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445 results on '"van Steenbergen W"'

2. Impaired facial emotion recognition in relation to social behaviours in de novo Parkinson's disease.

Author

Slomp, Anne Carien, van der Zee, Sygrid, Boertien, Jeffrey M., Gerritsen, Marleen J. J., van Laar, Teus, Spikman, Jacoba M., Verwey, N. A., Van Harten, B., Portman, A. T., Langedijk, M. J. H., Oomes, P. G., Jansen, B. J. A. M., Van Wieren, T., Van den Bogaard, S. J. A., Van Steenbergen, W., Duyff, R., Van Amerongen, J. P., Fransen, P. S. S., Polman, S. K. L., and Zwartbol, R. T.

Subjects
EMOTION recognition, PARKINSON'S disease, FACIAL expression & emotions (Psychology), APATHY, SOCIAL integration, SOCIAL perception, NEUROPSYCHOLOGICAL tests
Abstract

Facial emotion recognition (FER) is a crucial component of social cognition and is essential in social‐interpersonal behaviour regulation. Although FER impairment is well‐established in advanced PD, data about FER at the time of diagnosis and its relationship with social behavioural problems in daily life are lacking. The aim was to examine FER at the time of PD diagnosis compared to a matched healthy control (HC) group and to associate FER with indices of social behavioural problems. In total, 142 de novo, treatment‐naïve PD patients and 142 HC were included. FER was assessed by the Ekman 60 faces test (EFT). Behavioural problems in PD patients were assessed using the Dysexecutive Questionnaire (DEX‐self and DEX‐proxy) and the Apathy Evaluation Scale (AES‐self). PD patients had significantly lower EFT‐total scores (p =.001) compared to HC, with worse recognition of Disgust (p =.001) and Sadness (p =.016). Correlational analyses yielded significant correlations between AES‐self and both EFT‐total (rs =.28) and Fear (rs =.22). Significant negative correlations were found between DEX‐proxy and both EFT‐total (rs = −.28) and Anger (rs = −.26). Analyses of DEX‐subscales showed that proxy ratings were significantly higher than patient‐ratings for the Social Conventions subscale (p =.047). This DEX‐proxy subscale had the strongest correlation with EFT‐total (rs = −.29). Results show that de novo PD patients already show impaired FER compared to HC. In addition, lower FER is linked to self‐reported apathy and proxy‐reported social‐behavioural problems, especially concerning social conventions. These findings validate the importance of the inclusion of social cognition measures in the neuropsychological assessment even in early PD. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Clinical models are inaccurate in predicting bile duct stones in situ for patients with gallbladder

Author

Topal, B., Fieuws, S., Tomczyk, K., Aerts, R., Van Steenbergen, W., Verslype, C., and Penninckx, F.

Abstract

Abstract: Background: The probability that a patient has common bile duct stones (CBDS) is a key factor in determining diagnostic and treatment strategies. This prospective cohort study evaluated the accuracy of clinical models in predicting CBDS for patients who will undergo cholecystectomy for lithiasis. Methods: From October 2005 until September 2006, 335 consecutive patients with symptoms of gallstone disease underwent cholecystectomy. Statistical analysis was performed on prospective patient data obtained at the time of first presentation to the hospital. Demonstrable CBDS at the time of endoscopic retrograde cholangiopancreatography (ERCP) or intraoperative cholangiography (IOC) was considered the gold standard for the presence of CBDS. Results: Common bile duct stones were demonstrated in 53 patients. For 35 patients, ERCP was performed, with successful stone clearance in 24 of 30 patients who had proven CBDS. In 29 patients, IOC showed CBDS, which were managed successfully via laparoscopic common bile duct exploration, with stone extraction at the time of cholecystectomy. Prospective validation of the existing model for CBDS resulted in a predictive accuracy rate of 73%. The new model showed a predictive accuracy rate of 79%. Conclusion: Clinical models are inaccurate in predicting CBDS in patients with cholelithiasis. Management strategies should be based on the local availability of therapeutic expertise.

