156 results on '"van der Graaf, P H"'
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2. Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases
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3. QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool
4. Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
5. Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics
6. Application of Quantitative Systems Pharmacology to guide the optimal dosing of COVID-19 vaccines
7. Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model
8. Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling
9. Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations
10. A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis
11. A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
12. Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1
13. Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling
14. Correction to: Mathematical Modelling of Alternative Pathway of Complement System
15. Design principles of collateral sensitivity-based dosing strategies
16. FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective
17. Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models
18. Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
19. How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review
20. Mathematical Modelling of Alternative Pathway of Complement System
21. Optimization of Cancer Treatment in the Frequency Domain
22. Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
23. A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
24. A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds
25. A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback
26. Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends
27. Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae
28. Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy
29. Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling
30. Topics in Mathematical Pharmacology
31. Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid
32. The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation
33. Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats
34. Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans
35. Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling
36. A mathematical analysis of rebound in a target-mediated drug disposition model: I.Without feedback
37. Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
38. Inter-study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta-analysis
39. PL Translational pharmacokinetics/pharmacodynamics (PKPD) and systems pharmacology in drug discovery and development: 22.1.
40. Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
41. Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans
42. A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat
43. Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
44. Allometric Scaling of Pharmacodynamic Responses: Application to 5-Ht1A Receptor Mediated Responses from Rat to Man
45. Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development
46. Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?
47. Pharmacokinetic-Pharmacodynamic Analysis of the EEG Effect of Alfentanil in Rats Followingβ-Funaltrexamine-Induced μOpioid Receptor “Knockdown”In Vivo
48. UK–414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve–stimulated increases in female genital blood flow in the anaesthetized rabbit
49. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for α1-adrenoceptor-mediated pressor activity
50. A Deconvolution Informed Pharmacodynamic Model For The Quantification Of Drug Effects On Highly Pulsatile Endogenous Profiles
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