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265 results on '"van der Poel, M."'

1. Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome

Author

Janssen, J. J. W. M., Löwenberg, B., Manz, M., Biemond, B. J., Westerweel, P. E., Klein, S. K., Fehr, M., Sinnige, H. A. M., Efthymiou, A., Legdeur, M. C. J. C., Pabst, T., Gregor, M., van der Poel, M. W. M., Deeren, D., Tick, L. W., Jongen-Lavrencic, M., van Obbergh, F., Boersma, R. S., de Weerdt, O., Chalandon, Y., Heim, D., Spertini, O., van Sluis, G., Graux, C., Stüssi, G., van Norden, Y., and Ossenkoppele, G. J.

Published
2022
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3. Build up of off-diagonal long-range order in microcavity exciton-polaritons across the parametric threshold

Author

Spano, R., Cuadra, J., Lingg, C., Sanvitto, D., Martin, M. D., Eastham, P. R., van der Poel, M., Hvam, J. M., and Vina, L.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

We report an experimental study of the spontaneous spatial and temporal coherence of polariton condensates generated in the optical parametric oscillator configuration, below and at the parametric threshold, and as a function of condensate area. Above the threshold we obtain very long coherence times (up to 3 ns) and a spatial coherence extending over the entire condensate (40 \mu m). The very long coherence time and its dependence on condensate area and pump power reflect the suppression of polariton-polariton interactions by an effect equivalent to motional narrowing., Comment: 5 pages, 3 figures

Published
2011

7. Cognitive functioning in survivors of hematopoietic stem cell transplantation compared with a matched general population sample: The MOSA study

Author

Wauben, B., van der Poel, M. W. M., Greevenbroek, M. M. J., van Yperen, N. C., Schram, M. T., van Boxtel, M. P. J., Sastry, M., Simons, S. O., Stehouwer, C. D. A., Dagnelie, P. C., Wesselius, A., Schouten, H. C., Köhler, S., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: MA Hematologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Psychology 2, Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, RS: NUTRIM - R3 - Respiratory & Age-related Health, Pulmonologie, MUMC+: MA Med Staf Spec Longziekten (9), MUMC+: MA Interne Geneeskunde (3), RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, and Psychology 5

Abstract

BACKGROUND: Although cognitive problems can recover over time, a subgroup of hematopoietic stem cell transplantation (HCT) survivors experiences persistent cognitive problems in the long-term. Despite these implications, studies assessing cognitive functioning in HCT survivors are limited. OBJECTIVES: The aim of the present study was (1) to quantify the prevalence of cognitive impairment in patients treated with HCT who survived at least 2 years, and to compare these with a matched reference group representing the general population; (2) to identify potential determinants of cognitive functioning within the HCT survivor group. STUDY DESIGN: Within the single-centre Maastricht Observational study of late effects after Stem cell trAnsplantation (MOSA) cognitive performance was assessed by a neuropsychological test battery divided into three cognitive domains respectively memory, information processing speed, and executive function & attention. An overall cognition score was calculated as the average of the domain scores. A total of 115 HCT survivors were group-matched on a 1:4 ratio to the reference group by age, sex, and level of education. Regression analyses adjusted for different sets of covariates including demographic, health- and lifestyle-related factors were used to test for differences in cognition between HCT survivors and the reference group resembling the general population. A limited set of clinical characteristics (diagnosis, type of transplant, time since treatment, conditioning regimen with TBI and age at time of transplant) were assessed as potential determinants of neurocognitive dysfunction among HCT survivors. Cognitive impairment was defined as scores in the cognitive domains < -1.5 SD from what can be expected based on someone's age, sex, and education. RESULTS: The mean age at time of transplant was 50.2 (SD 11.2) years, and the mean number of years after transplant was 8.7 (SD 5.7) years. The majority of HCT survivors were treated with autologous HCT (N = 73; 64%). The prevalence of cognitive dysfunction in HCT survivors was 34.8%, and 21.3% in the reference group (p = .002.) When adjusted for age, sex, and level of education HCT survivors had a worse overall cognition score (b=-.35, 95%CI=-.55, -.16, p

Published
2023

8. Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

Author

Ossenkoppele, G. J., Breems, D. A., Stuessi, G., van Norden, Y., Bargetzi, M., Biemond, B. J., A von dem Borne, P., Chalandon, Y., Cloos, J., Deeren, D., Fehr, M., Gjertsen, B., Graux, C., Huls, G., Janssen, J. J. J. W., Jaspers, A., Jongen-Lavrencic, M., de Jongh, E., Klein, S. K., van der Klift, M., van Marwijk Kooy, M., Maertens, J., Michaux, L., van der Poel, M. W. M., van Rhenen, A., Tick, L., Valk, P., Vekemans, M. C., van der Velden, W. J. F. M., de Weerdt, O., Pabst, T., Manz, M., and Löwenberg, B.