Published
2024
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8. Chronic Pancreatitis

Author

Laurent, F., Drouillard, J., Ponette, E., Brys, P., Van Steenbergen, W., Baert, Albert L., editor, and Delorme, Guy, editor

Published
1994
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28. Chronic Pancreatitis

Author

Laurent, F., primary, Drouillard, J., additional, Ponette, E., additional, Brys, P., additional, and Van Steenbergen, W., additional

Published
1994
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33. Study protocol of the DUtch PARkinson Cohort (DUPARC): a prospective, observational study of de novo Parkinson's disease patients for the identification and validation of biomarkers for Parkinson's disease subtypes, progression and pathophysiology.

Author

Boertien, Jeffrey M., van der Zee, Sygrid, Chrysou, Asterios, Gerritsen, Marleen J. J., Jansonius, Nomdo M., Spikman, Jacoba M., van Laar, Teus, the PPNN Study Group, Verwey, N. A., Van Harten, B., Portman, A. T., Langedijk, M. J. H., Oomes, P. G., Jansen, B. J. A. M., Van Wieren, T., Van den Bogaard, S. J. A., Van Steenbergen, W., Duyff, R., Van Amerongen, J. P., and Fransen, P. S. S.

Subjects
PARKINSON'S disease, OPTICAL coherence tomography, THERAPEUTICS, SCIENTIFIC observation, FECAL analysis
Abstract

Background: Parkinson's Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. Here, the study protocol of the Dutch Parkinson Cohort (DUPARC) is described. DUPARC is a longitudinal cohort study aimed at deeply phenotyping de novo PD patients who are treatment-naïve at baseline, to discover and validate biomarkers for PD progression, subtypes and pathophysiology.Methods/design: DUPARC is a prospective cohort study in which 150 de novo PD subjects will be recruited through a collaborative network of PD treating neurologists in the northern part of the Netherlands (Parkinson Platform Northern Netherlands, PPNN). Participants will receive follow-up assessments after 1 year and 3 years, with the intention of an extended follow-up with 3 year intervals. Subjects are extensively characterized to primarily assess objectives within three major domains of PD: cognition, gastrointestinal function and vision. This includes brain magnetic resonance imaging (MRI); brain cholinergic PET-imaging with fluoroethoxybenzovesamicol (FEOBV-PET); brain dopaminergic PET-imaging with fluorodopa (FDOPA-PET); detailed neuropsychological assessments, covering all cognitive domains; gut microbiome composition; intestinal wall permeability; optical coherence tomography (OCT); genotyping; motor and non-motor symptoms; overall clinical status and lifestyle factors, including a dietary assessment; storage of blood and feces for additional analyses of inflammation and metabolic parameters. Since the start of the inclusion, at the end of 2017, over 100 PD subjects with a confirmed dopaminergic deficit on FDOPA-PET have been included.Discussion: DUPARC is the first study to combine data within, but not limited to, the non-motor domains of cognition, gastrointestinal function and vision in PD subjects over time. As a de novo PD cohort, with treatment naïve subjects at baseline, DUPARC provides a unique opportunity for biomarker discovery and validation without the possible confounding influences of dopaminergic medication.Trial Registration: NCT04180865; registered retrospectively, November 28th 2019. [ABSTRACT FROM AUTHOR]

Published
2020
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35. The belgian national registry on chronic pancreatitis: A prospective multicentre study covering more than 800 patients in 1 year

Author

Fernandez, M., Arvanitakis, M, Musala, C, Deviere, J., van Steenbergen, W, Putzeys, V, Ausloos, F, Bastens, B, Gast, P., Roeyen, G., Cesmeli, E., Scheers, Isabelle, Delhaye, M, Deprez, Pierre Henri, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie, and UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique

