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1. From intra- to extra-uterine: early phase design of a transfer to extra-uterine life support through medical simulation.

Author

van Haren, J. S., Delbressine, F. L. M., Monincx, M., Hoveling, T., Meijer, N., Bangaru, C., Sterk, J., van der Woude, D. A. A., Oei, S. G., and van der Hout-van der Jagt, M. B.

Subjects
CESAREAN section, RISK assessment, DELIVERY (Obstetrics), VAGINA, MATERNAL health services, HUMAN anatomical models, INTERVIEWING, TECHNOLOGY, LIFE support systems in critical care, RESEARCH methodology, OBSTETRICS apparatus & instruments, SURGICAL instruments
Abstract

Introduction: Extra-uterine life support technology could provide a more physiologic alternative for the treatment of extremely premature infants, as it allows further fetal growth and development ex utero. Animal studies have been carried out which involved placing fetuses in a liquid-filled incubator, with oxygen supplied through an oxygenator connected to the umbilical vessels. Hence, by delaying lung exposure to air, further lung development and maturation can take place. This medical intervention requires adjustments to current obstetric procedures to maintain liquid-filled lungs through a so-called transfer procedure. Methods: Our objective was to develop obstetric device prototypes that allow clinicians to simulate this birth procedure to safely transfer the infant from the mother’s uterus to an extra-uterine life support system. To facilitate a usercentered design, implementation of medical simulation during early phase design of the prototype development was used. First, the requirements for the procedure and devices were established, by reviewing the literature and through interviewing direct stakeholders. The initial transfer device prototypes were tested on maternal and fetal manikins in participatory simulations with clinicians. Results & discussion: Through analysis of recordings of the simulations, the prototypes were evaluated on effectiveness, safety and usability with latent conditions being identified and improved. This medical simulation-based design process resulted in the development of a set of surgical prototypes and allowed for knowledge building on obstetric care in an extra-uterine life support context. [ABSTRACT FROM AUTHOR]

Published
2024
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2. T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination

Author

Verstegen, Niels J.M., Hagen, Ruth R., Kreher, Christine, Kuijper, Lisan H., van den Dijssel, Jet, Ashhurst, Thomas, Kummer, Laura Y.L., Cabeza, Virginia Palomares, Steenhuis, Maurice, Duurland, Mariël C., de Jongh, Rivka, van der Schoot, C. Ellen, Konijn, Veronique A.L., Mul, Erik, Kedzierska, Katherine, van Dam, Koos P.J., Stalman, Eileen W., Boekel, Laura, Wolbink, Gertjan, Tas, Sander W., Killestein, Joep, Rispens, Theo, Wieske, Luuk, Kuijpers, Taco W., Eftimov, Filip, van Kempen, Zoé L.E., van Ham, S. Marieke, ten Brinke, Anja, van de Sandt, Carolien E., vd Kooi, A. J., Raaphorst, J., Zwinderman, A. H.Koos, Löwenberg, M., Volkers, A. G., D'Haens, G. R.A.M., Takkenberg, R. B., Hilhorst, M. L., Keijzer, S., Keijser, J. B.D., Cristianawati, O., de Leeuw, K., Ruiter, A. M., van der Woude, D., Brusse, E., van Doorn, P. A., Baars, M. A.E., Hijnen, D. J., Schreurs, C. R.G., van der Pol, W. L., de Wit, J., Verstegen, Niels J.M., Hagen, Ruth R., Kreher, Christine, Kuijper, Lisan H., van den Dijssel, Jet, Ashhurst, Thomas, Kummer, Laura Y.L., Cabeza, Virginia Palomares, Steenhuis, Maurice, Duurland, Mariël C., de Jongh, Rivka, van der Schoot, C. Ellen, Konijn, Veronique A.L., Mul, Erik, Kedzierska, Katherine, van Dam, Koos P.J., Stalman, Eileen W., Boekel, Laura, Wolbink, Gertjan, Tas, Sander W., Killestein, Joep, Rispens, Theo, Wieske, Luuk, Kuijpers, Taco W., Eftimov, Filip, van Kempen, Zoé L.E., van Ham, S. Marieke, ten Brinke, Anja, van de Sandt, Carolien E., vd Kooi, A. J., Raaphorst, J., Zwinderman, A. H.Koos, Löwenberg, M., Volkers, A. G., D'Haens, G. R.A.M., Takkenberg, R. B., Hilhorst, M. L., Keijzer, S., Keijser, J. B.D., Cristianawati, O., de Leeuw, K., Ruiter, A. M., van der Woude, D., Brusse, E., van Doorn, P. A., Baars, M. A.E., Hijnen, D. J., Schreurs, C. R.G., van der Pol, W. L., and de Wit, J.

