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653 results on '"van den Heuvel, J."'

5. Low adoption of video consultations in post-COVID-19 general practice in Northern Europe: Barriers to use and potential action points

Author

Assing Hvidt, E., Atherton, H., Keuper, J.J., Kristiansen, E., Lüchau, E.C., Lonnebakke Norberg, B., Steinhauser, J., van den Heuvel, J., van Tuyl, L., Assing Hvidt, E., Atherton, H., Keuper, J.J., Kristiansen, E., Lüchau, E.C., Lonnebakke Norberg, B., Steinhauser, J., van den Heuvel, J., and van Tuyl, L.

Abstract

In the wake of the COVID-19 pandemic, video consultation was introduced in general practice in many countries around the world as a solution to provide remote health care to patients. It was assumed that video consultation would find widespread adoption in post–COVID-19 general practice. However, adoption rates remain low across countries in Northern Europe, suggesting that barriers to its use exist among general practitioners and other practice staff. In this viewpoint, we take a comparative approach, reflecting on similarities and differences in implementation conditions of video consultations in 5 Northern European countries’ general practice settings that might have created barriers to its use within general practice. We convened at a cross-disciplinary seminar in May 2022 with researchers and clinicians from 5 Northern European countries with expertise in digital care in general practice, and this viewpoint emerged out of dialogues from that seminar. We have reflected on barriers across general practice settings in our countries, such as lacking technological and financial support for general practitioners, that we feel are critical for adoption of video consultation in the coming years. Furthermore, there is a need to further investigate the contribution of cultural elements, such as professional norms and values, to adoption. This viewpoint may inform policy work to ensure that a sustainable level of video consultation use can be reached in the future, one that reflects the reality of general practice settings rather than policy optimism.

Published
2023

6. The cytomegalovirus M35 protein directly binds to the interferon-β enhancer and modulates transcription of (Ifnb1) and other IRF3-driven genes

Author

Schwanke, H., Gonçalves Magalhães, V., Schmelz, S., Wyler, E., Hennig, T., Günther, T., Grundhoff, A., Dölken, L., Landthaler, M., van Ham, M., Jänsch, L., Büssow, K., van den Heuvel, J., Blankenfeldt, W., Friedel, C.C., Erhard, F., and Brinkmann, M.M.

Subjects
Cancer Research
Abstract

Induction of type I interferon (IFN) gene expression is among the first lines of cellular defense a virus encounters during primary infection. We previously identified the tegument protein M35 of murine cytomegalovirus (MCMV) as an essential antagonist of this antiviral system, showing that M35 interferes with type I IFN induction downstream of pattern-recognition receptor (PRR) activation. Here, we report structural and mechanistic details of M35's function. Determination of M35's crystal structure combined with reverse genetics revealed that homodimerization is a key feature for M35's immunomodulatory activity. In electrophoretic mobility shift assays (EMSAs), purified M35 protein specifically bound to the regulatory DNA element that governs transcription of the first type I IFN gene induced in nonimmune cells, (Ifnb1). DNA-binding sites of M35 overlapped with the recognition elements of interferon regulatory factor 3 (IRF3), a key transcription factor activated by PRR signaling. Chromatin immunoprecipitation (ChIP) showed reduced binding of IRF3 to the host (Ifnb1) promoter in the presence of M35. We furthermore defined the IRF3-dependent and the type I IFN signaling-responsive genes in murine fibroblasts by RNA sequencing of metabolically labeled transcripts (SLAM-seq) and assessed M35's global effect on gene expression. Stable expression of M35 broadly influenced the transcriptome in untreated cells and specifically downregulated basal expression of IRF3-dependent genes. During MCMV infection, M35 impaired expression of IRF3-responsive genes aside of (Ifnb1). Our results suggest that M35-DNA binding directly antagonizes gene induction mediated by IRF3 and impairs the antiviral response more broadly than formerly recognized. (IMPORTANCE) Replication of the ubiquitous human cytomegalovirus (HCMV) in healthy individuals mostly goes unnoticed but can impair fetal development or cause life-threatening symptoms in immunosuppressed or -deficient patients. Like other herpesviruses, CMV extensively manipulates its hosts and establishes lifelong latent infections. Murine CMV (MCMV) presents an important model system as it allows the study of CMV infection in the host organism. We previously showed that during entry into host cells, MCMV virions release the evolutionary conserved protein M35 protein to immediately dampen the antiviral type I interferon (IFN) response induced by pathogen detection. Here, we show that M35 dimers bind to regulatory DNA elements and interfere with recruitment of interferon regulatory factor 3 (IRF3), a key cellular factor for antiviral gene expression. Thereby, M35 interferes with expression of type I IFNs and other IRF3-dependent genes, reflecting the importance for herpesviruses to avoid IRF3-mediated gene induction.