Subjects
Radiology Nuclear Medicine and imaging, Gastroenterology
Abstract

AIMS: This multi-centre prospective observational study aims to improve the knowledge regarding epidemiology of chronic pancreatitis (CP). METHODS: All patients for this study were deemed eligible based on the diagnosis of CP using imaging tests. 809 patients were included between 1/9/2014 and 31/8/2015. Data gathered included epidemiological, etiological items as well as CP complications (exocrine and endocrine insufficiency, pain) and type of treatment received. RESULTS: The majority of patients were male (74%) and were out-patients (69%). The median age of onset of symptoms was 47 (38-47) years; at the time of inclusion the median duration of the disease was 7 (3-13) years and the median Izbicki pain score (IPS) was 96 (0-195). The main etiological risk factors according to the TIGARO classification system were alcohol and tobacco (67%) followed by idiopathic causes in 19% of cases. Current alcohol drinkers had a lower BMI (21 vs 25 kg/m2, P < 0.001), a higher IPS (121 vs 90, P < 0.001) and higher inability to work. Similarly, active smoking was linked to lower BMI (21 vs 25 kg/m2, P < 0.0001) and higher IPS (137 vs 82, P < 0.001). Endocrine and exocrine insufficiencies were reported in 41% and 36% respectively. Patients with a BMI

Published
2017

38. Een jonge man met dyspepsie en icterus

Author

null MISPELAERE B, null FERRANTE M, null AERTS R, null OP DE BEECK K, null VANBECKEVOORT D, null LIBBRECHT L, null ROSKAMS T, null VAN STEENBERGEN W, and null VERSLYPE C

Subjects
General Medicine
Published
2006
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40. The belgian national registry on chronic pancreatitis: A prospective multicentre study covering more than 800 patients in 1 year

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Fernandez, M., Arvanitakis, M, Musala, C, Deviere, J., van Steenbergen, W, Putzeys, V, Ausloos, F, Bastens, B, Gast, P., Roeyen, G., Cesmeli, E., Scheers, Isabelle, Delhaye, M, Deprez, Pierre Henri, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Fernandez, M., Arvanitakis, M, Musala, C, Deviere, J., van Steenbergen, W, Putzeys, V, Ausloos, F, Bastens, B, Gast, P., Roeyen, G., Cesmeli, E., Scheers, Isabelle, Delhaye, M, and Deprez, Pierre Henri

Abstract

AIMS: This multi-centre prospective observational study aims to improve the knowledge regarding epidemiology of chronic pancreatitis (CP). METHODS: All patients for this study were deemed eligible based on the diagnosis of CP using imaging tests. 809 patients were included between 1/9/2014 and 31/8/2015. Data gathered included epidemiological, etiological items as well as CP complications (exocrine and endocrine insufficiency, pain) and type of treatment received. RESULTS: The majority of patients were male (74%) and were out-patients (69%). The median age of onset of symptoms was 47 (38-47) years; at the time of inclusion the median duration of the disease was 7 (3-13) years and the median Izbicki pain score (IPS) was 96 (0-195). The main etiological risk factors according to the TIGARO classification system were alcohol and tobacco (67%) followed by idiopathic causes in 19% of cases. Current alcohol drinkers had a lower BMI (21 vs 25 kg/m2, P < 0.001), a higher IPS (121 vs 90, P < 0.001) and higher inability to work. Similarly, active smoking was linked to lower BMI (21 vs 25 kg/m2, P < 0.0001) and higher IPS (137 vs 82, P < 0.001). Endocrine and exocrine insufficiencies were reported in 41% and 36% respectively. Patients with a BMI <20 kg/m2 had significantly more exocrine insufficiency (44 vs 34 %), weight loss (32% vs 16%), experienced increased pain levels (IPS: 146 vs 75) and included more smokers (78% vs 46%) and alcohol drinkers (30 vs 15 %), (P < 0.001). Highest IPS were reported in patients ongoing endoscopy with or without surgery, 244/400 and 163/ 400 respectively. Of the 15% of patients who had previously had surgery, 25% amongst them had initial surgery without previous endoscopic treatment. CONCLUSIONS: This national Belgian study on 809 CP patients could provide a useful tool to emphasize the management of these patients in terms of complications and treatment.

Published
2017

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