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Your search keyword '"van der Zwaluw, Carmen S."' showing total 23 results
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23. Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans.

Author

van der Zwaluw CS, van den Wildenberg E, Wiers RW, Franke B, Buitelaar J, Scholte RH, and Engels RC

Subjects
Case-Control Studies, Clinical Trials as Topic, Genetic Variation, Humans, Phenotype, Racial Groups genetics, Reference Values, Alcoholism genetics, Polymorphism, Genetic, Receptors, Opioid, mu genetics
Abstract

Twin and adoption studies have shown that alcohol dependence contains a substantial genetic component. In attempts to identify the genetic factors involved, association studies have linked the opioid system to alcohol dependence, with a main focus on the OPRM1 gene encoding the mu-opioid receptor. Our aim was to conduct a systematic review of the literature on the associations between polymorphisms in OPRM1 and alcohol dependence. We addressed findings of 12 studies that met our inclusion criteria. All studies employed a case-control design and included alcohol dependence as a dependent outcome measure. Our review showed that clinical studies do not unequivocally support an association between polymorphisms in OPRM1 and alcohol dependence. Factors that complicate genetic research on alcohol dependence, such as gene-environment interaction, and genetic and clinical heterogeneity, are discussed.

Published
2007
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