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1. Empirical Evidence That There Is No Such Thing As A Validated Prediction Model

Author

van Leeuwen, Florian D., Steyerberg, Ewout W., van Klaveren, David, Wessler, Ben, Kent, David M., and van Zwet, Erik W.

Subjects
Statistics - Methodology
Abstract

Background: External validations are essential to assess clinical prediction models (CPMs) before deployment. Apart from model misspecification, differences in patient population and other factors influence a model's AUC (c-statistic). We aimed to quantify variation in AUCs across external validation studies and adjust expectations of a model's performance in a new setting. Methods: The Tufts-PACE CPM Registry contains CPMs for cardiovascular disease prognosis. We analyzed the AUCs of 469 CPMs with a total of 1,603 external validations. For each CPM, we performed a random effects meta-analysis to estimate the between-study standard deviation $\tau$ among the AUCs. Since the majority of these meta-analyses has only a handful of validations, this leads to very poor estimates of $\tau$. So, we estimated a log normal distribution of $\tau$ across all CPMs and used this as an empirical prior. We compared this empirical Bayesian approach with frequentist meta-analyses using cross-validation. Results: The 469 CPMs had a median of 2 external validations (IQR: [1-3]). The estimated distribution of $\tau$ had a mean of 0.055 and a standard deviation of 0.015. If $\tau$ = 0.05, the 95% prediction interval for the AUC in a new setting is at least +/- 0.1, regardless of the number of validations. Frequentist methods underestimate the uncertainty about the AUC in a new setting. Accounting for $\tau$ in a Bayesian approach achieved near nominal coverage. Conclusion: Due to large heterogeneity among the validated AUC values of a CPM, there is great irreducible uncertainty in predicting the AUC in a new setting. This uncertainty is underestimated by existing methods. The proposed empirical Bayes approach addresses this problem which merits wide application in judging the validity of prediction models.

Published
2024

3. Correction: Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid angiopathy

Author

Rasing, Ingeborg, Voigt, Sabine, Koemans, Emma A., de Kort, Anna M., van Harten, Thijs W., van Etten, Ellis S., van Zwet, Erik W., Stoops, Erik, Francois, Cindy, Kuiperij, H. Bea, Klijn, Catharina J.M., Schreuder, Floris H.B.M., van der Weerd, Louise, van Osch, Matthias J.P., van Walderveen, Marianne A.A., Verbeek, Marcel M., Terwindt, Gisela M., and Wermer, Marieke J.H.

Published
2024
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4. Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy

Author

Rasing, Ingeborg, Voigt, Sabine, Koemans, Emma A., de Kort, Anna M., van Harten, Thijs W., van Etten, Ellis S., van Zwet, Erik W., Stoops, Erik, Francois, Cindy, Kuiperij, H. Bea, Klijn, Catharina J.M., Schreuder, Floris H.B.M., van der Weerd, Louise, van Osch, Matthias J.P., van Walderveen, Marianne A.A., Verbeek, Marcel M., Terwindt, Gisela M., and Wermer, Marieke J.H.

Published
2024
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5. Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy

Author

Kaushik, Kanishk, de Kort, Anna M., van Dort, Rosemarie, van der Zwet, Reinier G.J., Siegerink, Bob, Voigt, Sabine, van Zwet, Erik W., van der Plas, Maaike C., Koemans, Emma A., Rasing, Ingeborg, Kessels, Roy P.C., Middelkoop, Huub A.M., Schreuder, Floris H.B.M., Klijn, Catharina J.M., Verbeek, Marcel M., Terwindt, Gisela M., van Etten, Ellis S., and Wermer, Marieke J.H.

Published
2024
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6. G-formula for causal inference via multiple imputation

Author

Bartlett, Jonathan W., Parra, Camila Olarte, Granger, Emily, Keogh, Ruth H., van Zwet, Erik W., and Daniel, Rhian M.

Subjects
Statistics - Methodology
Abstract

G-formula is a popular approach for estimating treatment or exposure effects from longitudinal data that are subject to time-varying confounding. G-formula estimation is typically performed by Monte-Carlo simulation, with non-parametric bootstrapping used for inference. We show that G-formula can be implemented by exploiting existing methods for multiple imputation (MI) for synthetic data. This involves using an existing modified version of Rubin's variance estimator. In practice missing data is ubiquitous in longitudinal datasets. We show that such missing data can be readily accommodated as part of the MI procedure when using G-formula, and describe how MI software can be used to implement the approach. We explore its performance using a simulation study and an application from cystic fibrosis., Comment: 28 pages, 6 tables, 2 figures. Updated version includes cystic fibrosis data analysis and some added details on the possibility of obtaining a negative variance estimate

Published
2023

7. Think before you shrink: Alternatives to default shrinkage methods can improve prediction accuracy, calibration and coverage

Author

van de Wiel, Mark A., Leday, Gwenaël G. R., Hoogland, Jeroen, Heymans, Martijn W., van Zwet, Erik W., and Zwinderman, Ailko H.

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

While shrinkage is essential in high-dimensional settings, its use for low-dimensional regression-based prediction has been debated. It reduces variance, often leading to improved prediction accuracy. However, it also inevitably introduces bias, which may harm two other measures of predictive performance: calibration and coverage of confidence intervals. Much of the criticism stems from the usage of standard shrinkage methods, such as lasso and ridge with a single, cross-validated penalty. Our aim is to show that readily available alternatives can strongly improve predictive performance, in terms of accuracy, calibration or coverage. For linear regression, we use small sample splits of a large, fairly typical epidemiological data set to illustrate this. We show that usage of differential ridge penalties for covariate groups may enhance prediction accuracy, while calibration and coverage benefit from additional shrinkage of the penalties. In the logistic setting, we apply an external simulation to demonstrate that local shrinkage improves calibration with respect to global shrinkage, while providing better prediction accuracy than other solutions, like Firth's correction. The benefits of the alternative shrinkage methods are easily accessible via example implementations using \texttt{mgcv} and \texttt{r-stan}, including the estimation of multiple penalties. A synthetic copy of the large data set is shared for reproducibility., Comment: 35 pages including Supplementary Information