Published
2020
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9. OS03.6.A Rituximab in primary CNS lymphoma - long term follow-up of the phase III HOVON 105/ALLG NHL 24 Study

Author

Bromberg, J E C, primary, Issa, S, additional, van der Holt, B, additional, Minnema, M C, additional, Seute, T, additional, Durian, M F, additional, Cull, G, additional, van der Poel, M W M, additional, Stevens, W B C, additional, Zijlstra, J M, additional, Nijland, M, additional, Mason, K D, additional, Beeker, A, additional, Brandsma, D, additional, van den Bent, M J, additional, Gonzalez, M, additional, de Jong, D, additional, and Doorduijn, J K, additional

Published
2022
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10. P1209: INCIDENCE, TREATMENT AND OUTCOME OF BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA: A POPULATION-BASED COHORT STUDY IN THE NETHERLANDS

Author

Meeuwes, F. O., primary, Brink, M., additional, Van der Poel, M. W., additional, Kersten, M. J., additional, Wondergem, M. J., additional, Mutsaers, P. G., additional, Böhmer, L. H., additional, Woei-A-Jin, F. J. S. H., additional, Visser, O., additional, Oostvogels, R., additional, Jansen, P. M., additional, Plattel, W. J., additional, Huls, G. A., additional, Vermaat, J. S., additional, and Nijland, M., additional

Published
2022
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11. P1176: RITUXIMAB IN PRIMARY CNS LYMPHOMA – LONG TERM FOLLOW-UP OF THE PHASE III HOVON 105/ALLG NHL 24 STUDY

Author

Doorduijn, J., primary, Issa, S., additional, van der Holt, B., additional, Minnema, M., additional, Seute, T., additional, Durian, M., additional, Cull, G., additional, van der Poel, M., additional, Stevens, W., additional, Zijlstra, J., additional, Nijland, M., additional, Mason, K., additional, Beeker, A., additional, Brandsma, D., additional, van den Bent, M., additional, Gonzalez, M., additional, de Jong, D., additional, and Bromberg, J., additional

Published
2022
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12. P1462: POPULATION-BASED REAL WORLD RESULTS OF CD19-DIRECTED CAR T-CELL THERAPY FOR PATIENTS WITH RELAPSED OR REFRACTORY LARGE B-CELL LYMPHOMA: A DUTCH CAR T-CELL TUMORBOARD EXPERIENCE

Author

Spanjaart, A. M., primary, Pennings, E., additional, Mutsaers, P., additional, van Dorp, S., additional, Jak, M., additional, van Doesem, J., additional, de Boer, J., additional, Vermaat, J., additional, Sijs-Szabo, A., additional, van der Poel, M., additional, Kuipers, I., additional, Chamuleau, M., additional, Nijhof, I., additional, Minnema, M., additional, Lugtenburg, P., additional, van Meerten, T., additional, and Kersten, M. J., additional

Published
2022
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13. P1254: RESPONSE TO DA-EPOCH-R IN PATIENTS WITH HIGH GRADE B CELL LYMPHOMA IS ASSOCIATED WITH A REDUCTION OF PD1 POSITIVE EXHAUSTED CD8 T CELLS

Author

de Jonge, V., primary, Duetz, C., additional, Bruins, W., additional, van Werkhoven, E., additional, Nijland, M., additional, de Heer, K., additional, van der Poel, M., additional, Sandberg, Y., additional, Klerk, C., additional, de Jong, D., additional, Zijlstra, J., additional, Kersten, M. J., additional, Mutis, T., additional, and Chamuleau, M., additional

Published
2022
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14. Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Janssen, J J W M, Löwenberg, B, Manz, M, Biemond, B J, Westerweel, P E, Klein, S K, Fehr, M, Sinnige, H A M, Efthymiou, A, Legdeur, M C J C, Pabst, T, Gregor, M, van der Poel, M W M, Deeren, D, Tick, L W, Jongen-Lavrencic, M, van Obbergh, F, Boersma, R S, de Weerdt, O, Chalandon, Y, Heim, D, Spertini, O, van Sluis, G, Graux, Carlos, Stüssi, G, van Norden, Y, Ossenkoppele, G J, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Janssen, J J W M, Löwenberg, B, Manz, M, Biemond, B J, Westerweel, P E, Klein, S K, Fehr, M, Sinnige, H A M, Efthymiou, A, Legdeur, M C J C, Pabst, T, Gregor, M, van der Poel, M W M, Deeren, D, Tick, L W, Jongen-Lavrencic, M, van Obbergh, F, Boersma, R S, de Weerdt, O, Chalandon, Y, Heim, D, Spertini, O, van Sluis, G, Graux, Carlos, Stüssi, G, van Norden, Y, and Ossenkoppele, G J

