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Do genetic defects of DNA repair relevant proteins alter susceptibility to hypertension? A case–control study in northeastern Han Chinese.
- Source :
-
Clinica Chimica Acta . Feb2015, Vol. 441, p171-175. 5p. - Publication Year :
- 2015
-
Abstract
- The aim of this study was to examine the individual and interactive associations of five non-synonymous variants of four DNA repair relevant genes (XRCC1, XRCC3, hOGG1, NQO1) with hypertension in a large northeastern Han Chinese population. This was a hospital-based study involving 1009 hypertensive patients and 756 normotensive controls. All five variants satisfied the Hardy–Weinberg equilibrium. With a Bonferroni corrected alpha of 0.05/5, significance was only attained in the genotype (P = 0.007) and allele (P = 0.006) distributions of rs25487 in XRCC1 gene between patients and controls, with its mutant allele conferring 29% (95% CI: 1.09–1.53; P = 0.003), 31% (95% CI: 1.05–1.62; P = 0.015) and 66% (95%CI: 1.10–2.52; P = 0.016) increased risks of hypertension under the additive, dominant and recessive models, respectively after adjusting for confounders. The frequency of allele combination C-A-C-G-C (alleles in order of rs1799782, rs25487, rs861539, rs1052133 and rs1800566) was significantly higher in patients than in controls (P = 0.003), while that of C-G-C-C-C was significantly lower (P = 0.001). Interaction analysis failed to identify any suggestive evidence of synergism across five examined variants. Our findings provide evidence for a contributory role of XRCC1 gene rs25487 variant in the development of hypertension, and this variant possibly acted in a recessive pattern. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 441
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 100793830
- Full Text :
- https://doi.org/10.1016/j.cca.2014.12.017