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189 results on '"van den Bogaard, Bas"'

1. Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers

Author: Hilderink, Bashar N., Crane, Reinier F., van den Bogaard, Bas, Pillay, Janesh, and Juffermans, Nicole P.
Published: 2024
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2. Phosphodiesterase 3 inhibitors do not influence lactate kinetics and clinical outcomes in patients with septic shock: A multicentre cohort study

Author: Tai-Passmann, Sharon, Slegers, Claire A.D., Hemelaar, Pleun, Waalders, Nicole, Koopmans, Matty, van den Bogaard, Bas, van Lookeren Campagne, Michiel, Goedegebuur, Jamilla, Kuindersma, Marnix, Schroten, Nicolas, van der Elsen, Fieke, Grady, Bart P.X., van den Beuken, Wisse M.F., Kiers, Dorien, Pickkers, Peter, and van den Oever, Huub L.A.
Published: 2024
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3. Effects of Plasmapheresis on Serum Lithium Levels in an ICU Patient with Bipolar Disorder: A Case Study

Author: Lien, Thuy N. T., Mohamed, Sherin M. M., van den Bogaard, Bas, Touw, Daan J., and Franssen, Eric J. F.
Published: 2024
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4. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy

Author: Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Published: 2024
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5. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author: Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S. R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P. S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P. J.
Published: 2023
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6. International Survey on Mechanical Ventilation During Extracorporeal Membrane Oxygenation

Author: van Minnen, Olivier, Jolink, Floris E.J., van den Bergh, Walter M., Droogh, Joep M., Oude Lansink-Hartgring, Annemieke, Vlaar, Alexander P. J., Raasveld, S. Jorinde, Donker, Dirk W., Hermens, Jeannine A. J., Cornet, Alexander D., Vermeijden, J. Wytze, Oude Velthuis, Bob, van den Brule, Judith M. D., Kraemer, C. V. Elzo, Maas, Jacinta J., Janson, Jeroen, Lopez Matta, Jorge, Delnoij, Thijs S. R., van de Poll, Marcel, Akin, Sakir, de Metz, Jesse, van den Bogaard, Bas, Otterspoor, Luuk, Scholten, Erik, van de Pol, Ineke, Kuijpers, Marijn, van Koppenhagen, Laurien, Dos Reis Miranda, Dinis, Meuwese, Christiaan, and Bunge, Jeroen
Published: 2024
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7. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices

Author: van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.
Published: 2023
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8. Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial

Author: Roggeveen, Luca F., Guo, Tingjie, Fleuren, Lucas M., Driessen, Ronald, Thoral, Patrick, van Hest, Reinier M., Mathot, Ron A. A., Swart, Eleonora L., de Grooth, Harm-Jan, van den Bogaard, Bas, Girbes, Armand R. J., Bosman, Rob J., and Elbers, Paul W. G.
Published: 2022
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9. Long-term survival and health-related quality of life after in-hospital cardiac arrest

Author: Schluep, Marc, Hoeks, Sanne Elisabeth, Blans, Michiel, van den Bogaard, Bas, Koopman-van Gemert, Ankie, Kuijs, Cees, Hukshorn, Chris, van der Meer, Nardo, Knook, Marco, van Melsen, Trudy, Peters, René, Perik, Patrick, Simons, Koen, Spijkers, Gerben, Vermeijden, Wytze, Wils, Evert-Jan, (Robert Jan) Stolker, R.J., and (Rik) Endeman, H.
Published: 2021
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10. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author: Lemkes, Jorrit S., Spoormans, Eva M., Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Rémon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Jessurun, Gillian A.J., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van de Ven, Peter M., van Loon, Ramon B., and van Royen, Niels
Published: 2021
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11. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author: Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., van de Ven, Peter M., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., der Harst, Pim van, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Jessurun, Gillian A.J., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., Appelman, Yolande, and van Royen, Niels
Published: 2021
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12. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation:A COACT Substudy

