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U-Bang-Haequi Tang: A Herbal Prescription that Prevents Acute Inflammation through Inhibition of NF-κB-Mediated Inducible Nitric Oxide Synthase.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2014, Vol. 2014, p1-12. 12p. 2 Color Photographs, 2 Charts, 4 Graphs. - Publication Year :
- 2014
-
Abstract
- Since antiquity, medical herbs have been prescribed for both treatment and preventative purposes. Herbal formulas are used to reduce toxicity as well as increase efficacy in traditional Korean medicine. U-bang-haequi tang (UBT) is a herbal prescription containing Arctii fructus and Forsythia suspensa as its main components and has treated many human diseases in traditional Korean medicine. This research investigated the effects of UBT against an acute phase of inflammation. For this, we measured induction of nitric oxide (NO) and related proteins in macrophage cell line stimulated by lipopolysaccharide (LPS). Further, paw swelling was measured in carrageenan-treated rats. Carrageenan significantly induced activation of inflammatory cells and increases in paw volume, whereas oral administration of 0.3 or 1 g/kg/day of UBT inhibited the acute inflammatory response. In RAW264.7 cells, UBT inhibited mRNA and protein expression levels of iNOS. UBT treatment also blocked elevation of NO production, nuclear translocation of NF-κB, phosphorylation of Iκ-Bα induced by LPS. Moreover, UBT treatment significantly blocked the phosphorylation of p38 and c-Jun NH2-terminal kinases by LPS. In conclusion, UBT prevented both acute inflammation in rats as well as LPS-induced NO and iNOS gene expression through inhibition of NF-κB in RAW264.7 cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFLAMMATION prevention
*CHINESE medicine
*ANALYSIS of variance
*ANIMAL experimentation
*COMBINATION drug therapy
*CONFIDENCE intervals
*ENZYME-linked immunosorbent assay
*HERBAL medicine
*HISTOLOGICAL techniques
*IMMUNOBLOTTING
*MICE
*MICROSCOPY
*NITRIC oxide
*POLYMERASE chain reaction
*RATS
*RESEARCH funding
*DESCRIPTIVE statistics
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2014
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 100527886
- Full Text :
- https://doi.org/10.1155/2014/542825