Abstract

Background:Messenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting anti-CD20 monoclonal antibody, is not yet fully understood. Methods:In this study, deep immune profiling techniques were employed to investigate the immune response induced by SARS-CoV-2 mRNA vaccines in untreated patients with MS (n=21), OCR-treated patients with MS (n=57) and healthy individuals (n=30). Results:Among OCR-treated patients with MS, 63% did not produce detectable levels of antibodies (non-seroconverted), and those who did have lower spike receptor-binding domain-specific IgG responses compared with healthy individuals and untreated patients with MS. Before vaccination, no discernible immunological differences were observed between non-seroconverted and seroconverted OCR-treated patients with MS. However, non-seroconverted patients received overall more OCR infusions, had shorter intervals since their last OCR infusion and displayed higher OCR serum concentrations at the time of their initial vaccination. Following two vaccinations, non-seroconverted patients displayed smaller B cell compartments but instead exhibited more robust activation of general CD4+ and CD8+ T cell compartments, as indicated by upregulation of CD38 and HLA-DR surface expression, when compared with seroconverted patients. Conclusion:These findings highlight the importance of optimising treatment regimens when scheduling SARS-CoV-2 vaccination for OCR-treated patients with MS to maximise their humoral and cellular immune responses. This study provides valuable insights for optimising vaccination strategies in OCR-treated patients with MS, including the identification of CD38 and HLA-DR as potential markers to explore vaccine efficacy in non-seroc

Published
2024

3. Nonlinear Flux Approximation Scheme for Burgers Equation Derived from a Local BVP

Author

ten Thije Boonkkamp, J. H. M., Kumar, N., Koren, B., van der Woude, D. A. M., Linke, A., Barth, Timothy J., Series Editor, Griebel, Michael, Series Editor, Keyes, David E., Series Editor, Nieminen, Risto M., Series Editor, Roose, Dirk, Series Editor, Schlick, Tamar, Series Editor, Radu, Florin Adrian, editor, Kumar, Kundan, editor, Berre, Inga, editor, Nordbotten, Jan Martin, editor, and Pop, Iuliu Sorin, editor

Published
2019
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4. Late-time backreaction from inflationary fluctuations of a non-minimally coupled massless scalar

Author

Glavan, D., Prokopec, T., and van der Woude, D.

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory
Abstract

We consider the late time one-loop quantum backreaction from inflationary fluctuations of a non-minimally coupled, massless scalar field. The scalar is assumed to be a spectator field in an inflationary model with a constant principal slow roll $\epsilon$ parameter. We regulate the infrared by matching onto a pre-inflationary radiation era. We find a large late time backreaction when the nonminimal coupling $\xi$ is negative (in which case the scalar exhibits a negative mass term during inflation). The one-loop quantum backreaction becomes significant today for moderately small non-minimal couplings, $\xi\sim -1/20$, and it changes sign (from negative to positive) at a recent epoch when inflation lasts not much longer than what is minimally required, $N \gtrsim 66$. Since currently we do not have a way of treating the classical fluid and the quantum backreaction in a self-consistent manner, we cannot say decidely whether the backreaction from inflationary quantum fluctuations of a non-minimally coupled scalar can mimic dark energy., Comment: 45 pages, 5 figures, uses RevTeX4.1

Published
2014
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8. POS0181 THE IMPACT OF AUTOANTIBODIES (RF AND ACPA) ON THE EFFICACY OF BIOLOGICAL DISEASE-MODIFYING ANTIRHEUMATIC DRUGS IN RHEUMATOID ARTHRITIS: META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Author

Takase-Minegishi, K., primary, Böhringer, S., additional, Nam, J., additional, Kaneko, Y., additional, Behrens, F., additional, Saevarsdottir, S., additional, Detert, J., additional, Leirisalo-Repo, M., additional, Van der Heijde, D., additional, Landewé, R. B. M., additional, Ramiro, S., additional, and Van der Woude, D., additional

Published
2023
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10. NT-proBNP and sRAGE levels in early rheumatoid arthritis

Author

UMC Utrecht Holding, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Heslinga, M., Teunissen, C., Agca, R., van der Woude, D., Huizinga, T. W.J., van Laar, J., den Broeder, A., Lems, W., Nurmohamed, M., UMC Utrecht Holding, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Heslinga, M., Teunissen, C., Agca, R., van der Woude, D., Huizinga, T. W.J., van Laar, J., den Broeder, A., Lems, W., and Nurmohamed, M.