Abstract

Treatment results of AML in elderly patients are unsatisfactory. In an open label randomized phase II study, we investigated whether addition of the XPO1 inhibitor selinexor to intensive chemotherapy would improve outcome in this population. 102 AML patients > 65 years of age (median 69 (65-80)) were randomly assigned to standard chemotherapy (3 + 7) with or without oral selinexor 60 mg twice weekly (both arms n = 51), days 1-24. In the second cycle, cytarabine 1000 mg/m twice daily, days 1-6 with or without selinexor was given. CR/CRi rates were significantly higher in the control arm than in the investigational arm (80% (95% C.I. 69-91%) vs. 59% (45-72%; p = 0.018), respectively). At 18 months, event-free survival was 45% for the control arm versus 26% for the investigational arm (Cox-p = 0.012) and overall survival 58% vs. 33%, respectively (p = 0.009). AML and infectious complications accounted for an increased death rate in the investigational arm. Irrespective of treatment, MRD status after two cycles appeared to be correlated with survival. We conclude that the addition of selinexor to standard chemotherapy does negatively affect the therapeutic outcome of elderly AML patients. (Netherlands Trial Registry number NL5748 (NTR5902), www.trialregister.nl ).

Published
2022

17. Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Author

Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J.K.H., Hsiao, C.-C., Mizee, M.R., Adelia, Vincenten, M.C.J., Kunkel, D., Huitinga, I., Hamann, J., Priller, J., Netherlands Institute for Neuroscience (NIN), Graduate School, AII - Inflammatory diseases, Experimental Immunology, and Structural and Functional Plasticity of the nervous system (SILS, FNWI)

Subjects
methods [Cell Separation], methods [Single-Cell Analysis], Research, methods [Flow Cytometry], Brain, Cell Separation, Multiple Sclerosis, Chronic Progressive, Flow Cytometry, pathology [Multiple Sclerosis, Chronic Progressive], lcsh:RC346-429, Active lesion, pathology [Brain], Myeloid cells, Humans, Myeloid Cells, Mass cytometry, ddc:610, Microglia, Single-Cell Analysis, Progressive multiple sclerosis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, lcsh:Neurology. Diseases of the nervous system
Abstract

Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progressive MS (PMS). Here, we have harnessed the power of single-cell mass cytometry (CyTOF) to compare myeloid cell phenotypes in active lesions of PMS donors with those in normal-appearing white matter from the same donors and control white matter from non-MS donors. CyTOF measurements of a total of 74 targeted proteins revealed a decreased abundance of homeostatic and TNFhi microglia, and an increase in highly phagocytic and activated microglia states in active lesions of PMS donors. Interestingly, in contrast to results obtained from studies of the inflammatory early disease stages of MS, infiltrating monocyte-derived macrophages were scarce in active lesions of PMS, suggesting fundamental differences of myeloid cell composition in advanced stages of PMS.

Published
2020

19. Relief of Symptoms and Quality of Life after Conservative versus Surgical Treatment of Benign Liver Tumors (CONSULT): A Retrospective Propensity Score Matched Study

Author

van Rosmalen, B., primary, Furumaya, A., additional, de Graeff, J.J., additional, van der Poel, M., additional, Ramsoekh, S., additional, Kazemier, G., additional, Verheij, J., additional, Takkenberg, B., additional, Besselink, M., additional, Erdmann, J., additional, and van Gulik, T., additional

Published
2022
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21. SUBCUTANEOUS EPCORITAMAB INDUCES DEEP, DURABLE COMPLETE REMISSIONS IN RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA: LONGER FOLLOW‐UP FROM THE PIVOTAL EPCORE NHL‐1 TRIAL.

Author

Thieblemont, C., Karimi, Y., Jurczak, W., Cheah, C. Y., Clausen, M. R., Cunningham, D., Do, Y. R., Lewis, D. J., Gasiorowski, R., Kim, T. M., van der Poel, M., Poon, M. L., Feldman, T., Linton, K. M., Sureda, A., Hutchings, M., Cottereau, A., Al Tabaa, Y., Stirner, M. Cota, and Liu, Y.

