New Ansamycin Derivatives Generated by SimultaneousMutasynthesis.

Authors :: Song, Ya Nan
Jiao, Rui Hua
Zhang, Wen Jing
Zhao, Guo Yan
Dou, Huan
Jiang, Rong
Zhang, Ai Hua
Hou, Ya Yi
Bi, Shu Feng
Ge, Hui Ming
Tan, Ren Xiang
Source :: Organic Letters. Feb2015, Vol. 17 Issue 3, p556-559. 4p.
Publication Year :: 2015
Abstract: The conversion from triene- to diene-typedansamycins is clarifiedstep by step in Streptomyces seoulensisIFB-A01.Such an intertype convertibility is adopted to establish for the firsttime the simultaneous mutasynthesis of both types of C17-benzene ansamycins(C17BAs). Three of the newly generated unnatural compounds showedpotent cytotoxicity. [ABSTRACT FROM AUTHOR]