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2. Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer – Results of the international randomized RAPIDO-trial

Author

van der Valk, Maxime J.M., Marijnen, Corrie A.M., van Etten, Boudewijn, Dijkstra, Esmée A., Hilling, Denise E., Kranenbarg, Elma Meershoek-Klein, Putter, Hein, Roodvoets, Annet G.H., Bahadoer, Renu R., Fokstuen, Tone, ten Tije, Albert Jan, Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andrès M.R., de Groot, Derk Jan A., Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J.H., and Hospers, Geke A.P.

Published
2020
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3. Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Author

Geffen, Eline G.M. van, primary, Nederend, Joost, additional, Sluckin, Tania C., additional, Hazen, Sanne-Marije J.A., additional, Horsthuis, Karin, additional, Beets-Tan, Regina G.H., additional, Marijnen, Corrie A.M., additional, Tanis, Pieter J., additional, Kusters, Miranda, additional, Aalbers, Arend G.J., additional, van Aalten, Susanna M., additional, Amelung, Femke J., additional, Ankersmit, Marjolein, additional, Antonisse, Imogeen E., additional, Ashruf, Jesse F., additional, Aukema, Tjeerd S., additional, Avenarius, Henk, additional, Bahadoer, Renu R., additional, Bakers, Frans C.H., additional, Bakker, Ilsalien S., additional, Bangert, Fleur, additional, Barendse, Renée M., additional, Beekhuis, Heleen M.D., additional, Beets, Geerard L., additional, Bemelman, Willem A., additional, Berbée, Maaike, additional, de Bie, Shira H., additional, Bisschops, Robert H.C., additional, Blok, Robin D., additional, van Bockel, Liselotte W., additional, Boer, Anniek H., additional, den Boer, Frank C., additional, Boerma, Evert-Jan G., additional, Boogerd, Leonora S.F., additional, Borstlap, Jaap, additional, Borstlap, Wernard A.A., additional, Bouwman, Johanna E., additional, Braak, Sicco J., additional, Braat, Manon N.G.J.A., additional, Bradshaw, Jennifer, additional, Brandsma, Amarins T.A., additional, van Breest Smallenburg, Vivian, additional, van den Broek, Wim T., additional, van der Burg, Sjirk W., additional, Burger, Jacobus W.A., additional, Burghgraef, Thijs A., additional, ten Cate, David W.G., additional, Ceha, Heleen M., additional, Cnossen, Jeltsje S., additional, Coebergh van den Braak, Robert R.J., additional, Consten, Esther C.J., additional, Corver, Maaike, additional, Crolla, Rogier M.P.H., additional, Curutchet, Sam, additional, Daniëls-Gooszen, Alette W., additional, Davids, Paul H.P., additional, Dekker, Emmelie N., additional, Dekker, Jan Willem T., additional, Demirkiran, Ahmet, additional, Derksen, Tyche, additional, Diederik, Arjen L., additional, Dinaux, Anne M., additional, Dogan, Kemal, additional, van Dop, Ilse M., additional, Droogh-de Greve, Kitty E., additional, Duijsens, Hanneke M.H., additional, Dunker, Michalda S., additional, Duyck, Johan, additional, van Duyn, Eino B., additional, van Egdom, Laurentine S.E., additional, Eijlers, Bram, additional, El-Massoudi, Youssef, additional, van Elderen, Saskia, additional, Emmen, Anouk M.L.H., additional, Engelbrecht, Marc, additional, van Erp, Anne C., additional, van Essen, Jeroen A., additional, Fabry, Hans F.J., additional, Fassaert, Thomas, additional, Feitsma, Eline A., additional, Feshtali, Shirin S., additional, Frietman, Bas, additional, Furnée, Edgar J.B., additional, van Geel, Anne M., additional, Geijsen, Elisabeth D., additional, van Geloven, Anna A.W., additional, Gerhards, Michael F., additional, Gielkens, Hugo, additional, van Gils, Renza A.H., additional, Goense, Lucas, additional, Govaert, Marc J.P.M., additional, van Grevenstein, Wilhelmina M.U., additional, Joline de Groof, E., additional, de Groot, Irene, additional, de Haas, Robbert J., additional, Hakkenbrak, Nadia A.G., additional, den Hartogh, Mariska D., additional, Heesink, Vera, additional, Heikens, Joost T., additional, Hendriksen, Ellen M., additional, van den Hoek, Sjoerd, additional, van der Hoeven, Erik J.R.J., additional, Hoff, Christiaan, additional, Hogewoning, Anna, additional, Hogewoning, Cornelis R.C., additional, Hoogendoorn, Stefan, additional, van Hoorn, Francois, additional, van der Hul, René L., additional, van Hulst, Rieke, additional, Imani, Farshad, additional, Inberg, Bas, additional, Intven, Martijn P.W., additional, Janssen, Pedro, additional, de Jong, Chris