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Transition Metal Complexes with 1-Adamantoyl Hydrazones - Cytotoxic Copper(II) Complexes of Tri- and Tetradentate Pyridine Chelators Containing an Adamantane Ring System.
- Source :
-
European Journal of Inorganic Chemistry . Feb2015, Vol. 2015 Issue 5, p882-895. 14p. - Publication Year :
- 2015
-
Abstract
- Five pentacoordinate copper(II) complexes with 2-acetylpyridine or di(2-pyridyl) ketone 1-adamantoyl hydrazone ligands (Adpy and Addpy, respectively) of the formulae [CuCl2(Adpy)] ( 1), [Cu2(μ-Cl)2(Adpy-H)2] ( 2), [Cu(NCS)2(Adpy)] ( 3), [Cu2(μ-Cl)2(Addpy-H)2] ( 4), and [Cu2(NCS)2(μ-Addpy-H)2] ( 5) were synthesized and characterized by spectral, electrochemical, and X-ray structural analysis. Flow cytometry and morphological analysis confirmed that the copper(II) complexes 2 and 5 induced accumulation of a sub-G1 phase population, and fluorescence microscopy indicated the presence of large cells in apoptosis. The interaction of the copper(II) complexes with calf thymus DNA (CT-DNA) was monitored by changes in their UV/Vis spectra. The observed intrinsic binding constants for 2 and 5 ( Kb = 1.77 × 106 and 3.58 × 106 M-1, respectively) together with ethidium displacement fluorescence experiments indicate intercalative binding. Complexes 2 and 5 showed nuclease activity against pUC19 plasmid DNA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14341948
- Volume :
- 2015
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 100823920
- Full Text :
- https://doi.org/10.1002/ejic.201403050