Published
2023

11. Correction to: Risdiplam in Patients Previously Treated with Other Therapies for Spinal Muscular Atrophy: An Interim Analysis from the JEWELFISH Study (Neurology and Therapy, (2023), 12, 2, (543-557), 10.1007/s40120-023-00444-1)

Author

Chiriboga, C. A., Bruno, C., Duong, T., Fischer, D., Mercuri, Eugenio Maria, Kirschner, J., Kostera-Pruszczyk, A., Jaber, B., Gorni, K., Kletzl, H., Carruthers, I., Martin, Craig, Warren, F., Scalco, R. S., Wagner, K. R., Muntoni, F., Deconinck, N., Balikova, I., Joniau, I., Tahon, V., Wittevrongel, S., Goemans, N., Cassiman, C., Prove, L., Vancampenhout, L., van den Hauwe, M., Van Impe, A., Cances, C., Soler, V., De La Morandais, L. M., Vovan, D., Cintas, P., Auriol, F., Mus, M., Alphonsa, G., Bellio, V., Gil Mato, O., Flamein, F., Evrard, C., Ziouche, A., Bouacha-Allou, I., Debruyne, P., Derlyn, G., Defoort, S., Leroy, F., Danjoux, L., Desguerre, I., Bremond-Gignac, D., Rateuax, M., Deladriere, E., Vuillerot, C., Veillerot, Q., Sibille-Dabadi, B., Barriere, A., Tinat, M., Saidi, M., Fontaine, S., De Montferrand, C., Le-Goff, L., Portefaix, A., Louvier, U. W., Duval, P. -A., Caradec, P., Touati, S., Herranz, A. Z., Bollig, J., Molnar, F., Vogt, S., Pechmann, A., Schorling, D., Wider, S., Kolbel, H., Schara, U., Braun, F., Gangfuss, A., Hagenacker, T., Eckstein, A., Dekowski, D., Oeverhaus, M., Stoehr, M., Andres, B., Smuda, K., Bertini, Enrico Silvio, D'Amico, A., Petroni, S., Valente, Paola, Bonetti, A. M., Carlesi, A., Mizzoni, I., Pedemonte, M., Brolatti, N., Priolo, E., Rao, G., Sposetti, L., Morando, S., Comi, G., Osnaghi, S., Minorini, V., Abbati, F., Fassini, F., Foa, M., Lopopolo, M. A., Magri, F., Govoni, A., Meneri, M., Parente, V., Antonaci, Laura, Pera, Maria Carmela, Pane, Marika, Amorelli, Giulia Maria, Barresi, C., D'Amico, Guglielmo, Orazi, Lorenzo, Coratti, Giorgia, De Sanctis, Roberto, Vita, G., Sframeli, M., Vita, G. L., Aragona, P., Inferrera, L., Postorino, E. I., Montanini, D., Di Bella, V., Donato, C., Cala, E., Van der Pol, L., Aalbers, J., de Boer, J., Imhof, S., Cooijmans, P., Ruyten, T., Van Der Woude, D., Klimaszewska, B., Romanczak, D., Gierlak-Wojcicka, Z., Kepa, M., Sikorski, A., Sobieraj, M., Lusakowska, A., Kierdaszuk, B., Czeczko, K., Henzi, B., Gugleta, K., Kusnyerik, A., Siems, P., Akos, S., Frei, N., Seppi, C., Haschke, C. W., Guglieri, M., Straub, V., Bell, R., Nassar, M., Page, S., Clarke, M. P., Regan, A., Mayhew, A., Lofra, R. M., Parasuraman, D., Bruschi, Sara, Ghauri, A. -J., Castle, A., Naqvi, S., Patt, N., Scoto, M., Trucco, F., Henderson, R. H., Kukadia, R., Moore, W., Milev, E., Rye, C., Selby, V., Wolfe, A., Darras, B., Baglieri, A. M., Fulton, A., Lucken, C., Maczek, E., Pasternak, A., Kane, S., Bautista, M. E. M., Frommer, E., Pensec, N., Salazar, R., Yochai, C., Rodrigues-Torres, R., Chawla, M., Day, J., Beres, S., Gee, R., Young, S. D., Finkel, R., Nazario, A. N., Fasiuddin, A., Wells, J. A., Wilson, J., Berry, D., Rizzo, V., Duke, J., Monduy, M., Collado, J., Mercuri E. (ORCID:0000-0002-9851-5365), Martin C., Bertini E., Valente P., Antonaci L., Pera M. C. (ORCID:0000-0001-6777-1721), Pane