Published
2023

9. A prospective open label 2–8 year extension of the randomised controlled ICON trial on the long-term efficacy and safety of occipital nerve stimulation in medically intractable chronic cluster headache

Author

Ferrari, Michel D., Wilbrink, Leopoldine A., De Coo, Ilse F., Doesborg, Patty G., Bartels, Eveline C., Van Zwet, Erik W., Huygen, Frank J.P.M., Mulleners, Wim M., Kurt, Erkan, Van Dongen, Robert T.M., Teernstra, Onno P.M., Koehler, Peter J., Spincemaille, Geert H., Wille, Frank, Burger, Katja, Haan, Joost, Couturier, Emile G.M., Kallewaard, Jan Willem, Veltink, Peter H., Buschman, R., Brandt, Roemer B., de Coo, Ilse F., van Zwet, Erik W., and Fronczek, Rolf

Published
2023
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11. Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy

Author

Koemans, Emma A., Rasing, Ingeborg, Voigt, Sabine, van Harten, Thijs W., van der Zwet, Reinier G.J., Kaushik, Kanishk, Schipper, Manon R., van der Weerd, Nelleke, van Zwet, Erik W., van Etten, Ellis S., van Osch, Matthias J.P., Kuiperij, Bea, Verbeek, Marcel M., Terwindt, Gisela M., Greenberg, Steven M., van Walderveen, Marianne A.A., and Wermer, Marieke J.H.

Published
2024
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12. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Author

Zonneveld, Thomas P, Vermeer, Sarah E, van Zwet, Erik W, Groot, Adrien E D, Algra, Ale, Aerden, Leo A M, Alblas, Kees C L, de Beer, Frank, Brouwers, Paul J A M, de Gans, Koen, van Gemert, H Maarten A, van Ginneken, Bart C A M, Grooters, Gerke S, Halkes, Patricia H A, van der Heijden-Montfroy, Tonny A M H G, Jellema, Korné, de Jong, Sonja W, Lövenich-Ciccarello, Harry, van der Meulen, Willem D M, Peters, Edwin W, van der Ree, Taco C, Remmers, Michel J M, Richard, Edo, Rovers, Jörgen M P, Saxena, Ritu, van Schaik, Sander M, Schonewille, Wouter J, Schreuder, Tobien A H C M L, de Schryver, Els L L M, Schuiling, Wouter J, Spaander, Fianne H, van Tuijl, Julia H, Visser, Marieke C, Zinkstok, Sanne M, Zock, Elles, Dippel, Diederik W J, Kappelle, L Jaap, van Oostenbrugge, Robert J, Roos, Yvo B W E M, Vermeij, Frederique H, Wermer, Marieke J H, van der Worp, H Bart, Nederkoorn, Paul J, and Kruyt, Nyika D

Published
2024
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18. Benchmarking survival outcomes: A funnel plot for survival data

Author

Putter, Hein, Eikema, Dirk-Jan, de Wreede, Liesbeth C., McGrath, Eoin, Sanchez-Ortega, Isabel, Saccardi, Riccardo, Snowden, John A., and van Zwet, Erik W.

Subjects
Statistics - Methodology, 62N03 (Primary), 62N05 (Secondary)
Abstract

Benchmarking is commonly used in many healthcare settings to monitor clinical performance, with the aim of increasing cost-effectiveness and safe care of patients. The funnel plot is a popular tool in visualizing the performance of a healthcare center in relation to other centers and to a target, taking into account statistical uncertainty. In this paper we develop methodology for constructing funnel plots for survival data. The method takes into account censoring and can deal with differences in censoring distributions across centers. Practical issues in implementing the methodology are discussed, particularly in the setting of benchmarking clinical outcomes for hematopoietic stem cell transplantation. A simulation study is performed to assess the performance of the funnel plots under several scenarios. Our methodology is illustrated using data from the EBMT benchmarking project., Comment: 24 pages, 4 figures, 1 table

Published
2021

19. Sex Differences in Prehospital Identification of Large Vessel Occlusion in Patients With Suspected Stroke

Author

Ali, Mariam, Dekker, Luuk, Daems, Jasper D., Ali, Mahsoem, van Zwet, Erik W., Steyerberg, Ewout W., Duvekot, Martijne H.C., Nguyen, T. Truc My, Moudrous, Walid, van de Wijdeven, Ruben M., Visser, Marieke C., de Laat, Karlijn F., Kerkhoff, Henk, van den Wijngaard, Ido R., Dippel, Diederik W.J., Roozenbeek, Bob, Kruyt, Nyika D., Wermer, Marieke J.H., Aerden, Leo A.M., Alblas, Kees C.L., Bakker, Jeannette, van Belle, Eduard, Bevelander, Timo, Bosch, Jan, Buijck, Bianca, Dofferhoff-Vermeulen, Tamara, van Doormaal, Pieter Jan, Dorresteijn, Kirsten R.I.S., Duijndam, Dion, van Eijkelenburg, Roeland P.J., van Es, Adriaan C.G.M., Hensen, Jan-Hein, Hoek, Amber, Kloos, Loet M.H., Koster, Gaia T., Kuiper, Jan Willem, de Leeuw, Arnoud M., Lingsma, Hester F., van der Lugt, Aad, Lycklama À Nijeholt, Geert, Maasland, Lisette, van Moll, Bruno J.M., Mulder, Laus J.M.M., Noordam-Reijm, Anja, Oskam, Erick, Plaisier, Aarnout, Rozeman, Anouk D., de Schryver, Els L.L.M., Venema, Esmee, Wijnhoud, Annemarie D., Willeboer, Merel L., Woudenberg, Mirjam, van der Zon, Mandy M.A., Zwets, Egon D., and Zylicz, Stas A.

