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A chiral stationary phase coated by surface molecularly imprinted polymer for separating 1,1′-binaphthalene-2,2′-diamine enantiomer by high performance liquid chromatography.
- Source :
-
Journal of Chromatography A . Jan2015, Vol. 1376, p172-176. 5p. - Publication Year :
- 2015
-
Abstract
- This report describes novel pathway for the development of a new type of CSP. A chiral stationary phase (CSP) prepared by coating a molecularly imprinted polymer (MIP) on the surface of silica gel (SMIP-CSP) showed a high separation factor (3.39) in separating racemic 1,1′-binaphthalene-2,2′-diamine (DABN) by high performance liquid chromatography (HPLC). Being the crosslinking agent, ethylene glycol dimethacrylate (EGDMA) was copolymerized with the monomer, methacrylic acid (MAA), in the presence of ( R )-DABN as the template molecules on the surface of the silica gel particles to produce the SMIP-CSPs. The effects of the pretreatment temperature, the ( R )-DABN content and the type of silica gel and monomer in the SMIP-CSPs on the separation of the racemic DABN were systematically investigated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1376
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 100236656
- Full Text :
- https://doi.org/10.1016/j.chroma.2014.12.009