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Regiodivergent heterocyclization: a strategy for the synthesis of substituted pyrroles and furans using α-formyl ketene dithioacetals as common precursors.
- Source :
-
Chemical Communications . 2014, Vol. 50 Issue 15, p1797-1800. 4p. - Publication Year :
- 2014
-
Abstract
- The selective construction of a diverse array of five-membered aromatic heterocycles from common starting materials is an attractive and challenging task. We report here that 5-alkylthio-pyrroles, 4-alkylthiocarbonyl-pyrroles and 2-alkylthio-4-tosyl-furans can be prepared, selectively, in a single operation using the readily available α-formyl ketene dithioacetals as common precursors, through their regiodivergent heterocyclization with α-acidic isocyanides controlled by the choice of suitable catalysts/promoters. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 50
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 100388377
- Full Text :
- https://doi.org/10.1039/c3cc48546c