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2. The EORTC 22922/10925 trial investigating regional nodal irradiation in stage I-III breast cancer: Outcomes according to locoregional and systemic therapies

Author

Kaidar-Person, Orit, Boersma, Liesbeth J., De Brouwer, Peter, Weltens, Caroline, Kirkove, Carine, Peignaux-Casasnovas, Karine, Budach, Volker, van der Leij, Femke, Peters, Max, Weidner, Nicola, Rivera, Sofia, van Tienhoven, Geertjan, Fourquet, Alain, Noel, Georges, Valli, Mariacarla, Guckenberger, Matthias, Koiter, Eveline, Racadot, Severine, Abdah-Bortnyak, Roxolyana, Bartelink, Harry, Struikmans, Henk, Fortpied, Catherine, and Poortmans, Philip M.

Published
2024
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4. Preoperative Magnetic Resonance Guided Single-Dose Partial Breast Irradiation: 5-Year Results of the Prospective Single-Arm ABLATIVE Trial

Author

Civil, Yasmin A., Vasmel, Jeanine E., Charaghvandi, Ramona K., Houweling, Anette C., Vreuls, Celien P.H., van Diest, Paul J., Witkamp, Arjen J., Doeksen, Annemiek, van Dalen, Thijs, Felderhof, Joeke, van Dam, Iris, Slotman, Ben J., Kirby, Anna M., Verkooijen, Helena M., van der Velde, Susanne, van der Leij, Femke, and van den Bongard, H.J.G. Desirée

Published
2024
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6. Physical and mental health of breast cancer patients and survivors before and during successive SARS-CoV-2-infection waves

Author

Bargon, Claudia A., Mink van der Molen, Dieuwke R., Batenburg, Marilot C. T., van Stam, Lilianne E., van Dam, Iris E., Baas, Inge O., Veenendaal, Liesbeth M., Maarse, Wiesje, Sier, Maartje, Schoenmaeckers, Ernst J. P., Burgmans, Josephina P. J., Bijlsma, Rhodé M., van der Leij, Femke, Doeksen, Annemiek, Young-Afat, Danny A., and Verkooijen, Helena M.

Published
2023
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7. Mapping the location of local and regional recurrences according to breast cancer surgery and radiation therapy: Results from EORTC 22922/10925

Author

Kaidar-Person, Orit, Giasafaki, Peggy, Boersma, Liesbeth, De Brouwer, Peter, Weltens, Caroline, Kirkove, Carine, Peignaux-Casasnovas, Karine, Budach, Volker, van der Leij, Femke, Vonk, Ernest, Weidner, Nicola, Rivera, Sofia, van Tienhoven, Geertjan, Fourquet, Alain, Noel, Georges, Valli, Mariacarla, Guckenberger, Matthias, Koiter, Eveline, Racadot, Severine, Abdah-Bortnyak, Roxolyana, Bartelink, Harry, Struikmans, Henk, Fortpied, Catherine, and Poortmans, Philip M.

Published
2023
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11. The impact of the COVID-19 pandemic on perceived access to health care and preferences for health care provision in individuals (being) treated for breast cancer

Author

Mink van der Molen, Dieuwke R., Bargon, Claudia A., Batenburg, Marilot C. T., van Stam, Lilianne E., van Dam, Iris E., Baas, Inge O., Ernst, Miranda F., Maarse, Wiesje, Sier, Maartje, Schoenmaeckers, Ernst J. P., van Dalen, Thijs, Bijlsma, Rhodé M., Doeksen, Annemiek, van der Leij, Femke, Young-Afat, Danny A., and Verkooijen, Helena M.

Published
2022
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15. Adaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging

Author

Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Van Vliet-van den Ende, Katelijne M., Hoogendoorn-Mulder, Paulien G., Schokker, Rogier I., Moerland, Marinus A., Kroon, Petra S., Roesink, Judith M., Fajardo, Raquel Dávila, Van der Leij, Femke, Jürgenliemk-Schulz, Ina M., Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Van Vliet-van den Ende, Katelijne M., Hoogendoorn-Mulder, Paulien G., Schokker, Rogier I., Moerland, Marinus A., Kroon, Petra S., Roesink, Judith M., Fajardo, Raquel Dávila, Van der Leij, Femke, and Jürgenliemk-Schulz, Ina M.

