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Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media.
- Source :
-
Acta Oto-Laryngologica . Mar2015, Vol. 135 Issue 3, p217-225. 9p. - Publication Year :
- 2015
-
Abstract
- Conclusion: Additional treatment with clarithromycin (CAM) reduced persistent middle ear inflammation after acute otitis media (AOM) caused by Haemophilus influenzae in children. CAM is a treatment option for persistent inflammation following AOM and to prevent continuing otitis media with effusion. Objective: We conducted a clinical study to evaluate a new method of treatment for persistent inflammation after AOM in children. Methods: H. influenzae-infected children with AOM were treated acutely with antimicrobial agents, after which those still demonstrating effusion of the middle ear cavity received additional treatment with carbocysteine (S-CMC) alone or S-CMC combined with clarithromycin (CAM) for 1 week. The two regimens were compared in terms of clinical effects. Results: After the initial acute treatment, many patients still showed abnormal otoscopic findings. At the completion of additional treatment, there were no significant differences between the two treatment groups. However, 1 week after completion of additional treatment, the prevalence of a diminished light reflex was significantly lower in the CAM + S-CMC group than in the S-CMC group ( p = 0.017). The prevalence of redness of the tympanic membrane also tended to be lower in the combined treatment group than in those receiving a single drug ( p = 0.097). [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYSTEINE
*OTITIS media with effusion
*ACADEMIC medical centers
*ANTI-infective agents
*HAEMOPHILUS diseases
*INFLAMMATION
*OTITIS media
*OTOSCOPY
*PEDIATRICS
*QUESTIONNAIRES
*RESEARCH funding
*TYMPANIC membrane
*PRE-tests & post-tests
*SEVERITY of illness index
*DESCRIPTIVE statistics
*CLARITHROMYCIN
*DISEASE complications
*PREVENTION
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 135
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 100781709
- Full Text :
- https://doi.org/10.3109/00016489.2014.975893