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The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias.
- Source :
-
Cancer Letters . Feb2015, Vol. 357 Issue 2, p535-541. 7p. - Publication Year :
- 2015
-
Abstract
- We have previously reported that the expression of the CL2/CCDC80 gene is downregulated in human papillary thyroid carcinomas, particularly in follicular variants. We have also reported that the restoration of CL2/CCDC80 expression reverted the malignant phenotype of thyroid carcinoma cell lines and that CL2/CCDC80 positively regulated E-cadherin expression, an ability that likely accounts for the role of the CL2/CCDC80 gene in thyroid cancer progression. In order to validate the tumour suppressor role of the CL2/CCDC80 gene in thyroid carcinogenesis we generated cl2/ccdc80 knock-out mice. We found that embryonic fibroblasts from cl2/ccdc80 −/− mice showed higher proliferation rate and lower susceptibility to apoptosis. Furthermore, cl2/ccdc80 −/− mice developed thyroid adenomas and ovarian carcinomas. Finally, ret/PTC1 transgenic mice crossed with the cl2/ccdc80 knock-out mice developed more aggressive thyroid carcinomas compared with those observed in the single ret/PTC1 transgenic mice. Together, these results indicate CL2/CCDC80 as a putative tumour suppressor gene in human thyroid carcinogenesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THYROID cancer
*LABORATORY mice
*CADHERINS
*CARCINOGENESIS
*EMBRYOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 357
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 100362948
- Full Text :
- https://doi.org/10.1016/j.canlet.2014.12.010