Published
2024

16. Competing risk analysis of cardiovascular disease risk in breast cancer patients receiving a radiation boost

Author

Circulatory Health, Cancer, Cardiometabolic Health, Trialbureau Beeld, MS Radiotherapie, Koop, Yvonne, Atsma, Femke, Batenburg, Marilot C T, Meijer, Hanneke, van der Leij, Femke, Gal, Roxanne, van Velzen, Sanne G M, Išgum, Ivana, Vermeulen, Hester, Maas, Angela H E M, Messaoudi, Saloua El, Verkooijen, Helena M, Circulatory Health, Cancer, Cardiometabolic Health, Trialbureau Beeld, MS Radiotherapie, Koop, Yvonne, Atsma, Femke, Batenburg, Marilot C T, Meijer, Hanneke, van der Leij, Femke, Gal, Roxanne, van Velzen, Sanne G M, Išgum, Ivana, Vermeulen, Hester, Maas, Angela H E M, Messaoudi, Saloua El, and Verkooijen, Helena M

Published
2024

17. Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial

Author

Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, Verkooijen, Helena M, Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), CTM & Statistical consultation, MS Radiotherapie, Mink van der Molen, Dieuwke R, Batenburg, Marilot C T, Maarse, Wiesje, van den Bongard, Desiree H J G, Doeksen, Annemiek, de Lange, Marjoleine Y, van der Pol, Carmen C, Evers, Daniel J, Lansdorp, Corine A, van der Laan, Jacco, van de Ven, Peter M, van der Leij, Femke, and Verkooijen, Helena M

Published
2024

18. Internal mammary and medial supraclavicular lymph node chain irradiation in stage I–III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial

Author

Poortmans, Philip M, Weltens, Caroline, Fortpied, Catherine, Kirkove, Carine, Peignaux-Casasnovas, Karine, Budach, Volker, van der Leij, Femke, Vonk, Ernest, Weidner, Nicola, Rivera, Sofia, van Tienhoven, Geertjan, Fourquet, Alain, Noel, Georges, Valli, Mariacarla, Guckenberger, Matthias, Koiter, Eveline, Racadot, Severine, Abdah-Bortnyak, Roxolyana, Van Limbergen, Erik F, Engelen, Antoine, De Brouwer, Peter, Struikmans, Henk, and Bartelink, Harry

Published
2020
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25. The association of internal mammary and medial supraclavicular lymph node radiation technique with clinical outcomes

Author

Kaidar-Person, Orit, Fortpied, Catherine, Hol, Sandra, Weltens, Caroline, Kirkove, Carine, Budach, Volker, Peignaux-Casasnovas, Karine, van der Leij, Femke, Vonk, Ernest, Valli, Mariacarla, Weidner, Nicola, Guckenberger, Matthias, Koiter, Eveline, Fourquet, Alain, Bartelink, Harry, Struikmans, Henk, Poortmans, Philip, EORTC Radiation Oncology and Breast Cancer Groups, EORTC Radiation Oncology and Breast Cancer Groups, Radiotherapie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, UCL - (SLuc) Service de radiothérapie oncologique, University of Zurich, and Kaidar-Person, Orit

Subjects
QUALITY-ASSURANCE, 2720 Hematology, 610 Medicine & health, Breast Neoplasms, HEART-DISEASE, BREAST-CANCER RADIOTHERAPY, THERAPY, Disease-Free Survival, Breast cancer, MASTECTOMY, 2741 Radiology, Nuclear Medicine and Imaging, Humans, Radiology, Nuclear Medicine and imaging, Breast, Thoracic Wall, RECURRENCE, Lymph nodes, Computer. Automation, RISK, Radiotherapy, MORTALITY, WOMEN, Hematology, 10044 Clinic for Radiation Oncology, Quality assurance, Techniques, EORTC, Oncology, 2730 Oncology, Female, CHAIN IRRADIATION, Lymph Nodes, Human medicine
Abstract