Author: Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, van Royen, Niels, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Abstract: Background: In out-of-hospital cardiac arrest (OHCA) without ST-elevation, predictive markers that can identify those with a high risk of acute coronary syndrome are lacking. Methods: In this post hoc analysis of the Coronary Angiography after Cardiac Arrest (COACT) trial, the baseline, median, peak, and time-concentration curves of troponin-T (cTnT) (T-AUC) in OHCA patients without ST-elevation were studied. cTnT values were obtained at predefined time points at 0, 3, 6, 12, 24, 36, 28, and 72 hours after admission. All patients who died within the measurement period were not included. The primary outcome was the association between cTnT and 90-day survival. Secondary outcomes included the association of cTnT and acute thrombotic occlusions, acute unstable lesions, and left ventricular function. Results: In total, 352 patients were included in the analysis. The mean age was 64 ± 13 years (80.4% men). All cTnT measures were independent prognostic factors for mortality after adjustment for potential confounders age, sex, history of coronary artery disease, witnessed arrest, time to BLS, and time to return of spontaneous circulation (eg, for T-AUC: hazard ratio, 1.44; 95% CI, 1.06-1.94; P = .02; P value for all variables ≤ .02). Median cTnT (odds ratio [OR], 1.58; 95% CI, 1.18-2.12; P = .002) and T-AUC (OR, 2.03; 95% CI, 1.25-3.29; P = .004) were independent predictors for acute unstable lesions. Median cTnT (OR, 1.62; 95% CI, 1.17-2.23; P = .003) and T-AUC (OR, 2.16; 95% CI, 1.27-3.68; P = .004) were independent predictors for acute thrombotic occlusions. CTnT values were not associated with the left ventricular function (eg, for T-AUC: OR, 2.01; 95% CI, 0.65-6.19; P = .22; P value for all variables ≥ .14)Conclusion:In OHCA patients without ST-segment elevation, cTnT release during the first 72 hours after return of spontaneous circulation was associated with clinical outcomes.
Published: 2024

13. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy

Author: Cardiologie, Team Medisch, Gezonde Vaten, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, van Royen, Niels, Cardiologie, Team Medisch, Gezonde Vaten, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Published: 2024

14. Hyperoxemia and hypoxemia impair cellular oxygenation:a study in healthy volunteers

Author: Hilderink, Bashar N., Crane, Reinier F., van den Bogaard, Bas, Pillay, Janesh, Juffermans, Nicole P., Hilderink, Bashar N., Crane, Reinier F., van den Bogaard, Bas, Pillay, Janesh, and Juffermans, Nicole P.
Abstract: Introduction: Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in clinical practice remain unresolved. The novel PpIX technique measures the mitochondrial oxygen tension in the skin (mitoPO2) which allows for non-invasive investigation on the effect of hypoxemia and hyperoxemia on cellular oxygen availability. Results: During hypoxemia, SpO2 was 80 (77–83)% and PaO2 45(38–50) mmHg for 15 min. MitoPO2 decreased from 42(35–51) at baseline to 6(4.3–9)mmHg (p < 0.001), despite 16(12–16)% increase in cardiac output which maintained global oxygen delivery (DO2). During hyperoxic breathing, an FiO2 of 40% decreased mitoPO2 to 20 (9–27) mmHg. Cardiac output was unaltered during hyperoxia, but perfused De Backer density was reduced by one-third (p < 0.01). A PaO2 < 100 mmHg and > 200 mmHg were both associated with a reduction in mitoPO2. Conclusions: Hypoxemia decreases mitoPO2 profoundly, despite complete compensation of global oxygen delivery. In addition, hyperoxemia also decreases mitoPO2, accompanied by a reduction in microcirculatory perfusion. These results suggest that mitoPO2 can be used to titrate oxygen support.
Published: 2024

15. Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Author: Rozemeijer, Sander, de Grooth, Harm-Jan, Elbers, Paul W. G., Girbes, Armand R. J., den Uil, Corstiaan A., Dubois, Eric A., Wils, Evert-Jan, Rettig, Thijs C. D., van Zanten, Arthur R. H., Vink, Roel, van den Bogaard, Bas, Bosman, Rob J., Oudemans-van Straaten, Heleen M., and de Man, Angélique M. E.
Published: 2021
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16. Cost-effectiveness of extracorporeal cardiopulmonary resuscitation vs. conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a pre-planned, trial-based economic evaluation.

