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2. High prevalence of heavy menstrual bleeding in women with rare bleeding disorders in the Netherlands: retrospective data from the RBiN study

Author

Maas, D.P.M.S.M., Saes, J.L., Meijer, K., Cnossen, M.H., Schutgens, R.E.G., Peters, M., Nieuwenhuizen, L., den Exter, P.L., Kruis, I.C., van Heerde, W.L., Schols, S.E.M., Maas, Dominique P.M.S.M., Saes, Joline L., Blijlevens, Nicole M.A., Cnossen, Marjon H., den Exter, Paul L., van der Heijden, Olivier W.H., Kruis, Ilmar C., Meijer, Karina, Peters, Marjolein, Schutgens, Roger E.G., van Heerde, Waander L., Nieuwenhuizen, Laurens, and Schols, Saskia E.M.

Published
2023
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3. High prevalence of postpartum hemorrhage in women with rare bleeding disorders in the Netherlands: retrospective data from the RBiN study

Author

Maas, D.P.M.S.M., Saes, J.L., Meijer, K., Cnossen, M.H., Schutgens, R.E.G., Peters, M., Nieuwenhuizen, L., Exter, P.L. den, Kruis, I.C., van Heerde, W.L., Schols, S.E.M., Maas, Dominique P.M.S.M., Saes, Joline L., Blijlevens, Nicole M.A., Cnossen, Marjon H., den Exter, Paul L., van der Heijden, Olivier W.H., Kruis, Ilmar C., Meijer, Karina, Peters, Marjolein, Schutgens, Roger E.G., van Heerde, Waander L., Nieuwenhuizen, Laurens, and Schols, Saskia E.M.

Published
2023
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8. Inter- and intraobserver agreement of antenatal cardiotocography assessments by maternity care professionals:A prospective study

Author

Neppelenbroek, Elise M., van der Heijden, Olivier W.H., de Vet, Henrica C.W., de Groot, Amanda J.J., Daemers, Darie O.A., de Jonge, Ank, Verhoeven, Corine J.M., Neppelenbroek, Elise M., van der Heijden, Olivier W.H., de Vet, Henrica C.W., de Groot, Amanda J.J., Daemers, Darie O.A., de Jonge, Ank, and Verhoeven, Corine J.M.

Abstract

Objective: In the Netherlands, antenatal cardiotocography (aCTG) to assess fetal well-being is performed in obstetrician-led care. An innovative initiative was started to evaluate whether aCTG for specific indications—reduced fetal movements, external cephalic version, or postdate pregnancy—is feasible in non-obstetrician-led care settings by independent primary care midwives. Quality assessment is essential when reorganizing and shifting tasks and responsibilities. Therefore, we aimed to assess the inter- and intraobserver agreement for aCTG assessments between and within four professional groups involved in Dutch maternity care regarding the overall classification and assessment of the various components of aCTG. Method: This was a prospective study among 47 Dutch primary care midwives, hospital-based midwives, residents, and obstetricians. Ten aCTG traces were assessed twice at a 1 month interval. To ensure a representative sample, we used two different sets of 10 aCTG traces each. We calculated the degree of agreement using the proportions of agreement. Results: The proportions of agreement for interobserver agreement on the classification of aCTG between and within the four professional groups varied from 0.82 to 0.94. The proportions of agreement for each professional group were slightly higher for intraobserver (0.86–0.94) than for interobserver agreement. For the various aCTG components, the proportions of agreement for interobserver agreement varied from 0.64 (presence of contractions) to 0.98 (baseline heart frequency). Conclusion: The proportion of agreement levels between and within the maternity care professionals in the classification of aCTG traces among healthy women were comparable. This means that these professional groups are equally well able to classify aCTGs in healthy pregnant women.