BACKGROUND AND PURPOSE: The multicentre EORTC 22922/10925 trial (ClinicalTrials.gov, NCT00002851) was conducted between 1996 and 2004. The trial evaluated the effect of irradiation of the internal mammary and medial supraclavicular lymph node chains (IM-MS) vs no further radiation therapy (RT) on survival and cause of death in breast cancer stage I-III patients. At 15.7 years of median follow-up, a significant reduction of breast cancer specific mortality (BCSM) and any recurrence, not translating in improved overall survival (OS), and low absolute rates of side effects were found. The aim of the current analysis was to evaluate the association of RT techniques of IM-MS lymph node irradiation with long-term outcomes.PATIENTS AND METHODS: Three RT techniques were used for IM-MS: a standard technique using a fixed set-up combining photon/electron beams to the IM and tangential fields to the breast or chest wall vs a standard-modified technique with minor adaptation for beam settings vs a more individualised technique based on individual localisation of the IM. Techniques used were fixed per institution over the duration of the trial. We performed an exploratory and descriptive analysis of the outcomes after 15 years follow-up for the three RT techniques.RESULTS: Between July 1996 and January 2004, 46 radiation oncology departments from 13 countries accrued 4004 patients. Median follow-up was 15.7 years. The number of patients treated by each technique was 2440 (61%) by standard vs 635 (16%) by standard-modified vs 929 (23%) patients by individualised technique. The absolute improvements of oncological outcomes in terms of disease-free survival (DFS), OS and BCSM with IM-MS RT compared to no IM-MS RT were 6.8%, 4.9% and -5.8% for the individualised technique, vs 1.6%, 2.9% and -4.3% for modified standard and -1.4%, 1.1% and -3% for standard technique, respectively. The increase in 15-year rates of side effects due to IM-MS RT, both scored longitudinally and cross-sectionally, were similar among the techniques.CONCLUSION: Even though a straightforward comparison by technique is not possible because of variations in baseline characteristics between institutions, our findings suggest that the use of more individualised RT techniques is associated with higher rates of oncological improvements without increased risks for late side effects.

Published
2022

26. Physical and mental health of breast cancer patients and survivors before and during successive SARS-CoV-2-infection waves

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Bargon, Claudia A., Mink van der Molen, Dieuwke R., Batenburg, Marilot C.T., van Stam, Lilianne E., van Dam, Iris E., Baas, Inge O., Veenendaal, Liesbeth M., Maarse, Wiesje, Sier, Maartje, Schoenmaeckers, Ernst J.P., Burgmans, Josephina P.J., Bijlsma, Rhodé M., van der Leij, Femke, Doeksen, Annemiek, Young-Afat, Danny A., Verkooijen, Helena M., Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Bargon, Claudia A., Mink van der Molen, Dieuwke R., Batenburg, Marilot C.T., van Stam, Lilianne E., van Dam, Iris E., Baas, Inge O., Veenendaal, Liesbeth M., Maarse, Wiesje, Sier, Maartje, Schoenmaeckers, Ernst J.P., Burgmans, Josephina P.J., Bijlsma, Rhodé M., van der Leij, Femke, Doeksen, Annemiek, Young-Afat, Danny A., and Verkooijen, Helena M.

Published
2023

27. Late gevolgen van radiotherapie na borstkanker

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, Batenburg, Marilot, Accord-Maass, Saskia, van der Leij, Femke, Verkooijen, Helena, Trialbureau Beeld, Cancer, MS Radiotherapie, Batenburg, Marilot, Accord-Maass, Saskia, van der Leij, Femke, and Verkooijen, Helena

Published
2023

29. Patient-reported and clinical outcomes of oncoplastic breast conserving surgery compared with standard breast conserving surgery - results of the multicenter UMBRELLA breast cancer cohort