Published
2024
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22. Simultaneous Confidence Intervals for Ranks With Application to Ranking Institutions

Author

Mohamad, Diaa Al, Goeman, Jelle J., and van Zwet, Erik W.

Subjects
Statistics - Methodology
Abstract

When a ranking of institutions such as medical centers or universities is based on an indicator provided with a standard error, confidence intervals should be calculated to assess the quality of these ranks. We consider the problem of constructing simultaneous confidence intervals for the ranks of means based on an observed sample. For this aim, the only available method from the literature uses Monte-Carlo simulations and is highly anticonservative especially when the means are close to each other or have ties. We present a novel method based on Tukey's honest significant difference test (HSD). Our new method is on the contrary conservative when there are no ties. By properly rescaling these two methods to the nominal confidence level, they surprisingly perform very similarly. The Monte-Carlo method is however unscalable when the number of institutions is large than 30 to 50 and stays thus anticonservative. We provide extensive simulations to support our claims and the two methods are compared in terms of their simultaneous coverage and their efficiency. We provide a data analysis for 64 hospitals in the Netherlands and compare both methods. Software for our new methods is available online in package ICRanks downloadable from CRAN. Supplementary materials include supplementary R code for the simulations and proofs of the propositions presented in this paper., Comment: Working paper 20 pages to be submitted soon. This paper differs from our paper "An improvement of Tukey's HSD with application to ranking institutions". The sequential Tukey is not there, and a new practical method is proposed. arXiv admin note: substantial text overlap with arXiv:1708.02428

Published
2018

24. Comparison of Prehospital Assessment by Paramedics and In-Hospital Assessment by Physicians in Suspected Stroke Patients: Results From 2 Prospective Cohort Studies

Author

Dekker, Luuk, Daems, Jasper D., Duvekot, Martijne H.C., Nguyen, T. Truc My, Venema, Esmee, van Es, Adriaan C.G.M., Rozeman, Anouk D., Moudrous, Walid, Dorresteijn, Kirsten R.I.S., Hensen, Jan-Hein J., Bosch, Jan, van Zwet, Erik W., de Schryver, Els L.L.M., Kloos, Loet M.H., de Laat, Karlijn F., Aerden, Leo A.M., van den Wijngaard, Ido R., Dippel, Diederik W.J., Kerkhoff, Henk, Wermer, Marieke J.H., Roozenbeek, Bob, Kruyt, Nyika D., Alblas, Kees C.L., Bakker, Jeannette, van Belle, Eduard, Bevelander, Timo, Buijck, Bianca, Dofferhoff-Vermeulen, Tamara, van Doormaal, Pieter Jan, Duijndam, Dion, van Eijkelenburg, Roeland P.J., Hoek, Amber, Koster, Gaia T., Kuiper, Jan Willem, de Leeuw, Arnoud M., Lingsma, Hester F., van der Lugt, Aad, Lycklama À Nijeholt, Geert, Maasland, Lisette, van Moll, Bruno J.M., Mulder, Laus J.M.M., Noordam-Reijm, Anja, Oskam, Erick, Plaisier, Aarnout, van de Wijdeven, Ruben M., Wijnhoud, Annemarie D., Willeboer, Merel L., Woudenberg, Mirjam, van der Zon, Mandy M.A., Zwets, Egon D., and Zylicz, Stas A.

Published
2023
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27. Adaptive Critical Value for Constrained Likelihood Ratio Testing

Author

Mohamad, Diaa Al, Goeman, Jelle J., van Zwet, Erik W., and Cator, Eric A.

Subjects
Statistics - Methodology
Abstract

We present a new way of testing ordered hypotheses against all alternatives which overpowers the classical approach both in simplicity and statistical power. Our new method tests the constrained likelihood ratio statistic against the quantile of one and only one chi-squared random variable with a data-dependent degrees of freedom instead of a mixture of chi-squares. Our new test is proved to have a valid finite-sample significance level $\alpha$ and provides more power especially for sparse alternatives (those with a few or moderate number of null constraints violations) in comparison to the classical approach. Our method is also easier to use than the classical approach which requires to calculate or simulate a set of complicated weights. Two special cases are considered with more details, namely the case of testing orthants $\mu_1<0, \cdots, \mu_n<0$ and the isotonic case of testing $\mu_1<\mu_2<\mu_3$ against all alternatives. Contours of the difference in power are shown for these examples showing the interest of our new approach., Comment: We proved the conjecture from last version. We found out that some part of this works was already published in the literature and was made clear in the current version. The main text is the first 16 pages. The appendix includes other ideas and a part that was already discussed in the literature

Published
2018

30. Simultaneous confidence sets for ranks using the partitioning principle - Technical report

Author

Mohamad, Diaa Al, van Zwet, Erik W., Goeman, Jelle J., and Solari, Aldo

Subjects
Statistics - Methodology
Abstract

Ranking institutions such as medical centers or universities is based on an indicator accompanied with an uncertainty measure such as a standard deviation, and confidence intervals should be calculated to assess the quality of these ranks. We consider the problem of constructing simultaneous confidence intervals for the ranks of centers based on an observed sample. We present in this paper a novel method based on multiple testing which uses the partitioning principle and employs the likelihood ratio (LR) test on the partitions. The complexity of the algorithm is super exponential. We present several ways and shortcuts to reduce this complexity. We provide also a polynomial algorithm which produces a very good bracketing for the multiple testing by linearizing the critical value of the LR test. We show that Tukey's Honest Significant Difference (HSD) test can be written as a partitioning procedure. The new methodology has promising properties in the sens that it opens the door in a simple and easy way to construct new methods which may trade the exponential complexity with power of the test or vice versa. In comparison to Tukey's HSD test, the LR test seems to give better results when the centers are close to each others or the uncertainty in the data is high which is confirmed during a simulation study., Comment: Technical report. A reduced version will be submitted soon to JRSSB

Published
2017

31. An improvement of Tukey's HSD with application to ranking institutions

Author

Mohamad, Diaa Al, Goeman, Jelle J., and van Zwet, Erik W.