Author: Delnoij, Thijs S R, Suverein, Martje M, Essers, Brigitte A B, Hermanides, Renicus C, Otterspoor, Luuk, Elzo Kraemer, Carlos V, Vlaar, Alexander P J, van der Heijden, Joris J, Scholten, Erik, den Uil, Corstiaan, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C C, Maessen, Jos G, Lorusso, Roberto, van de Poll, Marcel C G, Bruinsma, George J Brandon Bravo, Kraemer, Carlos V Elzo, Jansen, Tim, and van den Bogaard, Bas
Published: 2024
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17. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit

Author: de Metz, Jesse, Thoral, Patrick J., Chorus, Caspar G., Elbers, Paul W. G., and van den Bogaard, Bas
Published: 2021
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18. The Prognostic Value of Troponin-T in OHCA Without ST-Segment Elevation: A COACT Trial’s Secondary Analysis

Author: Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, van der Harst, Pim, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, van der Pas, Stéphanie, additional, and van Royen, Niels, additional
Published: 2023
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19. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author: Raasveld, Senta Jorinde, primary, Karami, Mina, additional, Schenk, Jimmy, additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, van den Bergh, Walter M., additional, Oude Lansink‐Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, Taccone, Fabio Silvio, additional, Peluso, Lorenzo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Scholten, Erik, additional, Overmars, Martijn, additional, Ivančan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, Hermans, Greet, additional, Broman, Lars Mikael, additional, Henriques, José P. S., additional, and Vlaar, Alexander P. J., additional
Published: 2023
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20. A simulation of skin mitochondrial Po2 in circulatory shock

Author: Hilderink, Bashar N., primary, Crane, Reinier F., additional, Baysan, Meryem, additional, Arbous, Sesmu M., additional, van den Bogaard, Bas, additional, Mik, Egbert G., additional, Ince, Can, additional, Pillay, Janesh, additional, and Juffermans, Nicole P., additional
Published: 2023
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21. Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Author: Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, Jawa, Randeep, Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, and Jawa, Randeep
Abstract: Background: Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods: This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results: Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions: Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04
Published: 2023

22. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation:A multicenter retrospective observational cohort study

Author: Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.
Abstract: Background: Evidence-based recommendations for transfusion in patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) are scarce. The current literature is limited to single-center studies with small sample sizes, therefore complicating generalizability. This study aims to create an overview of red blood cell (RBC) transfusion in VA ECMO patients. Methods: This international mixed-method study combined a survey with a retrospective observational study in 16 centers. The survey inventoried local transfusion guidelines. Additionally, retrospective data of all adult patients with a VA ECMO run >24 h (January 2018 until July 2019) was collected of patient, ECMO, outcome, and daily transfusion parameters. All patients that received VA ECMO for primary cardiac support were included, including surgical (i.e., post-cardiotomy) and non-surgical (i.e., myocardial infarction) indications. The primary outcome was the number of RBC transfusions per day and in total. Univariable logistic regressions and a generalized linear mixed model (GLMM) were performed to assess factors associated with RBC transfusion. Results: Out of 419 patients, 374 (89%) received one or more RBC transfusions. During a median ECMO run of 5 days (1st–3rd quartile 3–8), patients received a median total of eight RBC units (1st–3rd quartile 3–17). A lower hemoglobin (Hb) prior to ECMO, longer ECMO-run duration, and hemorrhage were associated with RBC transfusion. After correcting for duration and hemorrhage using a GLMM, a different transfusion trend was found among the regimens. No unadjusted differences were found in overall survival between either transfusion status or the different regimens, which remained after adjustment for potential confounders. Conclusion: RBC transfusion in patients on VA ECMO is very common. The sum of RBC transfusions increases rapidly after ECMO initiation, and is dependent on the
Published: 2023

23. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation:A Secondary Analysis of an International Observational Study on Current Practices

Author: Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.
Abstract: OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of plasma, fibrinogen concentrate, tranexamic acid (TXA), and prothrombin complex concentrate (PCC) in patients on ECMO.DESIGN: A prespecified subanalysis of a multicenter retrospective study. Venovenous (VV)-ECMO and venoarterial (VA)-ECMO are analyzed as separate populations, comparing patients with and without bleeding and with and without thrombotic complications. SETTING: Sixteen international ICUs.PATIENTS: Adult patients on VA-ECMO or VV-ECMO.INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 420 VA-ECMO patients, 59% (n = 247) received plasma, 20% (n = 82) received fibrinogen concentrate, 17% (n = 70) received TXA, and 7% of patients (n = 28) received PCC. Fifty percent of patients (n = 208) suffered bleeding complications and 27% (n = 112) suffered thrombotic complications. More patients with bleeding complications than patients without bleeding complications received plasma (77% vs. 41%, p < 0.001), fibrinogen concentrate (28% vs 11%, p < 0.001), and TXA (23% vs 10%, p < 0.001). More patients with than without thrombotic complications received TXA (24% vs 14%, p = 0.02, odds ratio 1.75) in VA-ECMO, where no difference was seen in VV-ECMO. Of 205 VV-ECMO patients, 40% (n = 81) received plasma, 6% (n = 12) fibrinogen concentrate, 7% (n = 14) TXA, and 5% (n = 10) PCC. Thirty-nine percent (n = 80) of VV-ECMO patients suffered bleeding complications and 23% (n = 48) of patients suffered thrombotic complications. More patients with than without bleeding complications received plasma (58% vs 28%, p < 0.001), fibrinogen concentrate (13% vs 2%, p < 0.01), and TXA (11% vs 2%, p < 0.01).
Published: 2023

24. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation:a multicenter observational study

Author

Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.

Abstract

Background: Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-center experiences with high degrees of heterogeneity. Therefore, we aimed to ascertain in a multicenter study the course and occurrence rate of thrombocytopenia, and to assess the association between thrombocytopenia, hemorrhage and platelet transfusion during VA ECMO. Methods: This was a sub-study of a multicenter (N = 16) study on transfusion practices in patients on VA ECMO, in which a retrospective cohort (Jan-2018–Jul-2019) focusing on platelets was selected. The primary outcome was thrombocytopenia during VA ECMO, defined as mild (100–150·109/L), moderate (50–100·109/L) and severe (< 50·109/L). Secondary outcomes included the occurrence rate of platelet transfusion, and the association between thrombocytopenia, hemorrhage and platelet transfusion, assessed through mixed-effect models.Results: Of the 419 patients included, median platelet count at admission was 179·109/L. During VA ECMO, almost all (N = 398, 95%) patients developed a thrombocytopenia, of which a significant part severe (N = 179, 45%). One or more platelet transfusions were administered in 226 patients (54%), whereas 207 patients (49%) suffered a hemorrhagic event during VA ECMO. In non-bleeding patients, still one in three patients received a platelet transfusion. The strongest association to receive a platelet transfusion was found in the presence of severe thrombocytopenia (adjusted OR 31.8, 95% CI 17.9–56.5). After including an interaction term of hemorrhage and thrombocytopenia, this even increased up to an OR of 110 (95% CI 34–360). Conclusions: Thrombocytopenia has a higher occurrence than is currently recognized. Severe thrombocytopenia is strongl

Published

2023

25. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.

Published

2023

26. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.

Published

2023

27. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.

