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Thermodynamics and preliminary pharmaceutical characterization of a melatonin-pimelic acid cocrystal prepared by a melt crystallization method.
- Source :
-
CrystEngComm . 2015, Vol. 17 Issue 3, p612-620. 9p. - Publication Year :
- 2015
-
Abstract
- Pharmaceutical cocrystals have been extensively investigated as a promising approach to improve drugs' physicochemical properties. Cocrystals are usually prepared using solution-mediated methods and grinding methods. In this study, a cocrystal of pimelic acid with poorly soluble melatonin was produced using a melt crystallization method by controlling the crystallization within a specific temperature range. The cocrystal was characterized by infrared spectroscopy, powder and single crystal X-ray diffraction. The binary phase diagram and the formation enthalpy established by differential scanning calorimetry provided the rationale for this spontaneous cocrystallization system. The cocrystal exhibited higher apparent solubility, a faster dissolution rate and acceptable stability as compared to the original melatonin. The study has shown that the melt crystallization method can be considered as a competitive route for producing pharmaceutical cocrystals with improved properties and the thermodynamic investigation can provide in depth understanding and guidance on the melt crystallization of cocrystals. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERMODYNAMICS
*MELATONIN
*X-ray diffraction
*CRYSTALS
*MELT crystallization
Subjects
Details
- Language :
- English
- ISSN :
- 14668033
- Volume :
- 17
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- CrystEngComm
- Publication Type :
- Academic Journal
- Accession number :
- 100154683
- Full Text :
- https://doi.org/10.1039/c4ce01921k