Subjects
LYMPHOMAS, BISPECIFIC antibodies
Abstract

B Introduction: b Outcomes are poor for patients with relapsed/refractory ( I R i / I R i ) large B-cell lymphoma (LBCL). SUBCUTANEOUS EPCORITAMAB INDUCES DEEP, DURABLE COMPLETE REMISSIONS IN RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA: LONGER FOLLOW-UP FROM THE PIVOTAL EPCORE NHL-1 TRIAL. [Extracted from the article]

Published
2023
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22. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Görgec, B, primary, Fichtinger, R S, additional, Ratti, F, additional, Aghayan, D, additional, Van der Poel, M J, additional, Al-Jarrah, R, additional, Armstrong, T, additional, Cipriani, F, additional, Fretland, Å A, additional, Suhool, A, additional, Bemelmans, M, additional, Bosscha, K, additional, Braat, A E, additional, De Boer, M T, additional, Dejong, C H C, additional, Doornebosch, P G, additional, Draaisma, W A, additional, Gerhards, M F, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, Kazemier, G, additional, Klaase, J, additional, Leclercq, W K G, additional, Liem, M S, additional, Lips, D J, additional, Marsman, H A, additional, Mieog, J S D, additional, Molenaar, Q I, additional, Nieuwenhuijs, V B, additional, Nota, C L, additional, Patijn, G A, additional, Rijken, A M, additional, Slooter, G D, additional, Stommel, M W J, additional, Swijnenburg, R J, additional, Tanis, P J, additional, Te Riele, W W, additional, Terkivatan, T, additional, Van den Tol, P M P, additional, Van den Boezem, P B, additional, Van der Hoeven, J A, additional, Vermaas, M, additional, Edwin, B, additional, Aldrighetti, L A, additional, Van Dam, R M, additional, Abu Hilal, M, additional, and Besselink, M G, additional

Published
2021
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23. IMPACT OF RITUXIMAB ON TREATMENT OUTCOMES OF PATIENTS WITH ANGIOIMMUNOBLASTIC T‐CELL LYMPHOMA; A POPULATION‐BASED ANALYSIS

Author

Meeuwes, F. O., primary, Brink, M., additional, van der Poel, M. W.M., additional, Kersten, M. J., additional, Wondergem, Mariël., additional, Mutsaers, P. G.N.J., additional, Böhmer, L. H., additional, Woei‐A‐Jin, S., additional, Visser, O., additional, Oostvogels, R., additional, Janssen, P. M., additional, Huls, G. A., additional, Vermaat, J. S.P., additional, and Nijland, M., additional

Published
2021
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24. Inferior outcome of addition of the aminopeptidase inhibitor tosedostat to standard intensive treatment for elderly patients with aml and high risk mds