Published

2023

28. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest

Author

Medische Staf Intensive Care, Team Medisch, Other research (not in main researchprogram), Suverein, Martje M., Delnoij, Thijs S.R., Lorusso, Roberto, Brandon Bravo Bruinsma, George J., Otterspoor, Luuk, Elzo Kraemer, Carlos V., Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Jansen, Tim, van den Bogaard, Bas, Kuijpers, Marijn, Lam, Ka Yan, Montero Cabezas, José M., Driessen, Antoine H.G., Rittersma, Saskia Z.H., Heijnen, Bram G., Dos Reis Miranda, Dinis, Bleeker, Gabe, de Metz, Jesse, Hermanides, Renicus S., Lopez Matta, Jorge, Eberl, Susanne, Donker, Dirk W., van Thiel, Robert J., Akin, Sakir, van Meer, Oene, Henriques, José, Bokhoven, Karen C., Mandigers, Loes, Bunge, Jeroen J.H., Bol, Martine E., Winkens, Bjorn, Essers, Brigitte, Weerwind, Patrick W., Maessen, Jos G., van de Poll, Marcel C.G., Medische Staf Intensive Care, Team Medisch, Other research (not in main researchprogram), Suverein, Martje M., Delnoij, Thijs S.R., Lorusso, Roberto, Brandon Bravo Bruinsma, George J., Otterspoor, Luuk, Elzo Kraemer, Carlos V., Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Jansen, Tim, van den Bogaard, Bas, Kuijpers, Marijn, Lam, Ka Yan, Montero Cabezas, José M., Driessen, Antoine H.G., Rittersma, Saskia Z.H., Heijnen, Bram G., Dos Reis Miranda, Dinis, Bleeker, Gabe, de Metz, Jesse, Hermanides, Renicus S., Lopez Matta, Jorge, Eberl, Susanne, Donker, Dirk W., van Thiel, Robert J., Akin, Sakir, van Meer, Oene, Henriques, José, Bokhoven, Karen C., Mandigers, Loes, Bunge, Jeroen J.H., Bol, Martine E., Winkens, Bjorn, Essers, Brigitte, Weerwind, Patrick W., Maessen, Jos G., and van de Poll, Marcel C.G.

Published

2023

29. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest

Author

Suverein, Martje M., primary, Delnoij, Thijs S.R., additional, Lorusso, Roberto, additional, Brandon Bravo Bruinsma, George J., additional, Otterspoor, Luuk, additional, Elzo Kraemer, Carlos V., additional, Vlaar, Alexander P.J., additional, van der Heijden, Joris J., additional, Scholten, Erik, additional, den Uil, Corstiaan, additional, Jansen, Tim, additional, van den Bogaard, Bas, additional, Kuijpers, Marijn, additional, Lam, Ka Yan, additional, Montero Cabezas, José M., additional, Driessen, Antoine H.G., additional, Rittersma, Saskia Z.H., additional, Heijnen, Bram G., additional, Dos Reis Miranda, Dinis, additional, Bleeker, Gabe, additional, de Metz, Jesse, additional, Hermanides, Renicus S., additional, Lopez Matta, Jorge, additional, Eberl, Susanne, additional, Donker, Dirk W., additional, van Thiel, Robert J., additional, Akin, Sakir, additional, van Meer, Oene, additional, Henriques, José, additional, Bokhoven, Karen C., additional, Mandigers, Loes, additional, Bunge, Jeroen J.H., additional, Bol, Martine E., additional, Winkens, Bjorn, additional, Essers, Brigitte, additional, Weerwind, Patrick W., additional, Maessen, Jos G., additional, and van de Poll, Marcel C.G., additional

Published

2023

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30. Myocardial preload alters central pressure augmentation through changes in the forward wave

Author

van de Velde, Lennart, Eeftinck Schattenkerk, Daan W., Venema, Pascale A.H.T., Best, Hendrik J., van den Bogaard, Bas, Stok, Wim J., Westerhof, Berend E., and van den Born, Bert Jan H.

Published

2018

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31. A simulation of skin mitochondrial Po2 in circulatory shock.

Author

Hilderink, Bashar N., Crane, Reinier F., Baysan, Meryem, Arbous, Sesmu M., van den Bogaard, Bas, Mik, Egbert G., Ince, Can, Pillay, Janesh, and Juffermans, Nicole P.