Author

Bargon, Claudia, primary, Mink van der Molen, Dieuwke, additional, van Dam, Iris, additional, Baas, Inge, additional, Veenendaal, Liesbeth, additional, Maarse, Wiesje, additional, Sier, Maartje, additional, Schoenmaeckers, Ernst, additional, Burgmans, Josephina, additional, Bijlsma, Rhode, additional, van der Leij, Femke, additional, Rakhorst, Hinne, additional, Mureau, Marc, additional, Doeksen, Annemiek, additional, and Verkooijen, Helena, additional

Published
2023
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31. The association of internal mammary and medial supraclavicular lymph node radiation technique with clinical outcomes: Results from the EORTC 22922/10925 randomised trial.

Author

UCL - (SLuc) Service de radiothérapie oncologique, Kaidar-Person, Orit, Fortpied, Catherine, Hol, Sandra, Weltens, Caroline, Kirkove, Carine, Budach, Volker, Peignaux-Casasnovas, Karine, van der Leij, Femke, Vonk, Ernest, Valli, Mariacarla, Weidner, Nicola, Guckenberger, Matthias, Koiter, Eveline, Fourquet, Alain, Bartelink, Harry, Struikmans, Henk, Poortmans, Philip, EORTC Radiation Oncology and Breast Cancer Groups, UCL - (SLuc) Service de radiothérapie oncologique, Kaidar-Person, Orit, Fortpied, Catherine, Hol, Sandra, Weltens, Caroline, Kirkove, Carine, Budach, Volker, Peignaux-Casasnovas, Karine, van der Leij, Femke, Vonk, Ernest, Valli, Mariacarla, Weidner, Nicola, Guckenberger, Matthias, Koiter, Eveline, Fourquet, Alain, Bartelink, Harry, Struikmans, Henk, Poortmans, Philip, and EORTC Radiation Oncology and Breast Cancer Groups

Abstract

The multicentre EORTC 22922/10925 trial (ClinicalTrials.gov, NCT00002851) was conducted between 1996 and 2004. The trial evaluated the effect of irradiation of the internal mammary and medial supraclavicular lymph node chains (IM-MS) vs no further radiation therapy (RT) on survival and cause of death in breast cancer stage I-III patients. At 15.7 years of median follow-up, a significant reduction of breast cancer specific mortality (BCSM) and any recurrence, not translating in improved overall survival (OS), and low absolute rates of side effects were found. The aim of the current analysis was to evaluate the association of RT techniques of IM-MS lymph node irradiation with long-term outcomes. Three RT techniques were used for IM-MS: a standard technique using a fixed set-up combining photon/electron beams to the IM and tangential fields to the breast or chest wall vs a standard-modified technique with minor adaptation for beam settings vs a more individualised technique based on individual localisation of the IM. Techniques used were fixed per institution over the duration of the trial. We performed an exploratory and descriptive analysis of the outcomes after 15 years follow-up for the three RT techniques. Between July 1996 and January 2004, 46 radiation oncology departments from 13 countries accrued 4004 patients. Median follow-up was 15.7 years. The number of patients treated by each technique was 2440 (61%) by standard vs 635 (16%) by standard-modified vs 929 (23%) patients by individualised technique. The absolute improvements of oncological outcomes in terms of disease-free survival (DFS), OS and BCSM with IM-MS RT compared to no IM-MS RT were 6.8%, 4.9% and -5.8% for the individualised technique, vs 1.6%, 2.9% and -4.3% for modified standard and -1.4%, 1.1% and -3% for standard technique, respectively. The increase in 15-year rates of side effects due to IM-MS RT, both scored longitudinally and cross-sectionally, were similar among the techniques. Even thoug

Published
2022

32. Intrafraction motion during radiotherapy of breast tumor, breast tumor bed, and individual axillary lymph nodes on cine magnetic resonance imaging

Author

Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Computational Imaging, Groot Koerkamp, Maureen L, van den Bongard, H J G Desirée, Philippens, Marielle E P, van der Leij, Femke, Mandija, Stefano, Houweling, Antonetta C, Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Computational Imaging, Groot Koerkamp, Maureen L, van den Bongard, H J G Desirée, Philippens, Marielle E P, van der Leij, Femke, Mandija, Stefano, and Houweling, Antonetta C

