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Participation of NMDA receptors in the lateral hypothalamus in gastric erosion induced by cold-water restraint.
- Source :
-
Physiology & Behavior . Mar2015, Vol. 140, p209-214. 6p. - Publication Year :
- 2015
-
Abstract
- The present study investigated whether neurons in the lateral hypothalamus (LH) play a role in the occurrence of gastric ulcerations induced by cold-water restraint. The first experiment indicated that bilateral N -methyl- d -aspartate (NMDA) lesions of the LH (20 μg/1 μl per side) reduced the amount of gastric ulceration induced by cold-water restraint. In the second experiment, the NMDA antagonist DL-2-amino-5-phosphonovaleric acid (APV; 2.5 μg/0.5 μl per side) or its vehicle was microinjected bilaterally into the LH prior to the cold-water restraint procedure. APV did not induce gastric ulcerations but reduced the amount of ulceration induced by cold-water restraint. These results indicate that NMDA receptors in the LH play an important role in the occurrence of gastric ulceration induced by cold-water restraint. The participation of the LH and possible neuronal circuitry involved in stress-induced ulceration are discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319384
- Volume :
- 140
- Database :
- Academic Search Index
- Journal :
- Physiology & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 100427589
- Full Text :
- https://doi.org/10.1016/j.physbeh.2014.12.038