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Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.
- Source :
-
Nature Immunology . Mar2015, Vol. 16 Issue 3, p267-275. 9p. 9 Graphs. - Publication Year :
- 2015
-
Abstract
- The quality of the adaptive immune response depends on the differentiation of distinct CD4+ helper T cell subsets, and the magnitude of an immune response is controlled by CD4+Foxp3+ regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated by T helper type 2 (TH2) cells was dependent on the activity of the protein kinase CK2. Genetic ablation of the β-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3+ Treg cell subpopulation that was unable to control the maturation of IRF4+PD-L2+ dendritic cells required for the development of TH2 responses in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 101025250
- Full Text :
- https://doi.org/10.1038/ni.3083