Published
2022

33. The impact of para-aortic lymph node irradiation on disease-free survival in patients with cervical cancer: A systematic review and meta-analysis

Author

MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, MS Gynaecologische Oncologie, Bukkems, Leslie J H, Jürgenliemk-Schulz, Ina M, van der Leij, Femke, Peters, Max, Gerestein, Cornelis G, Zweemer, Ronald P, van Rossum, Peter S N, MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, MS Gynaecologische Oncologie, Bukkems, Leslie J H, Jürgenliemk-Schulz, Ina M, van der Leij, Femke, Peters, Max, Gerestein, Cornelis G, Zweemer, Ronald P, and van Rossum, Peter S N

Published
2022

34. Prognostic impact of waiting time between diagnosis and treatment in patients with cervical cancer: A nationwide population-based study

Author

MS Gynaecologische Oncologie, Cancer, Pathologie Pathologen staf, MS Radiotherapie, Arts-assistenten Radiotherapie, Hack, Amy P., Zweemer, Ronald P., Jonges, Trudy N., van der Leij, Femke, Gerestein, Cornelis G., Peters, Max, Jürgenliemk-Schulz, Ina M., van Rossum, Peter S.N., MS Gynaecologische Oncologie, Cancer, Pathologie Pathologen staf, MS Radiotherapie, Arts-assistenten Radiotherapie, Hack, Amy P., Zweemer, Ronald P., Jonges, Trudy N., van der Leij, Femke, Gerestein, Cornelis G., Peters, Max, Jürgenliemk-Schulz, Ina M., and van Rossum, Peter S.N.

Published
2022

35. Upstaging by para-aortic lymph node dissection in patients with locally advanced cervical cancer: A systematic review and meta-analysis

Author

MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, MS Gynaecologische Oncologie, Thelissen, Annelou A.B., Jürgenliemk-Schulz, Ina M., van der Leij, Femke, Peters, Max, Gerestein, Cornelis G., Zweemer, Ronald P., van Rossum, Peter S.N., MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, MS Gynaecologische Oncologie, Thelissen, Annelou A.B., Jürgenliemk-Schulz, Ina M., van der Leij, Femke, Peters, Max, Gerestein, Cornelis G., Zweemer, Ronald P., and van Rossum, Peter S.N.

Published
2022

36. AI-Based Radiation Dose Quantification for Estimation of Heart Disease Risk in Breast Cancer Survivors After Radiation Therapy

Author

Beeldverwerking ISI, Cancer, Trialbureau Beeld, Team Medisch, Circulatory Health, MS Radiotherapie, JC onderzoeksprogramma Kanker, Brain, van Velzen, Sanne G M, Gal, Roxanne, Teske, Arco J, van der Leij, Femke, van den Bongard, Desirée H J G, Viergever, Max A, Verkooijen, Helena M, Išgum, Ivana, Beeldverwerking ISI, Cancer, Trialbureau Beeld, Team Medisch, Circulatory Health, MS Radiotherapie, JC onderzoeksprogramma Kanker, Brain, van Velzen, Sanne G M, Gal, Roxanne, Teske, Arco J, van der Leij, Femke, van den Bongard, Desirée H J G, Viergever, Max A, Verkooijen, Helena M, and Išgum, Ivana

Published
2022

40. Corrigendum to "A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients" [Radiother Oncol 156 (2021) 127-135]

Author

Bosma, Sophie C.J., primary, Hoogstraat, Marlous, additional, van Werkhoven, Erik, additional, de Maaker, Michiel, additional, van der Leij, Femke, additional, Elkhuizen, Paula H.M., additional, Fourquet, Alain, additional, Poortmans, Philip, additional, Boersma, Liesbeth J., additional, Bartelink, Harry, additional, and van de Vijver, Marc J., additional

Published
2021
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42. Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients With Breast Cancer