Subjects
Statistics - Methodology
Abstract

When a ranking of institutions such as medical centers or universities is based on an indicator provided with a standard error, confidence intervals should be calculated to assess the quality of these ranks. We consider the problem of constructing simultaneous confidence intervals (CIs) for the ranks of centers based on an observed sample. We present a novel method based on Tukey's honest significant difference test (HSD) which is the first method to produce valid simultaneous CIs for ranks. Moreover, we introduce a new variant of Tukey's HSD based on the sequential rejection principle. The new algorithm ensures familywise error control, and produces simultaneous confidence intervals for the ranks uniformly shorter than those provided by Tukey's HSD for the same level of significance. We illustrate the method through both simulations and real data analysis from 64 hospitals in the Netherlands. Software for our new methods is available online in package \texttt{ICRanks} downloadable from CRAN. Supplementary materials include supplementary R code for the simulations and proofs of the propositions presented in this paper., Comment: Working paper. 19 pages with R code

Published
2017

32. Cognition in (pre)symptomatic Dutch‐type hereditary and sporadic cerebral amyloid angiopathy.

Author

van Dort, Rosemarie, Kaushik, Kanishk, Rasing, Ingeborg, van der Zwet, Reinier G. J., Schipper, Manon R., van der Grond, Jeroen, van Rooden, Sanneke, van Zwet, Erik W., Terwindt, Gisela M., Middelkoop, Huub A. M., Hart, Ellen P., van Osch, Matthias J. P., van Walderveen, Marianne A. A., and Wermer, Marieke J. H.

Abstract

INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited. METHODS: We included Dutch‐type hereditary CAA (D‐CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age‐matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI‐cSVD burden and cognition. RESULTS: D‐CAA ICH− mutation carriers exhibited poorer global cognition and executive function compared to age‐matched controls. Patients with sCAA performed worse across all cognitive domains compared to D‐CAA ICH+ mutation carriers and age‐matched controls. MRI‐cSVD burden is associated with decreased processing speed. DISCUSSION: CAA is associated with dysfunction in multiple cognitive domains, even before ICH, with increased MRI‐cSVD burden being associated with slower processing speed. Highlights: Cognitive dysfunction is present in early disease stages of cerebral amyloid angiopathy (CAA) before the occurrence of symptomatic intracerebral hemorrhage (sICH).Presymptomatic Dutch‐type CAA (D‐CAA) mutation carriers show worse cognition than age‐matched controls.More early awareness of cognitive dysfunction in CAA before first sICH is needed.Increased cerebral small vessel disease CAA‐burden on magnetic resonance imaging is linked to a decrease in processing speed. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy.

Author

Rasing, Ingeborg, Vlegels, Naomi, Schipper, Manon R, Voigt, Sabine, Koemans, Emma A, Kaushik, Kanishk, van Dort, Rosemarie, van Harten, Thijs W, De Luca, Alberto, van Etten, Ellis S, van Zwet, Erik W, van Buchem, Mark A, Middelkoop, Huub AM, Biessels, Geert Jan, Terwindt, Gisela M, van Osch, Matthias JP, van Walderveen, Marianne AA, and Wermer, Marieke JH

Abstract

Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/symptomatic; mean age 39/58 y). PSMD-levels increased with disease severity and were higher in symptomatic D-CAA mutation-carriers (median [range] 4.90 [2.77–9.50]mm2/s × 10−4) compared with presymptomatic mutation-carriers (2.62 [1.96–3.43]mm2/s × 10−4) p = <0.001. PSMD was positively correlated with age, CAA-SVD burden on MRI (adj.B [confidence interval] = 0.42 [0.16–0.67], p = 0.002), with number of cerebral microbleeds (adj.B = 0.30 [0.08–0.53], p = 0.009), and with both deep (adj.B = 0.46 [0.22–0.69], p = <0.001) and periventricular (adj.B = 0.38 [0.13–0.62], p = 0.004) white matter hyperintensities. Increasing PSMD was associated with decreasing Trail Making Test (TMT)-A performance (B = −0.42 [−0.69–0.14], p = 0.04. In D-CAA mutation-carriers microstructural white matter damage is associated with disease phase, CAA burden on MRI and cognitive impairment as reflected by a decrease in information processing speed. PSMD, as a global measure of alterations to the white matter microstructure, may be a useful tool to monitor disease progression in CAA. [ABSTRACT FROM AUTHOR]

Published
2024
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34. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

Author

Richard, Melissa A, Huan, Tianxiao, Ligthart, Symen, Gondalia, Rahul, Jhun, Min A, Brody, Jennifer A, Irvin, Marguerite R, Marioni, Riccardo, Shen, Jincheng, Tsai, Pei-Chien, Montasser, May E, Jia, Yucheng, Syme, Catriona, Salfati, Elias L, Boerwinkle, Eric, Guan, Weihua, Mosley, Thomas H, Bressler, Jan, Morrison, Alanna C, Liu, Chunyu, Mendelson, Michael M, Uitterlinden, André G, van Meurs, Joyce B, Consortium, BIOS, Heijmans, Bastiaan T, Hoen, Peter AC ’t, van Meurs, Joyce, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, Dorret I, Pool, René, van Dongen, Jenny, Hottenga, Jouke J, van Greevenbroek, Marleen MJ, Stehouwer, Coen DA, van der Kallen, Carla JH, Schalkwijk, Casper G, Wijmenga, Cisca, Zhernakova, Alexandra, Tigchelaar, Ettje F, Slagboom, P Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H, van den Berg, Leonard H, van Duijn, Cornelia M, Hofman, Albert, Jhamai, P Mila, Verbiest, Michael, Suchiman, H Eka D, Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M, Swertz, Morris A, van Zwet, Erik W, Franco, Oscar H, Zhang, Guosheng, Li, Yun, Stewart, James D, Bis, Joshua C, Psaty, Bruce M, Chen, Yii-Der Ida, Kardia, Sharon LR, Zhao, Wei, Turner, Stephen T, Absher, Devin, Aslibekyan, Stella, Starr, John M, McRae, Allan F, Hou, Lifang, Just, Allan C, Schwartz, Joel D, Vokonas, Pantel S, Menni, Cristina, Spector, Tim D, Shuldiner, Alan, Damcott, Coleen M, Rotter, Jerome I, Palmas, Walter, Liu, Yongmei, and Paus, Tomáš

