1. Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men
- Author
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Angela Callejo, Maria del Mar Molina, Maria Carme Dinares, Javier Hernández-Losa, Bibiana Planas, Jorge Garcia, Adria Curran, Jordi Navarro, Paula Suanzes, Vicenç Falcó, Joaquin Burgos, Institut Català de la Salut, [Callejo A] Universitat Autònoma de Barcelona, Bellaterra, Spain. Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Department of Otorhinolaryngology. [Del Mar Molina M, Planas B, Garcia J, Curran A, Navarro J, Suanzes P, Falcó V, Burgos J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Dinares MC, Hernández-Losa J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Adult ,Male ,Anus - Malalties - Epidemiologia ,Papillomavirus Infections ,Immunology ,Anal Canal ,HIV Infections ,Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections [DISEASES] ,Anus Neoplasms ,Infeccions per VIH - Epidemiologia ,Virus Diseases::Virus Diseases::Tumor Virus Infections::Papillomavirus Infections [DISEASES] ,Sexual and Gender Minorities ,Infectious Diseases ,Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms::Anus Neoplasms [DISEASES] ,Prevalence ,neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto::neoplasias del ano [ENFERMEDADES] ,Humans ,Immunology and Allergy ,virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH [ENFERMEDADES] ,Prospective Studies ,Homosexuality, Male ,virosis::virosis::infecciones por virus oncógenos::infecciones por Papillomavirus [ENFERMEDADES] ,Papil·lomavirus ,Papillomaviridae - Abstract
Dysplasia; Screening; HIV-infected Displasia; Cribado; Infectado por el VIH Displàsia; Cribratge; Infectat pel VIH Background: HIV-infected men who have sex with men (MSM) are at high risk to develop human papilloma virus (HPV)-related oropharyngeal cancer. The aim of our study was to assess the usefulness of a pilot oral dysplasia screening program and its correlation with an anal dysplasia screening program. Methods: This was a prospective study with HIV-infected MSM. Oral and anal screenings were performed based on HPV determination, liquid cytology, direct and microscopy oral examinations, high-resolution anoscopy and biopsies, if necessary. Results: A total of 103 patients were included. The mean age of the patients was 44.6 years, 55.3% were smokers, and 57.3% had a history of previous anal high-grade squamous intraepithelial lesions (HSILs). The prevalence of oral HPV infections was 14% (9% HPV-high risk), the prevalence of abnormal cytology was 25.2%, and in 4.8% of the patients, oral examinations showed suspicious HSILs. Oral microscopy did not detect additional lesions that visual inspection. Five oral biopsies were performed and the results were normal. No risk factors for oral HPV infections were identified. The prevalence of anal HPV infections was 88.3% (76.7% HPV-high risk), 52.9% of the patients had altered cytology, and in 45.6% anoscopy showed changes suggestive of HSILs. Seventy-two anal biopsies were performed, detecting 25 cases of HSILs (24.3%). A poor correlation was observed between oral and anal HPV infections (κ = 0.037). Conclusions: The prevalence of oral HPV infections, abnormal cytology and lesions in HIV-infected MSM was low, and their correlation with anal HPV-related lesions was slight. These results confirm the current barriers to oral dysplasia screening techniques. Study funded by program MISP of MSD (Merck HPV Investigator Study Program). MISP project code 58237.
- Published
- 2022