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20 results on '"van de Laar, Thijs J.W."'

5. Direct-Acting Antiviral Treatment for Hepatitis C Genotypes Uncommon in High-Income Countries:: A Dutch Nationwide Cohort Study

Author

Isfordink, Cas J., van de Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, van Hoek, Bart, Brakenhoff, Sylvia, Blokzijl, Hans, Arends, Joop E., van der Valk, Marc, Schinkel, Janke, Isfordink, Cas J., van de Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, van Hoek, Bart, Brakenhoff, Sylvia, Blokzijl, Hans, Arends, Joop E., van der Valk, Marc, and Schinkel, Janke

Abstract

Background. The majority of hepatitis C virus (HCV) infections are found in low- and middle-income countries, which harbor many region-specific HCV subtypes. Nevertheless, direct-acting antiviral (DAA) trials have almost exclusively been conducted in high-income countries, where mainly epidemically spread HCV subtypes are present. Recently, several studies have demonstrated suboptimal DAA efficacy for certain nonepidemic subtypes, which could hamper global HCV elimination. Therefore, we aimed to evaluate DAA efficacy in patients treated for a nonepidemic HCV genotype infection in the Netherlands. Methods. We performed a nationwide retrospective study including patients treated with interferon-free DAAs for an HCV genotype other than 1a/1b/2a/2b/3a/4a/4d. The genotype was determined by NS5B region phylogenetic analysis. The primary end point was SVR-12. If stored samples were available, NS5A and NS5B sequences were obtained for resistance-associated substitutions (RAS) evaluation. Results. We included 160 patients, mainly infected with nonepidemic genotype 2 (41%) and 4 (31%) subtypes. Most patients were from Africa (45%) or South America (24%); 51 (32%) were cirrhotic. SVR-12 was achieved in 92% (140/152) of patients with available SVR-12 data. Only 73% (8/11) genotype 3–infected patients achieved SVR-12, the majority being genotype 3b patients with 63% (5/8) SVR. Regardless of SVR, all genotype 3b patients had 30K and 31M RAS. Conclusions. The DAA efficacy we observed in most nonepidemic genotypes in the Netherlands seems reassuring. However, the low SVR-12 rate in subtype 3b infections is alarming, especially as it is common in several HCV-endemic countries. Alongside earlier results, our results indicate that a remaining challenge for global HCV elimination is confirming and monitoring DAA efficacy in nonepidemic genotypes.

Published
2021

6. Erratum to: Direct-Acting Antiviral Treatment for Hepatitis C Genotypes Uncommon in High-Income Countries: A Dutch Nationwide Cohort Study

Author

Research UMC Utrecht, MS MDL 1, MS Interne Geneeskunde, Infection & Immunity, Isfordink, Cas J., Van De Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, Van Hoek, Bart, Brakenhoff, Sylvia M., Blokzijl, Hans, Arends, Joop E., Van Der Valk, Marc, Schinkel, Janke, Research UMC Utrecht, MS MDL 1, MS Interne Geneeskunde, Infection & Immunity, Isfordink, Cas J., Van De Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, Van Hoek, Bart, Brakenhoff, Sylvia M., Blokzijl, Hans, Arends, Joop E., Van Der Valk, Marc, and Schinkel, Janke

Published
2021

7. Direct-Acting Antiviral Treatment for Hepatitis C Genotypes Uncommon in High-Income Countries: A Dutch Nationwide Cohort Study

Author

KTO Office, MS MDL 1, MS Interne Geneeskunde, Infection & Immunity, Isfordink, Cas J., Van De Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, Van Hoek, Bart, Brakenhoff, Sylvia M., Blokzijl, Hans, Arends, Joop E., Van Der Valk, Marc, Schinkel, Janke, KTO Office, MS MDL 1, MS Interne Geneeskunde, Infection & Immunity, Isfordink, Cas J., Van De Laar, Thijs J.W., Rebers, Sjoerd P.H., Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C., Van Nieuwkoop, Cees, Van Hoek, Bart, Brakenhoff, Sylvia M., Blokzijl, Hans, Arends, Joop E., Van Der Valk, Marc, and Schinkel, Janke

