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Targeting of a Thermosensitive Nanogel Copolymerized With Macromonomer for Cell Uptake and Drug Controlled Release.
- Source :
-
International Journal of Polymeric Materials & Polymeric Biomaterials . 2015, Vol. 64 Issue 8, p400-405. 6p. - Publication Year :
- 2015
-
Abstract
- In this study,N-isopropylacrylamide (NIPAAm), propyl acrylic acid (PAAC), and poly(N-isopropylacrylamide-co-undecylenic acid) acrylamide were introduced to synthesize PNIPAAm-based nanogels (NG). The morphology of NG particles was characterizedviatransmission electron microscopy (TEM). The nanogels exhibited a lower critical solution temperature (LCST) of 34°C and a temperature-induced drug releasein vitro. After conjugation of arginine-glycine-aspartic acid (RGD)–containing peptide (GRGDS), the cellular uptake of doxorubicin (Dox)-loaded nanogel by HeLa cells had been greatly enhanced. The Dox molecules in endocytosed nanogels could be released efficiently at 37°C and subsequently kill tumor cells, suggesting that the nanogel has great potential for targeting delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00914037
- Volume :
- 64
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- International Journal of Polymeric Materials & Polymeric Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 100298854
- Full Text :
- https://doi.org/10.1080/00914037.2014.958827