E.J., additional, Jonkers, Jacoline, additional, Jou-Valencia, Daniela, additional, Keizers, Bas, additional, Ketelaers, Stijn H.J., additional, Knöps, Eva, additional, van Koeverden, Sebastiaan, additional, Kok, Sylvia, additional, Kolderman, Stephanie E.M., additional, de Korte, Fleur I., additional, Kortekaas, Robert T.J., additional, Korving, Julie C., additional, Koster, Ingrid M., additional, Krdzalic, Jasenko, additional, Krielen, Pepijn, additional, Kroese, Leonard F., additional, Krul, Eveline J.T., additional, Lahuis, Derk H.H., additional, Lamme, Bas, additional, van Landeghem, An A.G., additional, Leijtens, Jeroen W.A., additional, Leseman-Hoogenboom, Mathilde M., additional, de Lijster, Manou S., additional, Marsman, Martijn S., additional, Martens, MilouH., additional, Masselink, Ilse, additional, van der Meij, Wout, additional, Meijnen, Philip, additional, Melenhorst, Jarno, additional, de Mey, Dietrich J.L., additional, Moelker-Galuzina, Julia, additional, Morsink, Linda, additional, Mulder, Erik J., additional, Muller, Karin, additional, Musters, Gijsbert D., additional, Neijenhuis, Peter A., additional, de Nes, Lindsey C.F., additional, Nielen, M., additional, van den Nieuwboer, Jan B.J., additional, Nieuwenhuis, Jonanne F., additional, Nonner, Joost, additional, Noordman, Bo J., additional, Nordkamp, Stefi, additional, Olthof, Pim B., additional, Oosterling, Steven J., additional, Ootes, Daan, additional, Oppedijk, Vera, additional, Ott, Pieter, additional, Paulusma, Ida, additional, Peeters, Koen C.M.J., additional, Pereboom, Ilona T.A., additional, Peringa, Jan, additional, Pironet, Zoë, additional, Plate, Joost D.J., additional, Polat, Fatih, additional, Poodt, Ingrid G.M., additional, Posma, Lisanne A.E., additional, Prette, Jeroen F., additional, Pultrum, Bareld B., additional, Qaderi, Seyed M., additional, van Rees, Jan M., additional, Renger, Rutger-Jan, additional, Rombouts, Anouk J.M., additional, Roosen, Lodewijk J., additional, Roskott-ten Brinke, Ellen A., additional, Rothbarth, Joost, additional, Rouw, Dennis B., additional, Rozema, Tom, additional, Rütten, Heidi, additional, Rutten, Harm J.T., additional, van der Sande, Marit E., additional, Schaafsma, Boudewijn E., additional, Schasfoort, Renske A., additional, Scheurkogel, Merel M., additional, Schouten van der Velden, Arjan P., additional, Schreurs, Wilhelmina H., additional, Schuivens, Puck M.E., additional, Sietses, Colin, additional, Simons, Petra C.G., additional, Slob, Marjan J., additional, Slooter, Gerrit D., additional, van der Sluis, Martsje, additional, Smalbroek, Bo P., additional, Smits, Anke B., additional, Spillenaar-Bilgen, Ernst J., additional, Spruit, Patty H., additional, Stam, Tanja C., additional, Stoker, Jaap, additional, Talsma, Aaldert K., additional, Temmink, Sofieke J.D., additional, The, G.Y. Mireille, additional, Tielbeek, Jeroen A.W., additional, van Tilborg, Aukje A.J.M., additional, van Tilborg, Fiek, additional, van Trier, Dorothée, additional, Tuynman, Jurriaan B., additional, van der Valk, Maxime J.M., additional, Vanhooymissen, Inge J.S., additional, Vasbinder, G. Boudewijn C., additional, Veeken, Cornelis J., additional, Velema, Laura A., additional, van de Ven, Anthony W.H., additional, Verdaasdonk, Emiel G.G., additional, Verduin, Wouter M., additional, Verhagen, Tim, additional, Verheijen, Paul M., additional, Vermaas, Maarten, additional, Verrijssen, An-Sofie E., additional, Verschuur, Anna V.D., additional, Schaik, Harmke Verwoerd-van, additional, Vliegen, Roy F.A., additional, Voets, Sophie, additional, Vogelaar, F. Jeroen, additional, Vogelij, Clementine L.A., additional, Vos-Westerman, Johanna, additional, de Vries, Marianne, additional, Vroemen, Joy C., additional, van Vugt, Bas S.T., additional, Wegdam, Johannes A., additional, van Wely, Bob J., additional, Westerterp, Marinke, additional, van Westerveld, Paul P., additional, van Westreenen, Henderik L., additional, Wijma, Allard G., additional, de Wilt, Johannes H.W., additional, de Wit, Bart W.K., additional, Wit, Fennie, additional, Woensdregt, Karlijn, additional, van Woerden, Victor, additional, van der Wolf, Floor S.W., additional, van der Wolk, Sander, additional, Wybenga, Johannes M., additional, van der Zaag, Edwin S., additional, Zamaray, Bobby, additional, Zandvoort, Herman J.A., additional, van der Zee, Dennis, additional, Zeilstra, Annette P., additional, Zheng, Kang J., additional, Zimmerman, David D.E., additional, and Zorgdrager, Marcel, additional

