Back to Search
Start Over
Development of an In-labeled dihydropyridine complex for L-type calcium channel imaging.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Mar2015, Vol. 303 Issue 3, p2361-2369. 9p. 1 Color Photograph, 3 Diagrams, 7 Graphs. - Publication Year :
- 2015
-
Abstract
- [In]-DTPA-Amlodipine complex ([In]-DTPA-AMLO) was prepared starting high purity [In]indium chloride and conjugated DTPA-AMLO in 30 min at room temperature in acetate buffer in high radiochemical purity (>99 %, RTLC/HPLC; specific activity: 8-10 GBq/mmol). The log P, stability, biodistribution studies and imaging studies in untreated and amlodipine-pretreated rats were determined. The tracer is mostly washed out through kidneys as expected for a dihydropyridine compound. Blocking studies demonstrated high specific binding of the tracer in calcium channel-rich organs including intestine, heart and colon. SPECT images fully supported above results in normal and treated rats. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 303
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 101091138
- Full Text :
- https://doi.org/10.1007/s10967-014-3656-2