Published
2023

10. The long-term effects of genomic selection: allele frequency changes and fixation of loci

Author

Wientjes, Y.C.J., Bijma, P., van den Heuvel, J., Zwaan, B.J., Vitezica, Z.G., Calus, M.P.L., Wientjes, Y.C.J., Bijma, P., van den Heuvel, J., Zwaan, B.J., Vitezica, Z.G., and Calus, M.P.L.

Abstract

Allele frequencies change due to drift and selection. We investigated those changes for different selection methods. We simulated a livestock population with 50 generations of selection for an additive trait controlled by 2,000 segregating loci at the start of selection. Our results show that the average absolute change in allele frequency with genomic selection was slightly higher than with pedigree selection, and considerably higher than with mass selection. Genomic and pedigree selection both resulted in fixation of roughly three times more loci than mass selection, and roughly five times more loci became fixed for the unfavourable allele. While this was mainly a result of increased genetic drift, genomic selection also lost additional favourable alleles due to hitchhiking. This suggests that genomic selection can limit long-term genetic gain.

Published
2022

12. A Pharmacy-Based eHealth Intervention Promoting Correct Use of Medication in Patients With Asthma and COPD: Nonrandomized Pre-Post Study

Author

Schnoor, Kyma, primary, Versluis, Anke, additional, Bakema, Robbert, additional, van Luenen, Sanne, additional, Kooij, Marcel J, additional, van den Heuvel, J Maurik, additional, Teichert, Martina, additional, Honkoop, Persijn J, additional, van Boven, Job F M, additional, Chavannes, Niels H, additional, and Aardoom, Jiska J, additional

Published
2022
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17. A Pharmacy-Based eHealth Intervention Promoting Correct Use of Medication in Patients With Asthma and COPD: Nonrandomized Pre-Post Study (Preprint)

Author

Schnoor, Kyma, primary, Versluis, Anke, additional, Bakema, Robbert, additional, van Luenen, Sanne, additional, Kooij, Marcel J, additional, van den Heuvel, J Maurik, additional, Teichert, Martina, additional, Honkoop, Persijn J, additional, van Boven, Job F M, additional, Chavannes, Niels H, additional, and Aardoom, Jiska J, additional

Published
2021
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18. The long-term effects of genomic selection: Response to selection, additive genetic variance and genetic architecture

Author

Bas J. Zwaan, Mario P. L. Calus, Zulma G. Vitezica, Piter Bijma, van den Heuvel J, and Yvonne C. J. Wientjes

Subjects
Minor allele frequency, Fixation (population genetics), Genetic gain, Evolutionary biology, Genetic variation, Epistasis, Biology, Allele frequency, Genetic architecture, Selection (genetic algorithm)
Abstract

Genomic selection has revolutionized genetic improvement in animals and plants, but little is known of its long term effects. Here we investigate the long-term effects of genomic selection on the change in the genetic architecture of traits over generations. We defined the genetic architecture as the subset, allele frequencies and statistical additive effects of causal loci. We simulated a livestock population under 50 generations of phenotypic, pedigree, or genomic selection for a single trait, controlled by either only additive, additive and dominance, or additive, dominance and epistatic effects. The simulated epistasis was based on yeast data. The observed change in genetic architecture over generations was similar for genomic and pedigree selection, and slightly smaller for phenotypic selection. Short-term response was highest with genomic selection, while long-term response was highest with phenotypic selection, especially when non-additive effects were present. This was mainly because the loss in genetic variance and in segregating loci was much greater with genomic selection. Compared to pedigree selection, genomic selection lost a similar amount of the genetic variance but maintained more segregating loci, which on average had lower minor allele frequencies. For all selection methods, the presence of epistasis limited the changes in allele frequency and the fixation of causal loci, and substantially changed the statistical additive effects over generations. Our results show that non-additive effects can have a substantial impact on the change in genetic architecture. Therefore, non-additive effects can substantially impact the accuracy and future genetic gain of genomic selection.