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Aged, Blood Pressure, CpG Islands, Cross-Sectional Studies, DNA Methylation, Epigenesis, Genetic, Genetic Variation, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Middle Aged, Nerve Tissue Proteins, Quantitative Trait Loci, Tetraspanins, BIOS Consortium, DNA methylation, Mendelian randomization, blood pressure, epigenome-wide association study, gene expression, sequence variation, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry. Of 31 discovery-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferroni correction (discovery: N = 9,828, p < 1.0 × 10-7; replication: N = 7,182, p  30%) and independent of known BP genetic variants, explaining an additional 1.4% and 2.0% of the interindividual variation in systolic and diastolic BP, respectively. Bidirectional Mendelian randomization among up to 4,513 individuals of European ancestry from 4 cohorts suggested that methylation at cg08035323 (TAF1B-YWHAQ) influences BP, while BP influences methylation at cg00533891 (ZMIZ1), cg00574958 (CPT1A), and cg02711608 (SLC1A5). Gene expression analyses further identified six genes (TSPAN2, SLC7A11, UNC93B1, CPT1A, PTMS, and LPCAT3) with evidence of triangular associations between methylation, gene expression, and BP. Additional integrative Mendelian randomization analyses of gene expression and DNA methylation suggested that the expression of TSPAN2 is a putative mediator of association between DNA methylation at cg23999170 and BP. These findings suggest that heritable DNA methylation plays a role in regulating BP independently of previously known genetic variants.

Published
2017

35. Changes in migraine symptoms after ischemic stroke: a cohort study

Author

van der Weerd, Nelleke, primary, Pelzer, Nadine, additional, Egberts, Emma, additional, Mertens, Marit, additional, Bakker, Willemijn, additional, Linstra, Katie Marina, additional, van den Maagdenberg, Arn, additional, van Zwet, Erik W., additional, MaassenVanDenBrink, Antoinette, additional, Terwindt, Gisela M., additional, and Wermer, Marieke J. H., additional

Published
2024
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36. A prospective open label 2–8 year extension of the randomised controlled ICON trial on the long-term efficacy and safety of occipital nerve stimulation in medically intractable chronic cluster headache

Author

Brandt, Roemer B., primary, Wilbrink, Leopoldine A., additional, de Coo, Ilse F., additional, Haan, Joost, additional, Mulleners, Wim M., additional, Huygen, Frank J.P.M., additional, van Zwet, Erik W., additional, Ferrari, Michel D., additional, Fronczek, Rolf, additional, De Coo, Ilse F., additional, Doesborg, Patty G., additional, Bartels, Eveline C., additional, Van Zwet, Erik W., additional, Kurt, Erkan, additional, Van Dongen, Robert T.M., additional, Teernstra, Onno P.M., additional, Koehler, Peter J., additional, Spincemaille, Geert H., additional, Wille, Frank, additional, Burger, Katja, additional, Couturier, Emile G.M., additional, Kallewaard, Jan Willem, additional, Veltink, Peter H., additional, and Buschman, R., additional

Published
2023
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37. Safety and efficacy of occipital nerve stimulation for attack prevention in medically intractable chronic cluster headache (ICON): a randomised, double-blind, multicentre, phase 3, electrical dose-controlled trial

Author

Ferrari, M.D., Wilbrink, L.A., de Coo, I.F., Doesborg, P.G.G., Bartels, E.C., van Zwet, E.W., Huygen, F.J.P.M., Mulleners, W.M., van Dongen, R.T.M., Kurt, E., Teernstra, O.P.M., Koehler, P.J.J., Spincemaille, G.H., Wille, F., Burger, K., Haan, J., Couturier, E.G.M., Kallewaard, J.W., Veltink, P.H., Schoenen, J., Magis, D., Eross, L.G., Afra, J., Göbel, H., Heinze, A., Tronnier, V., Rasche, D., Wilbrink, Leopoldine A, de Coo, Ilse F, Doesborg, Patty G G, Mulleners, Wim M, Teernstra, Onno P M, Bartels, Eveline C, Burger, Katja, Wille, Frank, van Dongen, Robert T M, Kurt, Erkan, Spincemaille, Geert H, Haan, Joost, van Zwet, Erik W, Huygen, Frank J P M, and Ferrari, Michel D

Published
2021
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38. Case-mix adjustment to compare nationwide hospital performances after resection of colorectal liver metastases

Author

Besselink, Marc G.H., de Boer, Marieke T., Dejong, Cees H.C., van Gulik, Thomas M., Hagendoorn, Jeroen, Hoogwater, Frederik H.J., Molenaar, I. Quintus, Liem, Mike S.L., Elfrink, Arthur K.E., van Zwet, Erik W., Swijnenburg, Rutger-Jan, den Dulk, Marcel, van den Boezem, Peter B., Mieog, J. Sven D., te Riele, Wouter W., Patijn, Gijs A., Leclercq, Wouter K.G., Lips, Daan J., Rijken, Arjen M., Verhoef, Cornelis, Kuhlmann, Koert F.D., Buis, Carlijn I., Bosscha, Koop, Belt, Eric J.T., Vermaas, Maarten, van Heek, N. Tjarda, Oosterling, Steven J., Torrenga, Hans, Eker, Hasan H., Consten, Esther C.J., Marsman, Hendrik A., Wouters, Michel W.J.M., Kok, Niels F.M., Grünhagen, Dirk J., and Klaase, Joost M.

