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11 results on '"von Boehmer, Lisa"'

2. Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

Author

Fioretta, Emanuela S., Lintas, Valentina, Mallone, Anna, Motta, Sarah E., von Boehmer, Lisa, Dijkman, Petra E., Cesarovic, Nikola, Caliskan, Etem, Rodriguez Cetina Biefer, Héctor, Lipiski, Miriam, Sauer, Mareike, Putti, Matilde, Janssen, Henk M., Söntjens, Serge H., Smits, Anthal I.P.M., Bouten, Carlijn V.C., Emmert, Maximilian Y., and Hoerstrup, Simon P.

Published
2020
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5. Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Author

Fioretta, Emanuela, Lintas, Valentina, Mallone, Anna, Motta, Sarah E., von Boehmer, Lisa, Dijkman, Petra E., Cesarovic, Nikola, Caliskan, Etem, Rodriguez Cetina Biefer, Hector, Lipiski, Miriam, Sauer, Mareike, Putti, Matilde, Janssen, Henk M., Söntjens, Serge H.M., Smits, Anthal I.P.M., Bouten, Carlijn V.C., Emmert, M.Y., Hoerstrup, Simon P., Fioretta, Emanuela, Lintas, Valentina, Mallone, Anna, Motta, Sarah E., von Boehmer, Lisa, Dijkman, Petra E., Cesarovic, Nikola, Caliskan, Etem, Rodriguez Cetina Biefer, Hector, Lipiski, Miriam, Sauer, Mareike, Putti, Matilde, Janssen, Henk M., Söntjens, Serge H.M., Smits, Anthal I.P.M., Bouten, Carlijn V.C., Emmert, M.Y., and Hoerstrup, Simon P.

Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.

Published
2020

6. Off-the-Shelf Tissue-Engineered Vascular Conduits: Clinical Translation

Author

Walpoth, Beat, Bergmeister, Helga, Bowlin, Gary, Kong, Deling, Rotmans, Joris, Zilla, P, Walpoth, B ( Beat ), Bergmeister, H ( Helga ), Bowlin, G ( Gary ), Kong, D ( Deling ), Rotmans, J ( Joris ), Zilla, P ( P ), Fioretta, Emanuela S, von Boehmer, Lisa, Generali, Melanie, Hoerstrup, Simon P, Emmert, Maximilian Y, Walpoth, Beat, Bergmeister, Helga, Bowlin, Gary, Kong, Deling, Rotmans, Joris, Zilla, P, Walpoth, B ( Beat ), Bergmeister, H ( Helga ), Bowlin, G ( Gary ), Kong, D ( Deling ), Rotmans, J ( Joris ), Zilla, P ( P ), Fioretta, Emanuela S, von Boehmer, Lisa, Generali, Melanie, Hoerstrup, Simon P, and Emmert, Maximilian Y

Published
2020

7. Human cardiac organoids for modeling genetic cardiomyopathy

Author

Filippo Buono, Michele, von Boehmer, Lisa; https://orcid.org/0000-0002-9994-6327, Strang, Jaan, Hoerstrup, Simon P; https://orcid.org/0000-0003-4755-8776, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, Nugraha, Bramasta; https://orcid.org/0000-0002-0799-1594, Filippo Buono, Michele, von Boehmer, Lisa; https://orcid.org/0000-0002-9994-6327, Strang, Jaan, Hoerstrup, Simon P; https://orcid.org/0000-0003-4755-8776, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, and Nugraha, Bramasta; https://orcid.org/0000-0002-0799-1594

Abstract

Genetic cardiomyopathies are characterized by changes in the function and structure of the myocardium. The development of a novel in vitro model could help to better emulate healthy and diseased human heart conditions and may improve the understanding of disease mechanisms. In this study, for the first time, we demonstrated the generation of cardiac organoids using a triculture approach of human induced pluripotent stem-cell-derived cardiomyocytes (hiPS-CMs)-from healthy subjects and cardiomyopathy patients-human cardiac microvascular endothelial cells (HCMECs) and human cardiac fibroblasts (HCFs). We assessed the organoids' suitability as a 3D cellular model for the representation of phenotypical features of healthy and cardiomyopathic hearts. We observed clear differences in structure and beating behavior between the organoid groups, depending on the type of hiPS-CMs (healthy versus cardiomyopathic) used. Organoids may thus prove a promising tool for the design and testing of patient-specific treatments as well as provide a platform for safer and more efficacious drug development.

Published
2020

9. Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

Author

Fioretta, Emanuela S., Lintas, Valentina, Mallone, Anna, Motta, Sarah E., Von Boehmer, Lisa, Dijkman, Petra E., Cesarovic, Nikola, Caliskan, Etem, Biefer, Héctor R.C., Lipiski, Miriam, Sauer, Mareike, Putti, Matilde, Janssen, Henk M., Söntjens, Serge H., Smits, Anthal I.P.M., Bouten, Carlijn V.C., Emmert, Maximilian Y., and Hoerstrup, Simon P.

Subjects
3. Good health
Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach., JACC: Basic to Translational Science, 5 (1)

10. Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.

Author

Fioretta ES, Lintas V, Mallone A, Motta SE, von Boehmer L, Dijkman PE, Cesarovic N, Caliskan E, Rodriguez Cetina Biefer H, Lipiski M, Sauer M, Putti M, Janssen HM, Söntjens SH, Smits AIPM, Bouten CVC, Emmert MY, and Hoerstrup SP

Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell-scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach., (© 2020 The Authors.)

Published
2019
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11. Human Cardiac Organoids for Disease Modeling.

Author

Nugraha B, Buono MF, von Boehmer L, Hoerstrup SP, and Emmert MY

Subjects
Animals, Cells, Cultured, Heart Diseases physiopathology, Humans, Induced Pluripotent Stem Cells physiology, Myocytes, Cardiac physiology, Organ Culture Techniques, Organoids physiology, Heart Diseases pathology, Induced Pluripotent Stem Cells pathology, Myocytes, Cardiac pathology, Organoids pathology
Abstract

Human cardiac drug discovery and disease modeling face challenges in recapitulating cellular complexity and animal-to-human translation due to the limitations of conventional 2D cell culture and animal models. The development of human cardiac organoid technologies could help in stimulating and maintaining differentiated cell functions for extended periods of time. By closely mimicking in vivo organ functions in vitro they could thereby help in overcoming the obstacles mentioned above. Through the construction of human cardiac organoids from pluripotent stem cell-derived cells, derived from patients with specific known genotypes and phenotypes, more complex and robust in vitro tools have recently become available for disease modeling. In this review, we will describe the relevance and importance of evolving organoid platforms in disease biology. We further provide examples of cardiac organoid platforms, which may lead the way toward future personalized medicine and drug discovery., (© 2018 American Society for Clinical Pharmacology and Therapeutics.)

Published
2019
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