M. (ORCID:0000-0002-4851-6124), Amorelli G. M., D'Amico G., Orazi L., Coratti G. (ORCID:0000-0001-6666-5628), De Sanctis R., Bruschi S., Chiriboga, C. A., Bruno, C., Duong, T., Fischer, D., Mercuri, Eugenio Maria, Kirschner, J., Kostera-Pruszczyk, A., Jaber, B., Gorni, K., Kletzl, H., Carruthers, I., Martin, Craig, Warren, F., Scalco, R. S., Wagner, K. R., Muntoni, F., Deconinck, N., Balikova, I., Joniau, I., Tahon, V., Wittevrongel, S., Goemans, N., Cassiman, C., Prove, L., Vancampenhout, L., van den Hauwe, M., Van Impe, A., Cances, C., Soler, V., De La Morandais, L. M., Vovan, D., Cintas, P., Auriol, F., Mus, M., Alphonsa, G., Bellio, V., Gil Mato, O., Flamein, F., Evrard, C., Ziouche, A., Bouacha-Allou, I., Debruyne, P., Derlyn, G., Defoort, S., Leroy, F., Danjoux, L., Desguerre, I., Bremond-Gignac, D., Rateuax, M., Deladriere, E., Vuillerot, C., Veillerot, Q., Sibille-Dabadi, B., Barriere, A., Tinat, M., Saidi, M., Fontaine, S., De Montferrand, C., Le-Goff, L., Portefaix, A., Louvier, U. W., Duval, P. -A., Caradec, P., Touati, S., Herranz, A. Z., Bollig, J., Molnar, F., Vogt, S., Pechmann, A., Schorling, D., Wider, S., Kolbel, H., Schara, U., Braun, F., Gangfuss, A., Hagenacker, T., Eckstein, A., Dekowski, D., Oeverhaus, M., Stoehr, M., Andres, B., Smuda, K., Bertini, Enrico Silvio, D'Amico, A., Petroni, S., Valente, Paola, Bonetti, A. M., Carlesi, A., Mizzoni, I., Pedemonte, M., Brolatti, N., Priolo, E., Rao, G., Sposetti, L., Morando, S., Comi, G., Osnaghi, S., Minorini, V., Abbati, F., Fassini, F., Foa, M., Lopopolo, M. A., Magri, F., Govoni, A., Meneri, M., Parente, V., Antonaci, Laura, Pera, Maria Carmela, Pane, Marika, Amorelli, Giulia Maria, Barresi, C., D'Amico, Guglielmo, Orazi, Lorenzo, Coratti, Giorgia, De Sanctis, Roberto, Vita, G., Sframeli, M., Vita, G. L., Aragona, P., Inferrera, L., Postorino, E. I., Montanini, D., Di Bella, V., Donato, C., Cala, E., Van der Pol, L., Aalbers, J., de Boer, J., Imhof, S., Cooijmans, P., Ruyten, T., Van Der Woude, D., Klimaszewska, B., Romanczak, D., Gierlak-Wojcicka, Z., Kepa, M., Sikorski, A., Sobieraj, M., Lusakowska, A., Kierdaszuk, B., Czeczko, K., Henzi, B., Gugleta, K., Kusnyerik, A., Siems, P., Akos, S., Frei, N., Seppi, C., Haschke, C. W., Guglieri, M., Straub, V., Bell, R., Nassar, M., Page, S., Clarke, M. P., Regan, A., Mayhew, A., Lofra, R. M., Parasuraman, D., Bruschi, Sara, Ghauri, A. -J., Castle, A., Naqvi, S., Patt, N., Scoto, M., Trucco, F., Henderson, R. H., Kukadia, R., Moore, W., Milev, E., Rye, C., Selby, V., Wolfe, A., Darras, B., Baglieri, A. M., Fulton, A., Lucken, C., Maczek, E., Pasternak, A., Kane, S., Bautista, M. E. M., Frommer, E., Pensec, N., Salazar, R., Yochai, C., Rodrigues-Torres, R., Chawla, M., Day, J., Beres, S., Gee, R., Young, S. D., Finkel, R., Nazario, A. N., Fasiuddin, A., Wells, J. A., Wilson, J., Berry, D., Rizzo, V., Duke, J., Monduy, M., Collado, J., Mercuri E. (ORCID:0000-0002-9851-5365), Martin C., Bertini E., Valente P., Antonaci L., Pera M. C. (ORCID:0000-0001-6777-1721), Pane M. (ORCID:0000-0002-4851-6124), Amorelli G. M., D'Amico G., Orazi L., Coratti G. (ORCID:0000-0001-6666-5628), De Sanctis R., and Bruschi S.

