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Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression.
- Source :
-
Hepatitis Monthly . Dec2014, Vol. 14 Issue 12, p1-8. 8p. 1 Color Photograph, 3 Charts, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Background: Hepatocellular carcinoma (HCC) is one of the most important health problems in China. Objectives: This study analyzed expression of high-mobility group protein B1 (HMGB1) and inhibitor of apoptosis protein-2 (c-IAP2) proteins in HCC compared to paired para-tumor tissue samples to assess the association with HCC pathogenesis and progression. Materials and Methods: Sixty-eight HCC and para-tumor tissue samples were collected for Western blot, qRT-PCR and immunohistochemical analyses of HMGB1 and c-IAP2. Results: HMGB1 and c-IAP2 proteins were highly expressed in HCC tissue samples [85.3% (58/68) and 82.4% (56/68), respectively] compared to para-tumor tissue samples [32.3% and 27.9%, respectively]. Furthermore, expression of HMGB1 was significantly associated with enhanced c-IAP2 expression in HCC tissue samples (r = 0.878, P < 0.01). Expression of HMGB1 was associated with tumor multiplicity and size, alpha-fetoprotein (AFP) level and advanced TNM stage, while expression of c-IAP2 was associated with tumor size, AFP level and advanced TNM stage. Conclusions: Expression of HMGB1 and c-IAP2 proteins was associated with HCC development and progression, and the expression of HMGB1 and c-IAP2 proteins in HCC were significantly associated with each other. Additionally, these proteins may show promise as biomarkers to predict HCC progression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1735143X
- Volume :
- 14
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Hepatitis Monthly
- Publication Type :
- Academic Journal
- Accession number :
- 100227692
- Full Text :
- https://doi.org/10.5812/hepatmon.23552