Published
2021
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39. Quality of life, depression and anxiety in cerebral amyloid angiopathy: A cross‐sectional study.

Author

Kaushik, Kanishk, Waslam, Natasha G., van der Zwet, Reinier G. J., Voigt, Sabine, van Dort, Rosemarie, van Zwet, Erik W., Terwindt, Gisela M., van Etten, Ellis S., and Wermer, Marieke J. H.

Subjects
CEREBRAL amyloid angiopathy, COGNITION disorders, MENTAL depression, VISUAL analog scale, SOCIAL skills
Abstract

Background and Purpose: Data on health‐related quality of life (HRQoL) and mood in cerebral amyloid angiopathy (CAA), a disease characterized by stroke and cognitive decline, are limited. We aimed to investigate the impacted domains of life, value‐based HRQoL and the prevalence of depression and anxiety in patients with CAA. Methods: We conducted a cross‐sectional study of patients with sporadic (s)CAA, lobar dominant mixed CAA and hypertensive arteriopathy (mixed CAA‐HTA), or Dutch‐type hereditary (D‐)CAA, from prospective outpatient clinic cohorts. Participants completed four questionnaires: the EuroQoL 5 dimensions 5‐level questionnaire (EQ‐5D‐5L; EQ‐VAS for visual analogue scale; EQ‐Index for index rating), the Short‐Form 36 questionnaire (SF‐36), the Center for Epidemiologic Studies—Depression scale (CES‐D), and the Hospital Anxiety and Depression Scale (HADS; ‐D for depression and ‐A for anxiety subscales). The EQ‐5D‐5L assesses the domains mobility, self‐care, usual activities, pain/discomfort and anxiety/depression. The SF‐36 domains are physical functioning, social functioning, physical role limitations, emotional role limitations, mental health, vitality, bodily pain, and general health perceptions. We compared age‐ and sex‐ adjusted HRQoL (SF‐36 domain scores; EQ‐VAS; EQ‐Index) to the Dutch normative population, and estimated the prevalences of current depression (either: history of depression or current use of antidepressants, with high score on CES‐D [≥16] and/or HADS‐D [≥8]; or high score on both depression questionnaires) and anxiety (HADS‐A ≥ 8). Results: We included 179 patients: 77 with sCAA (mean age: 72 years, women: 36%), 31 with mixed CAA‐HTA (68 years, women: 29%), and 71 with D‐CAA (56 years, women: 52%, symptomatic: 35 [49%]). The SF‐36 profiles of all patient groups were similar, negatively differing from the norm in emotional role functioning, social functioning and vitality. The EQ‐VAS score of patients (mean [SD] sCAA: 76 [16], D‐CAA: 77 [15]) was similar to the norm, as was the EQ‐Index score. Fifteen patients with sCAA (23%; 95% confidence interval [CI] 13%–33%), seven with mixed CAA‐HTA (27%; 95% CI 10%–44%) and eight with D‐CAA (14%; 95% CI 5%–22%) were noted as having depression. The prevalences of anxiety and depression were equivalent. Conclusions: We found that CAA influenced emotional role functioning and aspects linked to social engagement consistently across its subtypes. One quarter of patients exhibited depressive or anxiety symptoms. Recognizing these impacted domains could enhance overall well‐being. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Author

Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., Kruyt, Nyika D., Communicatie, Cardiovasculaire Epi Team 5, Neurologen, Brain, Circulatory Health, Stroke, Zonneveld, Thomas P., Vermeer, Sarah E., van Zwet, Erik W., Groot, Adrien E.D., Algra, Ale, Aerden, Leo A.M., Alblas, Kees C.L., de Beer, Frank, Brouwers, Paul J.A.M., de Gans, Koen, van Gemert, H. Maarten A., van Ginneken, Bart C.A.M., Grooters, Gerke S., Halkes, Patricia H.A., van der Heijden-Montfroy, Tonny A.M.H.G., Jellema, Korné, de Jong, Sonja W., Lövenich-Ciccarello, Harry, van der Meulen, Willem D.M., Peters, Edwin W., van der Ree, Taco C., Remmers, Michel J.M., Richard, Edo, Rovers, Jörgen M.P., Saxena, Ritu, van Schaik, Sander M., Schonewille, Wouter J., Schreuder, Tobien A.H.C.M.L., de Schryver, Els L.L.M., Schuiling, Wouter J., Spaander, Fianne H., van Tuijl, Julia H., Visser, Marieke C., Zinkstok, Sanne M., Zock, Elles, Dippel, Diederik W.J., Kappelle, L. Jaap, van Oostenbrugge, Robert J., Roos, Yvo B.W.E.M., Vermeij, Frederique H., Wermer, Marieke J.H., van der Worp, H. Bart, Nederkoorn, Paul J., and Kruyt, Nyika D.

Published
2024

41. Surgical versus conservative treatment for odontoid fractures in older people: an international prospective comparative study

Author

MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Neurochirurgen, Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., Vleggeert-Lankamp, Carmen L.A., MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Neurochirurgen, Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., and Vleggeert-Lankamp, Carmen L.A.

Published
2024

42. Surgical versus conservative treatment for odontoid fractures in older people:an international prospective comparative study

Author

Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., Vleggeert-Lankamp, Carmen L.A., Huybregts, Jeroen G.J., Polak, Samuel B., Jacobs, Wilco C., Arts, Mark P., Meyer, Bernhard, Wostrack, Maria, Butenschön, Vicki M., Osti, Michael, Öner, F. Cumhur, Slooff, Willem Bart M., Feller, Ricardo E., Bouma, Gert Joan, Harhangi, Biswadjiet S., Depreitere, Bart, Nygaard, Øystein P., Weber, Clemens, Müller, Kay, Timothy, Jake, Pellisé, Ferran, Rasmussen, Mikkel M., van Zwet, Erik W., Steyerberg, Ewout W., Peul, Wilco C., and Vleggeert-Lankamp, Carmen L.A.

