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Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO2.
- Source :
-
Adsorption Science & Technology . 2014, Vol. 32 Issue 10, p833-844. 12p. - Publication Year :
- 2014
-
Abstract
- A computer simulation approach was developed to screen functional monomers for the rational design of molecularly imprinted polymers (MIPs). The proposed approach is based on a comparison of the binding energy of complexes, which are formed by the interaction between a template molecule and various functional monomers. According to the results of theoretical calculations, MIPs using thymopentin (TP5) as a template were prepared by a solution polymerization method, in which 2-methylacrylamide, N, N'-methylenebisacrylamide and poly(methylacrylic acid)/SiO2 were used as the functional monomer, cross-linker and support, respectively. Solid-phase extraction experiments were performed, and static and dynamic binding properties of the synthesized MIP (i.e. TP5-MIP) for TP5 were studied. Results show that TP5-MIP exhibits excellent binding affinity and specific selectivity for the template molecule (i.e. TP5). [ABSTRACT FROM AUTHOR]
- Subjects :
- *MACROMOLECULES
*POLYMERS
*DEPOLYMERIZATION
*METHACRYLIC acid
*COMPUTER simulation
Subjects
Details
- Language :
- English
- ISSN :
- 02636174
- Volume :
- 32
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Adsorption Science & Technology
- Publication Type :
- Academic Journal
- Accession number :
- 100517252
- Full Text :
- https://doi.org/10.1260/0263-6174.32.10.833