Published
2024

10. High prevalence of heavy menstrual bleeding in women with rare bleeding disorders in the Netherlands:retrospective data from the RBiN study

Author

Maas, D. P.M.S.M., Saes, J. L., Blijlevens, Nicole M.A., Cnossen, Marjon H., den Exter, P. L., van der Heijden, Olivier W.H., Kruis, I. C., Meijer, K., Peters, M., Schutgens, R. E.G., van Heerde, W. L., Nieuwenhuizen, L., Schols, S. E.M., Maas, D. P.M.S.M., Saes, J. L., Blijlevens, Nicole M.A., Cnossen, Marjon H., den Exter, P. L., van der Heijden, Olivier W.H., Kruis, I. C., Meijer, K., Peters, M., Schutgens, R. E.G., van Heerde, W. L., Nieuwenhuizen, L., and Schols, S. E.M.

Abstract

Background: Heavy menstrual bleeding (HMB) is associated with a reduced quality of life and limitations in social and physical functioning. Data on HMB in women with rare bleeding disorders (RBDs), including coagulation factor deficiencies and fibrinolytic disorders, are scarce. Objectives: To analyze the prevalence, severity, and treatment of HMB in Dutch women with an RBD. Methods:The Rare Bleeding Disorders in the Netherlands (RBiN) study included 263 patients with an RBD from all 6 hemophilia treatment centers (October 2017-November 2019). In this analysis, data of 111 women aged ≥16 years were studied. According to the International Society on Thrombosis and Haemostasis bleeding assessment tool, HMB symptoms were scored from 0 (no/trivial) to 4 (severe symptoms requiring medical intervention). HMB was defined as a score ≥1. Age at RBD diagnosis was extracted from patient files. Results: HMB was reported by 80% of women (89/111) and was more prevalent in women with a fibrinolytic disorder (33/35; 94%) than in women with a coagulation factor deficiency (56/76; 74%) (P = .011). Of the 89 women with HMB, 82% (n = 73) ever required treatment. Multiple treatment modalities were frequently used, both in severe and mild deficiencies. Hormonal treatment was mostly used (n = 64; 88%), while antifibrinolytics were prescribed less frequently (n = 18; 25%). In women with HMB since menarche (n = 61; 69%), median age at RBD diagnosis was 28 years (IQR, 14-41).Conclusion: HMB is common in women with RBDs. Women with mild deficiencies also frequently reported HMB. Only a minority of women were treated with hemostatic agents. A significant diagnostic delay was observed after the onset of HMB symptoms.