Subjects

CARDIOGENIC shock, FLOW velocity, BLOOD flow, MITOCHONDRIA, SEPTIC shock

Abstract

Circulatory shock is the inadequacy to supply mitochondria with enough oxygen to sustain aerobic energy metabolism. A novel noninvasive bedside measurement was recently introduced to monitor the mitochondrial oxygen tension in the skin (mitoP o2). As the most downstream marker of oxygen balance in the skin, mitoPo2 may provide additional information to improve shock management. However, a physiological basis for the interpretation of mitoPo2 values has not been established yet. In this paper, we developed a mathematical model of skin mitoPo2 using a network of parallel microvessels, based on Krogh's cylinder model. The model contains skin blood flow velocity, heterogeneity of blood flow, hematocrit, arteriolar oxygen saturation, and mitochondrial oxygen consumption as major variables. The major results of the model show that normal physiological mitoPo2 is in the range of 40-60 mmHg. The relationship of mitoPo2 with skin blood flow velocity follows a logarithmic growth curve, reaching a plateau at high skin blood flow velocity, suggesting that oxygen balance remains stable while peripheral perfusion declines. The model shows that a critical range exists where mitoPo2 rapidly deteriorates if skin perfusion further decreases. The model intuitively shows how tissue hypoxia could occur in the setting of septic shock, due to the profound impact of microcirculatory disturbance on mitoPo2, even at sustained cardiac output. MitoPo2 is the result of a complex interaction between all factors of oxygen delivery and microcirculation. This mathematical framework can be used to interpret mitoPo2 values in shock, with the potential to enhance personalized clinical trial design. [ABSTRACT FROM AUTHOR]

Published

2023

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32. Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

Author

van den Bogaard, Bas, Holleboom, Adriaan G., Duivenvoorden, Raphaël, Hutten, Barbara A., Kastelein, John J.P., Hovingh, G. Kees, Kuivenhoven, Jan Albert, Stroes, Erik S.G., and van den Born, Bert-Jan H.

Published

2012

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33. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials’ post-hoc subgroup analysis

Author

Spoormans, Eva M, primary, Lemkes, Jorrit S, additional, Janssens, Gladys N, additional, Soultana, Ouissal, additional, van der Hoeven, Nina W, additional, Jewbali, Lucia S D, additional, Dubois, Eric A, additional, Meuwissen, Martijn, additional, Rijpstra, Tom A, additional, Bosker, Hans A, additional, Blans, Michiel J, additional, Bleeker, Gabe B, additional, Baak, Remon, additional, Vlachojannis, Georgios J, additional, Eikemans, Bob J W, additional, van der Harst, Pim, additional, van der Horst, Iwan C C, additional, Voskuil, Michiel, additional, van der Heijden, Joris J, additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P, additional, Vlaar, Alexander P J, additional, Vink, Maarten A, additional, van den Bogaard, Bas, additional, Heestermans, Ton A C M, additional, de Ruijter, Wouter, additional, Delnoij, Thijs S R, additional, Crijns, Harry J G M, additional, Oemrawsingh, Pranobe V, additional, Gosselink, Marcel T M, additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W G, additional, van de Ven, Peter M, additional, and van Royen, Niels, additional

Published

2022

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34. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation:A Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.