Author

Janssen, J. (Jeroen), Löwenberg, B. (Bob), Manz, M. (Markus), Bargetzi, M. (Mario), Biemond, B.J. (Bart), Borne, P.A.K. (Peter) von dem, Breems, D.A. (Dimitri), Brouwer, R.E. (Rolf), Chalandon, Y. (Yves), Deeren, D. (Dries), Efthymiou, A. (Anna), Gjertsen, B.-T. (Bjørn-Tore), Graux, C. (Carlos), Gregor, M. (Michael), Heim, D. (Dominik), Hess, U. (Urs), Hoogendoorn, M. (Mels), Jaspers, A. (Aurelie), Jie, A. (Asiong), Jongen-Lavrencic, M. (Mojca), Klein, S. (Saskia), Klift, M. (Marjolein) van der, Kuball, J. (Jürgen), van Lammeren - Venema, D. (Danielle), Legdeur, M.C.J.C. (M. C J C), Loosdrecht, A.A. (Arjan) van de, Maertens, J. (Johan), Kooy, M.M. (Marinus van Marwijk), Moors, I. (Ine), Nijziel, M.R. (Marten), van Obbergh, F. (Florence), Oosterveld, M. (Margriet), Pabst, T. (Thomas), van der Poel, M. (Marjolein), Sinnige, H. (Harm), Spertini, O. (Olivier), Terpstra, W. (Wim), Tick, L.W. (Lidwine), Velden, W.J.F.M. (Walter) van der, Vekemans, M.-C. (Marie-Christiane), Vellenga, E. (Edo), Weerdt, O. (Okke) de, Westerweel, P. (Peter), Stussi, G. (Georg), Norden, Y. (Yvette) van, Ossenkoppele, G.J. (Gert), Janssen, J. (Jeroen), Löwenberg, B. (Bob), Manz, M. (Markus), Bargetzi, M. (Mario), Biemond, B.J. (Bart), Borne, P.A.K. (Peter) von dem, Breems, D.A. (Dimitri), Brouwer, R.E. (Rolf), Chalandon, Y. (Yves), Deeren, D. (Dries), Efthymiou, A. (Anna), Gjertsen, B.-T. (Bjørn-Tore), Graux, C. (Carlos), Gregor, M. (Michael), Heim, D. (Dominik), Hess, U. (Urs), Hoogendoorn, M. (Mels), Jaspers, A. (Aurelie), Jie, A. (Asiong), Jongen-Lavrencic, M. (Mojca), Klein, S. (Saskia), Klift, M. (Marjolein) van der, Kuball, J. (Jürgen), van Lammeren - Venema, D. (Danielle), Legdeur, M.C.J.C. (M. C J C), Loosdrecht, A.A. (Arjan) van de, Maertens, J. (Johan), Kooy, M.M. (Marinus van Marwijk), Moors, I. (Ine), Nijziel, M.R. (Marten), van Obbergh, F. (Florence), Oosterveld, M. (Margriet), Pabst, T. (Thomas), van der Poel, M. (Marjolein), Sinnige, H. (Harm), Spertini, O. (Olivier), Terpstra, W. (Wim), Tick, L.W. (Lidwine), Velden, W.J.F.M. (Walter) van der, Vekemans, M.-C. (Marie-Christiane), Vellenga, E. (Edo), Weerdt, O. (Okke) de, Westerweel, P. (Peter), Stussi, G. (Georg), Norden, Y. (Yvette) van, and Ossenkoppele, G.J. (Gert)

Abstract

Treatment results of AML in elderly patients are unsatisfactory. We hypothesized that addition of tosedostat, an aminopeptidase inhibitor, to intensive chemotherapy may improve outcome in this population. After establishing a safe dose in a run-in phase of the study in 22 patients, 231 eligible patients with AML above 65 years of age (median 70, range 66–81) were randomly assigned in this open label randomized Phase II study to receive standard chemotherapy (3+7) with or without tosedostat at the selected daily dose of 120 mg (n = 116), days 1–21. In the second cycle, patients received cytarabine 1000 mg/m2 twice daily on days 1-6 with or without tosedostat. CR/CRi rates in the 2 arms were not significantly different (69% (95% C.I. 60–77%) vs 64% (55–73%), respectively). At 24 months, event-free survival (EFS) was 20% for the standard arm versus 12% for the tosedostat arm (Cox-p = 0.01) and overall survival (OS) 33% vs 18% respectively (p = 0.006). Infectious complications accounted for an increased early death rate in the tosedostat arm. Atrial fibrillation wa

Published
2021
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25. Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improve Transplantation Outcomes in Older Patients with Myelodysplastic Syndromes

Author

Oran, B, Ahn, KW, Fretham, C, Beitinjaneh, A, Bashey, A, Pawarode, A, Wirk, B, Scott, BL, Savani, BN, Bredeson, C, Weisdorf, D, Marks, DI, Rizzieri, D, Copelan, E, Hildebrandt, GC, Hale, GA, Murthy, HS, Lazarus, HM, Cerny, J, Liesveld, JL, Yared, JA, Yves-Cahn, J, Szer, J, Verdonck, LF, MahmoudAljurf, van der Poel, M, Litzow, M, Kalaycio, M, Grunwald, MR, AngelDiaz, M, Sabloff, M, Kharfan-Dabaja, MA, Majhail, NS, Farhadfar, N, Reshef, R, Olsson, RF, Gale, RP, Nakamura, R, Seo, S, Chhabra, S, Hashmi, S, Farhan, S, Ganguly, S, Nathan, S, TaigaNishihori, Jain, T, VaibhavAgrawal, Bacher, U, Popat, U, Saber, W, Oran, B, Ahn, KW, Fretham, C, Beitinjaneh, A, Bashey, A, Pawarode, A, Wirk, B, Scott, BL, Savani, BN, Bredeson, C, Weisdorf, D, Marks, DI, Rizzieri, D, Copelan, E, Hildebrandt, GC, Hale, GA, Murthy, HS, Lazarus, HM, Cerny, J, Liesveld, JL, Yared, JA, Yves-Cahn, J, Szer, J, Verdonck, LF, MahmoudAljurf, van der Poel, M, Litzow, M, Kalaycio, M, Grunwald, MR, AngelDiaz, M, Sabloff, M, Kharfan-Dabaja, MA, Majhail, NS, Farhadfar, N, Reshef, R, Olsson, RF, Gale, RP, Nakamura, R, Seo, S, Chhabra, S, Hashmi, S, Farhan, S, Ganguly, S, Nathan, S, TaigaNishihori, Jain, T, VaibhavAgrawal, Bacher, U, Popat, U, and Saber, W