Published
2023

16. SUGAR-DIP trial: oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial

Author

de Wit, Leon, Rademaker, Doortje, Voormolen, Daphne N., Akerboom, Bettina M.C., Kiewiet-Kemper, Rosalie M., Soeters, Maarten R., Verwij-Didden, Marion A.L., Assouiki, Fahima, Schippers, Daniela H., Vermeulen, Mechteld A.R., Kuppens, Simone M.I., Oosterwerff, Mirjam M., Zwart, Joost J., Diekman, Mattheus J.M., Vogelvang, Tatjana E., Gallas, P. Rob J., Galjaard, Sander, Visser, Willy, Horree, Nicole, Klooker, Tamira K., Laan, Rosemarie, Heijligenberg, Rik, Huisjes, Anjoke J.M., van Bemmel, Thomas, van Meir, Claudia A., van den Beld, Annewieke W., Hermes, Wietske, Vidarsdottir, Solrun, Veldhuis-Vlug, Anneke G., Dullemond, Remke C., Jansen, Henrique J., Sueters, Marieke, de Koning, Eelco J.P., van Laar, Judith O.E.H., Wouters-van Poppel, Pleun, Sanson-van Praag, Marina E., van den Akker, Eline S., Brouwer, Catherine B., Hermsen, Brenda B., Potter van Loon, Bert Jan, van der Heijden, Olivier W.H., de Galan, Bastiaan E., van Leeuwen, Marsha, Wijbenga, Johanna A.M., de Boer, Karin, van Bon, Arianne C., van der Made, Flip W., Eskes, Silvia A., Zandstra, Mirjam, van Houtum, William H., Braams-Lisman, Babette A.M., Daemen-Gubbels, Catharina R.G.M., Wouters, Maurice G.A.J., Ijzerman, Richard G., Mensing van Charante, Nico A., Zwertbroek, Rolf, Bosmans, Judith E., Evers, Inge M., Mol, Ben Willem, de Valk, Harold W., Groenendaal, Floris, Naaktgeboren, Christiana A., Painter, Rebecca C., de Vries, J. Hans, Franx, Arie, van Rijn, Bas B., de Wit, Leon, Rademaker, Doortje, Voormolen, Daphne N., Akerboom, Bettina M.C., Kiewiet-Kemper, Rosalie M., Soeters, Maarten R., Verwij-Didden, Marion A.L., Assouiki, Fahima, Schippers, Daniela H., Vermeulen, Mechteld A.R., Kuppens, Simone M.I., Oosterwerff, Mirjam M., Zwart, Joost J., Diekman, Mattheus J.M., Vogelvang, Tatjana E., Gallas, P. Rob J., Galjaard, Sander, Visser, Willy, Horree, Nicole, Klooker, Tamira K., Laan, Rosemarie, Heijligenberg, Rik, Huisjes, Anjoke J.M., van Bemmel, Thomas, van Meir, Claudia A., van den Beld, Annewieke W., Hermes, Wietske, Vidarsdottir, Solrun, Veldhuis-Vlug, Anneke G., Dullemond, Remke C., Jansen, Henrique J., Sueters, Marieke, de Koning, Eelco J.P., van Laar, Judith O.E.H., Wouters-van Poppel, Pleun, Sanson-van Praag, Marina E., van den Akker, Eline S., Brouwer, Catherine B., Hermsen, Brenda B., Potter van Loon, Bert Jan, van der Heijden, Olivier W.H., de Galan, Bastiaan E., van Leeuwen, Marsha, Wijbenga, Johanna A.M., de Boer, Karin, van Bon, Arianne C., van der Made, Flip W., Eskes, Silvia A., Zandstra, Mirjam, van Houtum, William H., Braams-Lisman, Babette A.M., Daemen-Gubbels, Catharina R.G.M., Wouters, Maurice G.A.J., Ijzerman, Richard G., Mensing van Charante, Nico A., Zwertbroek, Rolf, Bosmans, Judith E., Evers, Inge M., Mol, Ben Willem, de Valk, Harold W., Groenendaal, Floris, Naaktgeboren, Christiana A., Painter, Rebecca C., de Vries, J. Hans, Franx, Arie, and van Rijn, Bas B.

Abstract

Introduction In women with gestational diabetes mellitus (GDM) requiring pharmacotherapy, insulin was the established first-line treatment. More recently, oral glucose lowering drugs (OGLDs) have gained popularity as a patient-friendly, less expensive and safe alternative. Monotherapy with metformin or glibenclamide (glyburide) is incorporated in several international guidelines. In women who do not reach sufficient glucose control with OGLD monotherapy, usually insulin is added, either with or without continuation of OGLDs. No reliable data from clinical trials, however, are available on the effectiveness of a treatment strategy using all three agents, metformin, glibenclamide and insulin, in a stepwise approach, compared with insulin-only therapy for improving pregnancy outcomes. In this trial, we aim to assess the clinical effectiveness, cost-effectiveness and patient experience of a stepwise combined OGLD treatment protocol, compared with conventional insulin-based therapy for GDM. Methods The SUGAR-DIP trial is an open-label, multicentre randomised controlled non-inferiority trial. Participants are women with GDM who do not reach target glycaemic control with modification of diet, between 16 and 34 weeks of gestation. Participants will be randomised to either treatment with OGLDs, starting with metformin and supplemented as needed with glibenclamide, or randomised to treatment with insulin. In women who do not reach target glycaemic control with combined metformin and glibenclamide, glibenclamide will be substituted with insulin, while continuing metformin. The primary outcome will be the incidence of large-for-gestational-age infants (birth weight >90th percentile). Secondary outcome measures are maternal diabetes-related endpoints, obstetric complications, neonatal complications and cost-effectiveness analysis. Outcomes will be analysed according to the intention-to-treat principle. Ethics and dissemination The study protocol was approved by the Ethics

