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Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via S and cross-coupling reactions.
- Source :
-
Russian Chemical Bulletin . Jun2014, Vol. 63 Issue 6, p1350-1358. 9p. - Publication Year :
- 2014
-
Abstract
- It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (S), S and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)aryl-2-(thio)morpholinopyrimidine and 4,5-di(het)aryl-2-(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis HRv. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 63
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 101421674
- Full Text :
- https://doi.org/10.1007/s11172-014-0602-y