Oseltamivir-Resistant Influenza A(H1N1) pdm09 Viruses, United States, 2013-14.

Authors :: Okomo-Adhiambo, Margaret
Fry, Alicia M.
Su, Su
Nguyen, Ha T.
Elal, Anwar Abd
Negron, Elizabeth
Hand, Julie
Garten, Rebecca J.
Barnes, John
Xu Xiyan
Villanueva, Julie M.
Gubareva, Larisa V.
Source :: Emerging Infectious Diseases. Jan2015, Vol. 21 Issue 1, p136-141. 6p. 1 Diagram, 2 Charts, 1 Map.
Publication Year :: 2015
Abstract: The article presents a study on the characteristics of oseltamivir-resistant influenza A (H1N1) pdm09 viruses in the U.S. from 2013 to 2014. The study analyzes 4,968 influenza-positive specimens for virologic surveillance and neuraminidase (NA) inhibition assay for oseltamivir and zanamivir. It is suggested that majority of the patients had H275Y oseltamivir resistance-conferring neuraminidase substitution which calls for local surveillance for neuraminidase inhibitor susceptibility.