Abstract

OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane oxygenation, guidelines suggest liberal thresholds, and a clear overview of RBC transfusion practice is lacking. This study aims to create an overview of RBC transfusion in venovenous extracorporeal membrane oxygenation. DESIGN: Mixed method approach combining multicenter retrospective study and survey. SETTING: Sixteen ICUs worldwide. PATIENTS: Patients receiving venovenous extracorporeal membrane oxygenation between January 2018 and July 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the proportion receiving RBC, the amount of RBC units given daily and in total. Furthermore, the course of hemoglobin over time during extracorporeal membrane oxygenation was assessed. Demographics, extracorporeal membrane oxygenation characteristics, and patient outcome were collected. Two-hundred eight patients received venovenous extracorporeal membrane oxygenation, 63% male, with an age of 55 years (45–62 yr), mainly for acute respiratory distress syndrome. Extracorporeal membrane oxygenation duration was 9 days (5–14 d). Prior to extracorporeal membrane oxygenation, hemoglobin was 10.8g/dL (8.9–13.0g/dL), decreasing to 8.7g/dL (7.7–9.8g/dL) during extracorporeal membrane oxygenation. Nadir hemoglobin was lower on days when a transfusion was administered (8.1g/dL [7.4–9.3g/dL]). A vast majority of 88% patients received greater than or equal to 1 RBC transfusion, consisting of 1.6 U (1.3–2.3 U) on transfusion days. This high transfusion occurrence rate was also found in nonbleeding patients (81%). Patients with a liberal transfusion threshold (hemoglobin > 9g/dL) received more RBC in total per transfusion day and extracorporeal membrane oxygenation day. No differences in survival, hemorrhagic and thrombotic complication rates

Published

2022

35. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, and van Royen, Niels

Published

2022

36. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.

Published

2022

37. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, and van Royen, Niels

Published

2022

38. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, Elbers, Paul W G, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, and Elbers, Paul W G

Published

2022

39. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Camaro, Cyril, primary, Bonnes, Judith L., additional, Adang, Eddy M., additional, Spoormans, Eva M., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Rémon, additional, Vlachojannis, George J., additional, Eikemans, Bob J., additional, van der Harst, Pim, additional, van der Horst, Iwan C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Bert, additional, Stoel, Martin, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S., additional, Crijns, Harry J., additional, Jessurun, Gillian A., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W., additional, van de Ven, Peter M., additional, Lemkes, Jorrit S., additional, and van Royen, Niels, additional

Published

2022

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40. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, van den Bergh, Walter M., additional, Oude Lansink-Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Scholten, Erik, additional, Overmars, Martijn, additional, Silvio Taccone, Fabio, additional, Brasseur, Alexandre, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Hermans, Greet, additional, Meersseman, Philippe, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, Ivancan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, de Bruin, Sanne, additional, Lagrand, Wim K., additional, Henriques, José P. S., additional, Broman, Lars M., additional, and Vlaar, Alexander P. J., additional

Published

2022

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41. Additional file 1 of Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial

Author

Roggeveen, Luca F., Guo, Tingjie, Fleuren, Lucas M., Driessen, Ronald, Thoral, Patrick, van Hest, Reinier M., Mathot, Ron A. A., Swart, Eleonora L., de Grooth, Harm-Jan, van den Bogaard, Bas, Girbes, Armand R. J., Bosman, Rob J., and Elbers, Paul W. G.

Abstract

Additional file 1. Electronic supplementary material.

Published

2022

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42. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author

Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S. D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J. W., additional, Girbes, Armand R. J., additional, van der Harst, Pim, additional, van der Horst, Iwan C. C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P. J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A. C. M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S. R., additional, Crijns, Harry J. G. M., additional, Jessurun, Gillian A. J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T. M., additional, Plomp, Koos, additional, Magro, Michael, additional, van de Ven, Peter M., additional, van Royen, Niels, additional, and Elbers, Paul W. G., additional

Published

2021

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43. Additional file 2 of Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Author

Rozemeijer, Sander, de Grooth, Harm-Jan, Elbers, Paul W. G., Girbes, Armand R. J., den Uil, Corstiaan A., Dubois, Eric A., Wils, Evert-Jan, Rettig, Thijs C. D., van Zanten, Arthur R. H., Vink, Roel, van den Bogaard, Bas, Bosman, Rob J., Oudemans-van Straaten, Heleen M., and de Man, Angélique M. E.