Published
2019

17. SUGAR-DIP trial:Oral medication strategy versus insulin for diabetes in pregnancy, study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial

Author

De Wit, Leon, Rademaker, Doortje, Voormolen, Daphne N., Akerboom, Bettina M.C., Kiewiet-Kemper, Rosalie M., Soeters, Maarten R., Verwij-Didden, Marion A.L., Assouiki, Fahima, Schippers, Daniela H., Vermeulen, Mechteld A.R., Kuppens, Simone M.I., Oosterwerff, Mirjam M., Zwart, Joost J., Diekman, Mattheus J.M., Vogelvang, Tatjana E., Gallas, P. Rob J., Galjaard, Sander, Visser, Willy, Horree, Nicole, Klooker, Tamira K., Laan, Rosemarie, Heijligenberg, Rik, Huisjes, Anjoke J.M., Van Bemmel, Thomas, Van Meir, Claudia A., Van Den Beld, Annewieke W., Hermes, Wietske, Vidarsdottir, Solrun, Veldhuis-Vlug, Anneke G., Dullemond, Remke C., Jansen, Henrique J., Sueters, Marieke, De Koning, Eelco J.P., Van Laar, Judith O.E.H., Wouters-Van Poppel, Pleun, Sanson-Van Praag, Marina E., Van Den Akker, Eline S., Brouwer, Catherine B., Hermsen, Brenda B., Potter Van Loon, Bert Jan, Van Der Heijden, Olivier W.H., De Galan, Bastiaan E., Van Leeuwen, Marsha, Wijbenga, Johanna A.M., De Boer, Karin, Van Bon, Arianne C., Van Der Made, Flip W., Eskes, Silvia A., Zandstra, Mirjam, Van Houtum, William H., Braams-Lisman, Babette A.M., Daemen-Gubbels, Catharina R.G.M., Wouters, Maurice G.A.J., Ijzerman, Richard G., Mensing Van Charante, Nico A., Zwertbroek, Rolf, Bosmans, Judith E., Evers, Inge M., Mol, Ben Willem, De Valk, Harold W., Groenendaal, Floris, Naaktgeboren, Christiana A., Painter, Rebecca C., Devries, J. Hans, Franx, Arie, Van Rijn, Bas B., De Wit, Leon, Rademaker, Doortje, Voormolen, Daphne N., Akerboom, Bettina M.C., Kiewiet-Kemper, Rosalie M., Soeters, Maarten R., Verwij-Didden, Marion A.L., Assouiki, Fahima, Schippers, Daniela H., Vermeulen, Mechteld A.R., Kuppens, Simone M.I., Oosterwerff, Mirjam M., Zwart, Joost J., Diekman, Mattheus J.M., Vogelvang, Tatjana E., Gallas, P. Rob J., Galjaard, Sander, Visser, Willy, Horree, Nicole, Klooker, Tamira K., Laan, Rosemarie, Heijligenberg, Rik, Huisjes, Anjoke J.M., Van Bemmel, Thomas, Van Meir, Claudia A., Van Den Beld, Annewieke W., Hermes, Wietske, Vidarsdottir, Solrun, Veldhuis-Vlug, Anneke G., Dullemond, Remke C., Jansen, Henrique J., Sueters, Marieke, De Koning, Eelco J.P., Van Laar, Judith O.E.H., Wouters-Van Poppel, Pleun, Sanson-Van Praag, Marina E., Van Den Akker, Eline S., Brouwer, Catherine B., Hermsen, Brenda B., Potter Van Loon, Bert Jan, Van Der Heijden, Olivier W.H., De Galan, Bastiaan E., Van Leeuwen, Marsha, Wijbenga, Johanna A.M., De Boer, Karin, Van Bon, Arianne C., Van Der Made, Flip W., Eskes, Silvia A., Zandstra, Mirjam, Van Houtum, William H., Braams-Lisman, Babette A.M., Daemen-Gubbels, Catharina R.G.M., Wouters, Maurice G.A.J., Ijzerman, Richard G., Mensing Van Charante, Nico A., Zwertbroek, Rolf, Bosmans, Judith E., Evers, Inge M., Mol, Ben Willem, De Valk, Harold W., Groenendaal, Floris, Naaktgeboren, Christiana A., Painter, Rebecca C., Devries, J. Hans, Franx, Arie, and Van Rijn, Bas B.