Published
2021
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19. Decision-making in imminent extreme premature births: perceived shared decision-making, parental decisional conflict and decision regret

Author

MS Verloskunde, Child Health, Psychosociale zorg, Circulatory Health, Geurtzen, R., van den Heuvel, J. F.M., Huisman, J. J., Lutke Holzik, E. M., Bekker, M. N., Hogeveen, M., MS Verloskunde, Child Health, Psychosociale zorg, Circulatory Health, Geurtzen, R., van den Heuvel, J. F.M., Huisman, J. J., Lutke Holzik, E. M., Bekker, M. N., and Hogeveen, M.

Published
2021

29. Neuropeptide Y Signaling in the Lateral Hypothalamus Modulates Diet Component Selection and is Dysregulated in a Model of Diet-Induced Obesity

Author

Gumbs, M C R, Eggels, L, Kool, T, Unmehopa, U A, van den Heuvel, J K, Lamuadni, K, Mul, J D, la Fleur, S E, Gumbs, M C R, Eggels, L, Kool, T, Unmehopa, U A, van den Heuvel, J K, Lamuadni, K, Mul, J D, and la Fleur, S E

Abstract

The preclinical multicomponent free-choice high-fat high-sucrose (fcHFHS) diet has strong validity to model diet-induced obesity (DIO) and associated maladaptive molecular changes in the central nervous system. fcHFHS-induced obese rats demonstrate increased sensitivity to intracerebroventricular infusion of the orexigenic Neuropeptide Y (NPY). The brain region-specific effects of NPY signaling on fcHFHS diet component selection are not completely understood. For example, fcHFHS-fed rats have increased intake of chow and fat following intracerebroventricular NPY infusion, whereas NPY administration in the nucleus accumbens, a key hub of the reward circuitry, specifically increases fat intake. Here, we investigated whether NPY infusion in the lateral hypothalamic area (LHA), which is crucially involved in the regulation of intake, regulates fcHFHS component selection, and if LHA NPY receptor subtypes 1 or 5 (NPYR1/5) are involved. Male Wistar rats were fed a chow or fcHFHS diet for at least seven days and received intra-LHA vehicle or NPY infusions in a cross-over design. Diet component intake was measured two hours later. Separate experimental designs were used to test the efficacy of NPY1R- or NPY5R antagonism to prevent the orexigenic effects of intra-LHA NPY. Intra-LHA NPY increased caloric intake in chow- and fcHFHS-fed rats. This effect was mediated specifically by chow intake in fcHFHS-fed rats. The orexigenic effects of intra-LHA NPY were prevented by NPY1R and NPY5R antagonism in chow-fed rats, but only by NPY5R antagonism in fcHFHS-fed rats. Thus, NPY signaling has brain region-specific effects on fcHFHS component selection and LHA NPYR sensitivity is dysregulated during consumption of a fcHFHS diet.

Published
2020

37. Abstracts of presentations on plant protection issues at the xth international congress of virology: August 11–16, 1996 Binyanei haOoma, Jerusalem Iarael part 3(final part)