Author

Gal, Roxanne, primary, van Velzen, Sanne G. M., additional, Hooning, Maartje J., additional, Emaus, Marleen J., additional, van der Leij, Femke, additional, Gregorowitsch, Madelijn L., additional, Blezer, Erwin L. A., additional, Gernaat, Sofie A. M., additional, Lessmann, Nikolas, additional, Sattler, Margriet G. A., additional, Leiner, Tim, additional, de Jong, Pim A., additional, Teske, Arco J., additional, Verloop, Janneke, additional, Penninkhof, Joan J., additional, Vaartjes, Ilonca, additional, Meijer, Hanneke, additional, van Tol-Geerdink, Julia J., additional, Pignol, Jean-Philippe, additional, van den Bongard, Desirée H. J. G., additional, Išgum, Ivana, additional, and Verkooijen, Helena M., additional

Published
2021
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43. Side effects 15 years after lymph node irradiation in breast cancer : randomized EORTC trial 22922/10925

Author

Poortmans, Philip M, Struikmans, Henk, De Brouwer, Peter, Weltens, Caroline, Fortpied, Catherine, Kirkove, Carine, Budach, Volker, Peignaux-Casasnovas, Karine, van der Leij, Femke, Vonk, Ernest, Valli, Mariacarla, vanTienhoven, Geertjan, Weidner, Nicola, Noel, Georges, Guckenberger, Matthias, Koiter, Eveline, vanLimbergen, Erik, Engelen, Antoine, Fourquet, Alain, Bartelink, Harry, EORTC Radiation Oncology and Breast Cancer Groups, EORTC Radiation Oncology Breast Cancer Groups, UCL - (SLuc) Service de radiothérapie oncologique, UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/SLUC - Pôle St.-Luc, University of Zurich, and Poortmans, Philip M

Subjects
Cancer Research, medicine.medical_specialty, 610 Medicine & health, Breast Neoplasms, Gastroenterology, Breast cancer, Internal medicine, Medicine, Humans, Cumulative incidence, 1306 Cancer Research, Breast, Lymph node, Not evaluated, business.industry, Incidence (epidemiology), Cancer, medicine.disease, Primary tumor, 10044 Clinic for Radiation Oncology, Confidence interval, medicine.anatomical_structure, Oncology, Axilla, 2730 Oncology, Female, Lymph Nodes, Human medicine, business
Abstract

Background Uncertainty about the benefit–risk ratio of regional lymph node irradiation led to varying clinical protocols. We investigated long-term late side effects after internal mammary and medial supraclavicular (IM-MS) lymph node irradiation to improve shared decision making. Methods The multicenter European Organization for Research and Treatment of Cancer trial (ClinicalTrials.gov, NCT00002851) randomly assigned stage I-III breast cancer patients with involved axillary nodes and/or a medially located primary tumor. We analyzed late side effects both longitudinally at every follow-up and cross-sectionally at 5-year intervals. All statistical tests were 2-sided. Results Between 1996 and 2004, 46 departments from 13 countries accrued 4004 patients. Median follow-up was 15.7 years. Longitudinal follow-up data showed cumulative incidence rates at 15 years of 2.9% (95% confidence interval [CI] = 2.2% to 3.8%) vs 5.7% (95% CI = 4.7% to 6.9%) (P < .001) for lung fibrosis, 1.1% (95% CI = 0.7% to 1.7%) vs 1.9% (95% CI = 1.3% to 2.6%) (P = .07) for cardiac fibrosis, and 9.4% (95% CI = 8.0% to 10.8%) vs 11.1% (95% CI = 9.6% to 12.7%) (P = .04) for any cardiac disease when treated without or with IM-MS lymph node irradiation. There was no evidence for differences between left- and right-sided breast cancer (Wald χ2 test of treatment by breast side interaction, P = .33 and P = .35, for cardiac fibrosis and for any cardiac disease, respectively). The cumulative incidence probabilities of cross-sectionally reported side effects with a score of 2 or greater at 15 years were 0.1% (95% CI = 0.0% to 0.5%) vs 0.8% (95% CI = 0.4% to 1.4%) for pulmonary (P = .02), 1.8% (95% CI = 1.1% to 2.8%) vs 2.6% (95% CI = 1.8% to 3.7%) for cardiac (P = .15), and 0.0% (95% CI not evaluated) vs 0.1% (95% CI = 0.0% to 0.4%) for esophageal (P = .16), respectively. No difference was observed in the incidence of second malignancies, contralateral breast cancer, or cardiovascular deaths. Conclusions The incidence of late pulmonary side effects was statistically significantly higher after IM-MS lymph node irradiation, as were some of the cardiac events, without a difference between left- and right-sided treatments. Absolute rates and differences were very low, without increased non-breast cancer–related mortality, even before introducing heart-sparing techniques.

