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A pH-responsive pro drug for real-time drug release monitoring and targeted cancer therapy.

Authors :
Shi-Ying Li
Li-Han Liu
Hui-Zhen Jia
Wen-Xiu Qiu
Lei Rong
Hong Cheng
Xian-Zheng Zhang
Source :
Chemical Communications. 2014, Vol. 50 Issue 80, p11852-11855. 4p.
Publication Year :
2014

Abstract

A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
50
Issue :
80
Database :
Academic Search Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
100188713
Full Text :
https://doi.org/10.1039/c4cc05008h