Published
2021

10. High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis

Author

Hoornenborg, Elske, primary, Coyer, Liza, additional, Boyd, Anders, additional, Achterbergh, Roel Christiaan Alfons, additional, Schim van der Loeff, Maarten Franciscus, additional, Bruisten, Sylvia, additional, de Vries, Henry John Christiaan, additional, Koopsen, Jelle, additional, van de Laar, Thijs J.W., additional, Prins, Maria, additional, van Bergen, J.E.A.M., additional, de Bree, G.J., additional, Brokx, P., additional, Deug, F., additional, Heidenrijk, M., additional, Prins, M., additional, Reiss, P., additional, van der Valk, M., additional, Davidovich, U., additional, Geerlings, S.E., additional, Hoornenborg, E., additional, Oomen, A., additional, Sighem, A. van, additional, Zuilhof, W., additional, Bruinderink, M.L. Groot, additional, Achterbergh, R.C.A., additional, van Agtmael, M., additional, Ananworanich, J., additional, Van de Beek, D., additional, van den Berk, G.E.L., additional, Bezemer, D., additional, van Bijnen, A., additional, Blok, W.L., additional, Bogers, S., additional, Bomers, M., additional, Boucher, C.A.B., additional, Brokking, W., additional, Burger, D., additional, Brinkman, K., additional, Brinkman, N., additional, de Bruin, M., additional, Bruisten, S., additional, Coyer, L., additional, van Crevel, R., additional, Daans, C.G., additional, Dellemann, L., additional, Dijkstra, M., additional, van Duijnhoven, Y.T., additional, van Eeden, A., additional, Elsenburg, L., additional, van den Elshout, M.A.M., additional, Ester, C., additional, Ersan, E., additional, Felipa, P.E.V., additional, Frissen, P.H.J., additional, Geijtenbeek, T.B.H., additional, Godfried, M.H., additional, van Gool, J., additional, Goorhuis, A., additional, Groot, M., additional, Hankins, C.A., additional, Heijnen, A., additional, Hillebregt, M.M.J., additional, Hogewoning, A., additional, Hommenga, M., additional, Hovius, J.W., additional, Janssen, Y., additional, de Jong, K., additional, Jongen, V., additional, Kootstra, N.A., additional, Koup, R.A., additional, Kroon, F.P., additional, van de Laar, T.J.W., additional, Lauw, F., additional, van Leeuwen, M.M., additional, Lettinga, K., additional, Linde, I., additional, Loomans, D.S.E., additional, van der Meer, J.T., additional, Mouhebati, T., additional, Mulder, B.J., additional, Mulder, J., additional, Nellen, F.J., additional, Nijsters, A., additional, Nobel, H., additional, Oostvogel, P., additional, Op de Coul, E.L.M., additional, Peters, E., additional, Peters, I.S., additional, van der Poll, T., additional, Ratmann, O., additional, Rokx, C., additional, van Rooijen, M.S., additional, Schim van der Loeff, M.F., additional, Schoute, W.E.M., additional, Sonder, G.J., additional, Veenstra, J., additional, Verbon, A., additional, Verdult, F., additional, de Vocht, J., additional, de Vries, H.J., additional, Vrouenraets, S., additional, van Vugt, M., additional, Wiersinga, W.J., additional, Wit, F.W., additional, Woittiez, L.R., additional, Zaheri, S., additional, Zantkuijl, P., additional, van Zelm, M.C., additional, Żakowicz, A., additional, and Zimmermann, H.M.L., additional

Published
2020
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12. Increased in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission

Author

van de Laar, Thijs J.W., van der Bij, Akke K., Prins, Maria, Bruisten, Sylvia M., Brinkman, Kees, Ruys, Thomas A., van der Meer, Jan T.M., de Vries, Henry J.C., Mulder, Jan-Willem, van Agtmael, Michiel, Jurriaans, Suzanne, Wolthers, Katja C., and Coutinho, Roel A.

Subjects
Amsterdam, Netherlands -- Research, Gay men -- Sexual behavior, Gay men -- Risk factors, Hepatitis C virus -- Demographic aspects, Hepatitis C virus -- Risk factors, Sexually transmitted diseases -- Research, Health
Published
2007

17. Reply to Richardson et al., regarding 'sexual transmission of hepatitis C in MSM may not be confined to those with HIV infection

Author

van de Laar, Thijs J.W., Urbanus, Anouk T., Bruisten, Sylvia M., de Vries, Henry J.C., Thiesbrummel, Harold F.J., Coutinho, Roel A., and Prins, Maria

Subjects
Hepatitis C -- Research, Hepatitis C -- Health aspects, Disease transmission -- Research, Disease transmission -- Health aspects, HIV infection -- Research, HIV infection -- Health aspects, Health
Published
2008

19. Hepatitis C in the general population of various ethnic origins living in the Netherlands: Should non-Western migrants be screened?

Author

Urbanus, Anouk T., primary, van de Laar, Thijs J.W., additional, van den Hoek, Anneke, additional, Zuure, Freke R., additional, Speksnijder, Adrianus G.C.L., additional, Baaten, Gijs G.G., additional, Heijman, Titia, additional, Vriend, Henrike J., additional, Op de Coul, Eline L.M., additional, Coutinho, Roel A., additional, and Prins, Maria, additional

Published
2011
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