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miR-10a controls glioma migration and invasion through regulating epithelial–mesenchymal transition via EphA8.
- Source :
-
FEBS Letters . Mar2015, Vol. 589 Issue 6, p756-765. 10p. - Publication Year :
- 2015
-
Abstract
- MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 ( EphA8 ). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial–mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/ EphA8 pathway that regulates the progression of glioma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 589
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 101340042
- Full Text :
- https://doi.org/10.1016/j.febslet.2015.02.005