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Treatment of Nonalcoholic Fatty Liver Disease with Total Alkaloids in Rubus aleaefolius Poir through Regulation of Fat Metabolism.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2014, Vol. 2014, p1-7. 7p. 2 Color Photographs, 1 Diagram, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Total alkaloids in Rubus aleaefolius Poir (TARAP) is a folk medicinal herb that has been used clinically in China to treat nonalcoholic fatty liver disease (NAFLD) for many years. However, the mechanism of its anti-NAFLD effect is largely unknown. In this study, we developed a NAFLD rat model by supplying a modified high-fat diet (mHFD) ad libitum for 8 weeks and evaluated the therapeutic effect of TARAP in NAFLD rats as well as the underlying molecular mechanism. We found that TARAP could reduce the serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) levels and increase the serum high-density lipoprotein (HDL-C) level in NAFLD rats. In addition, TARAP treatment reduced expression of fatty acid synthetase (FAS), and acetyl-CoA carboxylase (ACC) and upregulated the expression of carnitine palmitoyltransferase (CPT). Our results suggest that regulation of lipid metabolism may be a mechanism by which TARAP treats NAFLD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPID metabolism
*THERAPEUTICS
*FATTY liver
*LIVER analysis
*ALKALOIDS
*ANALYSIS of variance
*ANIMAL experimentation
*BIOCHEMISTRY
*BIOLOGICAL assay
*BIOPHYSICS
*PHENOMENOLOGY
*RESEARCH methodology
*POLYMERASE chain reaction
*RATS
*RESEARCH funding
*STAINS & staining (Microscopy)
*STATISTICS
*T-test (Statistics)
*DATA analysis
*REVERSE transcriptase polymerase chain reaction
*DATA analysis software
*GENE expression profiling
THERAPEUTIC use of plant extracts
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2014
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 100528045
- Full Text :
- https://doi.org/10.1155/2014/768540