Published
2021

26. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cancer, Görgec, B., Fichtinger, R. S., Ratti, F., Aghayan, D., Van der Poel, M. J., Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, ÅA, Suhool, A., Bemelmans, M., Bosscha, K., Braat, A. E., De Boer, M. T., Dejong, C. H.C., Doornebosch, P. G., Draaisma, W. A., Gerhards, M. F., Gobardhan, P. D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W. K.G., Liem, M. S., Lips, D. J., Marsman, H. A., Mieog, J. S.D., Molenaar, Q. I., Nieuwenhuijs, V. B., Nota, C. L., Patijn, G. A., Rijken, A. M., Slooter, G. D., Stommel, M. W.J., Swijnenburg, R. J., Tanis, P. J., Te Riele, W. W., Terkivatan, T., Van den Tol, P. M.P., Van den Boezem, P. B., Van der Hoeven, J. A., Vermaas, M., Edwin, B., Aldrighetti, L. A., Van Dam, R. M., Abu Hilal, M., Besselink, M. G., Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cancer, Görgec, B., Fichtinger, R. S., Ratti, F., Aghayan, D., Van der Poel, M. J., Al-Jarrah, R., Armstrong, T., Cipriani, F., Fretland, ÅA, Suhool, A., Bemelmans, M., Bosscha, K., Braat, A. E., De Boer, M. T., Dejong, C. H.C., Doornebosch, P. G., Draaisma, W. A., Gerhards, M. F., Gobardhan, P. D., Hagendoorn, J., Kazemier, G., Klaase, J., Leclercq, W. K.G., Liem, M. S., Lips, D. J., Marsman, H. A., Mieog, J. S.D., Molenaar, Q. I., Nieuwenhuijs, V. B., Nota, C. L., Patijn, G. A., Rijken, A. M., Slooter, G. D., Stommel, M. W.J., Swijnenburg, R. J., Tanis, P. J., Te Riele, W. W., Terkivatan, T., Van den Tol, P. M.P., Van den Boezem, P. B., Van der Hoeven, J. A., Vermaas, M., Edwin, B., Aldrighetti, L. A., Van Dam, R. M., Abu Hilal, M., and Besselink, M. G.

Published
2021

27. Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

Author

Fransen, N.L. (Nina L.), Hsiao, C.-C. (Cheng-Chih), van der Poel, M. (Marlijn), Engelenburg, H.J. (Hendrik J.), Verdaasdonk, K. (Kim), Vincenten, M.C.J. (Maria C J), Remmerswaal, D. (Daniëlle), Kuhlmann, T. (Tanja), Mason, M.R.J. (Matthew R J), Hamann, J. (Jörg), Smolders, J. (Joost), Huitinga, I. (Inge), Fransen, N.L. (Nina L.), Hsiao, C.-C. (Cheng-Chih), van der Poel, M. (Marlijn), Engelenburg, H.J. (Hendrik J.), Verdaasdonk, K. (Kim), Vincenten, M.C.J. (Maria C J), Remmerswaal, D. (Daniëlle), Kuhlmann, T. (Tanja), Mason, M.R.J. (Matthew R J), Hamann, J. (Jörg), Smolders, J. (Joost), and Huitinga, I. (Inge)

Abstract

Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines. We recently showed in the Netherlands Brain Bank multiple sclerosis-autopsy cohort considerable ongoing inflammatory lesion activity also at the end stage of the disease, based on microglia/macrophage activity. We have now studied the role of T cells in this ongoing inflammatory lesion activity in chronic multiple sclerosis autopsy cases. We quantified T cells and perivascular T-cell cuffing at a standardized location in the medulla oblongata in 146 multiple sclerosis, 20 neurodegenerative control and 20 non-neurological control brain donors. In addition, we quantified CD3+, CD4+, and CD8+ T cells in 140 subcortical white matter lesions. The location of CD8+ T cells in either the perivascular space or the brain parenchyma was determined using CD8/laminin staining and confocal imaging. Finally, we analysed CD8+ T cells, isolated from fresh autopsy tissues from subcortical multiple sclerosis white matter lesions (n = 8), multiple sclerosis normal-app