Abstract

In this article the JEWELFISH Study Group members were missing in the Acknowledgements. The collaborator names are corrected in the supplementary material and the complete list is given below. In Table 1, footnote symbol ‘g’ was incorrectly written as ‘f’ in the entries Non-sitters—2 (14)g and Sitters-12 (86)g under column Onasemnogene abeparvovec of section Motor function, n (%)f. The original article has been corrected.

Published
2023

12. Reply

Author

de Vet, C. M., primary, van Oostrum, N. H. M., additional, Clur, S. B., additional, van der Woude, D. A. A., additional, Oei, S. G., additional, and van Laar, J. O. E. H., additional

Published
2023
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16. NT-proBNP and sRAGE levels in early rheumatoid arthritis.

Author

Heslinga, M, Teunissen, C, Agca, R, van der Woude, D, Huizinga, TWJ, van Laar, J, den Broeder, A, Lems, W, and Nurmohamed, M

Subjects
BRAIN natriuretic factor, RHEUMATOID arthritis, ADVANCED glycation end-products, BLOOD sedimentation, C-reactive protein
Abstract

Several biomarkers of cardiovascular function are found to be increased in rheumatoid arthritis (RA), with some suggesting a relationship with disease activity and improvement with adequate anti-rheumatic treatment. Promising biomarkers include N-terminal pro-brain natriuretic peptide (NT-proBNP) and the soluble receptor form of advanced glycation end-products (sRAGE). The objective of this study was to investigate associations between NT-proBNP and sRAGE levels and markers of inflammation and disease activity in early RA patients and their changes during (effective) anti-rheumatic treatment. Data from 342 consecutive early RA patients participating in the 'Parelsnoer' cohort were used. At baseline and after 6 months' disease activity, NT-proBNP and sRAGE levels were assessed. After 6 months, NT-proBNP decreased from 83 pmol/L (mean) at baseline to 69 pmol/L at follow-up (p < 0.001), while sRAGE increased from 997 pg/mL to 1125 pg/mL (p < 0.001). A larger decrease in erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) was associated with larger changes in NT-proBNP and sRAGE. For every point decrease in ESR, there was a 1.7-point decrease in NT-proBNP and a 2.2-point increase in sRAGE. For CRP, these values were 1.7 and 2.7, respectively (p < 0.001). Suppressing inflammation, independently of achieving remission, increases sRAGE levels and decreases NT-proBNP levels significantly. Whether this translates into a decrease in incident cardiovascular disease remains to be elucidated. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Presence of SARS-CoV-2 antibodies in patients with COVID-19 like symptoms from the IENIMINI cohort.

Author

van Ouwerkerk, L, van der Woude, D, Rispens, T, Allaart, CF, and Huizinga, TWJ

Subjects
*COVID-19, *SARS-CoV-2, *IMMUNOGLOBULINS
Abstract

To evaluate the relationship between reported coronavirus disease 2019 (COVID-19)-like symptoms and the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in patients with an immune-mediated inflammatory disorder or post-solid organ transplantation (IMIDT) with and without immunosuppressive medication (imed) and controls. The IENIMINI cohort was a prospective cohort study set up in the Netherlands in March 2020, with 2 monthly (paper) or weekly (online) questionnaires about COVID-19-like symptoms. Participants from this cohort who reported these symptoms between March 2020 and November 2020 were approached for this substudy. SARS-CoV-2 antibodies were tested using a total antibody assay. Of the 1203 participants approached, 629 agreed to participate and were sent a fingerprick test; 565 participants collected a capillary blood sample, of which 562 were usable. Analysis showed that 57/202 (28.2%) of the tested IMIDT group with imed, 48/16 3(29.4%) of the IMIDT group without imed, and 69/197 (35.0%) of the control group tested positive for SARS-CoV-2 antibodies. Seroprevalences of SARS-CoV-2 antibodies between males and females, biological disease-modifying anti-rheumatic drug users and non-users, and those who had had a serious disease period (defined as an episode with dyspnoea and fever) and those who had not, were not statistically different between the three groups. Approximately 30% of patients who had reported COVID-19-like symptoms had SARS-CoV-2 antibodies. The seroprevalence of SARS-CoV-2 antibodies after reported COVID-19-like symptoms was similar in IMIDT patients with and without imed compared to controls. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Ultrathin GaAs Solar Cells with Rough GaP Light-Trapping Structure and Epitaxial Lift-Off

Author

Van Der Woude, D., Bauhuis, G., Van Der Krabben, L., Daemen, T., Kim, J.J., Mulder, P., Smits, J., Vlieg, E., and Schermer, J.

