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The dark side of Toll-like receptor signaling.
- Source :
-
OncoImmunology . Mar2014, Vol. 3 Issue 3, pN.PAG-N.PAG. 1p. - Publication Year :
- 2014
-
Abstract
- Radiation therapy is potentially immunogenic yet it rarely generates long-term antitumor effects. We have recently demonstrated that Toll-like receptor 9 (TLR9) jump-starts the signal transduction and activator of transcription 3 (STAT3)-dependent vascularization and regrowth of tumors that recur upon irradiation. We propose that the targeted inhibition of the TLR9/STAT3 signaling axis in myeloid cells can support the efficacy of local radiotherapy and prevent cancer recurrence. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 3
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 101348041
- Full Text :
- https://doi.org/10.4161/onci.27894