Published
2020
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29. Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

Author

UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'hématologie, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Ossenkoppele, G. J., Breems, D. A., Stuessi, G., van Norden, Y., Bargetzi, M., Biemond, B. J., A von dem Borne, P., Chalandon, Y., Cloos, J., Deeren, D., Fehr, M., Gjertsen, B., Graux, Carlos, Huls, G., Janssen, J. J. J. W., Jaspers, A., Jongen-Lavrencic, M., de Jongh, E., Klein, S. K., van der Klift, M., van Marwijk Kooy, M., Maertens, J., Michaux, L., van der Poel, M. W. M., van Rhenen, A., Tick, L., Valk, P., Vekemans, Marie-Christiane, van der Velden, W. J. F. M., de Weerdt, O., Pabst, T., Manz, M., Löwenberg, B., Havelange, Violaine, Sonet, Anne, UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'hématologie, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Ossenkoppele, G. J., Breems, D. A., Stuessi, G., van Norden, Y., Bargetzi, M., Biemond, B. J., A von dem Borne, P., Chalandon, Y., Cloos, J., Deeren, D., Fehr, M., Gjertsen, B., Graux, Carlos, Huls, G., Janssen, J. J. J. W., Jaspers, A., Jongen-Lavrencic, M., de Jongh, E., Klein, S. K., van der Klift, M., van Marwijk Kooy, M., Maertens, J., Michaux, L., van der Poel, M. W. M., van Rhenen, A., Tick, L., Valk, P., Vekemans, Marie-Christiane, van der Velden, W. J. F. M., de Weerdt, O., Pabst, T., Manz, M., Löwenberg, B., Havelange, Violaine, and Sonet, Anne

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

30. Comparing Practice and Outcome of Laparoscopic Liver Resection Between High-volume Expert Centres and Nationwide Low-medium Volume Centres

Author

Görgec, B., primary, Fichtinger, R., additional, Ratti, F., additional, Aghayan, D., additional, van der Poel, M., additional, Al-Jarrah, R., additional, Armstrong, T., additional, Cipriani, F., additional, Fretland, Å., additional, Suhool, A., additional, Bemelmans, M., additional, Bosscha, K., additional, Braat, A., additional, de Boer, M., additional, Dejong, C., additional, Doornebosch, P., additional, Draaisma, W., additional, Gerhards, M., additional, Gobardhan, P., additional, Hagendoorn, J., additional, Kazemier, G., additional, Klaase, J., additional, Leclerq, W., additional, Liem, M., additional, Lips, D., additional, Marsman, H., additional, Mieog, J., additional, Molenaar, Q., additional, Nieuwenhuijs, V., additional, Nota, C., additional, Patijn, G., additional, Rijken, A., additional, Slooter, G., additional, Stommel, M., additional, Swijnenburg, R., additional, Tanis, P., additional, Riele, W. Te, additional, Terkivatan, T., additional, van den Tol, P., additional, van den Boezem, P., additional, van der Hoeven, J., additional, Vermaas, M., additional, Edwin, B., additional, Aldrighetti, L., additional, van Dam, R., additional, Hilal, M. Abu, additional, and Besselink, M., additional

Published
2021
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31. Book reviews

Author

Samons, Loren J., Mossé, Claude, Barnes, Jonathan, Konstan, David, Newmyer, Stephen T., Fantham, Elaine, Heinen, Heinz, Delia, Diana, Vigo, Alejandro G., Laiou, Angeliki E., Bouchard, Constance B., Ewans, Michael, van der Poel, M., Sturdy, David J., Knape, Joachim, Zoberman, Pierre, Kennedy, George A., Tomory, Peter, Lambropoulos, Vassilis, Ziolkowski, John E., and Arkins, Brian

Published
2000
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32. Book reviews

Author

Buller, Jeffrey L., Evans, James Allan, Lapatin, Kenneth D. S., Lloyd-Jones, K., Zimmermann, Bernhard, Walter, Uwe, Gobbo, Elena, Newmyer, Stephen T., Galinsky, Karl, Benoist, Stéphane, Stok, Fabio, Finney, Paul Corby, Mundhenk, Christine, Delia, Diana, Ludwig, Walther, van der Poel, M., Braden, Gordon, King, Helen, Burrow, Colin, Maia Neto, José R., Knape, Joachim, Till, Dietmar, and Dyck, Andrew R.