Abstract

Introduction In women with gestational diabetes mellitus (GDM) requiring pharmacotherapy, insulin was the established first-line treatment. More recently, oral glucose lowering drugs (OGLDs) have gained popularity as a patient-friendly, less expensive and safe alternative. Monotherapy with metformin or glibenclamide (glyburide) is incorporated in several international guidelines. In women who do not reach sufficient glucose control with OGLD monotherapy, usually insulin is added, either with or without continuation of OGLDs. No reliable data from clinical trials, however, are available on the effectiveness of a treatment strategy using all three agents, metformin, glibenclamide and insulin, in a stepwise approach, compared with insulin-only therapy for improving pregnancy outcomes. In this trial, we aim to assess the clinical effectiveness, cost-effectiveness and patient experience of a stepwise combined OGLD treatment protocol, compared with conventional insulin-based therapy for GDM. Methods The SUGAR-DIP trial is an open-label, multicentre randomised controlled non-inferiority trial. Participants are women with GDM who do not reach target glycaemic control with modification of diet, between 16 and 34 weeks of gestation. Participants will be randomised to either treatment with OGLDs, starting with metformin and supplemented as needed with glibenclamide, or randomised to treatment with insulin. In women who do not reach target glycaemic control with combined metformin and glibenclamide, glibenclamide will be substituted with insulin, while continuing metformin. The primary outcome will be the incidence of large-for-gestational-age infants (birth weight >90th percentile). Secondary outcome measures are maternal diabetes-related endpoints, obstetric complications, neonatal complications and cost-effectiveness analysis. Outcomes will be analysed according to the intention-to-treat principle. Ethics and dissemination The study protocol was approved by the Ethics

Published
2019

18. Lymphoid Aggregates of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Uterus from Pre-Pregnancy to Delivery

Author

Benner, Marilen, primary, Feyaerts, Dorien, additional, García, Celia Cartagena, additional, İnci, Nurcan, additional, López, Sergi Cedó, additional, Fasse, Esther, additional, Shadmanfar, Wijs, additional, van der Heijden, Olivier W.H., additional, Ferwerda, Gerben, additional, Joosten, Irma, additional, and van der Molen, Renate G., additional

Published
2019
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19. Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): A multicentre randomized controlled trial