Subjects
III-V and Related Compound Semiconductors, Evolving and Emerging Technologies: Tandems, Thin Film absorbers, III-V, New Materials and Concepts, Advanced Modelling
Abstract

8th World Conference on Photovoltaic Energy Conversion; 399-401, In this work, ultrathin GaAs solar cells are presented with a rough backscattering structure based on lattice mismatched gallium phosphide, grown with MOCVD. This way, a simple and reproducible light-trapping scheme is introduced with low parasitic absorption and full compatibility with hydrofluoric acid-based epitaxial lift-off. Solar cells with two different GaP surface morphologies are demonstrated and shown to be compatible with epitaxial lift-off without any complications or performance loss. An increase in short-circuit current density of up to 9% is observed, a direct result of the increased photon absorption induced by the scattering of the rough GaP texture.

Published
2022
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27. Humoral immune response after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases treated with immunosuppressive therapy - a Target to B! study

Author

Volkers, A., Wieske, L., van Dam, K., Steenhuis, M., Stalman, E., Kummer, L., van Kempen, Z., Killestein, J., Tas, S., Boekel, L., Wolbink, G., Takkenberg, B., Spuls, P., Bosma, A., Rutgers, B., Verschuuren, J., van Ouwerkerk, L., van der Woude, D., van Paassen, P., Busch, M., Brusse, E., Hijnen, D., ten Brinke, A., Verstegen, N., D'Haens, G., van Ham, M., Kuijpers, T., Rispens, T., Lowenberg, M., Eftimov, F., Neurology, and Dermatology

Subjects
SDG 3 - Good Health and Well-being
Published
2022

29. DOP27 Humoral immune response after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases treated with immunosuppressive therapy - a Target to B! study

Author

Volkers, A, primary, Wieske, L, additional, van Dam, K, additional, Steenhuis, M, additional, Stalman, E, additional, Kummer, L, additional, van Kempen, Z, additional, Killestein, J, additional, Tas, S, additional, Boekel, L, additional, Wolbink, G, additional, Takkenberg, B, additional, Spuls, P, additional, Bosma, A, additional, Rutgers, B, additional, Verschuuren, J, additional, van Ouwerkerk, L, additional, van der Woude, D, additional, van Paassen, P, additional, Busch, M, additional, Brusse, E, additional, Hijnen, D, additional, ten Brinke, A, additional, Verstegen, N, additional, D’Haens, G, additional, van Ham, M, additional, Kuijpers, T, additional, Rispens, T, additional, Löwenberg, M, additional, and Eftimov, F, additional

Published
2022
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30. ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples

Author

Kissel, T., primary, Hafkenscheid, L., additional, Wesemael, T.J., additional, Tamai, M., additional, Kawashiri, S.Y., additional, Kawakami, A., additional, El-Gabalawy, H.S., additional, van Schaardenburg, D., additional, Rantapää-Dahlqvist, S., additional, Wuhrer, M., additional, van der Helm-van Mil, A.H.M., additional, Allaart, C.F., additional, van der Woude, D., additional, Scherer, H.U., additional, Toes, R.E.M., additional, and Huizinga, T.W.J., additional

Published
2021
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33. AB0020 ACPA ILLUSTRATING THE IMPACT OF IGG FAB-GLYCOSYLATION ON TRANSPLACENTAL TRANSFER OF ANTIBODIES AND THEIR BINDING TO THE NEONATAL FC-RECEPTOR (FCRN)

Author

Volkov, M., primary, Van Schie, K., additional, Bondt, A., additional, Kissel, T., additional, Brinkhaus, M., additional, Bentlage, A., additional, Koeleman, C., additional, De Taeye, S., additional, Dolhain, R., additional, Wuhrer, M., additional, Toes, R., additional, Vidarsson, G., additional, and Van der Woude, D., additional

Published
2021
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41. The association between uterine contraction frequency and fetal scalp pH in women with suspicious or pathological fetal heart rate tracings: A retrospective study.

