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Adipose tissue content, muscle performance and physical function in obese adults with type 2 diabetes mellitus and peripheral neuropathy.
- Source :
-
Journal of Diabetes & its Complications . 2015, Vol. 29 Issue 2, p250-257. 8p. - Publication Year :
- 2015
-
Abstract
- Aims: To determine leg intermuscular (IMAT) and subcutaneous (SQAT) adipose tissue and their relationships with muscle performance and function in obese adults with and without type 2 diabetes and peripheral neuropathy (T2DMPN). Methods: Seventy-nine age-matched obese adults were studied, 13 T2DM, 54 T2DMPN, and 24 obese controls. Leg fat (%IMAT, %SQAT) volumes were quantified using MRI. Ankle plantar flexion (PF) torque and power were assessed with isokinetic dynamometry. Physical function was assessed with 9-item Physical Performance Test (PPT), 6-minute walk distance, single-limb balance, and time to ascend 10 stairs. One-way ANOVAs determined group differences, and multiple regression predicted PPT score from disease status, % IMAT, and PF power. Results: T2DMPN participants had 37% greater IMAT volumes and 15% lower SQAT volumes than controls (p =.01). T2DMPNand T2DMshowed reduced PF torque and power compared to controls. T2DMPNparticipants had lower PPT score, 6-minute walk, single-limb balance, and stair climbing than controls (all p < .05). %IMAT volume correlated inversely, and %SQAT correlated directly, with PPT. Leg %IMAT and disease status predicted 49% of PPT score. Conclusions: T2DMPN may represent a shift in adipose tissue accumulation from SQAT to IMAT depots, which is inversely associated with muscle performance and physical function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10568727
- Volume :
- 29
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes & its Complications
- Publication Type :
- Academic Journal
- Accession number :
- 101022765
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2014.11.003