Back to Search
Start Over
Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.
- Source :
-
Trends in Endocrinology & Metabolism . Feb2015, Vol. 26 Issue 2, p75-83. 9p. - Publication Year :
- 2015
-
Abstract
- Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10432760
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Trends in Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 100680561
- Full Text :
- https://doi.org/10.1016/j.tem.2014.11.003