Abstract

Background: The optimal treatment for odontoid fractures in older people remains debated. Odontoid fractures are increasingly relevant to clinical practice due to ageing of the population.Methods: An international prospective comparative study was conducted in fifteen European centres, involving patients aged ≥55 years with type II/III odontoid fractures. The surgeon and patient jointly decided on the applied treatment. Surgical and conservative treatments were compared. Primary outcomes were Neck Disability Index (NDI) improvement, fracture union and stability at 52 weeks. Secondary outcomes were Visual Analogue Scale neck pain, Likert patient-perceived recovery and EuroQol-5D-3L at 52 weeks. Subgroup analyses considered age, type II and displaced fractures. Multivariable regression analyses adjusted for age, gender and fracture characteristics. Results: The study included 276 patients, of which 144 (52%) were treated surgically and 132 (48%) conservatively (mean (SD) age 77.3 (9.1) vs. 76.6 (9.7), P = 0.56). NDI improvement was largely similar between surgical and conservative treatments (mean (SE) −11 (2.4) vs. −14 (1.8), P = 0.08), as were union (86% vs. 78%, aOR 2.3, 95% CI 0.97–5.7) and stability (99% vs. 98%, aOR NA). NDI improvement did not differ between patients with union and persistent non-union (mean (SE) −13 (2.0) vs. −12 (2.8), P = 0.78). There was no difference for any of the secondary outcomes or subgroups. Conclusions: Clinical outcome and fracture healing at 52 weeks were similar between treatments. Clinical outcome and fracture union were not associated. Treatments should prioritize favourable clinical over radiological outcomes.

Published
2024

44. Patients with a Ruptured Abdominal Aortic Aneurysm Are Better Informed in Hospitals with an “EVAR-preferred” Strategy: An Instrumental Variable Analysis of the Dutch Surgical Aneurysm Audit