Abstract

Additional file 2:. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents

Published

2021

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44. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit

Author

de Metz, Jesse (author), Thoral, Patrick J. (author), Chorus, C.G. (author), Elbers, Paul W.G. (author), van den Bogaard, Bas (author), de Metz, Jesse (author), Thoral, Patrick J. (author), Chorus, C.G. (author), Elbers, Paul W.G. (author), and van den Bogaard, Bas (author)

Abstract

Transport and Logistics

Published

2021

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45. Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA):Study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Author

Rozemeijer, Sander, de Grooth, Harm Jan, Elbers, Paul W.G., Girbes, Armand R.J., den Uil, Corstiaan A., Dubois, Eric A., Wils, Evert Jan, Rettig, Thijs C.D., van Zanten, Arthur R.H., Vink, Roel, van den Bogaard, Bas, Bosman, Rob J., Oudemans-van Straaten, Heleen M., de Man, Angélique M.E., Rozemeijer, Sander, de Grooth, Harm Jan, Elbers, Paul W.G., Girbes, Armand R.J., den Uil, Corstiaan A., Dubois, Eric A., Wils, Evert Jan, Rettig, Thijs C.D., van Zanten, Arthur R.H., Vink, Roel, van den Bogaard, Bas, Bosman, Rob J., Oudemans-van Straaten, Heleen M., and de Man, Angélique M.E.

Abstract

Background: High-dose intravenous vitamin C directly scavenges and decreases the production of harmful reactive oxygen species (ROS) generated during ischemia/reperfusion after a cardiac arrest. The aim of this study is to investigate whether short-term treatment with a supplementary or very high-dose intravenous vitamin C reduces organ failure in post-cardiac arrest patients. Methods: This is a double-blind, multi-center, randomized placebo-controlled trial conducted in 7 intensive care units (ICUs) in The Netherlands. A total of 270 patients with cardiac arrest and return of spontaneous circulation will be randomly assigned to three groups of 90 patients (1:1:1 ratio, stratified by site and age). Patients will intravenously receive a placebo, a supplementation dose of 3 g of vitamin C or a pharmacological dose of 10 g of vitamin C per day for 96 h. The primary endpoint is organ failure at 96 h as measured by the Resuscitation-Sequential Organ Failure Assessment (R-SOFA) score at 96 h minus the baseline score (delta R-SOFA). Secondary endpoints are a neurological outcome, mortality, length of ICU and hospital stay, myocardial injury, vasopressor support, lung injury score, ventilator-free days, renal function, ICU-acquired weakness, delirium, oxidative stress parameters, and plasma vitamin C concentrations. Discussion: Vitamin C supplementation is safe and preclinical studies have shown beneficial effects of high-dose IV vitamin C in cardiac arrest models. This is the first RCT to assess the clinical effect of intravenous vitamin C on organ dysfunction in critically ill patients after cardiac arrest. Trial registration: ClinicalTrials.gov NCT03509662. Registered on April 26, 2018. https://clinicaltrials.gov/ct2/show/NCT03509662European Clinical Trials Database (EudraCT): 2017-004318-25. Registered on June 8, 2018. https://www.clinicaltrialsregister.eu/ctr-search/trial/2017-004318-25/NL

Published

2021

46. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, and van Royen, Niels

Published

2021

47. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, and van Royen, Niels

Published

2021

48. Does the beta 2 adrenergic receptor influence the wave reflection response to standing?

Author

van den Bogaard, Bas, de Peuter, Olav R., Westerhof, Berend E., Best, Hendrik, Truijen, Jasper, Kamphuisen, Pieter W., and van den Born, Bert-Jan H.

Published

2011

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49. Arterial stiffness is increased in families with premature coronary artery disease

Author

Mulders, Ties A, van den Bogaard, Bas, Bakker, Annemieke, Trip, Mieke D, Stroes, Erik S, van den Born, Bert-Jan H, and Pinto-Sietsma, Sara-Joan

Published

2012

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50. On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study

Author

van den Bogaard, Bas, van den Born, Bert-Jan H., Fayyad, Rana, Waters, David D., DeMicco, David A., LaRosa, John C., Kastelein, John J. P., and Holme, Ingar

Published

2011

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