Published
2021

44. Online Magnetic Resonance-Guided Radiotherapy (oMRgRT) for Gynecological Cancers

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Portelance, Lorraine, Corradini, Stefanie, Erickson, Beth, Lalondrelle, Susan, Padgett, Kyle, van der Leij, Femke, van Lier, Astrid, Jürgenliemk-Schulz, Ina, MS Radiotherapie, Cancer, Klinische Fysica RT, Portelance, Lorraine, Corradini, Stefanie, Erickson, Beth, Lalondrelle, Susan, Padgett, Kyle, van der Leij, Femke, van Lier, Astrid, and Jürgenliemk-Schulz, Ina

Published
2021

45. Coronary artery calcifications on breast cancer radiotherapy planning CT scans and cardiovascular risk: What do patients want to know?

Author

Trialbureau Beeld, Cancer, Onderzoek Radiotherapie, Epi Kanker Team A, Brain, MS Radiotherapie, Beeldverwerking ISI, Gal, Roxanne, Gregorowitsch, Madelijn L., Emaus, Marleen J., Blezer, Erwin LA, van der Leij, Femke, van Velzen, Sanne GM, van Tol-Geerdink, Julia J., Išgum, Ivana, Verkooijen, Helena M., Trialbureau Beeld, Cancer, Onderzoek Radiotherapie, Epi Kanker Team A, Brain, MS Radiotherapie, Beeldverwerking ISI, Gal, Roxanne, Gregorowitsch, Madelijn L., Emaus, Marleen J., Blezer, Erwin LA, van der Leij, Femke, van Velzen, Sanne GM, van Tol-Geerdink, Julia J., Išgum, Ivana, and Verkooijen, Helena M.

Published
2021

46. Evaluation of Early Response to Preoperative Accelerated Partial Breast Irradiation (PAPBI) by Histopathology, Magnetic Resonance Imaging, and 18F-fluorodexoyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT)

Author

MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Bosma, Sophie C J, van der Leij, Femke, Elkhuizen, Paula H M, Vreeswijk, S, Loo, Claudette E, Vogel, Wouter V, Bartelink, Harry, van de Vijver, Marc J, MS Radiotherapie, Cancer, Arts-assistenten Radiotherapie, Bosma, Sophie C J, van der Leij, Femke, Elkhuizen, Paula H M, Vreeswijk, S, Loo, Claudette E, Vogel, Wouter V, Bartelink, Harry, and van de Vijver, Marc J

Published
2021

47. The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patients

Author

Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, JC onderzoeksprogramma Kanker, Batenburg, Marilot C. T., Maarse, Wies, van der Leij, Femke, Baas, Inge O., Boonstra, Onno, Lansdorp, Nina, Doeksen, Annemiek, van den Bongard, HJGD, Verkooijen, Helena M., Trialbureau Beeld, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, JC onderzoeksprogramma Kanker, Batenburg, Marilot C. T., Maarse, Wies, van der Leij, Femke, Baas, Inge O., Boonstra, Onno, Lansdorp, Nina, Doeksen, Annemiek, van den Bongard, HJGD, and Verkooijen, Helena M.