Author

Van den Akker, P.J., Akkersdijk, G.J., Akkersdijk, G.P., Akkersdijk, W.L., van Andringa de Kempenaer, M.G., Arts, C.H., Avontuur, J.A., Bakker, O.J., Balm, R., Barendregt, W.B., Bekken, J.A., Bender, M.H., Bendermacher, B.L., van den Berg, M., Berger, P., Beuk, R.J., Blankensteijn, J.D., Bleker, R.J., Blok, J.J., Bode, A.S., Bodegom, M.E., van der Bogt, K.E., Boll, A.P., Booster, M.H., Borger van der Burg, B.L., de Borst, G.J., Bos- van Rossum, W.T., Bosma, J., Botman, J.M., Bouwman, L.H., Brehm, V., de Bruijn, M.T., de Bruin, J.L., Brummel, P., van Brussel, J.P., Buijk, S.E., Buijs, M.A., Buimer, M.G., Burger, D.H., Buscher, H.C., Cancrinus, E., Castenmiller, P.H., Cazander, G., Coester, A.M., Cuypers, P.H., Daemen, J.H., Dawson, I., Dierikx, J.E., Dijkstra, M.L., Diks, J., Dinkelman, M.K., Dirven, M., Dolmans, D.E., van Doorn, R.C., van Dortmont, L.M., Drouven, J.W., van der Eb, M.M., Eefting, D., van Eijck, G.J., Elshof, J.W., Elsman, B.H., van der Elst, A., van Engeland, M.I., van Eps, R.G., Faber, M.J., de Fijter, W.M., Fioole, B., Fokkema, T.M., Frans, F.A., Fritschy, W.M., Fung Kon Jin, P.H., Geelkerken, R.H., van Gent, W.B., Glade, G.J., Govaert, B., Groenendijk, R.P., de Groot, H.G., van den Haak, R.F., de Haan, E.F., Hajer, G.F., Hamming, J.F., van Hattum, E.S., Hazenberg, C.E., Hedeman Joosten, P.P., Helleman, J.N., van der Hem, L.G., Hendriks, J.M., van Herwaarden, J.A., Heyligers, J.M., Hinnen, J.W., Hissink, R.J., Ho, G.H., den Hoed, P.T., Hoedt, M.T., van Hoek, F., Hoencamp, R., Hoffmann, W.H., Hogendoorn, W., Hoksbergen, A.W., Hollander, E.J., Hommes, M., Hopmans, C.J., Huisman, L.C., Hulsebos, R.G., Huntjens, K.M., Idu, M.M., Jacobs, M.J., van der Jagt, M.F., Jansbeken, J.R., Janssen, R.J., Jiang, H.H., de Jong, S.C., Jongbloed-Winkel, T.A., Jongkind, V., Kapma, M.R., Keller, B.P., Khodadade Jahrome, A., Kievit, J.K., Klemm, P.L., Klinkert, P., Koedam, N.A., Koelemaij, M.J., Kolkert, J.L., Koning, G.G., Koning, O.H., Konings, R., Krasznai, A.G., Krol, R.M., Kropman, R.H., Kruse, R.R., van der Laan, L., van der Laan, M.J., van Laanen, J.H., van Lammeren, G.W., Lamprou, D.A., Lardenoye, J.H., Lauret, G.J., Leenders, B.J., Legemate, D.A., Leijdekkers, V.J., Lemson, M.S., Lensvelt, M.M., Lijkwan, M.A., Lind, R.C., van der Linden, F.T., Liqui Lung, P.F., Loos, M.J., Loubert, M.C., van de Luijtgaarden, K.M., Mahmoud, D.E., Manshanden, C.G., Mattens, E.C., Meerwaldt, R., Mees, B.M., von Meijenfeldt, G.C., Menting, T.P., Metz, R., Minnee, R.C., de Mol van Otterloo, J.C., Molegraaf, M.J., Montauban van Swijndregt, Y.C., Morak, M.J., van de Mortel, R.H., Mulder, W., Nagesser, S.K., Naves, C.C., Nederhoed, J.H., Nevenzel-Putters, A.M., de Nie, A.J., Nieuwenhuis, D.H., Nieuwenhuizen, J., van Nieuwenhuizen, R.C., Nio, D., Noyez, V.J., Oomen, A.P., Oranen, B.I., Oskam, J., Palamba, H.W., Peppelenbosch, A.G., van Petersen, A.S., Petri, B.J., Pierie, M.E., Ploeg, A.J., Pol, R.A., Ponfoort, E.D., Post, I.C., Poyck, P.P., Prent, A., ten Raa, S., Raymakers, J.T., Reichart, M., Reichmann, B.L., Reijnen, M.M., de Ridder, J.A., Rijbroek, A., van Rijn, M.J., de Roo, R.A., Rouwet, E.V., Saleem, B.R., Salemans, P.B., van Sambeek, M.R., Samyn, M.G., van ’t Sant, H.P., van Schaik, J., van Schaik, P.M., Scharn, D.M., Scheltinga, M.R., Schepers, A., Schlejen, P.M., Schlosser, F.J., Schol, F.P., Scholtes, V.P., Schouten, O., Schreve, M.A., Schurink, G.W., Sikkink, C.J., te Slaa, A., Smeets, H.J., Smeets, L., Smeets, R.R., de Smet, A.A., Smit, P.C., Smits, T.M., Snoeijs, M.G., Sondakh, A.O., Speijers, M.J., van der Steenhoven, T.J., van Sterkenburg, S.M., Stigter, D.A., Stokmans, R.A., Strating, R.P., Stultiëns, G.N., Sybrandy, J.E., Teijink, J.A., Telgenkamp, B.J., Teraa, M., Testroote, M.J., Tha-In, T., The, R.M., Thijsse, W.J., Thomassen, I., Tielliu, I.F., van Tongeren, R.B., Toorop, R.J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R.P., Ünlü, Ç., Vaes, R.H., Vafi, A.A., Vahl, A.C., Veen, E.J., Veger, H.T., Veldman, M.G., Velthuis, S., Verhagen, H.J., Verhoeven, B.A., Vermeulen, C.F., Vermeulen, E.G., Vierhout, B.P., van der Vijver-Coppen, R.J., Visser, M.J., van der Vliet, J.A., Vlijmen - van Keulen, C.J., Voorhoeve, R., van der Vorst, J.R., Vos, A.W., de Vos, B., Vos, C.G., Vos, G.A., Voute, M.T., Vriens, B.H., Vriens, P.W., de Vries, A.C., de Vries, D.K., de Vries, J.P., de Vries, M., van der Waal, C., Waasdorp, E.J., Wallis de Vries, B.M., van Walraven, L.A., van Wanroij, J.L., Warlé, M.C., van de Water, W., van Weel, V., van Well, A.M., Welten, G.M., Welten, R.J., Wever, J.J., Wiersema, A.M., Wikkeling, O.R., Willaert, W.I., Wille, J., Willems, M.C., Willigendael, E.M., Wilschut, E.D., Wisselink, W., Witte, M.E., Wittens, C.H., Wong, C.Y., Wouda, R., Yazar, O., Yeung, K.K., Zeebregts, C.J., van Zeeland, M.L., Karthaus, Eleonora G., Lijftogt, Niki, Vahl, Anco, van der Willik, Esmee M., Amodio, Sonia, van Zwet, Erik W., and Hamming, Jaap F.

Published
2020
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45. Oleic acid triggers CD4+T cells to be metabolically rewired and poised to differentiate into proinflammatory T cell subsets upon activation

Author

Reilly, Nathalie A., primary, Sonnet, Friederike, additional, Dekkers, Koen F., additional, Kwekkeboom, Joanneke C., additional, Sinke, Lucy, additional, Hilt, Stan, additional, Suleiman, Hayat M., additional, Hoeksema, Marten A., additional, Mei, Hailiang, additional, van Zwet, Erik W., additional, Everts, Bart, additional, Ioan-Facsinay, Andreea, additional, Jukema, J. Wouter, additional, and Heijmans, Bastiaan T., additional

Published
2024
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46. Sex differences in outcomes after endovascular treatment in posterior circulation stroke: results from the MR CLEAN Registry

Author

Ali, Mariam, primary, Dekker, Luuk, additional, Ali, Mahsoem, additional, Van Zwet, Erik W, additional, Hofmeijer, Jeanette, additional, Nederkoorn, Paul J, additional, Majoie, Charles BLM, additional, van Es, Adriaan CGM, additional, Uyttenboogaart, Maarten, additional, van der Meij, Anne, additional, van Walderveen, Marianne A A, additional, Visser, Marieke C, additional, Dippel, Diederik WJ, additional, Schonewille, Wouter J, additional, van den Wijngaard, Ido R, additional, Kruyt, Nyika D, additional, and Wermer, Marieke J H, additional

Published
2024
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49. Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

Author

Heijmans, Bastiaan T., ’t Hoen, Peter A.C., van Meurs, Joyce, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M.J., Stehouwer, Coen D.A., van der Kallen, Carla J.H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., Hof, Peter van ’t, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Hoen, Peter-Bram ’t, Zilhão, Nuno R., Sugden, Karen, Hannon, Eilis J., Mill, Jonathan, Caspi, Avshalom, Agnew-Blais, Jessica, Arseneault, Louise, Corcoran, David L., Moffitt, Terrie E., Poulton, Richie, and Franke, Barbara

Published
2019
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