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3. Fully Automated 3D Segmentation of MR-Imaged Calf Muscle Compartments: Neighborhood Relationship Enhanced Fully Convolutional Network

Author

Guo, Zhihui, Zhang, Honghai, Chen, Zhi, van der Plas, Ellen, Gutmann, Laurie, Thedens, Daniel, Nopoulos, Peggy, and Sonka, Milan

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Automated segmentation of individual calf muscle compartments from 3D magnetic resonance (MR) images is essential for developing quantitative biomarkers for muscular disease progression and its prediction. Achieving clinically acceptable results is a challenging task due to large variations in muscle shape and MR appearance. Although deep convolutional neural networks (DCNNs) achieved improved accuracy in various image segmentation tasks, certain problems such as utilizing long-range information and incorporating high-level constraints remain unsolved. We present a novel fully convolutional network (FCN), called FilterNet, that utilizes contextual information in a large neighborhood and embeds edge-aware constraints for individual calf muscle compartment segmentations. An encoder-decoder architecture with flexible backbone blocks is used to systematically enlarge convolution receptive field and preserve information at all resolutions. Edge positions derived from the FCN output muscle probability maps are explicitly regularized using kernel-based edge detection in an end-to-end optimization framework. Our FilterNet was evaluated on 40 T1-weighted MR images of 10 healthy and 30 diseased subjects by 4-fold cross-validation. Mean DICE coefficients of 88.00%--91.29% and mean absolute surface positioning errors of 1.04--1.66 mm were achieved for the five 3D muscle compartments., Comment: To be appeared in journal Computerized Medical Imaging and Graphics

Published
2020

6. Leveraging neuroimaging to understand the impact of chronic kidney disease on the brain

Author

van der Plas, Ellen and Harshman, Lyndsay

Subjects
Chronic kidney failure -- Complications and side effects -- Diagnosis, Neuroimaging -- Methods, Cognition disorders -- Risk factors, Pediatric research, Biological markers -- Health aspects, Health
Abstract

Author(s): Ellen van der Plas [sup.1] , Lyndsay Harshman [sup.2] Author Affiliations: (1) grid.214572.7, 0000 0004 1936 8294, Department of Psychiatry, University of Iowa Carver College of Medicine, , Iowa [...]

Published
2022
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10. Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.

Author

van der Plas, Ellen, Darji, Himani, Srivastava, Deo K., Schapiro, Melissa, Jeffe, Donna, Perkins, Stephanie, Howell, Rebecca, Leisenring, Wendy, Armstrong, Gregory T., Oeffinger, Kevin, Krull, Kevin, Edelstein, Kim, and Hayashi, Robert J.

Subjects
*QUALITY of life, *PSYCHOLOGICAL distress, *SOCIAL anxiety, *RHABDOMYOSARCOMA, *PHYSICAL mobility, *CHILDHOOD cancer
Abstract

Background: Prevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well‐established. Methods: Participants in this cross‐sectional, case‐control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health‐related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, and chronic conditions associated with impairment. Results: Relative to siblings, more survivors reported neurocognitive impairment (task efficiency: 21.1% vs. 13.7%, emotional regulation: 16.7% vs. 11.0%, memory: 19.3% vs. 15.1%), elevated emotional distress (somatic distress: 12.9% vs. 4.7%, anxiety: 11.7% vs. 5.9%, depression: 22.8% vs. 16.9%) and poorer HRQOL (physical functioning: 11.1% vs. 2.8%, role functioning due to physical problems: 16.8% vs. 8.2%, pain: 17.5% vs. 10.0%, vitality: 22.3% vs. 13.8%, social functioning: 14.4% vs. 6.8%, emotional functioning: 17.1% vs. 10.6%). Cranial radiation increased risk for impaired task efficiency (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.14–4.63), whereas chest and pelvic radiation predicted increased risk of physical functioning (OR, 2.68; 95% CI, 1.16–6.21 and OR, 3.44; 95% CI, 1.70–6.95, respectively). Smoking was associated with impaired task efficiency (OR, 2.06; 95% CI, 1.14–3.70), memory (OR, 2.23; 95% CI, 1.26–3.95), anxiety (OR, 2.71; 95% CI, 1.36–5.41) and depression (OR, 1.77; 95% CI, 1.01–3.11). Neurologic conditions increased risk of anxiety (OR, 2.30; 95% CI, 1.04–5.10), and hearing conditions increased risk of depression (OR, 1.79; 95% CI, 1.05–3.03). Neurologic and hearing conditions, respectively, were associated with impaired memory (OR, 2.44; 95% CI, 1.20–4.95 and OR, 1.87; 95% CI, 1.05–3.35) and poor health perception (OR, 2.62; 95% CI, 1.62–1.28 and OR, 2.33; 95% CI, 1.34–4.06). Conclusions: RMS survivors are at significant risk for poor psychological outcomes. Advancing therapies for local control, smoking cessation, and managing chronic medical conditions may mitigate poor outcomes following RMS. Research on psychological outcomes following pediatric rhabdomyosarcoma is scarce, limiting the understanding of the prevalence of and risk factors for neurocognitive impairment, emotional distress, and quality of life among survivors. This study showed that rhabdomyosarcoma survivors are at significant risk for poor psychological outcomes, and advancing therapies for local tumor control, smoking cessation, and managing chronic medical conditions may be important for mitigating risk. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/ Hyperactivity Traits and Response Inhibition in a Community Sample

Author

van der Plas, Ellen, Dupuis, Annie, and Arnold, Paul

Abstract

We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The "sibling effect" on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only.