Published
2000
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34. Book reviews

Author

Irigoin, Jean, Howe, Thomas N., Rayor, Diane J., Revermann, Martin, Wiesehöfer, Josef, Hadas-Lebel, Mireille, Feldman, Louis H., Lefèvre, Eckard, Giua, Maria Antonietta, Glei, Reinhold F., Clauss, James J., Putnam, Michael C. J., Sara Myers, K., Torjesen, Karen Jo, Winkler, Martin M., Beatrice, Pier Franco, Lewis, Catrin, van der Poel, M., Schuler, Christof, Burnett, Charles, Martin, Christopher, Fantazzi, Charles E., Feld, Helmut, Yoch, James J., Lyons, John D., Brinkmann, Klaus, Kunst, Christiane, and Richard, Carl J.

Published
2000
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35. Pure laparoscopic versus open hemihepatectomy: A critical assessment and realistic expectations. A propensity score based analysis of right and left hemihepatectomies from 9 European tertiary referral centers

Author

Cipriani, F., primary, Alzoubi, M., additional, Fuks, D., additional, Ratti, F., additional, Kawai, T., additional, Berardi, G., additional, Barkhatov, L., additional, Lainas, P., additional, Van der Poel, M., additional, Faoury, M., additional, Besselink, M., additional, D'Hondt, M., additional, Dagher, I., additional, Edwin, B., additional, Troisi, R., additional, Scatton, O., additional, Gayet, B., additional, Aldrighetti, L., additional, and Hilal, M Abu, additional

Published
2020
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38. Book reviews

Author

Freiert, William K., Kytzler, Bernhard, Corbeill, Anthony, Langer, Ullrich, Smith, Pamela H., Schmitz, Thomas A., Smarr, Janet Levarie, van der Poel, M., Finney, Paul Corby, Barnes, Timothy D., Tinnefeld, Franz, Köpf, Ulrich, IJsewijn, Jozef, Trapp, J. B., Muhlack, Ulrich, Mund-Dopchie, Monique, Behler, Ernst, Miller, Peter N., Tomory, Peter, Williams, Linda, and Jaumann, Herbert

Published
1997
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39. Book reviews

Author

Holzberg, Niklas, Smith, Warren S., van der Poel, M., Steadman, John M., and Delia, Diana

Published
1996
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41. Litterae Neolatinae

Author

van der Poel, M.

Subjects
Litterae Neolatinae (Book) -- Book reviews, Books -- Book reviews, Anthropology/archeology/folklore, History
Published
1994

44. Richtlijn Acute promyelocytenleukemie (APL): richtlijnen voor diagnostiek en behandeling

Author

Huls, Geert, Lowenberg, B., van de Loosdrecht, A.A., Janssen, J.J.W.M., Jongen-Lavrencic, M., Raaijmakers, M., Wouters, B., Von dem Borne, Peter A., Kuball, Jurgen, Biemond, Bart J., Van Gelder, Michel, van der Velden, W.J.F.M, de Weerdt, Okke, van Marwijk Kooy, Rien, Klein, Saskia, van der Poel, M., van Rhenen, A., Jong, J.J.M. de, Valk, P, van der Reijden, B., Cornelissen, J.J., Vellenga, Edo, Ossenkoppele, G., Stem Cell Aging Leukemia and Lymphoma, and Guided Treatment in Optimal Selected Cancer Patients

Abstract

Acute myeloïde leukemie (AML) is een heterogene ziekte die wordt gekenmerkt door (oligo)klonale maligne hematopoëse met een blokkade in de differentiatie en daardoor een excessieve toename van leukemische blasten. Acute promyelocytenleukemie (APL) is een zeldzame variant van AML die zich goed laat behandelen met ATRA-bevattende therapie. Vanwege complicaties van de ziekte (trombose, bloeding) is vroege herkenning en start van behandeling extreem belangrijk. Het is daarom belangrijk dat diagnostiek en behandeling van APL-patiënten in de dagelijkse praktijk zorgvuldig en gestructureerd plaatsvindt. Hieronder bespreken we de richtlijnen voor diagnostiek en behandeling zoals de HOVONLeukemiewerkgroep denkt dat die voor APL zou moeten plaatsvinden

Published
2018

47. Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases

Author

van der Poel, M J, primary, Barkhatov, L, additional, Fuks, D, additional, Berardi, G, additional, Cipriani, F, additional, Aljaiuossi, A, additional, Lainas, P, additional, Dagher, I, additional, D'Hondt, M, additional, Rotellar, F, additional, Besselink, M G, additional, Aldrighetti, L, additional, Troisi, R I, additional, Gayet, B, additional, Edwin, B, additional, and Abu Hilal, M, additional

Published
2019
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