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9 results on '"von Stemann, Jakob H."'

2. Elevated Levels of Interleukin-1β and Interleukin-10 Are Associated With Faster Lung Function Decline in People With Well-Treated Human Immunodeficiency Virus

Author

Thudium, Rebekka F, primary, Arentoft, Nicoline S, additional, Hoel, Hedda, additional, Afzal, Shoaib, additional, von Stemann, Jakob H, additional, Forman, Julie L, additional, Wilcke, Jon T, additional, Benfield, Thomas, additional, Trøseid, Marius, additional, Borges, Álvaro H, additional, Ostrowski, Sisse R, additional, Vestbo, Jørgen, additional, Kunisaki, Ken M, additional, Jensen, Jens-Ulrik S, additional, and Nielsen, Susanne D, additional

Published
2023
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3. Machine learning can identify newly diagnosed patients with CLL at high risk of infection

Author

Agius, Rudi, Brieghel, Christian, Andersen, Michael A., Pearson, Alexander T., Ledergerber, Bruno, Cozzi-Lepri, Alessandro, Louzoun, Yoram, Andersen, Christen L., Bergstedt, Jacob, von Stemann, Jakob H., Jørgensen, Mette, Tang, Man-Hung Eric, Fontes, Magnus, Bahlo, Jasmin, Herling, Carmen D., Hallek, Michael, Lundgren, Jens, MacPherson, Cameron Ross, Larsen, Jan, and Niemann, Carsten U.

Published
2020
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4. Cohort Profile:The Danish Blood Donor Study

Author

Erikstrup, Christian, Sørensen, Erik, Nielsen, Kaspar R, Bruun, Mie T, Petersen, Mikkel S, Rostgaard, Klaus, Thørner, Lise W, Larsen, Margit, Mikkelsen, Susan, Dinh, Khoa M, Schwinn, Michael, Rigas, Andreas S, Didriksen, Maria, Dowsett, Joseph, von Stemann, Jakob H, Brodersen, Thorsten, Paulsen, Isabella W, Hindhede, Lotte, Sækmose, Susanne G, Kaspersen, Kathrine A, Boldsen, Jens K, Kjerulff, Bertram, Werge, Thomas, Brunak, Søren, Banasik, Karina, Hansen, Thomas F, Ullum, Henrik, Hjalgrim, Henrik, Ostrowski, Sisse R, Pedersen, Ole B, Erikstrup, Christian, Sørensen, Erik, Nielsen, Kaspar R, Bruun, Mie T, Petersen, Mikkel S, Rostgaard, Klaus, Thørner, Lise W, Larsen, Margit, Mikkelsen, Susan, Dinh, Khoa M, Schwinn, Michael, Rigas, Andreas S, Didriksen, Maria, Dowsett, Joseph, von Stemann, Jakob H, Brodersen, Thorsten, Paulsen, Isabella W, Hindhede, Lotte, Sækmose, Susanne G, Kaspersen, Kathrine A, Boldsen, Jens K, Kjerulff, Bertram, Werge, Thomas, Brunak, Søren, Banasik, Karina, Hansen, Thomas F, Ullum, Henrik, Hjalgrim, Henrik, Ostrowski, Sisse R, and Pedersen, Ole B

Published
2023

5. Cohort Profile: The Danish Blood Donor Study

Author

Erikstrup, Christian, primary, Sørensen, Erik, additional, Nielsen, Kaspar R, additional, Bruun, Mie T, additional, Petersen, Mikkel S, additional, Rostgaard, Klaus, additional, Thørner, Lise W, additional, Larsen, Margit, additional, Mikkelsen, Susan, additional, Dinh, Khoa M, additional, Schwinn, Michael, additional, Rigas, Andreas S, additional, Didriksen, Maria, additional, Dowsett, Joseph, additional, von Stemann, Jakob H, additional, Brodersen, Thorsten, additional, Paulsen, Isabella W, additional, Hindhede, Lotte, additional, Sækmose, Susanne G, additional, Kaspersen, Kathrine A, additional, Boldsen, Jens K, additional, Kjerulff, Bertram, additional, Werge, Thomas, additional, Brunak, Søren, additional, Banasik, Karina, additional, Hansen, Thomas F, additional, Ullum, Henrik, additional, Hjalgrim, Henrik, additional, Ostrowski, Sisse R, additional, and Pedersen, Ole B, additional

Published
2022
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6. Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health:Results from the Danish Blood Donor Study

Author

von Stemann, Jakob H., Pedersen, Ole B., Hjalgrim, Henrik, Erikstrup, Christian, Ullum, Henrik, Thørner, Lise W., Larsen, Margit A.H., Burgdorf, Kristoffer S., Sørensen, Erik, Hansen, Morten B., Ostrowski, Sisse R., von Stemann, Jakob H., Pedersen, Ole B., Hjalgrim, Henrik, Erikstrup, Christian, Ullum, Henrik, Thørner, Lise W., Larsen, Margit A.H., Burgdorf, Kristoffer S., Sørensen, Erik, Hansen, Morten B., and Ostrowski, Sisse R.

Abstract

The presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results were linked to data from the Danish National Prescription Registry. The filing of an antimicrobial prescription following c-aAb measurement was used as a proxy for impaired immunocompetence. We found that c-aAb against pro-inflammatory cytokines IFNα and GM-CSF tended to associate with increased risk of prescription filings in women, whereas antibodies against anti-inflammatory IL-10 were associated with a lower predicted risk of antimicrobial prescriptions, as well as higher self-perceived health scores. We also observed an association of cumulative c-aAb presence with prescription risk. Our data show that cytokine autoantibodies in healthy individuals associate with various proxies for immunomodulation, with the exact association dependent on the pattern of pro- or anti-inflammatory cytokines targeted. This suggests that c-aAb may express cytokine-modulatory properties in healthy individuals and may be critical to further investigate as biomarkers of immunodeficiency.

Published
2020

7. Preoperative TruCulture® whole blood cytokine response predicts post‐operative inflammation in pancreaticoduodenectomy patients—A pilot cohort study

Author

Aasvang, Eske K., primary, Pitter, Sandra, additional, Hansen, Carsten P., additional, Storkholm, Jan H., additional, Krohn, Paul S., additional, Burgdorf, Stefan K., additional, Von Stemann, Jakob H., additional, Lundgren, Jens D., additional, Nielsen, Susanne D., additional, Kehlet, Henrik, additional, and Ostrowski, Sisse R., additional

Published
2020
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9. Cohort Profile: The Danish Blood Donor Study.

Author

Erikstrup C, Sørensen E, Nielsen KR, Bruun MT, Petersen MS, Rostgaard K, Thørner LW, Larsen M, Mikkelsen S, Dinh KM, Schwinn M, Rigas AS, Didriksen M, Dowsett J, von Stemann JH, Brodersen T, Paulsen IW, Hindhede L, Sækmose SG, Kaspersen KA, Boldsen JK, Kjerulff B, Werge T, Brunak S, Banasik K, Hansen TF, Ullum H, Hjalgrim H, Ostrowski SR, and Pedersen OB

Subjects
Humans, Denmark epidemiology, Blood Donors
Published
2023
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