Published
2024
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6. Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting

Author

Sluckin, Tania C., Hazen, Sanne Marije J.A., Horsthuis, Karin, Beets-Tan, Regina G.H., Aalbers, Arend G.J., Beets, Geerard L., Boerma, Evert Jan G., Borstlap, Jaap, van Breest Smallenburg, Vivian, Burger, Jacobus W.A., Crolla, Rogier M.P.H., Daniëls-Gooszen, Alette W., Davids, Paul H.P., Dunker, Michalda S., van Gils, Renza A.H., van Koeverden, Sebastiaan, Oosterling, Steven J., Rothbarth, Joost, Talsma, Aaldert K., Vanhooymissen, Inge J.S., Verdaasdonk, Emiel G.G., Vermaas, Maarten, de Vries, Marianne, Tanis, Pieter J., van Aalten, Susanna M., Antonisse, Imogeen E., Cate, David W.G.ten, Curutchet, Sam, Dekker, Emmelie N., Demirkiran, Ahmet, van Egdom, Laurentine S.E., El-Massoudi, Youssef, van Elderen, Saskia, van den Hoek, Sjoerd, Hoff, Christiaan, Imani, Farshad, Kok, Sylvia, Koster, Ingrid M., Kroese, Leonard F., Muller, Karin, Noordman, Bo J., Olthof, Pim B., van Rees, Jan M., Roosen, Lodewijk J., Spillenaar-Bilgen, Ernst J., van der Valk, Maxime J.M., Velema, Laura A., Verhagen, Tim, van Westerveld, Paul P., Zheng, Kang J., Sluckin, Tania C., Hazen, Sanne Marije J.A., Horsthuis, Karin, Beets-Tan, Regina G.H., Aalbers, Arend G.J., Beets, Geerard L., Boerma, Evert Jan G., Borstlap, Jaap, van Breest Smallenburg, Vivian, Burger, Jacobus W.A., Crolla, Rogier M.P.H., Daniëls-Gooszen, Alette W., Davids, Paul H.P., Dunker, Michalda S., van Gils, Renza A.H., van Koeverden, Sebastiaan, Oosterling, Steven J., Rothbarth, Joost, Talsma, Aaldert K., Vanhooymissen, Inge J.S., Verdaasdonk, Emiel G.G., Vermaas, Maarten, de Vries, Marianne, Tanis, Pieter J., van Aalten, Susanna M., Antonisse, Imogeen E., Cate, David W.G.ten, Curutchet, Sam, Dekker, Emmelie N., Demirkiran, Ahmet, van Egdom, Laurentine S.E., El-Massoudi, Youssef, van Elderen, Saskia, van den Hoek, Sjoerd, Hoff, Christiaan, Imani, Farshad, Kok, Sylvia, Koster, Ingrid M., Kroese, Leonard F., Muller, Karin, Noordman, Bo J., Olthof, Pim B., van Rees, Jan M., Roosen, Lodewijk J., Spillenaar-Bilgen, Ernst J., van der Valk, Maxime J.M., Velema, Laura A., Verhagen, Tim, van Westerveld, Paul P., and Zheng, Kang J.