Author

Frenken, M W E, van der Woude, D A A, Dieleman, J P, Oei, S G, and van Laar, J O E H

Abstract

Objective: Current guidelines provide little supporting literature for the definition of uterine tachysystole during labour and no distinction is made for optimal contraction frequency depending on the clinical situation. We hypothesize that fetal hypoxia is frequently caused by uterine tachysystole and that high uterine contraction frequencies are especially harmful when fetal heart rate (FHR) abnormalities are present. We studied the association between contraction frequency and fetal scalp pH values in women with an indication for fetal blood sampling (FBS) based on FHR abnormalities.Study Design: A retrospective study including 762 women was performed in a tertiary teaching hospital in the Netherlands from January 2015 until January 2020. Women with a singleton pregnancy with a gestational age ≥ 34+0 weeks were included when FBS was performed because of suspicious or pathological FHR tracings. Exclusion criteria were maternal age < 18 years, failed fetal scalp pH values, lack of thirty minute registration by tocodynamometry prior to FBS, poor quality of uterine monitoring, intrauterine resuscitation in the thirty minutes prior to FBS, maternal body mass index ≥ 30 kg/m2 and neonatal birth weight < 10th percentile. Uterine contractions in the thirty minutes prior to FBS were manually annotated by a researcher who was blinded to FBS values, FHR and other obstetrical data. Linear and logistic analysis were used to explore the association between uterine contraction frequency and FBS results.Results: Low fetal scalp pH values were significantly associated with contraction frequency prior to FBS. Fetuses of women with four to five contractions per ten minutes prior to FBS were 2.4 times more likely to have hypoxia as compared to fetuses of women with two to three contractions per ten minutes (aOR 2.4, 95% CI 1.1-5.4). With increasing contraction frequency, the risk of fetal hypoxia further increased.Conclusions: Contraction frequency above four per ten minutes prior to FBS is significantly associated with fetal hypoxia in women with FHR abnormalities. We suggest to aim for a maximum contraction frequency of four per ten minutes in these women. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Spectroradiometer comparison under outdoor direct normal irradiance and indoor highpower AM0-like conditions

Author

Galleano, R., Pavanello, D., Zaaiman, W., Jungst, G., Halwachs, M., Rennhofer, M., Santamaria Lancia, Adrian Alejo, Haverkamp, E., Van der Woude, D., Minuto, A., Celi, E., Theristis, M., Couderc, R., Voarino, P., Galleano, R., Pavanello, D., Zaaiman, W., Jungst, G., Halwachs, M., Rennhofer, M., Santamaria Lancia, Adrian Alejo, Haverkamp, E., Van der Woude, D., Minuto, A., Celi, E., Theristis, M., Couderc, R., and Voarino, P.

Abstract

Intercomparisons of primary instruments are of paramount importance to guarantee reproducibility and equivalence of calibration and are expressly required for laboratories applying the quality scheme outlined in IEC/ISO 17025 standard. The correct and reliable measurement of the spectral content of the used light source(s) is one of the main tasks in the process of a generic photovoltaic (PV) device calibration; this requirement has become more and more important since the technology biodiversity has increased in the PV world. The two afore mentioned issues were among the main driving forces to establish a network of European and International PV laboratories and industries willing to share good practices in spectroradiometric calibration and measurements, and to periodically check their equivalence-of-result in measuring the spectral content of the sun or of solar simulators. This paper will report on the preliminary results from a spectroradiometers intercomparison performed measuring solar direct normal incidence spectral irradiance and global normal incidence spectral irradiance under an indoor high-power AM0-like source.

Published
2019

43. Educational needs and preferences of young European clinicians and physician researchers working in the field of rheumatology

