Trifluoroethanol as an efficient reaction media for the synthesis of pyran skeleton through domino Knoevenagel-hetero-Diels-Alder reaction with non-activated alkynes.

Trifluoroethanol as an efficient media for the domino Knoevenagel-hetero-Diels-Alder reaction of O-propargyloxy benzaldehydes as non-activated terminal alkynes with some active methylene compounds has been described. Short reaction time, easy work-up, good to high yields, and mild reaction conditions are advantages of this new media. Graphical Abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]