Author

Liu, Sijun, Bedford, Ian D., Markham, Peter G., Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J. F. J. M., Taiwo, M. A., Dijkstra, J., Martinez, B., López-Moya, J. J., Llave, C., Díaz-Ruíz, J. R., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., López-Moya, J. J., Pirone, T. P., Visser, Peter B., Bol, John F., Hernández, Carmen, Brown, Derek J. F., Pappu, H. R., Culbreath, A. K., Todd, J. W., McPherson, R. M., Sherwood, J. L., Bertrand, P. F., Robbins, M. A., Reade, R. D., Rochon, D. M., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D. -E., Vetten, H. J., Manqussopoulos, I. N., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef J., Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I. B., Qu, Feng, Morris, T. Jack, Steinkellner, H., Puehringer, H., Machado, A. M. Laimer da Câmara, Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J. P., Bó, E. Dal, Torre, M. E. Sánchez de la, Djelouah, K., García, M. L., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y. G., Randles, J. W., Samson, A. C. R., Wilford, J. N., Chapman, S., Santa Cruz, S., Wilson, T. M. A., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B. K., Possee, R. D., French, T. J., Finkelstein, Y., Levi, B. Z., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Qi, Yipeng, Huang, Yongxiu, Lu, Liquan, Du, Quansheng, Watson, S. K., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E. A. van, Vlak, J. M., Heldens, J. G. M., Chejanovsky, N., Gershburg, E., Toister-Achituv, Mira, Faruchi, S., Kamensky, B., Faktor, O., Faktor, O., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Chejanovsky, N., Zilberberg, N., Gershburg, E., Stockholm, D., Rivkin, H., Chejanovsky, N., Gurevitz, M., Zilberberg, N., Gershburg, E., Smith, P., King, L. A., Bamett, A., Windass, J. D., Possee, R. D., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L. A., Jarvis, D. L., Reilly, L., Hoover, K., Schultz, C. M., Hammock, B. D., Gordon, K. H. J., Bawden, A. L., Brooks, E. M., Lincoln, M. R., Hanzlik, T. N., Larkin, P. J., Gordon, K. H. J., Bawden, A. L., van Hulten, M. C. W., Hanzlik, T. N., Hendry, D. A., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Possee, Robert, King, Linda, Phanis, Constantinos, O’Reilly, David R., Clarke, E., Tristem, Michael, Cory, Jennifer, O’Reilly, David R., Mayo, M. A., Duncan, G. H., Reavy, B., Gildow, F. E., Lamb, J. W., Hay, R. T., Li, Shoudong, Qi, Bing, Wang, Jiawang, Qi, Yipeng, O’Reilly, David R., Kang, WonKyung, Crook, Norman E., Winstanley, Doreen, Alaoui-Ismaili, M. H., Richardson, C. D., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D. L., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan Antonio, Wang, S., Miller, W. A., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas M., Hull, Roger, Hohn, Thomas, Hefferon, K. L., AbouHaider, M. G., Hulanicka, D., Juszczuk, M., Iskakov, B. K., Shmanov, M. A., Polimbetova, N. S., Zhanybekova, S. Sh., Lee, A. V., Galiakparov, N. N., Dale, J. L., Beetham, P. R., Hafner, G. J., Harding, R. M., and Dale, J. L.

Published
1998
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49. Multidisciplinaire Richtlijn Probleemgedrag bij volwassenen met een verstandelijke beperking

Author

Embregts, P.J.C.M., Kroezen, M., Mulder, E.J., van Bussel, C., van der Nagel, J., Budding, M., Busser, G., de Kuijper, G., Duinkerken-Van Gelderen, P., Haasnoot, M., Helder, M., Lenderink, B., Maes-Festen, D.A.M., Olivier-Pijpers, V., Oud, M., Oude Luttikhuis, I., Schilt, C.J., Smit, T., van den Heuvel, J., van Wouwe, H., Willems, A., Pasma, A., van den Akker, N., van Houwelingen, I., Wolkorte, R., Wieland, J., Embregts, P.J.C.M., Kroezen, M., Mulder, E.J., van Bussel, C., van der Nagel, J., Budding, M., Busser, G., de Kuijper, G., Duinkerken-Van Gelderen, P., Haasnoot, M., Helder, M., Lenderink, B., Maes-Festen, D.A.M., Olivier-Pijpers, V., Oud, M., Oude Luttikhuis, I., Schilt, C.J., Smit, T., van den Heuvel, J., van Wouwe, H., Willems, A., Pasma, A., van den Akker, N., van Houwelingen, I., Wolkorte, R., and Wieland, J.

Abstract

Probleemgedrag komt regelmatig voor bij mensen met een verstandelijke beperking (VB). Het kan een grote impact hebben op de persoon zelf, diens familie en op anderen in de omgeving. Zo kan probleemgedrag leiden tot een verminderde kwaliteit van leven en (mogelijk vermijdbaar) hoog zorggebruik. De richtlijn ‘Probleemgedrag bij volwassenen met een verstandelijke beperking’ is ontwikkeld om de kwaliteit van leven bij volwassenen met een VB en probleemgedrag te verbeteren en last en lijden bij deze groep én naastbetrokkenen te verminderen. Belangrijke bijkomende doelen zijn het beter signaleren, vaststellen en behandelen van psychiatrische stoornissen, het verbeteren van de inzet van niet-medicamenteuze behandelingen en de effectieve inzet van psychofarmaca.

Published
2019

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