Author

MS Verloskunde, Other research (not in main researchprogram), MS Interne Geneeskunde, Circulatory Health, Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Brain, Child Health, Voormolen, Daphne N., DeVries, J. Hans, Sanson, Rieneke M.E., Heringa, Martijn P., de Valk, Harold W., Kok, Marjolein, van Loon, Aren J., Hoogenberg, Klaas, Bekedam, Dick J., Brouwer, Teri C.B., Porath, Martina, Erdtsieck, Ronald J., NijBijvank, Bas, Kip, Huib, van der Heijden, Olivier W.H., Elving, Lammy D., Hermsen, Brenda B., Potter van Loon, B. J., Rijnders, Robert J.P., Jansen, Henry J., Langenveld, Josje, Akerboom, Bettina M.C., Kiewiet, Rosalie M., Naaktgeboren, Christiana A., Mol, Ben W.J., Franx, Arie, Evers, Inge M., MS Verloskunde, Other research (not in main researchprogram), MS Interne Geneeskunde, Circulatory Health, Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Brain, Child Health, Voormolen, Daphne N., DeVries, J. Hans, Sanson, Rieneke M.E., Heringa, Martijn P., de Valk, Harold W., Kok, Marjolein, van Loon, Aren J., Hoogenberg, Klaas, Bekedam, Dick J., Brouwer, Teri C.B., Porath, Martina, Erdtsieck, Ronald J., NijBijvank, Bas, Kip, Huib, van der Heijden, Olivier W.H., Elving, Lammy D., Hermsen, Brenda B., Potter van Loon, B. J., Rijnders, Robert J.P., Jansen, Henry J., Langenveld, Josje, Akerboom, Bettina M.C., Kiewiet, Rosalie M., Naaktgeboren, Christiana A., Mol, Ben W.J., Franx, Arie, and Evers, Inge M.

Published
2018

20. Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition

Author

Pieterse, Elmar, primary, Rother, Nils, additional, Garsen, Marjolein, additional, Hofstra, Julia M., additional, Satchell, Simon C., additional, Hoffmann, Markus, additional, Loeven, Markus A., additional, Knaapen, Hanneke K., additional, van der Heijden, Olivier W.H., additional, Berden, Jo H.M., additional, Hilbrands, Luuk B., additional, and van der Vlag, Johan, additional

Published
2017
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23. Immunosuppressive drugs influence uterine immune cells in vitro

Author

Schutten, Joselin H.F., primary, van Cranenbroek, Bram, additional, van Hamersvelt, Henk W., additional, Scholten, Ralph R., additional, van der Heijden, Olivier W.H., additional, Spaanderman, Marc E.A., additional, Hilbrands, Luuk B., additional, Joosten, Irma, additional, and van der Molen, Renate, additional

Published
2014
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26. Aging blunts remodeling of the uterine artery during murine pregnancy

Author

van der Heijden, Olivier W.H., Essers, Yvonne P.G., Simkens, Lieke H.J., Teunissen, Quirine G.A., Peeters, Louis L.H., De Mey, Jo G.R., and van Eys, Guillaume J.J.M.

Subjects
*AGING, *PREGNANCY, *DEVELOPMENTAL biology, *MICE
Abstract

: ObjectiveThe progressive increase in uterine blood flow (UBF) during pregnancy is accommodated by morphologic changes in the uterine artery (UA) in a process defined as arterial remodeling. This process is accompanied by changes in cytoskeletal architecture of the arterial smooth muscle cells (SMCs) and surrounding extracellular matrix (ECM). Aging reduces flow-induced arterial remodeling. We studied changes in the murine UA during pregnancy and on the effects of aging on the capacity of the UA to remodel in response to pregnancy.: MethodsWe determined morphologic and cytologic changes in UA from nonpregnant and pregnant mice aged 12 weeks (young) and 40 weeks (old) and correlated them with their reproductive performance.: ResultsIn young mice, pregnancy induced an early increase in UA wall mass, which preceded lumen widening. These changes were not accompanied by altered densities of elastin and collagen in the ECM of the medial layer. Smooth muscle cell proliferation increased in midpregnancy and was paralleled by a transient decrease in smoothelin and smooth muscle α-actin expression. In old mice, these pregnancy-dependent changes in the UA wall were either absent or markedly reduced. Although by day 11 of pregnancy litter size did not differ between both age groups, the number of viable pups in old mice by day 17 of pregnancy and at birth was 25% and 60% less than in young mice.: ConclusionOutward hypertrophic remodeling of the UA during pregnancy in young mice is characterized by transient phenotypic modulation and proliferation of SMCs and alterations in the composition of the ECM. In contrast, in older mice, UA remodeling is markedly reduced and accompanied with a loss of viable fetuses near term pregnancy. [Copyright &y& Elsevier]

Published
2004
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