Author

Beyer, C, Ramiro, S, Sivera, F, Mandl, P, Machado, P, Ospelt, C, Molto, A, Radner, H, Iagnocco, A, Bijlsma, J, Lundberg, I, Grigoriou, A, Fanouriakis, A, Hueber, A, Maurer, B, Scire, C, Gaujoux-Viala, C, Karpec, D, Van Der Woude, D, Rimar, D, Deseatnicova, E, Nikiphorou, E, De Langhe, E, Haavardsholm, E, Starodubtseva, I, Nagy, G, Biliavska, I, Sznajd, J, Karlsson, J, Zepa, J, Cassar, K, Senolt, L, Ghukasyan, L, Baresic, M, Frank-Bertoncelj, M, Ziade, N, Gobejishvili, N, Ostojic, P, Ostgard, R, Dobrota, R, Shumnalieva, R, Talli, S, Panchal, S, Volpinari, S, Rannio, T, Romao, V, Beyer C., Ramiro S., Sivera F., Mandl P., MacHado P. M., Ospelt C., Molto A., Radner H., Iagnocco A., Bijlsma J. W., Lundberg I. E., Grigoriou A., Fanouriakis A., Hueber A., Maurer B., Scire C. A., Gaujoux-Viala C., Karpec D., Van Der Woude D., Rimar D., Deseatnicova E., Nikiphorou E., De Langhe E., Haavardsholm E. A., Starodubtseva I., Nagy G., Biliavska I. V., Sznajd J., Karlsson J. A., Zepa J., Cassar K., Senolt L., Ghukasyan L., Baresic M., Frank-Bertoncelj M., Ziade N., Gobejishvili N., Ostojic P., Ostgard R., Dobrota R., Shumnalieva R., Talli S., Panchal S., Volpinari S., Rannio T., Romao V. C., Beyer, C, Ramiro, S, Sivera, F, Mandl, P, Machado, P, Ospelt, C, Molto, A, Radner, H, Iagnocco, A, Bijlsma, J, Lundberg, I, Grigoriou, A, Fanouriakis, A, Hueber, A, Maurer, B, Scire, C, Gaujoux-Viala, C, Karpec, D, Van Der Woude, D, Rimar, D, Deseatnicova, E, Nikiphorou, E, De Langhe, E, Haavardsholm, E, Starodubtseva, I, Nagy, G, Biliavska, I, Sznajd, J, Karlsson, J, Zepa, J, Cassar, K, Senolt, L, Ghukasyan, L, Baresic, M, Frank-Bertoncelj, M, Ziade, N, Gobejishvili, N, Ostojic, P, Ostgard, R, Dobrota, R, Shumnalieva, R, Talli, S, Panchal, S, Volpinari, S, Rannio, T, Romao, V, Beyer C., Ramiro S., Sivera F., Mandl P., MacHado P. M., Ospelt C., Molto A., Radner H., Iagnocco A., Bijlsma J. W., Lundberg I. E., Grigoriou A., Fanouriakis A., Hueber A., Maurer B., Scire C. A., Gaujoux-Viala C., Karpec D., Van Der Woude D., Rimar D., Deseatnicova E., Nikiphorou E., De Langhe E., Haavardsholm E. A., Starodubtseva I., Nagy G., Biliavska I. V., Sznajd J., Karlsson J. A., Zepa J., Cassar K., Senolt L., Ghukasyan L., Baresic M., Frank-Bertoncelj M., Ziade N., Gobejishvili N., Ostojic P., Ostgard R., Dobrota R., Shumnalieva R., Talli S., Panchal S., Volpinari S., Rannio T., and Romao V. C.

Abstract

Objectives: To understand the educational needs and preferences of young clinicians and physician researchers in the field of rheumatology in Europe. Methods: An international online survey was performed as a joint venture of ESCET and EMEUNET. The survey assessed the acceptance of and the access to the current European League Against Rheumatism (EULAR) educational portfolio, as well as the unmet educational needs and learning preferences among individuals below the age of 40 years working in rheumatology in Europe. Results: Among 568 European clinicians and physician researchers, 65% indicated that the existing EULAR educational portfolio adequately covers their educational needs. Within the EULAR portfolio, the online course on rheumatic diseases and the postgraduate course were the most appreciated. Participants were very much in favour of new educational courses on imaging techniques, and 63% of participants indicated a particular interest in musculoskeletal ultrasound. A strong interest in refresher (60%) and general review (55%) courses was observed. Lack of funding was considered the major obstacle to participating in existing EULAR programmes. Finally, participants showed diverse preferences regarding learning modalities with common interests in live courses and conferences. Conclusions: EULAR's training opportunities are well appreciated among young clinicians and physician researchers in rheumatology. The results from this survey will help to develop EULAR's future educational portfolio.

Published
2016

45. THU0069 In ra, becoming seronegative over the 1st year of dmard treatment does not translate to better chances of sustained drug-free remission in the long-term

Author

de Moel, E.C., primary, Derksen, V. F. A. M., additional, Trouw, L.A., additional, Bang, H., additional, Goekoop-Ruiterman, Y.P., additional, Steup-Beekman, G.M., additional, Huizinga, T.W.J., additional, Allaart, C.F., additional, Toes, R.E.M., additional, and van der Woude, D., additional

Published
2018
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