1. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
- Author
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Brouwer, P.J.M. (Philip J.M.), Brinkkemper, M. (Mitch), Maisonnasse, P. (Pauline), Dereuddre-Bosquet, N. (Nathalie), Grobben, M. (Marloes), Claireaux, M. (Mathieu), de Gast, M. (Marlon), Marlin, R. (Romain), Chesnais, V. (Virginie), Diry, S. (Ségolène), Allen, J.D. (Joel D.), Watanabe, Y. (Yasunori), Giezen, J.M. (Julia M.), Kerster, G. (Gius), Turner, H.L. (Hannah L.), van der Straten, K. (Karlijn), van der Linden, C.A. (Cynthia A.), Aldon, Y. (Yoann), Naninck, T. (Thibaut), Bontjer, I. (Ilja), Burger, J.A. (Judith A.), Poniman, M. (Meliawati), Mykytyn, A.Z. (Anna Z.), Okba, N.M.A. (Nisreen), Schermer, E.E. (Edith E.), Breemen, M.J. (Mariëlle) van, Ravichandran, R. (Rashmi), Caniels, T.G. (Tom G.), van Schooten, J. (Jelle), Kahlaoui, N. (Nidhal), Contreras, V. (Vanessa), Lemaître, J. (Julien), Chapon, C. (Catherine), Fang, R.H.T. (Raphaël Ho Tsong), Villaudy, J. (Julien), Sliepen, K. (Kwinten), van der Velden, Y.U. (Yme U.), Haagmans, B.L. (Bart), de Bree, G.J. (Godelieve J.), Ginoux, E. (Eric), Ward, A.B. (Andrew B.), Crispin, M. (Max), King, N.P. (Neil P.), Werf, S. (Sylvie) van der, van Gils, M.J. (Marit J.), Le Grand, R. (Roger), Sanders, R.W. (Rogier W.), Brouwer, P.J.M. (Philip J.M.), Brinkkemper, M. (Mitch), Maisonnasse, P. (Pauline), Dereuddre-Bosquet, N. (Nathalie), Grobben, M. (Marloes), Claireaux, M. (Mathieu), de Gast, M. (Marlon), Marlin, R. (Romain), Chesnais, V. (Virginie), Diry, S. (Ségolène), Allen, J.D. (Joel D.), Watanabe, Y. (Yasunori), Giezen, J.M. (Julia M.), Kerster, G. (Gius), Turner, H.L. (Hannah L.), van der Straten, K. (Karlijn), van der Linden, C.A. (Cynthia A.), Aldon, Y. (Yoann), Naninck, T. (Thibaut), Bontjer, I. (Ilja), Burger, J.A. (Judith A.), Poniman, M. (Meliawati), Mykytyn, A.Z. (Anna Z.), Okba, N.M.A. (Nisreen), Schermer, E.E. (Edith E.), Breemen, M.J. (Mariëlle) van, Ravichandran, R. (Rashmi), Caniels, T.G. (Tom G.), van Schooten, J. (Jelle), Kahlaoui, N. (Nidhal), Contreras, V. (Vanessa), Lemaître, J. (Julien), Chapon, C. (Catherine), Fang, R.H.T. (Raphaël Ho Tsong), Villaudy, J. (Julien), Sliepen, K. (Kwinten), van der Velden, Y.U. (Yme U.), Haagmans, B.L. (Bart), de Bree, G.J. (Godelieve J.), Ginoux, E. (Eric), Ward, A.B. (Andrew B.), Crispin, M. (Max), King, N.P. (Neil P.), Werf, S. (Sylvie) van der, van Gils, M.J. (Marit J.), Le Grand, R. (Roger), and Sanders, R.W. (Rogier W.)
- Abstract
Brouwer et al. present preclinical evidence in support of a COVID-19 vaccine candidate, designed as a self-assembling two-component protein nanoparticle displaying multiple copies of the SARS-CoV-2 spike protein, which induces strong neutralizing antibody responses and protects from high-dose SARS-CoV-2 challenge.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in
- Published
- 2021
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