Abstract

Background: Involved lateral lymph nodes (LLNs) have been associated with increased local recurrence (LR) and ipsi-lateral LR (LLR) rates. However, consensus regarding the indication and type of surgical treatment for suspicious LLNs is lacking. This study evaluated the surgical treatment of LLNs in an untrained setting at a national level. Methods: Patients who underwent additional LLN surgery were selected from a national cross-sectional cohort study regarding patients undergoing rectal cancer surgery in 69 Dutch hospitals in 2016. LLN surgery consisted of either ‘node-picking’ (the removal of an individual LLN) or ‘partial regional node dissection’ (PRND; an incomplete resection of the LLN area). For all patients with primarily enlarged (≥7 mm) LLNs, those undergoing rectal surgery with an additional LLN procedure were compared to those undergoing only rectal resection. Results: Out of 3057 patients, 64 underwent additional LLN surgery, with 4-year LR and LLR rates of 26% and 15%, respectively. Forty-eight patients (75%) had enlarged LLNs, with corresponding recurrence rates of 26% and 19%, respectively. Node-picking (n = 40) resulted in a 20% 4-year LLR, and a 14% LLR after PRND (n = 8; p = 0.677). Multivariable analysis of 158 patients with enlarged LLNs undergoing additional LLN surgery (n = 48) or rectal resection alone (n = 110) showed no significant association of LLN surgery with 4-year LR or LLR, but suggested higher recurrence risks after LLN surgery (LR: hazard ratio [HR] 1.5, 95% confidence interval [CI] 0.7–3.2, p = 0.264; LLR: HR 1.9, 95% CI 0.2–2.5, p = 0.874). Conclusion: Evaluation of Dutch practice in 2016 revealed that approximately one-third of patients with primarily enlarged LLNs underwent surgical treatment, mostly consisting of node-picking. Recurrence rates were not significantly affected by LLN surgery, but did suggest worse outcomes. Outcomes of LLN surgery after adequate training requires further research.

Published
2023

8. Intra-tumoral genomic heterogeneity in rectal cancer:Mutational status is dependent on preoperative biopsy depth and location

Author

Vuijk, Floris A., van de Water, Carlijn, Lent-Van Vliet, Shannon, van der Valk, Maxime J.M., Simmer, Femke, van de Velde, Cornelis J.H., Vahrmeijer, Alexander L., Nagtegaal, Iris D., Hilling, Denise E., Vuijk, Floris A., van de Water, Carlijn, Lent-Van Vliet, Shannon, van der Valk, Maxime J.M., Simmer, Femke, van de Velde, Cornelis J.H., Vahrmeijer, Alexander L., Nagtegaal, Iris D., and Hilling, Denise E.

Abstract

Neoadjuvant therapy before surgical resection is indicated for patients with locally advanced rectal cancer. However, a significant number of patients show minimal or no response to neoadjuvant therapy. Unfortunately, we are currently unable to predict response and identify non-responding patients before neoadjuvant treatment is given. Genomic mutational status might provide valuable prognostic information. However, it is unclear whether predictions based on genomic mutational status in single preoperative biopsies are reliable due to intra-tumoral heterogeneity. In this study we aim to investigate the reliability of genomic mutations found in single pre-operative biopsies by comparing genomic mutations to four other locations within the same tumor using next generation sequencing. Rectal cancer patients undergoing primary resection without neoadjuvant therapy were included. From each patient, one biopsy, two deep and two superficial samples were obtained and sequenced using a targeted next generation sequencing gene panel. Concordance between these five samples was assessed. In this feasibility study we included 11 patients. In 7 out of 11 (64%) patients, all 5 samples showed concordant mutations. In 4 out of 11 patients (36%) discordant mutations were observed. In conclusion, assessment of mutational status on a single pre-operative biopsy shows discordance with tumor tissue from other locations in 36% of cases. These results warrant careful interpretation of biopsy material analysis, as these might be influenced by tumor heterogeneity.

Published
2021

9. Importance of patient reported and clinical outcomes for patients with locally advanced rectal cancer and their treating physicians. Do clinicians know what patients want?

Author

van der Valk, Maxime J.M., primary, van der Sande, Marit E., additional, Toebes, Renee E., additional, Breukink, Stephanie O., additional, Bröker, Mirelle E.E., additional, Doornebosch, Pascal G., additional, Maliko, Nansi, additional, Neijenhuis, Peter A., additional, Marinelli, Andreas W.K.S., additional, Peters, Femke P., additional, Peeters, Koen C.M.J., additional, Beets, Geerard L., additional, Marang-van de Mheen, Perla J., additional, and Hilling, Denise E., additional

Published
2020
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10. Erratum to “Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer – Results of the international randomized RAPIDO-trial” [Radiother. Oncol. 147 (2020) 75–83]

Author

van der Valk, Maxime J.M., primary, Marijnen, Corrie A.M., additional, van Etten, Boudewijn, additional, Dijkstra, Esmée A., additional, Hilling, Denise E., additional, Meershoek-Klein Kranenbarg, Elma, additional, Putter, Hein, additional, Roodvoets, Annet G.H., additional, Bahadoer, Renu R., additional, Fokstuen, Tone, additional, Jan ten Tije, Albert, additional, Capdevila, Jaume, additional, Hendriks, Mathijs P., additional, Edhemovic, Ibrahim, additional, Cervantes, Andrès M.R., additional, de Groot, Derk Jan A., additional, Nilsson, Per J., additional, Glimelius, Bengt, additional, van de Velde, Cornelis J.H., additional, and Hospers, Geke A.P., additional

Published
2020
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