Published
2021

48. Prone vs. supine accelerated partial breast irradiation on an MR-Linac: A planning study

Author

Radiotherapie, Research UMC Utrecht, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Computational Imaging, Groot Koerkamp, Maureen L., van der Leij, Femke, van 't Westeinde, Tanja, Bol, Gijsbert H., Scholten, Vincent, Bouwmans, Roel, Mandija, Stefano, Philippens, Marielle E.P., van den Bongard, H. J.G.Desirée, Houweling, Antonetta C., Radiotherapie, Research UMC Utrecht, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Computational Imaging, Groot Koerkamp, Maureen L., van der Leij, Femke, van 't Westeinde, Tanja, Bol, Gijsbert H., Scholten, Vincent, Bouwmans, Roel, Mandija, Stefano, Philippens, Marielle E.P., van den Bongard, H. J.G.Desirée, and Houweling, Antonetta C.

Published
2021

49. Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients with Breast Cancer

Author

Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Beeldverwerking ISI, Epi Kanker Team A, MS Radiotherapie, Onderzoek Radiotherapie, Brain, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, Researchbureau DHL, Team Medisch, Datamanagement 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Gal, Roxanne, Van Velzen, Sanne G.M., Hooning, Maartje J., Emaus, Marleen J., Van Der Leij, Femke, Gregorowitsch, Madelijn L., Blezer, Erwin L.A., Gernaat, Sofie A.M., Lessmann, Nikolas, Sattler, Margriet G.A., Leiner, Tim, De Jong, Pim A., Teske, Arco J., Verloop, Janneke, Penninkhof, Joan J., Vaartjes, Ilonca, Meijer, Hanneke, Van Tol-Geerdink, Julia J., Pignol, Jean Philippe, Van Den Bongard, Desirée H.J.G., Išgum, Ivana, Verkooijen, Helena M., Trialbureau Beeld, Cancer, JC onderzoeksprogramma Kanker, Beeldverwerking ISI, Epi Kanker Team A, MS Radiotherapie, Onderzoek Radiotherapie, Brain, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, Researchbureau DHL, Team Medisch, Datamanagement 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Gal, Roxanne, Van Velzen, Sanne G.M., Hooning, Maartje J., Emaus, Marleen J., Van Der Leij, Femke, Gregorowitsch, Madelijn L., Blezer, Erwin L.A., Gernaat, Sofie A.M., Lessmann, Nikolas, Sattler, Margriet G.A., Leiner, Tim, De Jong, Pim A., Teske, Arco J., Verloop, Janneke, Penninkhof, Joan J., Vaartjes, Ilonca, Meijer, Hanneke, Van Tol-Geerdink, Julia J., Pignol, Jean Philippe, Van Den Bongard, Desirée H.J.G., Išgum, Ivana, and Verkooijen, Helena M.

Published
2021

50. Impact of the COVID-19 Pandemic on Patient-Reported Outcomes of Breast Cancer Patients and Survivors

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS CGO, Onderzoek Radiotherapie, JC onderzoeksprogramma Kanker, Bargon, Claudia A, Batenburg, Marilot C T, van Stam, Lilianne E, Mink van der Molen, Dieuwke R, van Dam, Iris E, van der Leij, Femke, Baas, Inge O, Ernst, Miranda F, Maarse, Wiesje, Vermulst, Nieke, Schoenmaeckers, Ernst J P, van Dalen, Thijs, Bijlsma, Rhodé M, Young-Afat, Danny A, Doeksen, Annemiek, Verkooijen, Helena M, Trialbureau Beeld, Cancer, MS Radiotherapie, MS Medische Oncologie, Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), MS CGO, Onderzoek Radiotherapie, JC onderzoeksprogramma Kanker, Bargon, Claudia A, Batenburg, Marilot C T, van Stam, Lilianne E, Mink van der Molen, Dieuwke R, van Dam, Iris E, van der Leij, Femke, Baas, Inge O, Ernst, Miranda F, Maarse, Wiesje, Vermulst, Nieke, Schoenmaeckers, Ernst J P, van Dalen, Thijs, Bijlsma, Rhodé M, Young-Afat, Danny A, Doeksen, Annemiek, and Verkooijen, Helena M

Published
2021

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