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Quercetin Inhibits Proliferation and Drug Resistance in KB/VCR Oral Cancer Cells and Enhances Its Sensitivity to Vincristine.
- Source :
-
Nutrition & Cancer . Jan2015, Vol. 67 Issue 1, p126-136. 11p. - Publication Year :
- 2015
-
Abstract
- Quercetin has been confirmed to possess antihistamine, anti-inflammatory, antiviral, immunomodulatory, and antioxidant properties. Herein, we evaluated their antitumor activity in vitro by using KB/VCR oral cancer cells. We found that quercetin at 25 to 100 μmol/L effectively inhibited the migration and invasion of KB/VCR cells. Quercetin at dose ranging from 25 to 100 μmol/L significantly inhibited the growth of the KB/VCR cells and at 50 μmol/L arrested cells at the G1 phase and decreased the amount of cells in the S and G2 phase. Apoptosis analysis showed that quercetin at 50 or 100 μmol/L induced apoptosis of KB/VCR cells by suppressing expression of Bax and inducing the expression of Caspase-3 and Bcl-2. Furthermore, we also confirmed that quercetin from 25 to 100 μmol/L reversed gene-encoded Pglycoprotein (P-gp)-mediated MDR in KB/VCR cells by inhibiting the expression of P-gp. For combination treatment with vincristin (0.375 μmol/L) and quercetin (50 μmol/L), the proliferation rate significantly decreased and apoptosis rate significantly increased. This study provided evidence that quercetin induced apoptosis and reversed drug resistance in oral tumor cells and may be a potential candidate for other tumors treatment. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *FLAVONOIDS
*DNA
*QUERCETIN
*ACADEMIC medical centers
*ANALYSIS of variance
*BIOLOGICAL assay
*CELL culture
*CELL physiology
*DRUG resistance
*FLOW cytometry
*GENE expression
*MOUTH tumors
*NUTRITION
*SERIAL publications
*STATISTICS
*VINCRISTINE
*DATA analysis
*BODY surface area
*IN vitro studies
*PHYSIOLOGY
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 67
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 100207789
- Full Text :
- https://doi.org/10.1080/01635581.2015.965334