Shading the TRF2 Recruiting Function: A New Horizon in Drug Development.

Authors :: Di Maro, Salvatore
Zizza, Pasquale
Salvati, Erica
De Luca, Viviana
Capasso, Clemente
Fotticchia, Iolanda
Pagano, Bruno
Marinelli, Luciana
Gilson, Eric
Novellino, Ettore
Cosconati, Sandro
Biroccio, Annamaria
Source :: Journal of the American Chemical Society. 12/3/2014, Vol. 136 Issue 48, p16708-16711. 4p.
Publication Year :: 2014
Abstract: The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2TRFH binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance. [ABSTRACT FROM AUTHOR]