Published
2016
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22. Longitudinal Clinical and Biological Characteristics in Juvenile‐Onset Huntington's Disease

Author

Schultz, Jordan L., primary, Langbehn, Douglas R., additional, Al‐Kaylani, Hend M., additional, van der Plas, Ellen, additional, Koscik, Timothy R., additional, Epping, Eric A., additional, Espe‐Pfeifer, Patricia B., additional, Martin, Erin P., additional, Moser, David J., additional, Magnotta, Vincent A., additional, and Nopoulos, Peggy C., additional

Published
2022
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29. Sex-Based Differences in Functional Brain Activity During Working Memory in Survivors of Pediatric Acute Lymphoblastic Leukemia

Author

Gandy, Kellen, primary, Scoggins, Matthew A, additional, Phillips, Nicholas, additional, van der Plas, Ellen, additional, Fellah, Slim, additional, Jacola, Lisa M, additional, Pui, Ching-Hon, additional, Hudson, Melissa M, additional, Reddick, Wilburn E, additional, Sitaram, Ranganatha, additional, and Krull, Kevin R, additional

Published
2022
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32. Longitudinal Clinical and Biological Characteristics in Juvenile‐Onset Huntington's Disease.

Author

Schultz, Jordan L., Langbehn, Douglas R., Al‐Kaylani, Hend M., van der Plas, Ellen, Koscik, Timothy R., Epping, Eric A., Espe‐Pfeifer, Patricia B., Martin, Erin P., Moser, David J., Magnotta, Vincent A., and Nopoulos, Peggy C.

Abstract

Background: Juvenile‐onset Huntington's disease (JOHD) is a rare form of Huntington's disease (HD) characterized by symptom onset before the age of 21 years. Observational data in this cohort is lacking. Objectives: Quantify measures of disease progression for use in clinical trials of patients with JOHD. Methods: Participants who received a motor diagnosis of HD before the age of 21 were included in the Kids‐JOHD study. The comparator group consisted of children and young adults who were at‐risk for inheriting the genetic mutation that causes HD, but who were found to have a CAG repeat in the non‐expanded range (gene non‐expanded [GNE]). Results: Data were obtained between March 17, 2006, and February 13, 2020. There were 26 JOHD participants and 78 GNE participants who were comparable on age (16.03 vs. 14.43, respectively) and sex (53.8% female vs. 57.7% female, respectively). The mean annualized decrease in striatal volume in the JOHD group was −3.99% compared to −0.06% in the GNE (mean difference [MD], −3.93%; 95% confidence intervals [CI], [−4.98 to −2.80], FDR < 0.0001). The mean increase in the Unified Huntington's Disease Rating Scale Total Motor Score per year in the JOHD group was 7.29 points compared to a mean decrease of −0.21 point in the GNE (MD, 7.5; 95% CI, [5.71–9.28], FDR < 0·0001). Conclusions: These findings demonstrate that structural brain imaging and clinical measures in JOHD may be potential biomarkers of disease progression for use in clinical trials. Collaborative efforts are required to validate these results in a larger cohort of patients with JOHD. © 2022 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Characterizing academic performance in pediatric acute lymphoblastic leukemia with population‐based achievement tests

Author

Al‐Kaylani, Hend M., primary, Reasoner, Erin E., additional, Loeffler, Bradley T., additional, Mott, Sarah L., additional, Madasu, Susan, additional, Liu, Audrey, additional, Langbehn, Kathleen, additional, Conrad, Amy L., additional, Dickens, David, additional, Grafft, Amanda, additional, Harshman, Lyndsay, additional, Modi, Arunkumar J., additional, and van der Plas, Ellen, additional

Published
2021
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47. Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia

Author

van der Plas, Ellen, primary, Spencer Noakes, T. Leigh, additional, Butcher, Darci T., additional, Weksberg, Rosanna, additional, Galin-Corini, Laura, additional, Wanstall, Elizabeth A., additional, Te, Patrick, additional, Hopf, Laura, additional, Guger, Sharon, additional, Hitzler, Johann, additional, Schachar, Russell J., additional, Ito, Shinya, additional, and Nieman, Brian J., additional

Published
2020
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48. Early pediatric chronic kidney disease is associated with brain volumetric gray matter abnormalities

Author

Solomon, Matthew A., primary, van der Plas, Ellen, additional, Langbehn, Kathleen E., additional, Novak, Marci, additional, Schultz, Jordan L., additional, Koscik, Timothy R., additional, Conrad, Amy L., additional, Brophy, Patrick D., additional, Furth, Susan L., additional, Nopoulos, Peggy C., additional, and Harshman, Lyndsay A., additional

Published
2020
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