The piece of hagiography he wrote in collaboration with a few younger monks is one of the strangest texts in the history of Latin literature. In trying to analyse and interpret the work it may be helpful to use concepts taken from twentieth-century literary theory, as I hope to demonstrate.

Published
2023

8. Safe Schools for LGBTQI Students: How Do Teachers View Their Role in Promoting Safe Schools?

Author

Vega, Stephanie, Crawford, Heather Glynn, and Van Pelt, J-Lynn

Abstract

This literature review presents insights from existing research on how teachers view their role in creating safe schools for lesbian, gay, bisexual, transgender, queer/questioning, and intersex (LGBTQI) students. Analysis of the literature shows that there are concerns for LGBTQI students' safety in schools, that educational settings operate from a position of heteronormativity, and that heterosexual teachers are uniquely positioned as part of the dominant group in which they help to define what is normal and what is deviant in school culture. Research findings on the ways heterosexual teachers respond to institutional heteronormativity are summarized and compared. This review of research provides considerations for and recommendations to school administrators and teacher educators to address needs of teachers. Areas for future research also are identified. (Contains 1 note and 1 table.)

Published
2012
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12. Anti-Cancer Activity of Acriflavine as Metabolic Inhibitor of OXPHOS in Pancreas Cancer Xenografts

Author

Bulle A, Dekervel J, Deschuttere L, Nittner D, Van Cutsem E, Verslype C, and van Pelt J

Subjects
gene set enrichment analysis (gsea), pancreatic ductal adenocarcinoma (pdac), hif1, tumor microenvironment, metabolic reprogramming, drug repurposing, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, digestive system diseases
Abstract

Ashenafi Bulle,1 Jeroen Dekervel,1 Lise Deschuttere,1 David Nittner,2,3 Eric Van Cutsem,1 Chris Verslype,1 Jos van Pelt1 1Laboratory of Clinical Digestive Oncology, Department of Oncology, KU Leuven & University Hospitals Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium; 2Histopathology Expertise Center, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium; 3Department of Oncology, KU Leuven, Leuven, BelgiumCorrespondence: Jos van PeltLaboratory of Clinical Digestive Oncology, Department of Oncology, KU Leuven & University Hospitals Leuven and Leuven Cancer Institute (LKI), Leuven, BelgiumTel +32-16-330 694Fax +32-16-330 718Email jos.vanpelt@kuleuven.bePurpose: All currently available therapies for the treatment of pancreatic ductal adenocarcinoma (PDAC) show limited success. PDACs fast progression depends on the tumor characteristics and can be influenced by the microenvironment. The antibacterial drug acriflavine (ACF) has been shown to have anti-cancer activities in cell lines.Materials and Methods: To understand the working mechanism of ACF on cancer progression and tumor-stromal interplay, we evaluated pancreatic cancer in cell culture (Panc-1) (morphology, cell invasion and RNA expression) and the macrophage cell line THP1 (representing innate immune stromal cells). In the translational arm, the activity of ACF on xenograft models of human PDAC tumors representing different clinical subclasses was investigated (tumor growth, morphology and immunofluorescence, RNA expression and pathway analysis).Results: In vitro, ACF reduces epithelial-to-mesenchymal transition (EMT) and invasion of Panc-1 cells and shifts macrophage polarization to a M1-like anti-tumoral phenotype. At non-toxic concentrations, ACF downregulates cell metabolism. In xenografts, effect on tumor growth and metabolism could be confirmed; however, the innate immune stromal cells did not respond. Importantly, only in the moderately differentiated PDAC model, ACF could significantly suppress tumor growth and not in the fast-growing EMT-high model. Pathway analysis shows that ACF highly significantly downregulates metabolic pathways, especially OXPHOS and MYC/cell proliferation pathways in xenografts.Conclusion: ACF, with known pleiotropic effects on cancer cells, is in this study shown to be an attractive therapeutic based on its novel observed metabolic activity. Repurposing this compound for cancer treatment should be in the setting with other targeting agents, which offers reduced chance of resistance development in PDAC. Further evaluation should best be done in biological complex models such as human xenografts or syngeneic cancer models.Keywords: pancreatic ductal adenocarcinoma, PDAC, tumor microenvironment, Hif1α, gene set enrichment analysis, GSEA, metabolic reprogramming, drug repurposing

Published
2020

31. Notes

Author

Hershaw, L. M., Towns, George A., Van Pelt, J. R., and Arnold, Edward A.

Published
1934

36. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa

Author

Smarius, LJCA, Jacobs, GE, Hoeberechts-Lefrandt, DHM, de Kam, ML, van der Post, JP, de Rijk, R, van Pelt, J, Schoemaker, RC, Zitman, FG, van Gerven, JMA, and Gijsman, HJ

Subjects
Evaluation, Physiological aspects, Dosage and administration, Pharmacology -- Evaluation -- Physiological aspects, Serotonin agents -- Dosage and administration -- Physiological aspects, 5-hydroxytryptophan -- Dosage and administration -- Physiological aspects -- Evaluation
Abstract

Keywords: 5-HTP; challenge test; 5-HT; serotonergic function; pharmacokinetics; pharmacodynamics; side effects; cortisol; prolactin; HPA-axis Pharmacological stimulation tests, using challenges with receptor agonists, release stimulators or re-uptake inhibitors, are used to [...]

Published
2008
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